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Items: 1 to 50 of 63

1.

Protein kinase D and Gβγ mediate sustained nociceptive signaling by biased agonists of protease-activated receptor-2.

Zhao P, Pattison LA, Jensen DD, Jimenez-Vargas NN, Latorre R, Lieu T, Jaramillo JO, Lopez-Lopez C, Poole DP, Vanner SJ, Schmidt BL, Bunnett NW.

J Biol Chem. 2019 May 29. pii: jbc.RA118.006935. doi: 10.1074/jbc.RA118.006935. [Epub ahead of print]

2.

Activation of Peripheral Blood CD4+ T-Cells in IBS is not Associated with Gastrointestinal or Psychological Symptoms.

Nasser Y, Petes C, Simmers C, Basso L, Altier C, Gee K, Vanner SJ.

Sci Rep. 2019 Mar 6;9(1):3710. doi: 10.1038/s41598-019-40124-5.

3.

Telomere length in the colon is related to colorectal adenoma prevalence.

Peacock SD, Massey TE, Vanner SJ, King WD.

PLoS One. 2018 Oct 17;13(10):e0205697. doi: 10.1371/journal.pone.0205697. eCollection 2018.

4.

Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome.

Jimenez-Vargas NN, Pattison LA, Zhao P, Lieu T, Latorre R, Jensen DD, Castro J, Aurelio L, Le GT, Flynn B, Herenbrink CK, Yeatman HR, Edgington-Mitchell L, Porter CJH, Halls ML, Canals M, Veldhuis NA, Poole DP, McLean P, Hicks GA, Scheff N, Chen E, Bhattacharya A, Schmidt BL, Brierley SM, Vanner SJ, Bunnett NW.

Proc Natl Acad Sci U S A. 2018 Jul 31;115(31):E7438-E7447. doi: 10.1073/pnas.1721891115. Epub 2018 Jul 16.

5.

Bulky DNA adduct levels in normal-appearing colon mucosa, and the prevalence of colorectal adenomas.

Ho V, Peacock S, Massey TE, Godschalk RW, van Schooten FJ, Ashbury JE, Vanner SJ, King WD.

Biomarkers. 2018 Dec;23(8):735-741. doi: 10.1080/1354750X.2018.1485055. Epub 2018 Jul 23.

PMID:
29871536
6.

Breath Testing Consensus Guidelines for SIBO: RES IPSA LOCQUITOR.

Paterson W, Camilleri M, Simren M, Boeckxstaens G, Vanner SJ.

Am J Gastroenterol. 2017 Dec;112(12):1888-1889. doi: 10.1038/ajg.2017.233. No abstract available.

PMID:
29215610
7.

Dietary therapies for functional bowel symptoms: Recent advances, challenges, and future directions.

Tuck CJ, Vanner SJ.

Neurogastroenterol Motil. 2018 Jan;30(1). doi: 10.1111/nmo.13238. Epub 2017 Nov 2. Review.

PMID:
29094792
8.

Protease-Mediated Suppression of DRG Neuron Excitability by Commensal Bacteria.

Sessenwein JL, Baker CC, Pradhananga S, Maitland ME, Petrof EO, Allen-Vercoe E, Noordhof C, Reed DE, Vanner SJ, Lomax AE.

J Neurosci. 2017 Nov 29;37(48):11758-11768. doi: 10.1523/JNEUROSCI.1672-17.2017. Epub 2017 Oct 31.

9.

Exposure to meat-derived carcinogens and bulky DNA adduct levels in normal-appearing colon mucosa.

Ho V, Brunetti V, Peacock S, Massey TE, Godschalk RWL, van Schooten FJ, Ashbury JE, Vanner SJ, King WD.

Mutat Res. 2017 Sep;821:5-12. doi: 10.1016/j.mrgentox.2017.06.005. Epub 2017 Jul 4.

PMID:
28735743
10.

A role for interleukin 17A in IBD-related neuroplasticity.

Cervi AL, Moynes DM, Chisholm SP, Nasser Y, Vanner SJ, Lomax AE.

Neurogastroenterol Motil. 2017 Nov;29(11). doi: 10.1111/nmo.13112. Epub 2017 May 30.

PMID:
28560787
11.

Sham acupuncture is as efficacious as true acupuncture for the treatment of IBS: A randomized placebo controlled trial.

Lowe C, Aiken A, Day AG, Depew W, Vanner SJ.

Neurogastroenterol Motil. 2017 Jul;29(7). doi: 10.1111/nmo.13040. Epub 2017 Mar 2.

PMID:
28251729
12.

Emerging studies of human visceral nociceptors.

Reed DE, Vanner SJ.

Am J Physiol Gastrointest Liver Physiol. 2017 Mar 1;312(3):G201-G207. doi: 10.1152/ajpgi.00391.2016. Epub 2016 Dec 22. Review.

13.

Stress activates pronociceptive endogenous opioid signalling in DRG neurons during chronic colitis.

Guerrero-Alba R, Valdez-Morales EE, Jimenez-Vargas NN, Lopez-Lopez C, Jaramillo-Polanco J, Okamoto T, Nasser Y, Bunnett NW, Lomax AE, Vanner SJ.

Gut. 2017 Dec;66(12):2121-2131. doi: 10.1136/gutjnl-2016-311456. Epub 2016 Sep 2.

PMID:
27590998
14.

Protein Kinase D and Gβγ Subunits Mediate Agonist-evoked Translocation of Protease-activated Receptor-2 from the Golgi Apparatus to the Plasma Membrane.

Jensen DD, Zhao P, Jimenez-Vargas NN, Lieu T, Gerges M, Yeatman HR, Canals M, Vanner SJ, Poole DP, Bunnett NW.

J Biol Chem. 2016 May 20;291(21):11285-99. doi: 10.1074/jbc.M115.710681. Epub 2016 Mar 30.

15.

Stress increases descending inhibition in mouse and human colon.

Reed DE, Zhang Y, Beyak MJ, Lourenssen S, Blennerhassett MG, Paterson WG, Vanner SJ.

Neurogastroenterol Motil. 2016 Apr;28(4):569-80. doi: 10.1111/nmo.12755. Epub 2016 Jan 6.

PMID:
26744175
16.

Demonstration of elevated levels of active cathepsin S in dextran sulfate sodium colitis using a new activatable probe.

Barlow N, Nasser Y, Zhao P, Sharma N, Guerrero-Alba R, Edgington-Mitchell LE, Lieu T, Veldhuis NA, Poole DP, Conner JW, Lindström E, Craig AW, Graham B, Vanner SJ, Bunnett NW.

Neurogastroenterol Motil. 2015 Nov;27(11):1675-80. doi: 10.1111/nmo.12656. Epub 2015 Aug 24.

PMID:
26303377
17.

Neutrophil Elastase Activates Protease-activated Receptor-2 (PAR2) and Transient Receptor Potential Vanilloid 4 (TRPV4) to Cause Inflammation and Pain.

Zhao P, Lieu T, Barlow N, Sostegni S, Haerteis S, Korbmacher C, Liedtke W, Jimenez-Vargas NN, Vanner SJ, Bunnett NW.

J Biol Chem. 2015 May 29;290(22):13875-87. doi: 10.1074/jbc.M115.642736. Epub 2015 Apr 15.

18.

Concurrent psychological stress and infectious colitis is key to sustaining enhanced peripheral sensory signaling.

Spreadbury I, Ochoa-Cortes F, Ibeakanma C, Martin N, Hurlbut D, Vanner SJ.

Neurogastroenterol Motil. 2015 Mar;27(3):347-55. doi: 10.1111/nmo.12497. Epub 2014 Dec 17.

PMID:
25521605
19.

Meat-derived carcinogens, genetic susceptibility and colorectal adenoma risk.

Ho V, Peacock S, Massey TE, Ashbury JE, Vanner SJ, King WD.

Genes Nutr. 2014 Nov;9(6):430. doi: 10.1007/s12263-014-0430-6. Epub 2014 Sep 18.

20.

Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4.

Zhao P, Lieu T, Barlow N, Metcalf M, Veldhuis NA, Jensen DD, Kocan M, Sostegni S, Haerteis S, Baraznenok V, Henderson I, Lindström E, Guerrero-Alba R, Valdez-Morales EE, Liedtke W, McIntyre P, Vanner SJ, Korbmacher C, Bunnett NW.

J Biol Chem. 2014 Sep 26;289(39):27215-34. doi: 10.1074/jbc.M114.599712. Epub 2014 Aug 12. Erratum in: J Biol Chem. 2014 Dec 26;289(52):35858.

21.

A cross-sectional study of global DNA methylation and risk of colorectal adenoma.

King WD, Ashbury JE, Taylor SA, Tse MY, Pang SC, Louw JA, Vanner SJ.

BMC Cancer. 2014 Jul 7;14:488. doi: 10.1186/1471-2407-14-488.

22.

Biomarkers measured in buccal and blood leukocyte DNA as proxies for colon tissue global methylation.

Ashbury JE, Taylor SA, Tse MY, Pang SC, Louw JA, Vanner SJ, King WD.

Int J Mol Epidemiol Genet. 2014 May 29;5(2):120-4. eCollection 2014.

23.

Sustained neurochemical plasticity in central terminals of mouse DRG neurons following colitis.

Benson JR, Xu J, Moynes DM, Lapointe TK, Altier C, Vanner SJ, Lomax AE.

Cell Tissue Res. 2014 May;356(2):309-17. doi: 10.1007/s00441-014-1832-x. Epub 2014 Apr 9.

PMID:
24715114
24.

Response to Hassan et al.

Hookey L, Maelicharkova A, Vanner SJ, Flemming J.

Am J Gastroenterol. 2014 Apr;109(4):599-600. doi: 10.1038/ajg.2014.2. No abstract available.

PMID:
24698866
25.

Participation of interleukin 17A in neuroimmune interactions.

Moynes DM, Vanner SJ, Lomax AE.

Brain Behav Immun. 2014 Oct;41:1-9. doi: 10.1016/j.bbi.2014.03.004. Epub 2014 Mar 15.

PMID:
24642072
26.

Stool substitute transplant therapy for the eradication of Clostridium difficile infection: 'RePOOPulating' the gut.

Petrof EO, Gloor GB, Vanner SJ, Weese SJ, Carter D, Daigneault MC, Brown EM, Schroeter K, Allen-Vercoe E.

Microbiome. 2013 Jan 9;1(1):3. doi: 10.1186/2049-2618-1-3.

27.

Chronic stress mediators act synergistically on colonic nociceptive mouse dorsal root ganglia neurons to increase excitability.

Ochoa-Cortes F, Guerrero-Alba R, Valdez-Morales EE, Spreadbury I, Barajas-Lopez C, Castro M, Bertrand J, Cenac N, Vergnolle N, Vanner SJ.

Neurogastroenterol Motil. 2014 Mar;26(3):334-45. doi: 10.1111/nmo.12268. Epub 2013 Nov 29.

PMID:
24286174
28.

Sensitization of peripheral sensory nerves by mediators from colonic biopsies of diarrhea-predominant irritable bowel syndrome patients: a role for PAR2.

Valdez-Morales EE, Overington J, Guerrero-Alba R, Ochoa-Cortes F, Ibeakanma CO, Spreadbury I, Bunnett NW, Beyak M, Vanner SJ.

Am J Gastroenterol. 2013 Oct;108(10):1634-43. doi: 10.1038/ajg.2013.241. Epub 2013 Aug 20.

PMID:
23958521
29.

The TGR5 receptor mediates bile acid-induced itch and analgesia.

Alemi F, Kwon E, Poole DP, Lieu T, Lyo V, Cattaruzza F, Cevikbas F, Steinhoff M, Nassini R, Materazzi S, Guerrero-Alba R, Valdez-Morales E, Cottrell GS, Schoonjans K, Geppetti P, Vanner SJ, Bunnett NW, Corvera CU.

J Clin Invest. 2013 Apr;123(4):1513-30. doi: 10.1172/JCI64551. Epub 2013 Mar 25.

30.

A Canadian Working Group report on fecal microbial therapy: microbial ecosystems therapeutics.

Allen-Vercoe E, Reid G, Viner N, Gloor GB, Hota S, Kim P, Lee C, O'Doherty K, Vanner SJ, Weese JS, Petrof EO.

Can J Gastroenterol. 2012 Jul;26(7):457-62. Review.

31.
32.
33.

Split-dose picosulfate, magnesium oxide, and citric acid solution markedly enhances colon cleansing before colonoscopy: a randomized, controlled trial.

Flemming JA, Vanner SJ, Hookey LC.

Gastrointest Endosc. 2012 Mar;75(3):537-44. doi: 10.1016/j.gie.2011.09.018. Epub 2011 Dec 21.

PMID:
22192423
34.

Cathepsin S is activated during colitis and causes visceral hyperalgesia by a PAR2-dependent mechanism in mice.

Cattaruzza F, Lyo V, Jones E, Pham D, Hawkins J, Kirkwood K, Valdez-Morales E, Ibeakanma C, Vanner SJ, Bogyo M, Bunnett NW.

Gastroenterology. 2011 Nov;141(5):1864-74.e1-3. doi: 10.1053/j.gastro.2011.07.035. Epub 2011 Jul 28.

35.

Characterization of the cysteinyl leukotriene 2 receptor in novel expression sites of the gastrointestinal tract.

Barajas-Espinosa A, Ochoa-Cortes F, Moos MP, Ramirez FD, Vanner SJ, Funk CD.

Am J Pathol. 2011 Jun;178(6):2682-9. doi: 10.1016/j.ajpath.2011.02.041.

36.

Opportunity costs of gastrointestinal endoscopic training in Canada.

Depew WT, Hookey LC, Vanner SJ, Louw JA, Lowe CE, Ropeleski MJ, Beyak MJ, Lazarescu A, Paterson WG.

Can J Gastroenterol. 2010 Dec;24(12):733-8.

37.

Presynaptic inhibition of neural vasodilator pathways to submucosal arterioles by release of purines from sympathetic nerves.

Lomax AE, Vanner SJ.

Am J Physiol Gastrointest Liver Physiol. 2010 May;298(5):G700-5. doi: 10.1152/ajpgi.00291.2009. Epub 2010 Feb 25.

38.

Colon cleansing before colonoscopy: does oral sodium phosphate solution still make sense?

Rex DK, Vanner SJ.

Can J Gastroenterol. 2009 Mar;23(3):210-4. Review.

39.

Trinitrobenzenesulphonic acid colitis alters Na 1.8 channel expression in mouse dorsal root ganglia neurons.

King DE, Macleod RJ, Vanner SJ.

Neurogastroenterol Motil. 2009 Aug;21(8):880-e64. doi: 10.1111/j.1365-2982.2009.01279.x. Epub 2009 Feb 23.

PMID:
19239624
40.

Pico-salax plus two-day bisacodyl is superior to pico-salax alone or oral sodium phosphate for colon cleansing before colonoscopy.

Hookey LC, Vanner SJ.

Am J Gastroenterol. 2009 Mar;104(3):703-9. doi: 10.1038/ajg.2008.167. Epub 2009 Feb 17.

PMID:
19223885
41.

Undifferentiated pancreatic carcinoma with osteoclast-like giant cells: report of a case with osteochondroid differentiation.

Manduch M, Dexter DF, Jalink DW, Vanner SJ, Hurlbut DJ.

Pathol Res Pract. 2009;205(5):353-9. doi: 10.1016/j.prp.2008.11.006. Epub 2009 Jan 15.

PMID:
19147301
42.

Sympathetic vasoconstrictor regulation of mouse colonic submucosal arterioles is altered in experimental colitis.

Lomax AE, O'Reilly M, Neshat S, Vanner SJ.

J Physiol. 2007 Sep 1;583(Pt 2):719-30. Epub 2007 Jul 5.

44.
46.

Two TTX-resistant Na+ currents in mouse colonic dorsal root ganglia neurons and their role in colitis-induced hyperexcitability.

Beyak MJ, Ramji N, Krol KM, Kawaja MD, Vanner SJ.

Am J Physiol Gastrointest Liver Physiol. 2004 Oct;287(4):G845-55. Epub 2004 Jun 17.

47.

Long vasodilator reflexes projecting through the myenteric plexus in guinea-pig ileum.

Reed DE, Vanner SJ.

J Physiol. 2003 Dec 15;553(Pt 3):911-24. Epub 2003 Oct 10.

48.

Mast cell tryptase and proteinase-activated receptor 2 induce hyperexcitability of guinea-pig submucosal neurons.

Reed DE, Barajas-Lopez C, Cottrell G, Velazquez-Rocha S, Dery O, Grady EF, Bunnett NW, Vanner SJ.

J Physiol. 2003 Mar 1;547(Pt 2):531-42. Epub 2003 Jan 24.

50.

TNBS ileitis evokes hyperexcitability and changes in ionic membrane properties of nociceptive DRG neurons.

Moore BA, Stewart TM, Hill C, Vanner SJ.

Am J Physiol Gastrointest Liver Physiol. 2002 Jun;282(6):G1045-51.

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