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Items: 1 to 50 of 71

1.

Patient-derived organoids from endometrial disease capture clinical heterogeneity and are amenable to drug screening.

Boretto M, Maenhoudt N, Luo X, Hennes A, Boeckx B, Bui B, Heremans R, Perneel L, Kobayashi H, Van Zundert I, Brems H, Cox B, Ferrante M, Uji-I H, Koh KP, D'Hooghe T, Vanhie A, Vergote I, Meuleman C, Tomassetti C, Lambrechts D, Vriens J, Timmerman D, Vankelecom H.

Nat Cell Biol. 2019 Aug;21(8):1041-1051. doi: 10.1038/s41556-019-0360-z. Epub 2019 Aug 1.

PMID:
31371824
2.

Traumatic brain injury and resultant pituitary dysfunction: insights from experimental animal models.

Vennekens A, Vankelecom H.

Pituitary. 2019 Jun;22(3):212-219. doi: 10.1007/s11102-019-00961-z. Review.

PMID:
31020506
3.

Functional expression of the mechanosensitive PIEZO1 channel in primary endometrial epithelial cells and endometrial organoids.

Hennes A, Held K, Boretto M, De Clercq K, Van den Eynde C, Vanhie A, Van Ranst N, Benoit M, Luyten C, Peeraer K, Tomassetti C, Meuleman C, Voets T, Vankelecom H, Vriens J.

Sci Rep. 2019 Feb 11;9(1):1779. doi: 10.1038/s41598-018-38376-8.

4.

Skin Epidermis and Adnexa Regrowth Induced by Treatment With Artificial Dermal Template After Full-Thickness Skin Wound.

Li B, Xue H, Zhao X, Weng Y, Li G, Wang K, Zhou P, Wu Y, Vankelecom H, Chen J.

Int J Low Extrem Wounds. 2019 Mar;18(1):42-55. doi: 10.1177/1534734618818909. Epub 2019 Jan 8.

PMID:
30616449
5.

Organoids from pituitary as a novel research model toward pituitary stem cell exploration.

Cox B, Laporte E, Vennekens A, Kobayashi H, Nys C, Van Zundert I, Uji-I H, Vercauteren Drubbel A, Beck B, Roose H, Boretto M, Vankelecom H.

J Endocrinol. 2019 Feb 1;240(2):287-308. doi: 10.1530/JOE-18-0462.

PMID:
30475227
6.

Inhibition of Notch signaling attenuates pituitary adenoma growth in Nude mice.

Zubeldía-Brenner L, De Winne C, Perrone S, Rodríguez-Seguí SA, Willems C, Ornstein AM, Lacau-Mengido I, Vankelecom H, Cristina C, Becu-Villalobos D.

Endocr Relat Cancer. 2019 Jan 1;26(1):13-29. doi: 10.1530/ERC-18-0337.

PMID:
30121620
7.

The Stem Cell Connection of Pituitary Tumors.

Vankelecom H, Roose H.

Front Endocrinol (Lausanne). 2017 Dec 4;8:339. doi: 10.3389/fendo.2017.00339. eCollection 2017.

8.

Major depletion of SOX2+ stem cells in the adult pituitary is not restored which does not affect hormonal cell homeostasis and remodelling.

Roose H, Cox B, Boretto M, Gysemans C, Vennekens A, Vankelecom H.

Sci Rep. 2017 Dec 5;7(1):16940. doi: 10.1038/s41598-017-16796-2.

9.

Notch system is differentially expressed and activated in pituitary adenomas of distinct histotype, tumor cell lines and normal pituitaries.

Perrone S, Zubeldia-Brenner L, Gazza E, Demarchi G, Baccarini L, Baricalla A, Mertens F, Luque G, Vankelecom H, Berner S, Becu-Villalobos D, Cristina C.

Oncotarget. 2017 Jul 6;8(34):57072-57088. doi: 10.18632/oncotarget.19046. eCollection 2017 Aug 22.

10.

An autophagy-driven pathway of ATP secretion supports the aggressive phenotype of BRAFV600E inhibitor-resistant metastatic melanoma cells.

Martin S, Dudek-Peric AM, Garg AD, Roose H, Demirsoy S, Van Eygen S, Mertens F, Vangheluwe P, Vankelecom H, Agostinis P.

Autophagy. 2017 Sep 2;13(9):1512-1527. doi: 10.1080/15548627.2017.1332550. Epub 2017 Jul 19. Erratum in: Autophagy. 2018;14(7):1290.

11.

Pituitary stem cell regulation: who is pulling the strings?

Cox B, Roose H, Vennekens A, Vankelecom H.

J Endocrinol. 2017 Sep;234(3):R135-R158. doi: 10.1530/JOE-17-0083. Epub 2017 Jun 14. Review.

PMID:
28615294
12.

Pituitary Stem Cells: Quest for Hidden Functions.

Vankelecom H.

In: Pfaff D, Christen Y, editors. Stem Cells in Neuroendocrinology [Internet]. Cham (CH): Springer; 2016.
2016 Jul 27.

13.

Development of organoids from mouse and human endometrium showing endometrial epithelium physiology and long-term expandability.

Boretto M, Cox B, Noben M, Hendriks N, Fassbender A, Roose H, Amant F, Timmerman D, Tomassetti C, Vanhie A, Meuleman C, Ferrante M, Vankelecom H.

Development. 2017 May 15;144(10):1775-1786. doi: 10.1242/dev.148478. Epub 2017 Apr 25.

14.

Regeneration in the Pituitary After Cell-Ablation Injury: Time-Related Aspects and Molecular Analysis.

Willems C, Fu Q, Roose H, Mertens F, Cox B, Chen J, Vankelecom H.

Endocrinology. 2016 Feb;157(2):705-21. doi: 10.1210/en.2015-1741. Epub 2015 Dec 14.

PMID:
26653762
15.

Laminin-332 sustains chemoresistance and quiescence as part of the human hepatic cancer stem cell niche.

Govaere O, Wouters J, Petz M, Vandewynckel YP, Van den Eynde K, Van den Broeck A, Verhulst S, Dollé L, Gremeaux L, Ceulemans A, Nevens F, van Grunsven LA, Topal B, Vankelecom H, Giannelli G, Van Vlierberghe H, Mikulits W, Komuta M, Roskams T.

J Hepatol. 2016 Mar;64(3):609-17. doi: 10.1016/j.jhep.2015.11.011. Epub 2015 Nov 17.

16.

Pituitary tumors contain a side population with tumor stem cell-associated characteristics.

Mertens F, Gremeaux L, Chen J, Fu Q, Willems C, Roose H, Govaere O, Roskams T, Cristina C, Becú-Villalobos D, Jorissen M, Poorten VV, Bex M, van Loon J, Vankelecom H.

Endocr Relat Cancer. 2015 Aug;22(4):481-504. doi: 10.1530/ERC-14-0546. Epub 2015 Apr 28.

PMID:
25921430
17.

The dwarf phenotype in GH240B mice, haploinsufficient for the autism candidate gene Neurobeachin, is caused by ectopic expression of recombinant human growth hormone.

Nuytens K, Tuand K, Fu Q, Stijnen P, Pruniau V, Meulemans S, Vankelecom H, Creemers JW.

PLoS One. 2014 Oct 15;9(10):e109598. doi: 10.1371/journal.pone.0109598. eCollection 2014.

18.

Pituitary cell differentiation from stem cells and other cells: toward restorative therapy for hypopituitarism?

Willems C, Vankelecom H.

Regen Med. 2014;9(4):513-34. doi: 10.2217/rme.14.19. Review.

PMID:
25159067
19.

Tumor vessel normalization by chloroquine independent of autophagy.

Maes H, Kuchnio A, Peric A, Moens S, Nys K, De Bock K, Quaegebeur A, Schoors S, Georgiadou M, Wouters J, Vinckier S, Vankelecom H, Garmyn M, Vion AC, Radtke F, Boulanger C, Gerhardt H, Dejana E, Dewerchin M, Ghesquière B, Annaert W, Agostinis P, Carmeliet P.

Cancer Cell. 2014 Aug 11;26(2):190-206. doi: 10.1016/j.ccr.2014.06.025.

20.

A novel hypoxia-associated subset of FN1 high MITF low melanoma cells: identification, characterization, and prognostic value.

Wouters J, Stas M, Govaere O, Barrette K, Dudek A, Vankelecom H, Haydu LE, Thompson JF, Scolyer RA, van den Oord JJ.

Mod Pathol. 2014 Aug;27(8):1088-100. doi: 10.1038/modpathol.2013.228. Epub 2014 Jan 3.

21.

The human melanoma side population displays molecular and functional characteristics of enriched chemoresistance and tumorigenesis.

Wouters J, Stas M, Gremeaux L, Govaere O, Van den Broeck A, Maes H, Agostinis P, Roskams T, van den Oord JJ, Vankelecom H.

PLoS One. 2013 Oct 3;8(10):e76550. doi: 10.1371/journal.pone.0076550. eCollection 2013.

22.

Human pancreatic cancer contains a side population expressing cancer stem cell-associated and prognostic genes.

Van den Broeck A, Vankelecom H, Van Delm W, Gremeaux L, Wouters J, Allemeersch J, Govaere O, Roskams T, Topal B.

PLoS One. 2013 Sep 17;8(9):e73968. doi: 10.1371/journal.pone.0073968. eCollection 2013.

23.

Pituitary stem cells: where do we stand?

Vankelecom H, Chen J.

Mol Cell Endocrinol. 2014 Mar 25;385(1-2):2-17. doi: 10.1016/j.mce.2013.08.018. Epub 2013 Aug 28. Review.

PMID:
23994027
24.

Keratin 19: a key role player in the invasion of human hepatocellular carcinomas.

Govaere O, Komuta M, Berkers J, Spee B, Janssen C, de Luca F, Katoonizadeh A, Wouters J, van Kempen LC, Durnez A, Verslype C, De Kock J, Rogiers V, van Grunsven LA, Topal B, Pirenne J, Vankelecom H, Nevens F, van den Oord J, Pinzani M, Roskams T.

Gut. 2014 Apr;63(4):674-85. doi: 10.1136/gutjnl-2012-304351. Epub 2013 Aug 19.

25.

Regenerative capacity of the adult pituitary: multiple mechanisms of lactotrope restoration after transgenic ablation.

Fu Q, Vankelecom H.

Stem Cells Dev. 2012 Dec 10;21(18):3245-57. doi: 10.1089/scd.2012.0290. Epub 2012 Oct 16.

PMID:
22970885
26.

Molecular markers associated with outcome and metastasis in human pancreatic cancer.

Van den Broeck A, Vankelecom H, Van Eijsden R, Govaere O, Topal B.

J Exp Clin Cancer Res. 2012 Aug 27;31:68. doi: 10.1186/1756-9966-31-68.

27.

Human pancreatic adenocarcinoma contains a side population resistant to gemcitabine.

Van den Broeck A, Gremeaux L, Topal B, Vankelecom H.

BMC Cancer. 2012 Aug 15;12:354. doi: 10.1186/1471-2407-12-354.

28.

The adult pituitary shows stem/progenitor cell activation in response to injury and is capable of regeneration.

Fu Q, Gremeaux L, Luque RM, Liekens D, Chen J, Buch T, Waisman A, Kineman R, Vankelecom H.

Endocrinology. 2012 Jul;153(7):3224-35. doi: 10.1210/en.2012-1152. Epub 2012 Apr 19.

PMID:
22518061
29.

Gene expression changes in melanoma metastases in response to high-dose chemotherapy during isolated limb perfusion.

Wouters J, Stas M, Govaere O, Van den Eynde K, Vankelecom H, van den Oord JJ.

Pigment Cell Melanoma Res. 2012 Jul;25(4):454-65. doi: 10.1111/j.1755-148X.2012.01004.x. Epub 2012 May 3.

PMID:
22486811
30.

Pituitary stem cells drop their mask.

Vankelecom H.

Curr Stem Cell Res Ther. 2012 Jan;7(1):36-71. Review.

PMID:
22023621
31.

Activated phenotype of the pituitary stem/progenitor cell compartment during the early-postnatal maturation phase of the gland.

Gremeaux L, Fu Q, Chen J, Vankelecom H.

Stem Cells Dev. 2012 Mar 20;21(5):801-13. doi: 10.1089/scd.2011.0496. Epub 2011 Nov 16.

PMID:
21970375
32.

Identification and characterisation of side population cells in the canine pituitary gland.

van Rijn SJ, Gremeaux L, Riemers FM, Brinkhof B, Vankelecom H, Penning LC, Meij BP.

Vet J. 2012 Jun;192(3):476-82. doi: 10.1016/j.tvjl.2011.06.030. Epub 2011 Aug 2.

PMID:
21813305
33.

Metabolic impact of adult-onset, isolated, growth hormone deficiency (AOiGHD) due to destruction of pituitary somatotropes.

Luque RM, Lin Q, Córdoba-Chacón J, Subbaiah PV, Buch T, Waisman A, Vankelecom H, Kineman RD.

PLoS One. 2011 Jan 19;6(1):e15767. doi: 10.1371/journal.pone.0015767.

34.

Pituitary stem/progenitor cells: embryonic players in the adult gland?

Vankelecom H.

Eur J Neurosci. 2010 Dec;32(12):2063-81. doi: 10.1111/j.1460-9568.2010.07523.x. Review.

PMID:
21143661
35.

Increased glucocorticoid receptor expression and activity mediate the LPS resistance of SPRET/EI mice.

Dejager L, Pinheiro I, Puimège L, Fan YD, Gremeaux L, Vankelecom H, Libert C.

J Biol Chem. 2010 Oct 1;285(40):31073-86. doi: 10.1074/jbc.M110.154484. Epub 2010 Jul 27.

36.

Fixation and paraffin-embedding of mouse tissues for GFP visualization.

Vankelecom H.

Cold Spring Harb Protoc. 2009 Oct;2009(10):pdb.prot5298. doi: 10.1101/pdb.prot5298.

PMID:
20147043
37.

Stem cells in the pituitary gland: A burgeoning field.

Vankelecom H, Gremeaux L.

Gen Comp Endocrinol. 2010 May 1;166(3):478-88. doi: 10.1016/j.ygcen.2009.11.007. Epub 2009 Nov 14. Review.

PMID:
19917287
38.

Role of cancer stem cells in pancreatic ductal adenocarcinoma.

Sergeant G, Vankelecom H, Gremeaux L, Topal B.

Nat Rev Clin Oncol. 2009 Oct;6(10):580-6. doi: 10.1038/nrclinonc.2009.127. Epub 2009 Aug 18. Review.

PMID:
19687789
39.

Pituitary progenitor cells tracked down by side population dissection.

Chen J, Gremeaux L, Fu Q, Liekens D, Van Laere S, Vankelecom H.

Stem Cells. 2009 May;27(5):1182-95. doi: 10.1002/stem.51.

40.

The dog liver contains a "side population" of cells with hepatic progenitor-like characteristics.

Arends B, Vankelecom H, Vander Borght S, Roskams T, Penning LC, Rothuizen J, Spee B.

Stem Cells Dev. 2009 Mar;18(2):343-50. doi: 10.1089/scd.2008.0022.

PMID:
18680393
41.

Beta1-adrenoceptor expression in rat anterior pituitary gonadotrophs and in mouse alphaT3-1 and LbetaT2 gonadotrophic cell lines.

Janssens K, Krylyshkina O, Hersmus N, Vankelecom H, Denef C.

Endocrinology. 2008 May;149(5):2313-24. doi: 10.1210/en.2007-1396. Epub 2008 Jan 17.

PMID:
18202120
42.

Non-hormonal cell types in the pituitary candidating for stem cell.

Vankelecom H.

Semin Cell Dev Biol. 2007 Aug;18(4):559-70. Epub 2007 Apr 19. Review.

PMID:
17509912
43.

Stem cells in the postnatal pituitary?

Vankelecom H.

Neuroendocrinology. 2007;85(2):110-30. Epub 2007 Feb 23. Review.

PMID:
17337880
44.

The dark side of EGFP: defective polyubiquitination.

Baens M, Noels H, Broeckx V, Hagens S, Fevery S, Billiau AD, Vankelecom H, Marynen P.

PLoS One. 2006 Dec 20;1:e54.

45.

The notch signaling system is present in the postnatal pituitary: marked expression and regulatory activity in the newly discovered side population.

Chen J, Crabbe A, Van Duppen V, Vankelecom H.

Mol Endocrinol. 2006 Dec;20(12):3293-307. Epub 2006 Sep 7.

PMID:
16959876
48.

History and perspectives of pituitary folliculo-stellate cell research.

Allaerts W, Vankelecom H.

Eur J Endocrinol. 2005 Jul;153(1):1-12.

PMID:
15994739
49.

The adult pituitary contains a cell population displaying stem/progenitor cell and early embryonic characteristics.

Chen J, Hersmus N, Van Duppen V, Caesens P, Denef C, Vankelecom H.

Endocrinology. 2005 Sep;146(9):3985-98. Epub 2005 Jun 2.

PMID:
15932930
50.

Combinatorial expression of phenotypes of different cell lineages in the rat and mouse pituitary.

Denef C, Pals K, Hauspie A, Vankelecom H, Seuntjens E.

Ann N Y Acad Sci. 2005 Apr;1040:84-8. Review.

PMID:
15891010

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