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Items: 1 to 50 of 138

1.

von Willebrand factor in experimental malaria-associated acute respiratory distress syndrome.

Kraisin S, Verhenne S, Pham TT, Martinod K, Tersteeg C, Vandeputte N, Deckmyn H, Vanhoorelbeke K, Van den Steen PE, De Meyer SF.

J Thromb Haemost. 2019 May 17. doi: 10.1111/jth.14485. [Epub ahead of print]

PMID:
31099973
2.

Structural analysis of ischemic stroke thrombi: histological indications for therapy resistance.

Staessens S, Denorme F, François O, Desender L, Dewaele T, Vanacker P, Deckmyn H, Vanhoorelbeke K, Andersson T, De Meyer SF.

Haematologica. 2019 May 2. pii: haematol.2019.219881. doi: 10.3324/haematol.2019.219881. [Epub ahead of print]

3.

Transfer of ADAMTS13 antibody-mediated thrombotic thrombocytopenic purpura via kidney transplantation.

Zafrani L, Dekimpe C, Joly BS, Roose E, Fieux F, Azoulay E, Peraldi MN, Durrbach A, Coppo P, Vanhoorelbeke K, Veyradier A.

Haematologica. 2019 Jun;104(6):e277-e280. doi: 10.3324/haematol.2019.219063. Epub 2019 Feb 28. No abstract available.

4.

Phylogenetic and functional analysis of ADAMTS13 identifies highly conserved domains essential for allosteric regulation.

Muia J, Zhu J, Greco SC, Vanhoorelbeke K, Gupta G, Westfield LA, Sadler JE.

Blood. 2019 Apr 25;133(17):1899-1908. doi: 10.1182/blood-2018-11-886275. Epub 2019 Jan 30.

PMID:
30700419
5.

Exploring the "minimal" structure of a functional ADAMTS13 by mutagenesis and small-angle X-ray scattering.

Zhu J, Muia J, Gupta G, Westfield LA, Vanhoorelbeke K, Tolia NH, Sadler JE.

Blood. 2019 Apr 25;133(17):1909-1918. doi: 10.1182/blood-2018-11-886309. Epub 2019 Jan 28.

PMID:
30692120
6.

Generation of anti-idiotypic antibodies to detect anti-spacer antibody idiotopes in acute thrombotic thrombocytopenic purpura patients.

Schelpe AS, Roose E, Joly BS, Pareyn I, Mancini I, Biganzoli M, Deckmyn H, Voorberg J, Fijnheer R, Peyvandi F, De Meyer SF, Coppo P, Veyradier A, Vanhoorelbeke K.

Haematologica. 2019 Jun;104(6):1268-1276. doi: 10.3324/haematol.2018.205666. Epub 2018 Dec 6.

7.

von Willebrand factor deficiency does not influence angiotensin II-induced abdominal aortic aneurysm formation in mice.

Portier I, Martinod K, Desender L, Vandeputte N, Deckmyn H, Vanhoorelbeke K, De Meyer SF.

Sci Rep. 2018 Nov 9;8(1):16645. doi: 10.1038/s41598-018-35029-8.

8.

Differences in von Willebrand factor function in type 2A von Willebrand disease and left ventricular assist device-induced acquired von Willebrand syndrome.

Deconinck S, Tersteeg C, Bailleul E, Delrue L, Vandeputte N, Pareyn I, Itzhar-Baikian N, Deckmyn H, De Meyer SF, Vanderheyden M, Vanhoorelbeke K.

Res Pract Thromb Haemost. 2018 Oct 8;2(4):762-766. doi: 10.1002/rth2.12150. eCollection 2018 Oct.

9.

ADAMTS13 Gene Mutations Influence ADAMTS13 Conformation and Disease Age-Onset in the French Cohort of Upshaw-Schulman Syndrome.

Joly BS, Boisseau P, Roose E, Stepanian A, Biebuyck N, Hogan J, Provot F, Delmas Y, Garrec C, Vanhoorelbeke K, Coppo P, Veyradier A; French Reference Center for Thrombotic Microangiopathies.

Thromb Haemost. 2018 Nov;118(11):1902-1917. doi: 10.1055/s-0038-1673686. Epub 2018 Oct 12.

PMID:
30312976
10.

Anti-ADAMTS13 Autoantibodies against Cryptic Epitopes in Immune-Mediated Thrombotic Thrombocytopenic Purpura.

Roose E, Vidarsson G, Kangro K, Verhagen OJHM, Mancini I, Desender L, Pareyn I, Vandeputte N, Vandenbulcke A, Vendramin C, Schelpe AS, Voorberg J, Azerad MA, Gilardin L, Scully M, Dierickx D, Deckmyn H, De Meyer SF, Peyvandi F, Vanhoorelbeke K.

Thromb Haemost. 2018 Oct;118(10):1729-1742. doi: 10.1055/s-0038-1669459. Epub 2018 Sep 20.

11.

Preemptive rituximab prevents long-term relapses in immune-mediated thrombotic thrombocytopenic purpura.

Jestin M, Benhamou Y, Schelpe AS, Roose E, Provôt F, Galicier L, Hié M, Presne C, Poullin P, Wynckel A, Saheb S, Deligny C, Servais A, Girault S, Delmas Y, Kanouni T, Lautrette A, Chauveau D, Mousson C, Perez P, Halimi JM, Charvet-Rumpler A, Hamidou M, Cathébras P, Vanhoorelbeke K, Veyradier A, Coppo P; French Thrombotic Microangiopathies Reference Center.

Blood. 2018 Nov 15;132(20):2143-2153. doi: 10.1182/blood-2018-04-840090. Epub 2018 Sep 10.

PMID:
30201758
12.

Deletion of GARP on mouse regulatory T cells is not sufficient to inhibit the growth of transplanted tumors.

Vermeersch E, Liénart S, Collignon A, Lucas S, Gallimore A, Gysemans C, Unutmaz D, Vanhoorelbeke K, De Meyer SF, Maes W, Deckmyn H.

Cell Immunol. 2018 Oct;332:129-133. doi: 10.1016/j.cellimm.2018.07.011. Epub 2018 Jul 30.

PMID:
30093071
13.

Major Changes of von Willebrand Factor Multimer Distribution in Cirrhotic Patients with Stable Disease or Acute Decompensation.

Palyu E, Harsfalvi J, Tornai T, Papp M, Udvardy M, Szekeres-Csiki K, Pataki L, Vanhoorelbeke K, Feys HB, Deckmyn H, Tornai I.

Thromb Haemost. 2018 Aug;118(8):1397-1408. doi: 10.1055/s-0038-1661393. Epub 2018 Jul 4.

14.

Child-onset thrombotic thrombocytopenic purpura caused by p.R498C and p.G259PfsX133 mutations in ADAMTS13.

Schelpe AS, Orlando C, Ercig B, Geeroms C, Pareyn I, Vandeputte N, Velásquez Pereira LC, Roose E, Fostier K, Nicolaes GAF, Deckmyn H, De Meyer SF, Vanhoorelbeke K, Jochmans K.

Eur J Haematol. 2018 May 15. doi: 10.1111/ejh.13094. [Epub ahead of print]

PMID:
29763513
15.

Improved molecular platform for the gene therapy of rare diseases by liver protein secretion.

Quiviger M, Giannakopoulos A, Verhenne S, Marie C, Stavrou EF, Vanhoorelbeke K, Izsvák Z, De Meyer SF, Athanassiadou A, Scherman D.

Eur J Med Genet. 2018 Nov;61(11):723-728. doi: 10.1016/j.ejmg.2018.04.010. Epub 2018 Apr 26. Review.

PMID:
29704684
16.

Dissecting the pathophysiology of immune thrombotic thrombocytopenic purpura: interplay between genes and environmental triggers.

Hrdinová J, D'Angelo S, Graça NAG, Ercig B, Vanhoorelbeke K, Veyradier A, Voorberg J, Coppo P.

Haematologica. 2018 Jul;103(7):1099-1109. doi: 10.3324/haematol.2016.151407. Epub 2018 Apr 19. Review.

17.

Mass spectrometry-assisted identification of ADAMTS13-derived peptides presented on HLA-DR and HLA-DQ.

Hrdinová J, Verbij FC, Kaijen PHP, Hartholt RB, van Alphen F, Lardy N, Ten Brinke A, Vanhoorelbeke K, Hindocha PJ, De Groot AS, Meijer AB, Voorberg J, Peyron I.

Haematologica. 2018 Jun;103(6):1083-1092. doi: 10.3324/haematol.2017.179119. Epub 2018 Mar 22.

18.

Insights into 3D Structure of ADAMTS13: A Stepping Stone towards Novel Therapeutic Treatment of Thrombotic Thrombocytopenic Purpura.

Ercig B, Wichapong K, Reutelingsperger CPM, Vanhoorelbeke K, Voorberg J, Nicolaes GAF.

Thromb Haemost. 2018 Jan;118(1):28-41. doi: 10.1160/TH17-06-0404. Epub 2018 Jan 5.

PMID:
29304523
19.

High and long-term von Willebrand factor expression after Sleeping Beauty transposon-mediated gene therapy in a mouse model of severe von Willebrand disease.

Portier I, Vanhoorelbeke K, Verhenne S, Pareyn I, Vandeputte N, Deckmyn H, Goldenberg DS, Samal HB, Singh M, Ivics Z, Izsvák Z, De Meyer SF.

J Thromb Haemost. 2018 Mar;16(3):592-604. doi: 10.1111/jth.13938. Epub 2018 Jan 31.

PMID:
29288565
20.

An open conformation of ADAMTS-13 is a hallmark of acute acquired thrombotic thrombocytopenic purpura.

Roose E, Schelpe AS, Joly BS, Peetermans M, Verhamme P, Voorberg J, Greinacher A, Deckmyn H, De Meyer SF, Coppo P, Veyradier A, Vanhoorelbeke K.

J Thromb Haemost. 2018 Feb;16(2):378-388. doi: 10.1111/jth.13922. Epub 2018 Jan 23.

PMID:
29222940
21.

Platelet rescue by macrophage depletion in obese ADAMTS-13-deficient mice at risk of thrombotic thrombocytopenic purpura.

Geys L, Roose E, Scroyen I, Rottensteiner H, Tersteeg C, Hoylaerts MF, Vanhoorelbeke K, Lijnen HR.

J Thromb Haemost. 2018 Jan;16(1):150-163. doi: 10.1111/jth.13901. Epub 2017 Nov 28.

PMID:
29121438
22.

Role of ADAMTS13 in diet-induced liver steatosis.

Geys L, Roose E, Vanhoorelbeke K, Bedossa P, Scroyen I, Lijnen HR.

Mol Med Rep. 2017 Aug;16(2):1451-1458. doi: 10.3892/mmr.2017.6714. Epub 2017 Jun 7.

PMID:
29067443
23.

Amplified endogenous plasmin activity resolves acute thrombotic thrombocytopenic purpura in mice.

Tersteeg C, Joly BS, Gils A, Lijnen R, Deckmyn H, Declerck PJ, Plaimauer B, Coppo P, Veyradier A, Maas C, De Meyer SF, Vanhoorelbeke K.

J Thromb Haemost. 2017 Dec;15(12):2432-2442. doi: 10.1111/jth.13859. Epub 2017 Oct 27.

PMID:
28981198
24.

Neutrophil extracellular traps in ischemic stroke thrombi.

Laridan E, Denorme F, Desender L, François O, Andersson T, Deckmyn H, Vanhoorelbeke K, De Meyer SF.

Ann Neurol. 2017 Aug;82(2):223-232. doi: 10.1002/ana.24993. Epub 2017 Aug 11.

PMID:
28696508
25.

Mechanisms of Autoantibody-Induced Pathology.

Ludwig RJ, Vanhoorelbeke K, Leypoldt F, Kaya Z, Bieber K, McLachlan SM, Komorowski L, Luo J, Cabral-Marques O, Hammers CM, Lindstrom JM, Lamprecht P, Fischer A, Riemekasten G, Tersteeg C, Sondermann P, Rapoport B, Wandinger KP, Probst C, El Beidaq A, Schmidt E, Verkman A, Manz RA, Nimmerjahn F.

Front Immunol. 2017 May 31;8:603. doi: 10.3389/fimmu.2017.00603. eCollection 2017. Review.

26.

Reduced ADAMTS13 levels in patients with acute and chronic cerebrovascular disease.

Denorme F, Kraft P, Pareyn I, Drechsler C, Deckmyn H, Vanhoorelbeke K, Kleinschnitz C, De Meyer SF.

PLoS One. 2017 Jun 7;12(6):e0179258. doi: 10.1371/journal.pone.0179258. eCollection 2017.

27.

Presenting ADAMTS13 antibody and antigen levels predict prognosis in immune-mediated thrombotic thrombocytopenic purpura.

Alwan F, Vendramin C, Vanhoorelbeke K, Langley K, McDonald V, Austin S, Clark A, Lester W, Gooding R, Biss T, Dutt T, Cooper N, Chapman O, Cranfield T, Douglas K, Watson HG, van Veen JJ, Sibson K, Thomas W, Manson L, Hill QA, Benjamin S, Ellis D, Westwood JP, Thomas M, Scully M.

Blood. 2017 Jul 27;130(4):466-471. doi: 10.1182/blood-2016-12-758656. Epub 2017 Jun 2.

28.

Thrombotic thrombocytopenic purpura.

Kremer Hovinga JA, Coppo P, Lämmle B, Moake JL, Miyata T, Vanhoorelbeke K.

Nat Rev Dis Primers. 2017 Apr 6;3:17020. doi: 10.1038/nrdp.2017.20. Review.

PMID:
28382967
29.

ADAMTS-13 glycans and conformation-dependent activity.

Nowak AA, O'Brien HER, Henne P, Doerr A, Vanhoorelbeke K, Laffan MA, McKinnon TAJ.

J Thromb Haemost. 2017 Jun;15(6):1155-1166. doi: 10.1111/jth.13688. Epub 2017 Apr 27.

30.

The role of platelet and endothelial GARP in thrombosis and hemostasis.

Vermeersch E, Denorme F, Maes W, De Meyer SF, Vanhoorelbeke K, Edwards J, Shevach EM, Unutmaz D, Fujii H, Deckmyn H, Tersteeg C.

PLoS One. 2017 Mar 9;12(3):e0173329. doi: 10.1371/journal.pone.0173329. eCollection 2017.

31.

Long-Term Prevention of Congenital Thrombotic Thrombocytopenic Purpura in ADAMTS13 Knockout Mice by Sleeping Beauty Transposon-Mediated Gene Therapy.

Verhenne S, Vandeputte N, Pareyn I, Izsvák Z, Rottensteiner H, Deckmyn H, De Meyer SF, Vanhoorelbeke K.

Arterioscler Thromb Vasc Biol. 2017 May;37(5):836-844. doi: 10.1161/ATVBAHA.116.308680. Epub 2017 Mar 2.

PMID:
28254814
32.

Understanding therapeutic targets in thrombotic thrombocytopenic purpura.

Joly BS, Vanhoorelbeke K, Veyradier A.

Intensive Care Med. 2017 Sep;43(9):1398-1400. doi: 10.1007/s00134-016-4662-3. Epub 2017 Jan 23. No abstract available.

PMID:
28116452
33.

N-acetylcysteine in preclinical mouse and baboon models of thrombotic thrombocytopenic purpura.

Tersteeg C, Roodt J, Van Rensburg WJ, Dekimpe C, Vandeputte N, Pareyn I, Vandenbulcke A, Plaimauer B, Lamprecht S, Deckmyn H, Lopez JA, De Meyer SF, Vanhoorelbeke K.

Blood. 2017 Feb 23;129(8):1030-1038. doi: 10.1182/blood-2016-09-738856. Epub 2016 Dec 23.

34.

Glycans of plasma ADAMTS13.

Vanhoorelbeke K.

Blood. 2016 Nov 24;128(21):2485-2486. No abstract available.

35.

ADAMTS13 deficiency promotes microthrombosis in a murine model of diet-induced liver steatosis.

Geys L, Bauters D, Roose E, Tersteeg C, Vanhoorelbeke K, Hoylaerts MF, Lijnen RH, Scroyen I.

Thromb Haemost. 2017 Jan 5;117(1):19-26. doi: 10.1160/TH16-03-0195. Epub 2016 Sep 8.

PMID:
27604194
36.

Generation of Anti-Murine ADAMTS13 Antibodies and Their Application in a Mouse Model for Acquired Thrombotic Thrombocytopenic Purpura.

Deforche L, Tersteeg C, Roose E, Vandenbulcke A, Vandeputte N, Pareyn I, De Cock E, Rottensteiner H, Deckmyn H, De Meyer SF, Vanhoorelbeke K.

PLoS One. 2016 Aug 1;11(8):e0160388. doi: 10.1371/journal.pone.0160388. eCollection 2016.

37.

Inhibition of Thrombin-Activatable Fibrinolysis Inhibitor and Plasminogen Activator Inhibitor-1 Reduces Ischemic Brain Damage in Mice.

Denorme F, Wyseure T, Peeters M, Vandeputte N, Gils A, Deckmyn H, Vanhoorelbeke K, Declerck PJ, De Meyer SF.

Stroke. 2016 Sep;47(9):2419-22. doi: 10.1161/STROKEAHA.116.014091. Epub 2016 Jul 28.

PMID:
27470988
38.

Thrombotic thrombocytopenic pupura (TTP) dinner symposium proceedings.

Pavenski K, Cataland S, Kremer Hovinga J, Thomas M, Vanhoorelbeke K.

Expert Rev Hematol. 2016 Aug;9(8):733-5. doi: 10.1080/17474086.2016.1198895. Epub 2016 Jun 22.

PMID:
27269186
39.

Corrigendum: Super-resolution mapping of glutamate receptors in C. elegans by confocal correlated PALM.

Vangindertael J, Beets I, Rocha S, Dedecker P, Schoofs L, Vanhoorelbeke K, Hofkens J, Mizuno H.

Sci Rep. 2016 May 20;7:26047. doi: 10.1038/srep26047. No abstract available.

40.

ADAMTS13-mediated thrombolysis of t-PA-resistant occlusions in ischemic stroke in mice.

Denorme F, Langhauser F, Desender L, Vandenbulcke A, Rottensteiner H, Plaimauer B, François O, Andersson T, Deckmyn H, Scheiflinger F, Kleinschnitz C, Vanhoorelbeke K, De Meyer SF.

Blood. 2016 May 12;127(19):2337-45. doi: 10.1182/blood-2015-08-662650. Epub 2016 Feb 29.

41.

Keeping von Willebrand Factor under Control: Alternatives for ADAMTS13.

Tersteeg C, Fijnheer R, Pasterkamp G, de Groot PG, Vanhoorelbeke K, de Maat S, Maas C.

Semin Thromb Hemost. 2016 Feb;42(1):9-17. doi: 10.1055/s-0035-1564838. Epub 2015 Nov 23. Review.

PMID:
26595154
42.

ADAMTS13 and anti-ADAMTS13 autoantibodies in thrombotic thrombocytopenic purpura - current perspectives and new treatment strategies.

Tersteeg C, Verhenne S, Roose E, Schelpe AS, Deckmyn H, De Meyer SF, Vanhoorelbeke K.

Expert Rev Hematol. 2016;9(2):209-21. doi: 10.1586/17474086.2016.1122515. Epub 2015 Dec 8. Review.

PMID:
26581428
43.

Linker regions and flexibility around the metalloprotease domain account for conformational activation of ADAMTS-13.

Deforche L, Roose E, Vandenbulcke A, Vandeputte N, Feys HB, Springer TA, Mi LZ, Muia J, Sadler JE, Soejima K, Rottensteiner H, Deckmyn H, De Meyer SF, Vanhoorelbeke K.

J Thromb Haemost. 2015 Nov;13(11):2063-75. doi: 10.1111/jth.13149. Epub 2015 Oct 20.

44.

Potential for Recombinant ADAMTS13 as an Effective Therapy for Acquired Thrombotic Thrombocytopenic Purpura.

Tersteeg C, Schiviz A, De Meyer SF, Plaimauer B, Scheiflinger F, Rottensteiner H, Vanhoorelbeke K.

Arterioscler Thromb Vasc Biol. 2015 Nov;35(11):2336-42. doi: 10.1161/ATVBAHA.115.306014. Epub 2015 Sep 3.

PMID:
26338302
45.

Super-resolution mapping of glutamate receptors in C. elegans by confocal correlated PALM.

Vangindertael J, Beets I, Rocha S, Dedecker P, Schoofs L, Vanhoorelbeke K, Hofkens J, Mizuno H.

Sci Rep. 2015 Sep 1;5:13532. doi: 10.1038/srep13532. Erratum in: Sci Rep. 2016;7:26047. Vanhoorelbeeke, Karen [corrected to Vanhoorelbeke, Karen].

46.

Platelet-derived VWF is not essential for normal thrombosis and hemostasis but fosters ischemic stroke injury in mice.

Verhenne S, Denorme F, Libbrecht S, Vandenbulcke A, Pareyn I, Deckmyn H, Lambrecht A, Nieswandt B, Kleinschnitz C, Vanhoorelbeke K, De Meyer SF.

Blood. 2015 Oct 1;126(14):1715-22. doi: 10.1182/blood-2015-03-632901. Epub 2015 Jul 24.

47.

Artificial MiRNA Knockdown of Platelet Glycoprotein lbα: A Tool for Platelet Gene Silencing.

Thijs T, Broos K, Soenen SJ, Vandenbulcke A, Vanhoorelbeke K, Deckmyn H, Salles-Crawley II.

PLoS One. 2015 Jul 15;10(7):e0132899. doi: 10.1371/journal.pone.0132899. eCollection 2015.

48.

ADAMTS13 deficiency in mice does not affect adipose tissue development.

Geys L, Scroyen I, Roose E, Vanhoorelbeke K, Lijnen HR.

Biochim Biophys Acta. 2015 Jul;1850(7):1368-74. doi: 10.1016/j.bbagen.2015.03.008. Epub 2015 Mar 24.

PMID:
25813552
49.

Response to letter regarding article, "plasmin cleavage of von willebrand factor as an emergency bypass for ADAMTS13 deficiency in thrombotic microangiopathy".

Tersteeg C, de Maat S, De Meyer SF, Smeets MW, Barendrecht AD, Roest M, Pasterkamp G, Fijnheer R, Vanhoorelbeke K, de Groot PG, Maas C.

Circulation. 2015 Jan 13;131(2):e19-20. doi: 10.1161/CIRCULATIONAHA.114.012802. No abstract available.

PMID:
25583061
50.

Riboflavin and amotosalen photochemical treatments of platelet concentrates reduce thrombus formation kinetics in vitro.

Van Aelst B, Feys HB, Devloo R, Vanhoorelbeke K, Vandekerckhove P, Compernolle V.

Vox Sang. 2015 May;108(4):328-39. doi: 10.1111/vox.12231. Epub 2014 Dec 30.

PMID:
25557250

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