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Items: 46


CAR T-cells that target acute B-lineage leukemia irrespective of CD19 expression.

Fousek K, Watanabe J, Joseph SK, George A, An X, Byrd TT, Morris JS, Luong A, Martínez-Paniagua MA, Sanber K, Navai SA, Gad AZ, Salsman VS, Mathew PR, Kim HN, Wagner DL, Brunetti L, Jang A, Baker ML, Varadarajan N, Hegde M, Kim YM, Heisterkamp N, Abdel-Azim H, Ahmed N.

Leukemia. 2020 Mar 24. doi: 10.1038/s41375-020-0792-2. [Epub ahead of print]


Engineered ChymotrypsiN for Mass Spectrometry-Based Detection of Protein Glycosylation.

Ramesh B, Abnouf S, Mali S, Moree WJ, Patil U, Bark SJ, Varadarajan N.

ACS Chem Biol. 2019 Dec 20;14(12):2616-2628. doi: 10.1021/acschembio.9b00506. Epub 2019 Nov 25.


Phasetime: Deep Learning Approach to Detect Nuclei in Time Lapse Phase Images.

Yuan P, Rezvan A, Li X, Varadarajan N, Van Nguyen H.

J Clin Med. 2019 Aug 2;8(8). pii: E1159. doi: 10.3390/jcm8081159.


Elucidating the molecular circuitry of autoimmunity.

Varadarajan N, Mohan C.

Nat Immunol. 2019 Jul;20(7):777-778. doi: 10.1038/s41590-019-0436-8. No abstract available.


Targeting the Interplay between Epithelial-to-Mesenchymal-Transition and the Immune System for Effective Immunotherapy.

Soundararajan R, Fradette JJ, Konen JM, Moulder S, Zhang X, Gibbons DL, Varadarajan N, Wistuba II, Tripathy D, Bernatchez C, Byers LA, Chang JT, Contreras A, Lim B, Parra ER, Roarty EB, Wang J, Yang F, Barton M, Rosen JM, Mani SA.

Cancers (Basel). 2019 May 24;11(5). pii: E714. doi: 10.3390/cancers11050714. Review.


Automated Classification of Apoptosis in Phase Contrast Microscopy Using Capsule Network.

Mobiny A, Lu H, Nguyen HV, Roysam B, Varadarajan N.

IEEE Trans Med Imaging. 2020 Jan;39(1):1-10. doi: 10.1109/TMI.2019.2918181. Epub 2019 May 22.


A microfluidic assay for the quantification of the metastatic propensity of breast cancer specimens.

Yankaskas CL, Thompson KN, Paul CD, Vitolo MI, Mistriotis P, Mahendra A, Bajpai VK, Shea DJ, Manto KM, Chai AC, Varadarajan N, Kontrogianni-Konstantopoulos A, Martin SS, Konstantopoulos K.

Nat Biomed Eng. 2019 Jun;3(6):452-465. doi: 10.1038/s41551-019-0400-9. Epub 2019 May 6.


Beyond Autoantibodies: Biologic Roles of Human Autoreactive B Cells in Rheumatoid Arthritis Revealed by RNA-Sequencing.

Mahendra A, Yang X, Abnouf S, Adolacion JRT, Park D, Soomro S, Roszik J, Coarfa C, Romain G, Wanzeck K, Bridges SL Jr, Aggarwal A, Qiu P, Agarwal SK, Mohan C, Varadarajan N.

Arthritis Rheumatol. 2019 Apr;71(4):529-541. doi: 10.1002/art.40772. Epub 2019 Feb 23.


TIMING 2.0: high-throughput single-cell profiling of dynamic cell-cell interactions by time-lapse imaging microscopy in nanowell grids.

Lu H, Li J, Martinez-Paniagua MA, Bandey IN, Amritkar A, Singh H, Mayerich D, Varadarajan N, Roysam B.

Bioinformatics. 2019 Feb 15;35(4):706-708. doi: 10.1093/bioinformatics/bty676.


Defining potency of CAR+ T cells: Fast and furious or slow and steady.

Liadi I, Singh H, Romain G, Roysam B, Cooper LJ, Varadarajan N.

Oncoimmunology. 2018 May 7;8(10):e1051298. doi: 10.1080/2162402X.2015.1051298. eCollection 2019.


Single-cell technologies for profiling T cells to enable monitoring of immunotherapies.

An X, Varadarajan N.

Curr Opin Chem Eng. 2018 Mar;19:142-152. doi: 10.1016/j.coche.2018.01.003. Epub 2018 Mar 6.


Corrigendum: IgG Fc domains that bind C1q but not effector Fcγ receptors delineate the importance of complement-mediated effector functions.

Lee CH, Romain G, Yan W, Watanabe M, Charab W, Todorova B, Lee J, Triplett K, Donkor M, Lungu OI, Lux A, Marshall N, Lindorfer MA, Goff OR, Balbino B, Kang TH, Tanno H, Delidakis G, Alford C, Taylor RP, Nimmerjahn F, Varadarajan N, Bruhns P, Zhang YJ, Georgiou G.

Nat Immunol. 2017 Sep 19;18(10):1173. doi: 10.1038/ni1017-1173c. No abstract available.


Single-cell profiling of dynamic cytokine secretion and the phenotype of immune cells.

An X, Sendra VG, Liadi I, Ramesh B, Romain G, Haymaker C, Martinez-Paniagua M, Lu Y, Radvanyi LG, Roysam B, Varadarajan N.

PLoS One. 2017 Aug 24;12(8):e0181904. doi: 10.1371/journal.pone.0181904. eCollection 2017.


Multifaceted Role of BTLA in the Control of CD8+ T-cell Fate after Antigen Encounter.

Ritthipichai K, Haymaker CL, Martinez M, Aschenbrenner A, Yi X, Zhang M, Kale C, Vence LM, Roszik J, Hailemichael Y, Overwijk WW, Varadarajan N, Nurieva R, Radvanyi LG, Hwu P, Bernatchez C.

Clin Cancer Res. 2017 Oct 15;23(20):6151-6164. doi: 10.1158/1078-0432.CCR-16-1217. Epub 2017 Jul 28.


Unmassked: Single-Cell Profiling of Immune Cell Populations in Tumors.

Varadarajan N.

Mol Ther. 2017 Aug 2;25(8):1745-1747. doi: 10.1016/j.ymthe.2017.06.024. Epub 2017 Jul 4. No abstract available.


IgG Fc domains that bind C1q but not effector Fcγ receptors delineate the importance of complement-mediated effector functions.

Lee CH, Romain G, Yan W, Watanabe M, Charab W, Todorova B, Lee J, Triplett K, Donkor M, Lungu OI, Lux A, Marshall N, Lindorfer MA, Goff OR, Balbino B, Kang TH, Tanno H, Delidakis G, Alford C, Taylor RP, Nimmerjahn F, Varadarajan N, Bruhns P, Zhang YJ, Georgiou G.

Nat Immunol. 2017 Aug;18(8):889-898. doi: 10.1038/ni.3770. Epub 2017 Jun 12. Erratum in: Nat Immunol. 2017 Sep 19;18(10 ):1173.


Constitutive Lck Activity Drives Sensitivity Differences between CD8+ Memory T Cell Subsets.

Moogk D, Zhong S, Yu Z, Liadi I, Rittase W, Fang V, Dougherty J, Perez-Garcia A, Osman I, Zhu C, Varadarajan N, Restifo NP, Frey AB, Krogsgaard M.

J Immunol. 2016 Jul 15;197(2):644-54. doi: 10.4049/jimmunol.1600178. Epub 2016 Jun 6.


Generation of Catalytic Antibodies Is an Intrinsic Property of an Individual's Immune System: A Study on a Large Cohort of Renal Transplant Patients.

Mahendra A, Peyron I, Thaunat O, Dollinger C, Gilardin L, Sharma M, Wootla B, Rao DN, Padiolleau-Lefevre S, Boquet D, More A, Varadarajan N, Kaveri SV, Legendre C, Lacroix-Desmazes S.

J Immunol. 2016 May 15;196(10):4075-81. doi: 10.4049/jimmunol.1403005. Epub 2016 Apr 11.


FLT3 Inhibitor-Associated Neutrophilic Dermatoses.

Varadarajan N, Boni A, Elder DE, Bagg A, Micheletti R, Perl AE, Rosenbach M.

JAMA Dermatol. 2016 Apr;152(4):480-2. doi: 10.1001/jamadermatol.2015.6121. No abstract available.


Automated profiling of individual cell-cell interactions from high-throughput time-lapse imaging microscopy in nanowell grids (TIMING).

Merouane A, Rey-Villamizar N, Lu Y, Liadi I, Romain G, Lu J, Singh H, Cooper LJ, Varadarajan N, Roysam B.

Bioinformatics. 2015 Oct 1;31(19):3189-97. doi: 10.1093/bioinformatics/btv355. Epub 2015 Jun 9.


Individual Motile CD4(+) T Cells Can Participate in Efficient Multikilling through Conjugation to Multiple Tumor Cells.

Liadi I, Singh H, Romain G, Rey-Villamizar N, Merouane A, Adolacion JR, Kebriaei P, Huls H, Qiu P, Roysam B, Cooper LJ, Varadarajan N.

Cancer Immunol Res. 2015 May;3(5):473-82. doi: 10.1158/2326-6066.CIR-14-0195. Epub 2015 Feb 24.


Plasmodium berghei glycine cleavage system T-protein is non-essential for parasite survival in vertebrate and invertebrate hosts.

Varadarajan NM, Sundaram B, Subramani PA, Kalappa DM, Ghosh SK, Nagaraj VA.

Mol Biochem Parasitol. 2014 Oct;197(1-2):50-5. doi: 10.1016/j.molbiopara.2014.10.003. Epub 2014 Oct 24.


Antibody Fc engineering improves frequency and promotes kinetic boosting of serial killing mediated by NK cells.

Romain G, Senyukov V, Rey-Villamizar N, Merouane A, Kelton W, Liadi I, Mahendra A, Charab W, Georgiou G, Roysam B, Lee DA, Varadarajan N.

Blood. 2014 Nov 20;124(22):3241-9. doi: 10.1182/blood-2014-04-569061. Epub 2014 Sep 16.


Purification of a recombinant histidine-tagged lactate dehydrogenase from the malaria parasite, Plasmodium vivax, and characterization of its properties.

Sundaram B, Varadarajan NM, Subramani PA, Ghosh SK, Nagaraj VA.

Biotechnol Lett. 2014 Dec;36(12):2473-80. doi: 10.1007/s10529-014-1622-2. Epub 2014 Jul 22.


Profiling human antibody responses by integrated single-cell analysis.

Ogunniyi AO, Thomas BA, Politano TJ, Varadarajan N, Landais E, Poignard P, Walker BD, Kwon DS, Love JC.

Vaccine. 2014 May 19;32(24):2866-73. doi: 10.1016/j.vaccine.2014.02.020. Epub 2014 Mar 3.


Functional enrichment by direct plasmid recovery after fluorescence activated cell sorting.

Ramesh B, Frei CS, Cirino PC, Varadarajan N.

Biotechniques. 2015 Sep 1;59(3):157-61. doi: 10.2144/000114329. eCollection 2015 Sep.


Malaria parasite-synthesized heme is essential in the mosquito and liver stages and complements host heme in the blood stages of infection.

Nagaraj VA, Sundaram B, Varadarajan NM, Subramani PA, Kalappa DM, Ghosh SK, Padmanaban G.

PLoS Pathog. 2013;9(8):e1003522. doi: 10.1371/journal.ppat.1003522. Epub 2013 Aug 1.


Gastroenterologists inconsistently advise against tobacco use in inflammatory bowel disease patients.

Davis J, Prakash P, Varadarajan N, Reich J, Borum ML.

Inflamm Bowel Dis. 2013 Sep;19(10):E83-4. doi: 10.1097/MIB.0b013e31829f03be. No abstract available.


Are inflammatory bowel disease patients undergoing surveillance colonoscopies at the recommended time?

Davis J, Varadarajan N, Reich J, Prakash P, Borum ML.

Inflamm Bowel Dis. 2013 Sep;19(10):E82-3. doi: 10.1097/MIB.0b013e31829ed8e9. No abstract available.


Detection and isolation of auto-reactive human antibodies from primary B cells.

Sendra VG, Lie A, Romain G, Agarwal SK, Varadarajan N.

Methods. 2013 Dec 1;64(2):153-9. doi: 10.1016/j.ymeth.2013.06.018. Epub 2013 Jun 26.


Quantitative high-throughput single-cell cytotoxicity assay for T cells.

Liadi I, Roszik J, Romain G, Cooper LJ, Varadarajan N.

J Vis Exp. 2013 Feb 2;(72):e50058. doi: 10.3791/50058.


High-throughput sequencing of the paired human immunoglobulin heavy and light chain repertoire.

DeKosky BJ, Ippolito GC, Deschner RP, Lavinder JJ, Wine Y, Rawlings BM, Varadarajan N, Giesecke C, Dörner T, Andrews SF, Wilson PC, Hunicke-Smith SP, Willson CG, Ellington AD, Georgiou G.

Nat Biotechnol. 2013 Feb;31(2):166-9. doi: 10.1038/nbt.2492. Epub 2013 Jan 20.


Single-cell characterization of autotransporter-mediated Escherichia coli surface display of disulfide bond-containing proteins.

Ramesh B, Sendra VG, Cirino PC, Varadarajan N.

J Biol Chem. 2012 Nov 9;287(46):38580-9. doi: 10.1074/jbc.M112.388199. Epub 2012 Sep 27.


Multi-copy genes that enhance the yield of mammalian G protein-coupled receptors in Escherichia coli.

Skretas G, Makino T, Varadarajan N, Pogson M, Georgiou G.

Metab Eng. 2012 Sep;14(5):591-602. doi: 10.1016/j.ymben.2012.05.001. Epub 2012 May 17.


Rapid, efficient functional characterization and recovery of HIV-specific human CD8+ T cells using microengraving.

Varadarajan N, Kwon DS, Law KM, Ogunniyi AO, Anahtar MN, Richter JM, Walker BD, Love JC.

Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3885-90. doi: 10.1073/pnas.1111205109. Epub 2012 Feb 21.


A high-throughput single-cell analysis of human CD8⁺ T cell functions reveals discordance for cytokine secretion and cytolysis.

Varadarajan N, Julg B, Yamanaka YJ, Chen H, Ogunniyi AO, McAndrew E, Porter LC, Piechocka-Trocha A, Hill BJ, Douek DC, Pereyra F, Walker BD, Love JC.

J Clin Invest. 2011 Nov;121(11):4322-31. doi: 10.1172/JCI58653. Epub 2011 Oct 3.


Assessment of groundwater quality in Ghataprabha command area, Karnataka, India.

Varadarajan N, Purandara BK, Kumar B.

J Environ Sci Eng. 2011 Jul;53(3):341-8.


Surface water quality evaluation and modeling of Ghataprabha River, Karnataka, India.

Purandara BK, Varadarajan N, Venkatesh B, Choubey VK.

Environ Monit Assess. 2012 Mar;184(3):1371-8. doi: 10.1007/s10661-011-2047-1. Epub 2011 Apr 15.


Proteases that can distinguish among different post-translational forms of tyrosine engineered using multicolor flow cytometry.

Varadarajan N, Pogson M, Georgiou G, Iverson BL.

J Am Chem Soc. 2009 Dec 23;131(50):18186-90. doi: 10.1021/ja907803k.


Construction and flow cytometric screening of targeted enzyme libraries.

Varadarajan N, Cantor JR, Georgiou G, Iverson BL.

Nat Protoc. 2009;4(6):893-901. doi: 10.1038/nprot.2009.60. Epub 2009 May 21.


Fluoride contamination in ground water of Malaprabha sub basin.

Varadarajan N, Purandara BK.

J Environ Sci Eng. 2008 Apr;50(2):121-6.


An engineered protease that cleaves specifically after sulfated tyrosine.

Varadarajan N, Georgiou G, Iverson BL.

Angew Chem Int Ed Engl. 2008;47(41):7861-3. doi: 10.1002/anie.200800736. No abstract available.


Highly active and selective endopeptidases with programmed substrate specificities.

Varadarajan N, Rodriguez S, Hwang BY, Georgiou G, Iverson BL.

Nat Chem Biol. 2008 May;4(5):290-4. doi: 10.1038/nchembio.80.


Substrate specificity of the Escherichia coli outer membrane protease OmpP.

Hwang BY, Varadarajan N, Li H, Rodriguez S, Iverson BL, Georgiou G.

J Bacteriol. 2007 Jan;189(2):522-30. Epub 2006 Nov 3.


Engineering of protease variants exhibiting high catalytic activity and exquisite substrate selectivity.

Varadarajan N, Gam J, Olsen MJ, Georgiou G, Iverson BL.

Proc Natl Acad Sci U S A. 2005 May 10;102(19):6855-60. Epub 2005 May 2.


Spectrophotometric determination of uranium using ascorbic acid as a chromogenic reagent.

Gupta KK, Kulkarni PG, Thomas G, Varadarajan N, Singh RK, Nair MK.

Talanta. 1993 Apr;40(4):507-10.


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