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Items: 1 to 50 of 439

1.

Age-related changes in the local intestinal renin-angiotensin system in normotensive and spontaneously hypertensive rats.

Pasanen L, Launonen H, Siltari A, Korpela R, Vapaatalo H, Salmenkari H, Forsgard RA.

J Physiol Pharmacol. 2019 Apr;70(2). doi: 10.26402/jpp.2019.2.03. Epub 2019 Jul 22.

2.

Beneficial anti-inflammatory effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker in the treatment of dextran sulfate sodium-induced colitis in mice.

Salmenkari H, Pasanen L, Linden J, Korpela R, Vapaatalo H.

J Physiol Pharmacol. 2018 Aug;69(4). doi: 10.26402/jpp.2018.4.07. Epub 2018 Nov 7.

3.

A Single Drop in the Eye - Effects on the Whole Body?

Vaajanen A, Vapaatalo H.

Open Ophthalmol J. 2017 Oct 31;11:305-314. doi: 10.2174/1874364101711010305. eCollection 2017.

4.
6.

Many Faces of Renin-angiotensin System - Focus on Eye.

Holappa M, Vapaatalo H, Vaajanen A.

Open Ophthalmol J. 2017 Jun 19;11:122-142. doi: 10.2174/1874364101711010122. eCollection 2017. Review.

7.

Vascular Calcification, Vitamin K and Warfarin Therapy - Possible or Plausible Connection?

Siltari A, Vapaatalo H.

Basic Clin Pharmacol Toxicol. 2018 Jan;122(1):19-24. doi: 10.1111/bcpt.12834. Epub 2017 Jul 17. Review.

8.

Bradykinin -induced vasodilatation: Role of age, ACE1-inhibitory peptide, mas- and bradykinin receptors.

Siltari A, Korpela R, Vapaatalo H.

Peptides. 2016 Nov;85:46-55. doi: 10.1016/j.peptides.2016.09.001. Epub 2016 Sep 11.

PMID:
27628189
9.

Can Vascular Calcification be Associated with Warfarin Treatment?

Siltari A, Helin T, Wickholm N, Lassila R, Korpela R, Kautiainen H, Vapaatalo H.

Clin Ther. 2016 Oct 6;38(10S):e25. doi: 10.1016/j.clinthera.2016.07.146. No abstract available.

PMID:
27673645
10.

Local corticosterone production and angiotensin-I converting enzyme shedding in a mouse model of intestinal inflammation.

Salmenkari H, Issakainen T, Vapaatalo H, Korpela R.

World J Gastroenterol. 2015 Sep 21;21(35):10072-9. doi: 10.3748/wjg.v21.i35.10072.

11.

Effect of fermented milk product containing lactotripeptides and plant sterol esters on haemodynamics in subjects with the metabolic syndrome--a randomised, double-blind, placebo-controlled study.

Hautaniemi EJ, Tikkakoski AJ, Tahvanainen A, Nordhausen K, Kähönen M, Mattsson T, Luhtala S, Turpeinen AM, Niemelä O, Vapaatalo H, Korpela R, Pörsti IH.

Br J Nutr. 2015 Aug 14;114(3):376-86. doi: 10.1017/S0007114515002032. Epub 2015 Jul 14.

PMID:
26168857
12.

The expression of Mas-receptor of the renin-angiotensin system in the human eye.

Vaajanen A, Kalesnykas G, Vapaatalo H, Uusitalo H.

Graefes Arch Clin Exp Ophthalmol. 2015 Jul;253(7):1053-9. doi: 10.1007/s00417-015-2952-z. Epub 2015 Feb 14.

13.

[Renin-angiotensin system (RAS) in the bowel].

Savinen A, Vapaatalo H.

Duodecim. 2014;130(20):2086-91. Review. Finnish.

PMID:
25558606
14.

Does the cis/trans configuration of peptide bonds in bioactive tripeptides play a role in ACE-1 enzyme inhibition?

Siltari A, Viitanen R, Kukkurainen S, Vapaatalo H, Valjakka J.

Biologics. 2014 Feb 11;8:59-65. doi: 10.2147/BTT.S54056. eCollection 2014.

15.

Low serum enterolactone concentration is associated with low colonic Lactobacillus-Enterococcus counts in men but is not affected by a synbiotic mixture in a randomised, placebo-controlled, double-blind, cross-over intervention study.

Holma R, Kekkonen RA, Hatakka K, Poussa T, Vapaatalo H, Adlercreutz H, Korpela R.

Br J Nutr. 2014 Jan 28;111(2):301-9. doi: 10.1017/S0007114513002420. Epub 2013 Aug 7.

PMID:
23919920
16.

Antihypertensive effects of bioactive tripeptides-a random effects meta-analysis.

Turpeinen AM, Järvenpää S, Kautiainen H, Korpela R, Vapaatalo H.

Ann Med. 2013 Feb;45(1):51-6. doi: 10.3109/07853890.2012.663926. Epub 2012 Mar 9. Review.

PMID:
23305234
17.

Effects of milk casein derived tripeptides on endothelial enzymes in vitro; a study with synthetic tripeptides.

Siltari A, Kivimäki AS, Ehlers PI, Korpela R, Vapaatalo H.

Arzneimittelforschung. 2012 Oct;62(10):477-81. doi: 10.1055/s-0032-1321846. Epub 2012 Aug 23.

PMID:
22918858
18.

Effects of long-term intake of lactotripeptides on cardiovascular risk factors in hypertensive subjects.

Jauhiainen T, Niittynen L, Orešič M, Järvenpää S, Hiltunen TP, Rönnback M, Vapaatalo H, Korpela R.

Eur J Clin Nutr. 2012 Jul;66(7):843-9. doi: 10.1038/ejcn.2012.44. Epub 2012 May 23.

PMID:
22617279
19.

Plant sterols and casein-derived tripeptides attenuate blood pressure increase in spontaneously hypertensive rats.

Ehlers PI, Kivimäki AS, Siltari A, Turpeinen AM, Korpela R, Vapaatalo H.

Nutr Res. 2012 Apr;32(4):292-300. doi: 10.1016/j.nutres.2012.03.004. Epub 2012 May 2.

PMID:
22575043
20.

Flavonoids eupatorin and sinensetin present in Orthosiphon stamineus leaves inhibit inflammatory gene expression and STAT1 activation.

Laavola M, Nieminen R, Yam MF, Sadikun A, Asmawi MZ, Basir R, Welling J, Vapaatalo H, Korhonen R, Moilanen E.

Planta Med. 2012 May;78(8):779-86. doi: 10.1055/s-0031-1298458. Epub 2012 Apr 19.

PMID:
22516932
21.

A spread containing bioactive milk peptides Ile-Pro-Pro and Val-Pro-Pro, and plant sterols has antihypertensive and cholesterol-lowering effects.

Turpeinen AM, Ikonen M, Kivimäki AS, Kautiainen H, Vapaatalo H, Korpela R.

Food Funct. 2012 Jun;3(6):621-7. doi: 10.1039/c2fo10286b.

PMID:
22398753
22.

Downregulation of Bradykinin type 2 receptor expression in cardiac endothelial cells during senescence.

Nurmi L, Heikkilä HM, Vapaatalo H, Kovanen PT, Lindstedt KA.

J Vasc Res. 2012;49(1):13-23. doi: 10.1159/000329615. Epub 2011 Oct 4.

23.

High blood pressure-lowering and vasoprotective effects of milk products in experimental hypertension.

Ehlers PI, Kivimäki AS, Turpeinen AM, Korpela R, Vapaatalo H.

Br J Nutr. 2011 Nov;106(9):1353-63. doi: 10.1017/S0007114511001723. Epub 2011 May 10.

PMID:
21736845
24.

Ile-Pro-Pro and Val-Pro-Pro tripeptide-containing milk product has acute blood pressure lowering effects in mildly hypertensive subjects.

Turpeinen AM, Ehlers PI, Kivimäki AS, Järvenpää S, Filler I, Wiegert E, Jähnchen E, Vapaatalo H, Korpela R, Wagner F.

Clin Exp Hypertens. 2011;33(6):388-96. doi: 10.3109/10641963.2010.549267. Epub 2011 Jun 7.

PMID:
21649532
25.

Local ocular renin-angiotensin system - a target for glaucoma therapy?

Vaajanen A, Vapaatalo H.

Basic Clin Pharmacol Toxicol. 2011 Oct;109(4):217-24. doi: 10.1111/j.1742-7843.2011.00729.x. Epub 2011 Jul 28. Review.

26.

Metabolism of ophthalmic timolol: new aspects of an old drug.

Volotinen M, Hakkola J, Pelkonen O, Vapaatalo H, Mäenpää J.

Basic Clin Pharmacol Toxicol. 2011 May;108(5):297-303. doi: 10.1111/j.1742-7843.2011.00694.x. Review.

27.

Effects of flavonoids on prostaglandin E2 production and on COX-2 and mPGES-1 expressions in activated macrophages.

Hämäläinen M, Nieminen R, Asmawi MZ, Vuorela P, Vapaatalo H, Moilanen E.

Planta Med. 2011 Sep;77(13):1504-11. doi: 10.1055/s-0030-1270762. Epub 2011 Feb 21.

PMID:
21341175
28.

Persistence of probiotic strains in the gastrointestinal tract when administered as capsules, yoghurt, or cheese.

Saxelin M, Lassig A, Karjalainen H, Tynkkynen S, Surakka A, Vapaatalo H, Järvenpää S, Korpela R, Mutanen M, Hatakka K.

Int J Food Microbiol. 2010 Dec 15;144(2):293-300. doi: 10.1016/j.ijfoodmicro.2010.10.009. Epub 2010 Oct 21.

PMID:
21074284
29.

Casein-derived tripeptide Ile-Pro-Pro improves angiotensin-(1-7)- and bradykinin-induced rat mesenteric artery relaxation.

Ehlers PI, Nurmi L, Turpeinen AM, Korpela R, Vapaatalo H.

Life Sci. 2011 Jan 31;88(5-6):206-11. doi: 10.1016/j.lfs.2010.11.001. Epub 2010 Nov 4.

PMID:
21056585
30.

Milk Products Containing Bioactive Tripeptides Have an Antihypertensive Effect in Double Transgenic Rats (dTGR) Harbouring Human Renin and Human Angiotensinogen Genes.

Jauhiainen T, Pilvi T, Cheng ZJ, Kautiainen H, Müller DN, Vapaatalo H, Korpela R, Mervaala E.

J Nutr Metab. 2010;2010. pii: 287030. doi: 10.1155/2010/287030. Epub 2009 Nov 30.

31.

Effects of milk casein-derived tripeptides Ile-Pro-Pro, Val-Pro-Pro, and Leu-Pro-Pro on enzymes processing vasoactive precursors in vitro.

Lehtinen R, Jauhiainen T, Kankuri E, Lindstedt K, Kovanen PT, Kerojoki O, Korpela R, Vapaatalo H.

Arzneimittelforschung. 2010;60(4):182-5. doi: 10.1055/s-0031-1296270.

PMID:
20486467
32.

Even low-grade inflammation impacts on small intestinal function.

Peuhkuri K, Vapaatalo H, Korpela R.

World J Gastroenterol. 2010 Mar 7;16(9):1057-62. Review.

33.

Long-term intervention with Lactobacillus helveticus fermented milk reduces augmentation index in hypertensive subjects.

Jauhiainen T, Rönnback M, Vapaatalo H, Wuolle K, Kautiainen H, Groop PH, Korpela R.

Eur J Clin Nutr. 2010 Apr;64(4):424-31. doi: 10.1038/ejcn.2010.3. Epub 2010 Feb 10.

34.

Antihypertensive Peptides from Milk Proteins.

Jäkälä P, Vapaatalo H.

Pharmaceuticals (Basel). 2010 Jan 19;3(1):251-272. Review.

35.

Cardiovascular activity of milk casein-derived tripeptides and plant sterols in spontaneously hypertensive rats.

Jakala P, Pere E, Lehtinen R, Turpeinen A, Korpela R, Vapaatalo H.

J Physiol Pharmacol. 2009 Dec;60(4):11-20.

36.

Elevated pro-inflammatory and lipotoxic mucosal lipids characterise irritable bowel syndrome.

Kajander K, Myllyluoma E, Kyrönpalo S, Rasmussen M, Sipponen P, Mattila I, Seppänen-Laakso T, Vapaatalo H, Oresic M, Korpela R.

World J Gastroenterol. 2009 Dec 28;15(48):6068-74.

37.

Angiotensin receptors in the eyes of arterial hypertensive rats.

Vaajanen A, Lakkisto P, Virtanen I, Kankuri E, Oksala O, Vapaatalo H, Tikkanen I.

Acta Ophthalmol. 2010 Jun;88(4):431-8. doi: 10.1111/j.1755-3768.2009.01563.x. Epub 2009 Sep 16.

38.

Activities of angiotensin-converting enzymes ACE1 and ACE2 and inhibition by bioactive peptides in porcine ocular tissues.

Luhtala S, Vaajanen A, Oksala O, Valjakka J, Vapaatalo H.

J Ocul Pharmacol Ther. 2009 Feb;25(1):23-8. doi: 10.1089/jop.2008.0081.

PMID:
19232015
39.

Does the renin-angiotensin system also regulate intra-ocular pressure?

Vaajanen A, Luhtala S, Oksala O, Vapaatalo H.

Ann Med. 2008;40(6):418-27. doi: 10.1080/07853890802043924. Review.

PMID:
19160528
40.

Ophthalmic timolol in a hydrogel vehicle leads to minor inter-individual variation in timolol concentration in aqueous humor.

Volotinen M, Mäenpää J, Kautiainen H, Tolonen A, Uusitalo J, Ropo A, Vapaatalo H, Aine E.

Eur J Pharm Sci. 2009 Feb 15;36(2-3):292-6. doi: 10.1016/j.ejps.2008.10.004. Epub 2008 Nov 1.

PMID:
19013521
41.

Effects of multispecies probiotic combination on helicobacter pylori infection in vitro.

Myllyluoma E, Ahonen AM, Korpela R, Vapaatalo H, Kankuri E.

Clin Vaccine Immunol. 2008 Sep;15(9):1472-82. doi: 10.1128/CVI.00080-08. Epub 2008 Jun 25.

42.

Effect of probiotic Lactobacillus rhamnosus GG intervention on global serum lipidomic profiles in healthy adults.

Kekkonen RA, Sysi-Aho M, Seppanen-Laakso T, Julkunen I, Vapaatalo H, Oresic M, Korpela R.

World J Gastroenterol. 2008 May 28;14(20):3188-94.

43.

Is there a relationship between blood pressure and intraocular pressure? An experimental study in hypertensive rats.

Vaajanen A, Mervaala E, Oksala O, Vapaatalo H.

Curr Eye Res. 2008 Apr;33(4):325-32. doi: 10.1080/02713680802011679.

PMID:
18398707
44.

Probiotic intervention has strain-specific anti-inflammatory effects in healthy adults.

Kekkonen RA, Lummela N, Karjalainen H, Latvala S, Tynkkynen S, Jarvenpaa S, Kautiainen H, Julkunen I, Vapaatalo H, Korpela R.

World J Gastroenterol. 2008 Apr 7;14(13):2029-36.

45.

Angiotensin (1-7) reduces intraocular pressure in the normotensive rabbit eye.

Vaajanen A, Vapaatalo H, Kautiainen H, Oksala O.

Invest Ophthalmol Vis Sci. 2008 Jun;49(6):2557-62. doi: 10.1167/iovs.07-1399. Epub 2008 Jan 25.

PMID:
18223252
46.

Prophylactic potential of montelukast against mild colitis induced by dextran sulphate sodium in rats.

Holma R, Salmenperä P, Virtanen I, Vapaatalo H, Korpela R.

J Physiol Pharmacol. 2007 Sep;58(3):455-67.

47.

Clinical trial: multispecies probiotic supplementation alleviates the symptoms of irritable bowel syndrome and stabilizes intestinal microbiota.

Kajander K, Myllyluoma E, Rajilić-Stojanović M, Kyrönpalo S, Rasmussen M, Järvenpää S, Zoetendal EG, de Vos WM, Vapaatalo H, Korpela R.

Aliment Pharmacol Ther. 2008 Jan 1;27(1):48-57. Epub 2007 Oct 5.

48.

Suomalainen sauna--terveytemme turva vai turma?

Vapaatalo H, Viinikka L.

Duodecim. 2007;123(13):1538-9. Finnish. No abstract available.

PMID:
17727145
49.

High-calcium diet with whey protein attenuates body-weight gain in high-fat-fed C57Bl/6J mice.

Pilvi TK, Korpela R, Huttunen M, Vapaatalo H, Mervaala EM.

Br J Nutr. 2007 Nov;98(5):900-7. Epub 2007 Aug 13.

PMID:
17692148
50.

A modified in vitro method for aqueous humor outflow studies in enucleated porcine eyes.

Vaajanen A, Vapaatalo H, Oksala O.

J Ocul Pharmacol Ther. 2007 Apr;23(2):124-31.

PMID:
17444800

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