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Items: 31


Post-translational modifications such as citrullination are excellent targets for cancer therapy.

Brentville VA, Vankemmelbeke M, Metheringham RL, Durrant LG.

Semin Immunol. 2020 Jan 10:101393. doi: 10.1016/j.smim.2020.101393. [Epub ahead of print] Review.


Monoclonal Antibody Targeting Sialyl-di-Lewisa-Containing Internalizing and Noninternalizing Glycoproteins with Cancer Immunotherapy Development Potential.

Tivadar ST, McIntosh RS, Chua JX, Moss R, Parsons T, Zaitoun AM, Madhusudan S, Durrant LG, Vankemmelbeke M.

Mol Cancer Ther. 2020 Mar;19(3):790-801. doi: 10.1158/1535-7163.MCT-19-0221. Epub 2019 Dec 23.


The terminal sialic acid of stage-specific embryonic antigen-4 has a crucial role in binding to a cancer-targeting antibody.

Soliman C, Chua JX, Vankemmelbeke M, McIntosh RS, Guy AJ, Spendlove I, Durrant LG, Ramsland PA.

J Biol Chem. 2020 Jan 24;295(4):1009-1020. doi: 10.1074/jbc.RA119.011518. Epub 2019 Dec 12.


ADAMTS9-Regulated Pericellular Matrix Dynamics Governs Focal Adhesion-Dependent Smooth Muscle Differentiation.

Mead TJ, Du Y, Nelson CM, Gueye NA, Drazba J, Dancevic CM, Vankemmelbeke M, Buttle DJ, Apte SS.

Cell Rep. 2018 Apr 10;23(2):485-498. doi: 10.1016/j.celrep.2018.03.034.


Cancer cell associated glycans as targets for immunotherapy.

Vankemmelbeke M, Chua JX, Durrant LG.

Oncoimmunology. 2015 Jul 15;5(1):e1061177. eCollection 2016.


Third-generation antibody drug conjugates for cancer therapy--a balancing act.

Vankemmelbeke M, Durrant L.

Ther Deliv. 2016;7(3):141-4. doi: 10.4155/tde-2016-0002. No abstract available.


Monoclonal Antibodies Targeting LecLex-Related Glycans with Potent Antitumor Activity.

Chua JX, Vankemmelbeke M, McIntosh RS, Clarke PA, Moss R, Parsons T, Spendlove I, Zaitoun AM, Madhusudan S, Durrant LG.

Clin Cancer Res. 2015 Jul 1;21(13):2963-74. doi: 10.1158/1078-0432.CCR-14-3030. Epub 2015 Mar 16.


Detection of induced synthesis of colicin E9 using ColE9p::gfpmut2 based reporter system.

Bano S, Vankemmelbeke M, Penfold CN, James R.

World J Microbiol Biotechnol. 2014 Jul;30(7):2091-9. doi: 10.1007/s11274-014-1635-y. Epub 2014 Mar 21.


Immunity protein release from a cell-bound nuclease colicin complex requires global conformational rearrangement.

Vankemmelbeke M, Housden NG, James R, Kleanthous C, Penfold CN.

Microbiologyopen. 2013 Oct;2(5):853-61. doi: 10.1002/mbo3.122. Epub 2013 Aug 28.


Pattern of induction of colicin E9 synthesis by sub MIC of Norfloxacin antibiotic.

Bano S, Vankemmelbeke M, Penfold CN, James R.

Microbiol Res. 2013 Dec 14;168(10):661-6. doi: 10.1016/j.micres.2013.04.005. Epub 2013 May 10.


Membrane activities of colicin nuclease domains: analogies with antimicrobial peptides.

Vankemmelbeke M, James R, Penfold CN.

Biochem Soc Trans. 2012 Dec 1;40(6):1517-21. doi: 10.1042/BST20120233. Review.


Colicin A binds to a novel binding site of TolA in the Escherichia coli periplasm.

Penfold CN, Li C, Zhang Y, Vankemmelbeke M, James R.

Biochem Soc Trans. 2012 Dec 1;40(6):1469-74. doi: 10.1042/BST20120239. Review.


Interaction of nuclease colicins with membranes: insertion depth correlates with bilayer perturbation.

Vankemmelbeke M, O Shea P, James R, Penfold CN.

PLoS One. 2012;7(9):e46656. doi: 10.1371/journal.pone.0046656. Epub 2012 Sep 28.


Structural evidence that colicin A protein binds to a novel binding site of TolA protein in Escherichia coli periplasm.

Li C, Zhang Y, Vankemmelbeke M, Hecht O, Aleanizy FS, Macdonald C, Moore GR, James R, Penfold CN.

J Biol Chem. 2012 Jun 1;287(23):19048-57. doi: 10.1074/jbc.M112.342246. Epub 2012 Apr 9.


Expression of recombinant ADAMTS in insect cells.

Jones GC, Vankemmelbeke MN, Buttle DJ.

Methods Mol Biol. 2010;622:83-98. doi: 10.1007/978-1-60327-299-5_5.


Allosteric beta-propeller signalling in TolB and its manipulation by translocating colicins.

Bonsor DA, Hecht O, Vankemmelbeke M, Sharma A, Krachler AM, Housden NG, Lilly KJ, James R, Moore GR, Kleanthous C.

EMBO J. 2009 Sep 16;28(18):2846-57. doi: 10.1038/emboj.2009.224. Epub 2009 Aug 20. Erratum in: EMBO J. 2009 Sep 16;28(18):2858.


The crystal structure of the TolB box of colicin A in complex with TolB reveals important differences in the recruitment of the common TolB translocation portal used by group A colicins.

Zhang Y, Li C, Vankemmelbeke MN, Bardelang P, Paoli M, Penfold CN, James R.

Mol Microbiol. 2010 Feb;75(3):623-36. doi: 10.1111/j.1365-2958.2009.06808.x. Epub 2009 Jul 21.


Energy-dependent immunity protein release during tol-dependent nuclease colicin translocation.

Vankemmelbeke M, Zhang Y, Moore GR, Kleanthous C, Penfold CN, James R.

J Biol Chem. 2009 Jul 10;284(28):18932-41. doi: 10.1074/jbc.M806149200. Epub 2009 May 19.


Design of a polypeptide FRET substrate that facilitates study of the antimicrobial protease lysostaphin.

Bardelang P, Vankemmelbeke M, Zhang Y, Jarvis H, Antoniadou E, Rochette S, Thomas NR, Penfold CN, James R.

Biochem J. 2009 Mar 15;418(3):615-24. doi: 10.1042/BJ20081765.


Investigating early events in receptor binding and translocation of colicin E9 using synchronized cell killing and proteolytic cleavage.

Zhang Y, Vankemmelbeke MN, Holland LE, Walker DC, James R, Penfold CN.

J Bacteriol. 2008 Jun;190(12):4342-50. doi: 10.1128/JB.00047-08. Epub 2008 Apr 11.


The role of electrostatics in colicin nuclease domain translocation into bacterial cells.

Walker D, Mosbahi K, Vankemmelbeke M, James R, Kleanthous C.

J Biol Chem. 2007 Oct 26;282(43):31389-97. Epub 2007 Aug 24.


Interactions of TolB with the translocation domain of colicin E9 require an extended TolB box.

Hands SL, Holland LE, Vankemmelbeke M, Fraser L, Macdonald CJ, Moore GR, James R, Penfold CN.

J Bacteriol. 2005 Oct;187(19):6733-41.


Rapid detection of colicin E9-induced DNA damage using Escherichia coli cells carrying SOS promoter-lux fusions.

Vankemmelbeke M, Healy B, Moore GR, Kleanthous C, Penfold CN, James R.

J Bacteriol. 2005 Jul;187(14):4900-7. Erratum in: J Bacteriol. 2005 Sep;187(18):6601.


Flexibility in the receptor-binding domain of the enzymatic colicin E9 is required for toxicity against Escherichia coli cells.

Penfold CN, Healy B, Housden NG, Boetzel R, Vankemmelbeke M, Moore GR, Kleanthous C, James R.

J Bacteriol. 2004 Jul;186(14):4520-7.


Cleavage of cartilage oligomeric matrix protein (thrombospondin-5) by matrix metalloproteinases and a disintegrin and metalloproteinase with thrombospondin motifs.

Dickinson SC, Vankemmelbeke MN, Buttle DJ, Rosenberg K, Heinegård D, Hollander AP.

Matrix Biol. 2003 May;22(3):267-78.


Selective inhibition of ADAMTS-1, -4 and -5 by catechin gallate esters.

Vankemmelbeke MN, Jones GC, Fowles C, Ilic MZ, Handley CJ, Day AJ, Knight CG, Mort JS, Buttle DJ.

Eur J Biochem. 2003 Jun;270(11):2394-403.


Differential expression patterns of matrix metalloproteinases and their inhibitors during development of osteoarthritis in a transgenic mouse model.

Salminen HJ, Säämänen AM, Vankemmelbeke MN, Auho PK, Perälä MP, Vuorio EI.

Ann Rheum Dis. 2002 Jul;61(7):591-7.


Expression and activity of ADAMTS-5 in synovium.

Vankemmelbeke MN, Holen I, Wilson AG, Ilic MZ, Handley CJ, Kelner GS, Clark M, Liu C, Maki RA, Burnett D, Buttle DJ.

Eur J Biochem. 2001 Mar;268(5):1259-68.


Bovine joint capsule and fibroblasts derived from joint capsule express aggrecanase activity.

Ilic MZ, Vankemmelbeke MN, Holen I, Buttle DJ, Clem Robinson H, Handley CJ.

Matrix Biol. 2000 Jul;19(3):257-65.


Coincubation of bovine synovial or capsular tissue with cartilage generates a soluble "Aggrecanase" activity.

Vankemmelbeke MN, Ilic MZ, Handley CJ, Knight CG, Buttle DJ.

Biochem Biophys Res Commun. 1999 Feb 24;255(3):686-91.


Characterization of helical cleavages in type II collagen generated by matrixins.

Vankemmelbeke M, Dekeyser PM, Hollander AP, Buttle DJ, Demeester J.

Biochem J. 1998 Mar 1;330 ( Pt 2):633-40.

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