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Demographics of healthcare professionals' knowledge and attitude toward deceased organ donation: Survey of critical care areas in a tertiary hospital.

Foong JW, Ong JS, Oo WL, Hossain MM, Baskaran ND, Haron H, Valappil M, Varadarajan R.

Med J Malaysia. 2019 Apr;74(2):109-115.


Bioinformatic and mutational studies of related toxin-antitoxin pairs in Mycobacterium tuberculosis predict and identify key functional residues.

Tandon H, Sharma A, Wadhwa S, Varadarajan R, Singh R, Srinivasan N, Sandhya S.

J Biol Chem. 2019 Jun 7;294(23):9048-9063. doi: 10.1074/jbc.RA118.006814. Epub 2019 Apr 24.


Facile measurement of protein stability and folding kinetics using a nano differential scanning fluorimeter.

Chattopadhyay G, Varadarajan R.

Protein Sci. 2019 Jun;28(6):1127-1134. doi: 10.1002/pro.3622. Epub 2019 Apr 29.


Are we reaping what we sow? Gender diversity in surgery: a survey of medical students.

Cronin C, Lucas M, McCarthy A, Boland F, Varadarajan R, Premnath N, Gillen P.

Postgrad Med J. 2019 Mar;95(1121):119-124. doi: 10.1136/postgradmedj-2018-136136. Epub 2019 Apr 11.


Molecular Determinants of Temperature-Sensitive Phenotypes.

Tripathi A, Swaroop S, Varadarajan R.

Biochemistry. 2019 Apr 2;58(13):1738-1750. doi: 10.1021/acs.biochem.8b00964. Epub 2019 Mar 15.


HIV-1 vaccination by needle-free oral injection induces strong mucosal immunity and protects against SHIV challenge.

Jones AT, Shen X, Walter KL, LaBranche CC, Wyatt LS, Tomaras GD, Montefiori DC, Moss B, Barouch DH, Clements JD, Kozlowski PA, Varadarajan R, Amara RR.

Nat Commun. 2019 Feb 18;10(1):798. doi: 10.1038/s41467-019-08739-4.


CcdB at pH 4 Forms a Partially Unfolded State with a Dry Core.

Baliga C, Selmke B, Worobiew I, Borbat P, Sarma SP, Trommer WE, Varadarajan R, Aghera N.

Biophys J. 2019 Mar 5;116(5):807-817. doi: 10.1016/j.bpj.2019.01.026. Epub 2019 Feb 1.


Fascetto interacting protein ensures proper cytokinesis and ploidy.

Swider ZT, Ng RK, Varadarajan R, Fagerstrom CJ, Rusan NM.

Mol Biol Cell. 2019 Apr 1;30(8):992-1007. doi: 10.1091/mbc.E18-09-0573. Epub 2019 Feb 6.


Management of Symmetrical Peripheral Gangrene.

Foead AI, Mathialagan A, Varadarajan R, Larvin M.

Indian J Crit Care Med. 2018 Dec;22(12):870-874. doi: 10.4103/ijccm.IJCCM_379_18. Review.


Protein model discrimination attempts using mutational sensitivity, predicted secondary structure, and model quality information.

Khare S, Bhasin M, Sahoo A, Varadarajan R.

Proteins. 2019 Apr;87(4):326-336. doi: 10.1002/prot.25654. Epub 2019 Jan 15.


Bridging centrioles and PCM in proper space and time.

Varadarajan R, Rusan NM.

Essays Biochem. 2018 Dec 7;62(6):793-801. doi: 10.1042/EBC20180036. Print 2018 Dec 7. Review.


Design, display and immunogenicity of HIV1 gp120 fragment immunogens on virus-like particles.

Purwar M, Pokorski JK, Singh P, Bhattacharyya S, Arendt H, DeStefano J, La Branche CC, Montefiori DC, Finn MG, Varadarajan R.

Vaccine. 2018 Oct 8;36(42):6345-6353. doi: 10.1016/j.vaccine.2018.07.032. Epub 2018 Sep 14.


Rv0474 is a copper-responsive transcriptional regulator that negatively regulates expression of RNA polymerase β subunit in Mycobacterium tuberculosis.

Raghunandanan S, Ramachandran R, Gomez RL, Devanarayanan S, Bommakanti A, Kondapi AK, Varadarajan R, Kumar RA.

FEBS J. 2018 Oct;285(20):3849-3869. doi: 10.1111/febs.14637. Epub 2018 Sep 5.


Bacterially expressed HIV-1 gp120 outer-domain fragment immunogens with improved stability and affinity for CD4-binding site neutralizing antibodies.

Rathore U, Purwar M, Vignesh VS, Das R, Kumar AA, Bhattacharyya S, Arendt H, DeStefano J, Wilson A, Parks C, La Branche CC, Montefiori DC, Varadarajan R.

J Biol Chem. 2018 Sep 28;293(39):15002-15020. doi: 10.1074/jbc.RA118.005006. Epub 2018 Aug 9.


Open and Closed Form of Maltose Binding Protein in Its Native and Molten Globule State As Studied by Electron Paramagnetic Resonance Spectroscopy.

Selmke B, Borbat PP, Nickolaus C, Varadarajan R, Freed JH, Trommer WE.

Biochemistry. 2018 Sep 25;57(38):5507-5512. doi: 10.1021/acs.biochem.8b00322. Epub 2018 Sep 13.


Isolation of an in Vitro Affinity-Matured, Thermostable "Headless" HA Stem Fragment That Binds Broadly Neutralizing Antibodies with High Affinity.

Najar TA, Kar U, Flynn JA, Varadarajan R.

Biochemistry. 2018 Jul 3;57(26):3817-3829. doi: 10.1021/acs.biochem.8b00267. Epub 2018 Jun 13.


Rapid Mapping of Protein Binding Sites and Conformational Epitopes by Coupling Yeast Surface Display to Chemical Labeling and Deep Sequencing.

Najar TA, Khare S, Varadarajan R.

Methods Mol Biol. 2018;1785:77-88. doi: 10.1007/978-1-4939-7841-0_6.


Evolution of Neutralization Response in HIV-1 Subtype C-Infected Individuals Exhibiting Broad Cross-Clade Neutralization of HIV-1 Strains.

Cheedarla N, Hemalatha B, Anangi B, Muthuramalingam K, Selvachithiram M, Sathyamurthi P, Kailasam N, Varadarajan R, Swaminathan S, Tripathy SP, Vaniambadi SK, Vadakkupattu DR, Hanna LE.

Front Immunol. 2018 Mar 27;9:618. doi: 10.3389/fimmu.2018.00618. eCollection 2018.


Insights into protein structure, stability and function from saturation mutagenesis.

Gupta K, Varadarajan R.

Curr Opin Struct Biol. 2018 Jun;50:117-125. doi: 10.1016/ Epub 2018 Mar 2. Review.


Protective efficacy of influenza group 2 hemagglutinin stem-fragment immunogen vaccines.

Sutton TC, Chakraborty S, Mallajosyula VVA, Lamirande EW, Ganti K, Bock KW, Moore IN, Varadarajan R, Subbarao K.

NPJ Vaccines. 2017 Dec 15;2:35. doi: 10.1038/s41541-017-0036-2. eCollection 2017.


A centrosomal scaffold shows some self-control.

Varadarajan R, Hammer JA, Rusan NM.

J Biol Chem. 2017 Dec 15;292(50):20410-20411. doi: 10.1074/jbc.H117.806018. Review.


A Trimeric HIV-1 Envelope gp120 Immunogen Induces Potent and Broad Anti-V1V2 Loop Antibodies against HIV-1 in Rabbits and Rhesus Macaques.

Jones AT, Chamcha V, Kesavardhana S, Shen X, Beaumont D, Das R, Wyatt LS, LaBranche CC, Stanfield-Oakley S, Ferrari G, Montefiori DC, Moss B, Tomaras GD, Varadarajan R, Amara RR.

J Virol. 2018 Feb 12;92(5). pii: e01796-17. doi: 10.1128/JVI.01796-17. Print 2018 Mar 1.


Contribution of the Chromosomal ccdAB Operon to Bacterial Drug Tolerance.

Gupta K, Tripathi A, Sahu A, Varadarajan R.

J Bacteriol. 2017 Sep 5;199(19). pii: e00397-17. doi: 10.1128/JB.00397-17. Print 2017 Oct 1.


Glycosylation of the core of the HIV-1 envelope subunit protein gp120 is not required for native trimer formation or viral infectivity.

Rathore U, Saha P, Kesavardhana S, Kumar AA, Datta R, Devanarayanan S, Das R, Mascola JR, Varadarajan R.

J Biol Chem. 2017 Jun 16;292(24):10197-10219. doi: 10.1074/jbc.M117.788919. Epub 2017 Apr 26.


Cross-neutralizing anti-HIV-1 human single chain variable fragments(scFvs) against CD4 binding site and N332 glycan identified from a recombinant phage library.

Khan L, Kumar R, Thiruvengadam R, Parray HA, Makhdoomi MA, Kumar S, Aggarwal H, Mohata M, Hussain AW, Das R, Varadarajan R, Bhattacharya J, Vajpayee M, Murugavel KG, Solomon S, Sinha S, Luthra K.

Sci Rep. 2017 Mar 23;7:45163. doi: 10.1038/srep45163.


Mapping Protein Binding Sites and Conformational Epitopes Using Cysteine Labeling and Yeast Surface Display.

Najar TA, Khare S, Pandey R, Gupta SK, Varadarajan R.

Structure. 2017 Mar 7;25(3):395-406. doi: 10.1016/j.str.2016.12.016. Epub 2017 Jan 26.


Generation and characterisation of monoclonal antibodies specific to avian influenza H7N9 haemagglutinin protein.

Malik A, Mallajosyula V, Mishra NN, Arukha AP, Varadarajan R, Gupta SK.

Indian J Med Microbiol. 2016 Oct-Dec;34(4):489-494. doi: 10.4103/0255-0857.195366.


Structure-based Design of Cyclically Permuted HIV-1 gp120 Trimers That Elicit Neutralizing Antibodies.

Kesavardhana S, Das R, Citron M, Datta R, Ecto L, Srilatha NS, DiStefano D, Swoyer R, Joyce JG, Dutta S, LaBranche CC, Montefiori DC, Flynn JA, Varadarajan R.

J Biol Chem. 2017 Jan 6;292(1):278-291. doi: 10.1074/jbc.M116.725614. Epub 2016 Nov 22.


The Fission Yeast Pre-mRNA-processing Factor 18 (prp18+) Has Intron-specific Splicing Functions with Links to G1-S Cell Cycle Progression.

Vijaykrishna N, Melangath G, Kumar R, Khandelia P, Bawa P, Varadarajan R, Vijayraghavan U.

J Biol Chem. 2016 Dec 30;291(53):27387-27402. doi: 10.1074/jbc.M116.751289. Epub 2016 Nov 15.


Homodimeric Escherichia coli Toxin CcdB (Controller of Cell Division or Death B Protein) Folds via Parallel Pathways.

Baliga C, Varadarajan R, Aghera N.

Biochemistry. 2016 Nov 1;55(43):6019-6031. Epub 2016 Oct 18.


Aid-in-dying practice in Europe and the United States: Legal and ethical perspectives for pharmacy.

Varadarajan R, Freeman RA, Parmar JR.

Res Social Adm Pharm. 2016 Nov - Dec;12(6):1016-1025. doi: 10.1016/j.sapharm.2015.11.008. Epub 2015 Nov 24.


Editorial overview: Engineering and design.

Tawfik DS, Varadarajan R.

Curr Opin Struct Biol. 2016 Aug;39:v-vi. doi: 10.1016/ Epub 2016 Aug 29. No abstract available.


Molecular Determinants of Mutant Phenotypes, Inferred from Saturation Mutagenesis Data.

Tripathi A, Gupta K, Khare S, Jain PC, Patel S, Kumar P, Pulianmackal AJ, Aghera N, Varadarajan R.

Mol Biol Evol. 2016 Nov;33(11):2960-2975. Epub 2016 Aug 25.


Neutralization and Binding Profile of Monoclonal Antibodies Generated Against Influenza A H1N1 Viruses.

Shembekar N, Mallajosyula VV, Malik A, Saini A, Varadarajan R, Gupta SK.

Monoclon Antib Immunodiagn Immunother. 2016 Aug;35(4):191-8. doi: 10.1089/mab.2016.0015. Epub 2016 Jul 27.


A Randomized Trial of Factor VIII and Neutralizing Antibodies in Hemophilia A.

Peyvandi F, Mannucci PM, Garagiola I, El-Beshlawy A, Elalfy M, Ramanan V, Eshghi P, Hanagavadi S, Varadarajan R, Karimi M, Manglani MV, Ross C, Young G, Seth T, Apte S, Nayak DM, Santagostino E, Mancuso ME, Sandoval Gonzalez AC, Mahlangu JN, Bonanad Boix S, Cerqueira M, Ewing NP, Male C, Owaidah T, Soto Arellano V, Kobrinsky NL, Majumdar S, Perez Garrido R, Sachdeva A, Simpson M, Thomas M, Zanon E, Antmen B, Kavakli K, Manco-Johnson MJ, Martinez M, Marzouka E, Mazzucconi MG, Neme D, Palomo Bravo A, Paredes Aguilera R, Prezotti A, Schmitt K, Wicklund BM, Zulfikar B, Rosendaal FR.

N Engl J Med. 2016 May 26;374(21):2054-64. doi: 10.1056/NEJMoa1516437.


Myt1 inhibition of Cyclin A/Cdk1 is essential for fusome integrity and premeiotic centriole engagement in Drosophila spermatocytes.

Varadarajan R, Ayeni J, Jin Z, Homola E, Campbell SD.

Mol Biol Cell. 2016 Jul 1;27(13):2051-63. doi: 10.1091/mbc.E16-02-0104. Epub 2016 May 11.


Rational elicitation of cold-sensitive phenotypes.

Baliga C, Majhi S, Mondal K, Bhattacharjee A, VijayRaghavan K, Varadarajan R.

Proc Natl Acad Sci U S A. 2016 May 3;113(18):E2506-15. doi: 10.1073/pnas.1604190113. Epub 2016 Apr 18.


Effect of Interbody Fusion on the Remaining Discs of the Lumbar Spine in Subjects with Disc Degeneration.

Ryu R, Techy F, Varadarajan R, Amirouche F.

Orthop Surg. 2016 Feb;8(1):27-33. doi: 10.1111/os.12219.


Stalking influenza by vaccination with pre-fusion headless HA mini-stem.

Valkenburg SA, Mallajosyula VV, Li OT, Chin AW, Carnell G, Temperton N, Varadarajan R, Poon LL.

Sci Rep. 2016 Mar 7;6:22666. doi: 10.1038/srep22666.


Residue proximity information and protein model discrimination using saturation-suppressor mutagenesis.

Sahoo A, Khare S, Devanarayanan S, Jain PC, Varadarajan R.

Elife. 2015 Dec 30;4. pii: e09532. doi: 10.7554/eLife.09532.


Generation and Characterization of Monoclonal Antibodies Specific to Avian Influenza H5N1 Hemagglutinin Protein.

Malik A, Mallajosyula VV, Mishra NN, Varadarajan R, Gupta SK.

Monoclon Antib Immunodiagn Immunother. 2015 Dec;34(6):436-41. doi: 10.1089/mab.2015.0047.


Hemagglutinin Sequence Conservation Guided Stem Immunogen Design from Influenza A H3 Subtype.

Mallajosyula VV, Citron M, Ferrara F, Temperton NJ, Liang X, Flynn JA, Varadarajan R.

Front Immunol. 2015 Jun 26;6:329. doi: 10.3389/fimmu.2015.00329. eCollection 2015.


Humanized antibody neutralizing 2009 pandemic H1N1 virus.

Shembekar N, Mallajosyula VV, Chaudhary P, Upadhyay V, Varadarajan R, Gupta SK.

Biotechnol J. 2014 Dec;9(12):1594-603. doi: 10.1002/biot.201400083. Epub 2014 Aug 8.


Influenza hemagglutinin stem-fragment immunogen elicits broadly neutralizing antibodies and confers heterologous protection.

Mallajosyula VV, Citron M, Ferrara F, Lu X, Callahan C, Heidecker GJ, Sarma SP, Flynn JA, Temperton NJ, Liang X, Varadarajan R.

Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):E2514-23. doi: 10.1073/pnas.1402766111. Epub 2014 Jun 9.


Stabilizing the native trimer of HIV-1 Env by destabilizing the heterodimeric interface of the gp41 postfusion six-helix bundle.

Kesavardhana S, Varadarajan R.

J Virol. 2014 Sep 1;88(17):9590-604. doi: 10.1128/JVI.00494-14. Epub 2014 Jun 11.


Immunogen design for HIV-1 and influenza.

Rathore U, Kesavardhana S, Mallajosyula VV, Varadarajan R.

Biochim Biophys Acta. 2014 Nov;1844(11):1891-1906. doi: 10.1016/j.bbapap.2014.05.010. Epub 2014 Jun 2. Review.


TSpred: a web server for the rational design of temperature-sensitive mutants.

Tan KP, Khare S, Varadarajan R, Madhusudhan MS.

Nucleic Acids Res. 2014 Jul;42(Web Server issue):W277-84. doi: 10.1093/nar/gku319. Epub 2014 Apr 29.


Residue specific contributions to stability and activity inferred from saturation mutagenesis and deep sequencing.

Tripathi A, Varadarajan R.

Curr Opin Struct Biol. 2014 Feb;24:63-71. doi: 10.1016/ Epub 2014 Jan 7. Review.


MazF-induced growth inhibition and persister generation in Escherichia coli.

Tripathi A, Dewan PC, Siddique SA, Varadarajan R.

J Biol Chem. 2014 Feb 14;289(7):4191-205. doi: 10.1074/jbc.M113.510511. Epub 2013 Dec 27.

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