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Items: 23


Anti-IL-13Rα2 therapy promotes recovery in a murine model of inflammatory bowel disease.

Karmele EP, Pasricha TS, Ramalingam TR, Thompson RW, Gieseck RL 3rd, Knilans KJ, Hegen M, Farmer M, Jin F, Kleinman A, Hinds DA; 23andMe Research Team, Almeida Pereira T, de Queiroz Prado R, Bing N, Tchistiakova L, Kasaian MT, Wynn TA, Vannella KM.

Mucosal Immunol. 2019 Sep;12(5):1174-1186. doi: 10.1038/s41385-019-0189-6. Epub 2019 Jul 15.


Fibroblast-specific integrin-alpha V differentially regulates type 17 and type 2 driven inflammation and fibrosis.

Sciurba JC, Gieseck RL, Jiwrajka N, White SD, Karmele EP, Redes J, Vannella KM, Henderson NC, Wynn TA, Hart KM.

J Pathol. 2019 May;248(1):16-29. doi: 10.1002/path.5215. Epub 2019 Jan 24.


Type 2 immunity is protective in metabolic disease but exacerbates NAFLD collaboratively with TGF-β.

Hart KM, Fabre T, Sciurba JC, Gieseck RL 3rd, Borthwick LA, Vannella KM, Acciani TH, de Queiroz Prado R, Thompson RW, White S, Soucy G, Bilodeau M, Ramalingam TR, Arron JR, Shoukry NH, Wynn TA.

Sci Transl Med. 2017 Jun 28;9(396). pii: eaal3694. doi: 10.1126/scitranslmed.aal3694.


Mechanisms of Organ Injury and Repair by Macrophages.

Vannella KM, Wynn TA.

Annu Rev Physiol. 2017 Feb 10;79:593-617. doi: 10.1146/annurev-physiol-022516-034356. Epub 2016 Dec 7. Review.


Interleukin-13 Activates Distinct Cellular Pathways Leading to Ductular Reaction, Steatosis, and Fibrosis.

Gieseck RL 3rd, Ramalingam TR, Hart KM, Vannella KM, Cantu DA, Lu WY, Ferreira-González S, Forbes SJ, Vallier L, Wynn TA.

Immunity. 2016 Jul 19;45(1):145-58. doi: 10.1016/j.immuni.2016.06.009. Epub 2016 Jul 12.


Combinatorial targeting of TSLP, IL-25, and IL-33 in type 2 cytokine-driven inflammation and fibrosis.

Vannella KM, Ramalingam TR, Borthwick LA, Barron L, Hart KM, Thompson RW, Kindrachuk KN, Cheever AW, White S, Budelsky AL, Comeau MR, Smith DE, Wynn TA.

Sci Transl Med. 2016 May 4;8(337):337ra65. doi: 10.1126/scitranslmed.aaf1938.


Enhanced protection from fibrosis and inflammation in the combined absence of IL-13 and IFN-γ.

Ramalingam TR, Gieseck RL, Acciani TH, M Hart K, Cheever AW, Mentink-Kane MM, Vannella KM, Wynn TA.

J Pathol. 2016 Jul;239(3):344-54. doi: 10.1002/path.4733. Epub 2016 Jun 10.


Acidic chitinase primes the protective immune response to gastrointestinal nematodes.

Vannella KM, Ramalingam TR, Hart KM, de Queiroz Prado R, Sciurba J, Barron L, Borthwick LA, Smith AD, Mentink-Kane M, White S, Thompson RW, Cheever AW, Bock K, Moore I, Fitz LJ, Urban JF Jr, Wynn TA.

Nat Immunol. 2016 May;17(5):538-44. doi: 10.1038/ni.3417. Epub 2016 Apr 4.


Macrophages in Tissue Repair, Regeneration, and Fibrosis.

Wynn TA, Vannella KM.

Immunity. 2016 Mar 15;44(3):450-462. doi: 10.1016/j.immuni.2016.02.015. Review.


TH2 and TH17 inflammatory pathways are reciprocally regulated in asthma.

Choy DF, Hart KM, Borthwick LA, Shikotra A, Nagarkar DR, Siddiqui S, Jia G, Ohri CM, Doran E, Vannella KM, Butler CA, Hargadon B, Sciurba JC, Gieseck RL, Thompson RW, White S, Abbas AR, Jackman J, Wu LC, Egen JG, Heaney LG, Ramalingam TR, Arron JR, Wynn TA, Bradding P.

Sci Transl Med. 2015 Aug 19;7(301):301ra129. doi: 10.1126/scitranslmed.aab3142.


Macrophages are critical to the maintenance of IL-13-dependent lung inflammation and fibrosis.

Borthwick LA, Barron L, Hart KM, Vannella KM, Thompson RW, Oland S, Cheever A, Sciurba J, Ramalingam TR, Fisher AJ, Wynn TA.

Mucosal Immunol. 2016 Jan;9(1):38-55. doi: 10.1038/mi.2015.34. Epub 2015 Apr 29.


Incomplete deletion of IL-4Rα by LysM(Cre) reveals distinct subsets of M2 macrophages controlling inflammation and fibrosis in chronic schistosomiasis.

Vannella KM, Barron L, Borthwick LA, Kindrachuk KN, Narasimhan PB, Hart KM, Thompson RW, White S, Cheever AW, Ramalingam TR, Wynn TA.

PLoS Pathog. 2014 Sep 11;10(9):e1004372. doi: 10.1371/journal.ppat.1004372. eCollection 2014 Sep.


Chitinase dependent control of protozoan cyst burden in the brain.

Nance JP, Vannella KM, Worth D, David C, Carter D, Noor S, Hubeau C, Fitz L, Lane TE, Wynn TA, Wilson EH.

PLoS Pathog. 2012;8(11):e1002990. doi: 10.1371/journal.ppat.1002990. Epub 2012 Nov 29.


TLR9-induced interferon β is associated with protection from gammaherpesvirus-induced exacerbation of lung fibrosis.

Luckhardt TR, Coomes SM, Trujillo G, Stoolman JS, Vannella KM, Bhan U, Wilke CA, Moore TA, Toews GB, Hogaboam C, Moore BB.

Fibrogenesis Tissue Repair. 2011 Aug 2;4:18. doi: 10.1186/1755-1536-4-18.


New concepts of IL-10-induced lung fibrosis: fibrocyte recruitment and M2 activation in a CCL2/CCR2 axis.

Sun L, Louie MC, Vannella KM, Wilke CA, LeVine AM, Moore BB, Shanley TP.

Am J Physiol Lung Cell Mol Physiol. 2011 Mar;300(3):L341-53. doi: 10.1152/ajplung.00122.2010. Epub 2010 Dec 3.


Latent infection by γherpesvirus stimulates profibrotic mediator release from multiple cell types.

Stoolman JS, Vannella KM, Coomes SM, Wilke CA, Sisson TH, Toews GB, Moore BB.

Am J Physiol Lung Cell Mol Physiol. 2011 Feb;300(2):L274-85. doi: 10.1152/ajplung.00028.2010. Epub 2010 Oct 29.


The antifibrotic effects of plasminogen activation occur via prostaglandin E2 synthesis in humans and mice.

Bauman KA, Wettlaufer SH, Okunishi K, Vannella KM, Stoolman JS, Huang SK, Courey AJ, White ES, Hogaboam CM, Simon RH, Toews GB, Sisson TH, Moore BB, Peters-Golden M.

J Clin Invest. 2010 Jun;120(6):1950-60. doi: 10.1172/JCI38369. Epub 2010 May 24.


Latent herpesvirus infection augments experimental pulmonary fibrosis.

Vannella KM, Luckhardt TR, Wilke CA, van Dyk LF, Toews GB, Moore BB.

Am J Respir Crit Care Med. 2010 Mar 1;181(5):465-77. doi: 10.1164/rccm.200905-0798OC. Epub 2009 Dec 10.


Secondary lymphoid organs contribute to, but are not required for the induction of graft-versus-host responses following allogeneic bone marrow transplantation: a shifting paradigm for T cell allo-activation.

Silva IA, Olkiewicz K, Askew D, Fisher JM, Chaudhary MN, Vannella KM, Deurloo DT, Choi SW, Pierce EM, Clouthier SG, Liu C, Cooke KR.

Biol Blood Marrow Transplant. 2010 May;16(5):598-611. doi: 10.1016/j.bbmt.2009.12.007. Epub 2010 Feb 1.


Viruses as co-factors for the initiation or exacerbation of lung fibrosis.

Vannella KM, Moore BB.

Fibrogenesis Tissue Repair. 2008 Oct 13;1(1):2. doi: 10.1186/1755-1536-1-2.


Exacerbation of established pulmonary fibrosis in a murine model by gammaherpesvirus.

McMillan TR, Moore BB, Weinberg JB, Vannella KM, Fields WB, Christensen PJ, van Dyk LF, Toews GB.

Am J Respir Crit Care Med. 2008 Apr 1;177(7):771-80. doi: 10.1164/rccm.200708-1184OC. Epub 2008 Jan 10.


Cysteinyl leukotrienes are autocrine and paracrine regulators of fibrocyte function.

Vannella KM, McMillan TR, Charbeneau RP, Wilke CA, Thomas PE, Toews GB, Peters-Golden M, Moore BB.

J Immunol. 2007 Dec 1;179(11):7883-90.


Functional divergence of a unique C-terminal domain of leucyl-tRNA synthetase to accommodate its splicing and aminoacylation roles.

Hsu JL, Rho SB, Vannella KM, Martinis SA.

J Biol Chem. 2006 Aug 11;281(32):23075-82. Epub 2006 Jun 14.

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