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Items: 20

1.

Exome sequencing of Finnish isolates enhances rare-variant association power.

Locke AE, Steinberg KM, Chiang CWK, Service SK, Havulinna AS, Stell L, Pirinen M, Abel HJ, Chiang CC, Fulton RS, Jackson AU, Kang CJ, Kanchi KL, Koboldt DC, Larson DE, Nelson J, Nicholas TJ, Pietilä A, Ramensky V, Ray D, Scott LJ, Stringham HM, Vangipurapu J, Welch R, Yajnik P, Yin X, Eriksson JG, Ala-Korpela M, Järvelin MR, Männikkö M, Laivuori H; FinnGen Project, Dutcher SK, Stitziel NO, Wilson RK, Hall IM, Sabatti C, Palotie A, Salomaa V, Laakso M, Ripatti S, Boehnke M, Freimer NB.

Nature. 2019 Aug;572(7769):323-328. doi: 10.1038/s41586-019-1457-z. Epub 2019 Jul 31.

PMID:
31367044
2.

New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders.

Evangelou E, Gao H, Chu C, Ntritsos G, Blakeley P, Butts AR, Pazoki R, Suzuki H, Koskeridis F, Yiorkas AM, Karaman I, Elliott J, Luo Q, Aeschbacher S, Bartz TM, Baumeister SE, Braund PS, Brown MR, Brody JA, Clarke TK, Dimou N, Faul JD, Homuth G, Jackson AU, Kentistou KA, Joshi PK, Lemaitre RN, Lind PA, Lyytikäinen LP, Mangino M, Milaneschi Y, Nelson CP, Nolte IM, Perälä MM, Polasek O, Porteous D, Ratliff SM, Smith JA, Stančáková A, Teumer A, Tuominen S, Thériault S, Vangipurapu J, Whitfield JB, Wood A, Yao J, Yu B, Zhao W, Arking DE, Auvinen J, Liu C, Männikkö M, Risch L, Rotter JI, Snieder H, Veijola J, Blakemore AI, Boehnke M, Campbell H, Conen D, Eriksson JG, Grabe HJ, Guo X, van der Harst P, Hartman CA, Hayward C, Heath AC, Jarvelin MR, Kähönen M, Kardia SLR, Kühne M, Kuusisto J, Laakso M, Lahti J, Lehtimäki T, McIntosh AM, Mohlke KL, Morrison AC, Martin NG, Oldehinkel AJ, Penninx BWJH, Psaty BM, Raitakari OT, Rudan I, Samani NJ, Scott LJ, Spector TD, Verweij N, Weir DR, Wilson JF, Levy D, Tzoulaki I, Bell JD, Matthews PM, Rothenfluh A, Desrivières S, Schumann G, Elliott P.

Nat Hum Behav. 2019 Sep;3(9):950-961. doi: 10.1038/s41562-019-0653-z. Epub 2019 Jul 29.

PMID:
31358974
3.

An intronic variant in the GCKR gene is associated with multiple lipids.

Fernandes Silva L, Vangipurapu J, Kuulasmaa T, Laakso M.

Sci Rep. 2019 Jul 15;9(1):10240. doi: 10.1038/s41598-019-46750-3.

4.

Nine Amino Acids Are Associated With Decreased Insulin Secretion and Elevated Glucose Levels in a 7.4-Year Follow-up Study of 5,181 Finnish Men.

Vangipurapu J, Stancáková A, Smith U, Kuusisto J, Laakso M.

Diabetes. 2019 Jun;68(6):1353-1358. doi: 10.2337/db18-1076. Epub 2019 Mar 18.

PMID:
30885989
5.

Genetic basis and outcome in a nationwide study of Finnish patients with hypertrophic cardiomyopathy.

Jääskeläinen P, Vangipurapu J, Raivo J, Kuulasmaa T, Heliö T, Aalto-Setälä K, Kaartinen M, Ilveskoski E, Vanninen S, Hämäläinen L, Melin J, Kokkonen J, Nieminen MS; FinHCM Study Group, Laakso M, Kuusisto J.

ESC Heart Fail. 2019 Apr;6(2):436-445. doi: 10.1002/ehf2.12420. Epub 2019 Feb 18.

6.

Functional Variant in the GCKR Gene Affects Lactate Levels Differentially in the Fasting State and During Hyperglycemia.

López Rodríguez M, Fernandes Silva L, Vangipurapu J, Modi S, Kuusisto J, Kaikkonen MU, Laakso M.

Sci Rep. 2018 Oct 30;8(1):15989. doi: 10.1038/s41598-018-34501-9.

7.

Short Adult Stature Predicts Impaired β-Cell Function, Insulin Resistance, Glycemia, and Type 2 Diabetes in Finnish Men.

Vangipurapu J, Stancáková A, Jauhiainen R, Kuusisto J, Laakso M.

J Clin Endocrinol Metab. 2017 Feb 1;102(2):443-450. doi: 10.1210/jc.2016-2933.

PMID:
27906553
8.

Detection of Novel Gene Variants Associated with Congenital Hypothyroidism in a Finnish Patient Cohort.

Löf C, Patyra K, Kuulasmaa T, Vangipurapu J, Undeutsch H, Jaeschke H, Pajunen T, Kero A, Krude H, Biebermann H, Kleinau G, Kühnen P, Rantakari K, Miettinen P, Kirjavainen T, Pursiheimo JP, Mustila T, Jääskeläinen J, Ojaniemi M, Toppari J, Ignatius J, Laakso M, Kero J.

Thyroid. 2016 Sep;26(9):1215-24. doi: 10.1089/thy.2016.0016. Epub 2016 Aug 2.

9.

Clinical, Genetic, and Biochemical Characteristics of Early-Onset Diabetes in the Finnish Population.

Huopio H, Miettinen PJ, Ilonen J, Nykänen P, Veijola R, Keskinen P, Näntö-Salonen K, Vangipurapu J, Raivo J, Stančáková A, Männistö J, Kuulasmaa T, Knip M, Otonkoski T, Laakso M.

J Clin Endocrinol Metab. 2016 Aug;101(8):3018-26. doi: 10.1210/jc.2015-4296. Epub 2016 May 11.

PMID:
27167055
10.

Both fasting and glucose-stimulated proinsulin levels predict hyperglycemia and incident type 2 diabetes: a population-based study of 9,396 Finnish men.

Vangipurapu J, Stančáková A, Kuulasmaa T, Kuusisto J, Laakso M.

PLoS One. 2015 Apr 8;10(4):e0124028. doi: 10.1371/journal.pone.0124028. eCollection 2015.

11.

Association analysis of 29,956 individuals confirms that a low-frequency variant at CCND2 halves the risk of type 2 diabetes by enhancing insulin secretion.

Yaghootkar H, Stancáková A, Freathy RM, Vangipurapu J, Weedon MN, Xie W, Wood AR, Ferrannini E, Mari A, Ring SM, Lawlor DA, Davey Smith G, Jørgensen T, Hansen T, Pedersen O, Steinthorsdottir V, Guðbjartsson DF, Thorleifsson G, Thorsteinsdottir U, Stefansson K, Hattersley AT, Walker M, Morris AD, McCarthy MI, Palmer CN, Laakso M, Frayling TM.

Diabetes. 2015 Jun;64(6):2279-85. doi: 10.2337/db14-1456. Epub 2015 Jan 20.

12.

Markers of tissue-specific insulin resistance predict the worsening of hyperglycemia, incident type 2 diabetes and cardiovascular disease.

Fízel'ová M, Cederberg H, Stančáková A, Jauhiainen R, Vangipurapu J, Kuusisto J, Laakso M.

PLoS One. 2014 Oct 13;9(10):e109772. doi: 10.1371/journal.pone.0109772. eCollection 2014. Erratum in: PLoS One. PLoS One. 2014;9(12):doi/10.1371/journal.pone.0114705. FízeI'ová, Mária [corrected to Fízel'ová, Mária].

13.

Association of erythrocyte membrane fatty acids with changes in glycemia and risk of type 2 diabetes.

Mahendran Y, Ågren J, Uusitupa M, Cederberg H, Vangipurapu J, Stančáková A, Schwab U, Kuusisto J, Laakso M.

Am J Clin Nutr. 2014 Jan;99(1):79-85. doi: 10.3945/ajcn.113.069740. Epub 2013 Oct 23.

PMID:
24153340
14.

Glycerol and fatty acids in serum predict the development of hyperglycemia and type 2 diabetes in Finnish men.

Mahendran Y, Cederberg H, Vangipurapu J, Kangas AJ, Soininen P, Kuusisto J, Uusitupa M, Ala-Korpela M, Laakso M.

Diabetes Care. 2013 Nov;36(11):3732-8. doi: 10.2337/dc13-0800. Epub 2013 Sep 11.

15.

Non-cholesterol sterol levels predict hyperglycemia and conversion to type 2 diabetes in Finnish men.

Cederberg H, Gylling H, Miettinen TA, Paananen J, Vangipurapu J, Pihlajamäki J, Kuulasmaa T, Stančáková A, Smith U, Kuusisto J, Laakso M.

PLoS One. 2013 Jun 28;8(6):e67406. doi: 10.1371/journal.pone.0067406. Print 2013.

16.

Association of risk variants for type 2 diabetes and hyperglycemia with gestational diabetes.

Huopio H, Cederberg H, Vangipurapu J, Hakkarainen H, Pääkkönen M, Kuulasmaa T, Heinonen S, Laakso M.

Eur J Endocrinol. 2013 Jul 29;169(3):291-7. doi: 10.1530/EJE-13-0286. Print 2013 Sep.

PMID:
23761423
17.

Association of ketone body levels with hyperglycemia and type 2 diabetes in 9,398 Finnish men.

Mahendran Y, Vangipurapu J, Cederberg H, Stancáková A, Pihlajamäki J, Soininen P, Kangas AJ, Paananen J, Civelek M, Saleem NK, Pajukanta P, Lusis AJ, Bonnycastle LL, Morken MA, Collins FS, Mohlke KL, Boehnke M, Ala-Korpela M, Kuusisto J, Laakso M.

Diabetes. 2013 Oct;62(10):3618-26. doi: 10.2337/db12-1363. Epub 2013 Apr 4.

18.

Association between liver insulin resistance and cardiovascular risk factors.

Vangipurapu J, Stančáková A, Kuulasmaa T, Soininen P, Kangas AJ, Ala-Korpela M, Kuusisto J, Laakso M.

J Intern Med. 2012 Oct;272(4):402-8. doi: 10.1111/j.1365-2796.2012.02540.x. Epub 2012 Apr 19.

19.

Association of indices of liver and adipocyte insulin resistance with 19 confirmed susceptibility loci for type 2 diabetes in 6,733 non-diabetic Finnish men.

Vangipurapu J, Stančáková A, Pihlajamäki J, Kuulasmaa TM, Kuulasmaa T, Paananen J, Kuusisto J, Ferrannini E, Laakso M.

Diabetologia. 2011 Mar;54(3):563-71. doi: 10.1007/s00125-010-1977-4. Epub 2010 Dec 12.

PMID:
21153532
20.

A novel surrogate index for hepatic insulin resistance.

Vangipurapu J, Stančáková A, Kuulasmaa T, Paananen J, Kuusisto J; EGIR-RISC Study Group, Ferrannini E, Laakso M.

Diabetologia. 2011 Mar;54(3):540-3. doi: 10.1007/s00125-010-1966-7. Epub 2010 Nov 25.

PMID:
21107521

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