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Items: 6


The strange case of AMPK and cancer: Dr Jekyll or Mr Hyde? .

Vara-Ciruelos D, Russell FM, Hardie DG.

Open Biol. 2019 Jul 26;9(7):190099. doi: 10.1098/rsob.190099. Epub 2019 Jul 10.


Phenformin, But Not Metformin, Delays Development of T Cell Acute Lymphoblastic Leukemia/Lymphoma via Cell-Autonomous AMPK Activation.

Vara-Ciruelos D, Dandapani M, Russell FM, Grzes KM, Atrih A, Foretz M, Viollet B, Lamont DJ, Cantrell DA, Hardie DG.

Cell Rep. 2019 Apr 16;27(3):690-698.e4. doi: 10.1016/j.celrep.2019.03.067.


Targeting AMP-activated kinase impacts hepatocellular cancer stem cells induced by long-term treatment with sorafenib.

Bort A, Sánchez BG, Mateos-Gómez PA, Vara-Ciruelos D, Rodríguez-Henche N, Díaz-Laviada I.

Mol Oncol. 2019 May;13(5):1311-1331. doi: 10.1002/1878-0261.12488. Epub 2019 Apr 15.


Genotoxic Damage Activates the AMPK-α1 Isoform in the Nucleus via Ca2+/CaMKK2 Signaling to Enhance Tumor Cell Survival.

Vara-Ciruelos D, Dandapani M, Gray A, Egbani EO, Evans AM, Hardie DG.

Mol Cancer Res. 2018 Feb;16(2):345-357. doi: 10.1158/1541-7786.MCR-17-0323. Epub 2017 Nov 13.


Up-Regulated Expression of LAMP2 and Autophagy Activity during Neuroendocrine Differentiation of Prostate Cancer LNCaP Cells.

Morell C, Bort A, Vara-Ciruelos D, Ramos-Torres Á, Altamirano-Dimas M, Díaz-Laviada I, Rodríguez-Henche N.

PLoS One. 2016 Sep 14;11(9):e0162977. doi: 10.1371/journal.pone.0162977. eCollection 2016.


AMPK Causes Cell Cycle Arrest in LKB1-Deficient Cells via Activation of CAMKK2.

Fogarty S, Ross FA, Vara Ciruelos D, Gray A, Gowans GJ, Hardie DG.

Mol Cancer Res. 2016 Aug;14(8):683-95. doi: 10.1158/1541-7786.MCR-15-0479. Epub 2016 May 2.

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