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The STELVIO trial, a game changer for bronchoscopic lung volume reduction in patients with severe emphysema.

Posthuma R, Vanfleteren LEGW.

Breathe (Sheff). 2020 Mar;16(1):200004. doi: 10.1183/20734735.0004-2020.


ERS International Congress, Madrid, 2019: highlights from the General Pneumology Assembly.

Vanfleteren LEGW, Blervaque L, Franssen FME, Daines L, Kocks JWH, Honkoop PJ, Poberezhets V.

ERJ Open Res. 2020 Mar 2;6(1). pii: 00323-2019. doi: 10.1183/23120541.00323-2019. eCollection 2020 Jan. Review.


Troponin as a biomarker for mortality in stable COPD.

Nilsson U, Vanfleteren LEGW.

Eur Respir J. 2020 Feb 27;55(2). pii: 1902447. doi: 10.1183/13993003.02447-2019. Print 2020 Feb. No abstract available.



Vanfleteren LEGW, Fabbri LM.

Chest. 2020 Feb;157(2):475-476. doi: 10.1016/j.chest.2019.10.020. No abstract available.


Seeing the world through different lenses: activity registration differs between two validated accelerometers.

van der Molen MC, Hartman JE, Vanfleteren LEGW, Slebos DJ.

ERJ Open Res. 2020 Jan 20;6(1). pii: 00262-2019. doi: 10.1183/23120541.00262-2019. eCollection 2020 Jan.


Multimorbidity in COPD, does sleep matter?

Vanfleteren LE, Beghe B, Andersson A, Hansson D, Fabbri LM, Grote L.

Eur J Intern Med. 2020 Mar;73:7-15. doi: 10.1016/j.ejim.2019.12.032. Epub 2020 Jan 21. Review.


Emerging Techniques in the World of Respiratory Imaging.

Vanfleteren LEGW, Slebos DJ.

Respiration. 2020;99(2):97-98. doi: 10.1159/000504986. Epub 2019 Dec 13. No abstract available.


Effects of Non-Invasive Ventilation Combined with Oxygen Supplementation on Exercise Performance in COPD Patients with Static Lung Hyperinflation and Exercise-Induced Oxygen Desaturation: A Single Blind, Randomized Cross-Over Trial.

Koopman M, Spruit MA, Franssen FME, Delbressine J, Wouters EFM, Mathew D, Vink A, Vanfleteren LEGW.

J Clin Med. 2019 Nov 18;8(11). pii: E2012. doi: 10.3390/jcm8112012.


Self-management interventions in COPD patients with multimorbidity.

Vanfleteren LEGW, Fabbri LM.

Eur Respir J. 2019 Nov 7;54(5). pii: 1901850. doi: 10.1183/13993003.01850-2019. Print 2019 Nov. No abstract available.


Fatigue is highly prevalent in patients with COPD and correlates poorly with the degree of airflow limitation.

Goërtz YMJ, Spruit MA, Van 't Hul AJ, Peters JB, Van Herck M, Nakken N, Djamin RS, Burtin C, Thong MSY, Coors A, Meertens-Kerris Y, Wouters EFM, Prins JB, Franssen FME, Muris JWM, Vanfleteren LEGW, Sprangers MAG, Janssen DJA, Vercoulen JH.

Ther Adv Respir Dis. 2019 Jan-Dec;13:1753466619878128. doi: 10.1177/1753466619878128.


Effects of a comprehensive, inpatient pulmonary rehabilitation programme in a cachectic patient with very severe COPD and chronic respiratory failure.

Franssen FME, Vanfleteren LEGW, Janssen DJA, Wouters EFM, Spruit MA.

Breathe (Sheff). 2019 Sep;15(3):227-233. doi: 10.1183/20734735.0186-2019.


COPD: What's in a Name?: Mismatch of Diagnostic Labels and Required Physiologic Features.

Vanfleteren LEGW, Andersson AE, Fabbri LM.

Chest. 2019 Aug;156(2):195-196. doi: 10.1016/j.chest.2019.05.008. No abstract available.


The superexacerbator phenotype in patients with COPD: a descriptive analysis.

Vanfleteren LEGW, Boonen LMC, Spruit MA, Janssen DJA, Wouters EFM, Franssen FME.

ERJ Open Res. 2019 Jun 4;5(2). pii: 00235-2018. doi: 10.1183/23120541.00235-2018. eCollection 2019 Apr.


Airflow Obstruction and Cardio-metabolic Comorbidities.

Triest FJJ, Studnicka M, Franssen FME, Vollmer WM, Lamprecht B, Wouters EFM, Burney PGJ, Vanfleteren LEGW.

COPD. 2019 Apr;16(2):109-117. doi: 10.1080/15412555.2019.1614550. Epub 2019 May 27.


Add-on interventions during pulmonary rehabilitation.

Vanfleteren LEGW, Gloeckl R.

Respirology. 2019 Sep;24(9):899-908. doi: 10.1111/resp.13585. Epub 2019 May 21. Review.


Disease-Specific Comorbidity Clusters in COPD and Accelerated Aging.

Triest FJJ, Franssen FME, Reynaert N, Gaffron S, Spruit MA, Janssen DJA, Rutten EPA, Wouters EFM, Vanfleteren LEGW.

J Clin Med. 2019 Apr 14;8(4). pii: E511. doi: 10.3390/jcm8040511.


Endobronchial valves for severe emphysema.

Hartman JE, Vanfleteren LEGW, van Rikxoort EM, Klooster K, Slebos DJ.

Eur Respir Rev. 2019 Apr 17;28(152). pii: 180121. doi: 10.1183/16000617.0121-2018. Print 2019 Jun 30. Review.


Revealing Methodological Challenges in Chronic Obstructive Pulmonary Disease Studies Assessing Comorbidities: A Narrative Review.

Houben-Wilke S, Triest FJJ, Franssen FME, Janssen DJA, Wouters EFM, Vanfleteren LEGW.

Chronic Obstr Pulm Dis. 2019 Apr 9;6(2):166-177. doi: 10.15326/jcopdf.6.2.2018.0145. Epub 2019 Apr 9. Review.


Chronic Airway Diseases Early Stratification (CADSET): a new ERS Clinical Research Collaboration.

Agusti A, Faner R, Donaldson G, Heuvelin E, Breyer-Kohansal R, Melén E, Maitland-van der Zee AH, Vestbo J, Allinson JP, Vanfleteren LEGW, van den Berge M, Adcock IM, Lahousse L, Brusselle G, Wedzicha JA; on behalf of the CADSET Clinical Research Collaboration; Current members of the CADSET Clinical Research Collaboration.

Eur Respir J. 2019 Mar 18;53(3). pii: 1900217. doi: 10.1183/13993003.00217-2019. Print 2019 Mar. No abstract available.


European Respiratory Society International Congress, Paris, 2018: highlights from the Clinical Assembly.

Vanfleteren LEGW, Ojanguren I, Nolan CM, Franssen FME, Andrianopoulos V, Grgic A, van Dijk M, Slebos DJ, Daines L, Kocks JWH, Kahn N.

ERJ Open Res. 2019 Feb 11;5(1). pii: 00176-2018. doi: 10.1183/23120541.00176-2018. eCollection 2019 Feb. Review.


Triple therapy (ICS/LABA/LAMA) in COPD: thinking out of the box.

Vanfleteren LEGW, Ullman A, Nordenson A, Andersson A, Andelid K, Fabbri LM.

ERJ Open Res. 2019 Feb 11;5(1). pii: 00185-2018. doi: 10.1183/23120541.00185-2018. eCollection 2019 Feb.


Impact of pulmonary rehabilitation on activities of daily living in patients with chronic obstructive pulmonary disease.

Vaes AW, Delbressine JML, Mesquita R, Goertz YMJ, Janssen DJA, Nakken N, Franssen FME, Vanfleteren LEGW, Wouters EFM, Spruit MA.

J Appl Physiol (1985). 2019 Mar 1;126(3):607-615. doi: 10.1152/japplphysiol.00790.2018. Epub 2018 Nov 29.


Contribution of individual COPD assessment test (CAT) items to CAT total score and effects of pulmonary rehabilitation on CAT scores.

Houben-Wilke S, Janssen DJA, Franssen FME, Vanfleteren LEGW, Wouters EFM, Spruit MA.

Health Qual Life Outcomes. 2018 Oct 30;16(1):205. doi: 10.1186/s12955-018-1034-4.


When the Heart Steals Your Breath Away.

Lahousse L, Vanfleteren LEGW.

Respiration. 2019;97(3):199-201. doi: 10.1159/000493760. Epub 2018 Oct 25. No abstract available.


Preview of highlighted presentations from the European Respiratory Society' clinical assembly.

Kahn N, Vanfleteren LEGW, Kaltsakas G, Andrianopoulos V, Gompelmann D, de Jong C, Herth FJF.

J Thorac Dis. 2018 Sep;10(Suppl 25):S3034-S3042. doi: 10.21037/jtd.2018.09.17. No abstract available.


Bronchoscopic Lung Volume Reduction Treatment Using Endobronchial Valves for Emphysema: Emerging Questions.

Hartman JE, Vanfleteren LEGW, van Rikxoort EM, Slebos DJ; on behalf of the SOLVE consortium.

Respiration. 2018;96(6):588-589. doi: 10.1159/000491675. Epub 2018 Oct 4. No abstract available.


The respiratory physiome: Clustering based on a comprehensive lung function assessment in patients with COPD.

Augustin IML, Spruit MA, Houben-Wilke S, Franssen FME, Vanfleteren LEGW, Gaffron S, Janssen DJA, Wouters EFM.

PLoS One. 2018 Sep 12;13(9):e0201593. doi: 10.1371/journal.pone.0201593. eCollection 2018.


CT-derived muscle remodelling after bronchoscopic lung volume reduction in advanced emphysema.

Sanders KJC, Klooster K, Vanfleteren LEGW, Slebos DJ, Schols AMWJ.

Thorax. 2019 Feb;74(2):206-207. doi: 10.1136/thoraxjnl-2018-211931. Epub 2018 Aug 12.


Bronchiectasis Economics: Spend Money to Save Money.

Goeminne PC, Vanfleteren LEGW.

Respiration. 2018;96(5):399-402. doi: 10.1159/000490550. Epub 2018 Jul 24. No abstract available.


Effectiveness of Pulmonary Rehabilitation in Patients With Chronic Obstructive Pulmonary Disease With Different Degrees of Static Lung Hyperinflation.

Vanfleteren MJ, Koopman M, Spruit MA, Pennings HJ, Smeenk F, Pieters W, van den Bergh JJ, Michels AJ, Wouters EF, Groenen MT, Franssen FM, Vanfleteren LE.

Arch Phys Med Rehabil. 2018 Nov;99(11):2279-2286.e3. doi: 10.1016/j.apmr.2018.05.011. Epub 2018 Jun 12.


Looking into the eye of patients with chronic obstructive pulmonary disease: an opportunity for better microvascular profiling of these complex patients.

Vaes AW, Spruit MA, Theunis J, Goswami N, Vanfleteren LE, Franssen FME, Wouters EFM, De Boever P.

Acta Ophthalmol. 2018 Sep;96(6):539-549. doi: 10.1111/aos.13765. Epub 2018 May 16. Review.


Determinants of functional, peak and endurance exercise capacity in people with chronic obstructive pulmonary disease.

McNamara RJ, Houben-Wilke S, Franssen FME, Smid DE, Vanfleteren LEGW, Groenen MTJ, Uszko-Lencer NHMK, Wouters EFM, Alison JA, Spruit MA.

Respir Med. 2018 May;138:81-87. doi: 10.1016/j.rmed.2018.03.032. Epub 2018 Mar 29.


Personalised pulmonary rehabilitation in COPD.

Wouters EFM, Wouters BBREF, Augustin IML, Houben-Wilke S, Vanfleteren LEGW, Franssen FME.

Eur Respir Rev. 2018 Mar 28;27(147). pii: 170125. doi: 10.1183/16000617.0125-2017. Print 2018 Mar 31. Review.


Pulmonary rehabilitation for patients with COPD during and after an exacerbation-related hospitalisation: back to the future?

Spruit MA, Singh SJ, Rochester CL, Greening NJ, Franssen FME, Pitta F, Troosters T, Nolan C, Vogiatzis I, Clini EM, Man WD, Burtin C, Goldstein RS, Vanfleteren LEGW, Kenn K, Nici L, Janssen DJA, Casaburi R, Shioya T, Garvey C, Carlin BW, ZuWallack RL, Steiner M, Wouters EFM, Puhan MA.

Eur Respir J. 2018 Jan 11;51(1). pii: 1701312. doi: 10.1183/13993003.01312-2017. Print 2018 Jan. No abstract available.


Time for a longer and better life for patients with COPD.

Vanfleteren LEGW, Ullman A, Fabbri LM.

Eur Respir J. 2018 Jan 11;51(1). pii: 1702569. doi: 10.1183/13993003.02569-2017. Print 2018 Jan. No abstract available.


The Fat Lady Sings Again.

Vanfleteren LEGW, Slebos DJ.

Respiration. 2017;94(6):488-490. doi: 10.1159/000481574. Epub 2017 Oct 19. No abstract available.


Redefining Cut-Points for High Symptom Burden of the Global Initiative for Chronic Obstructive Lung Disease Classification in 18,577 Patients With Chronic Obstructive Pulmonary Disease.

Smid DE, Franssen FME, Gonik M, Miravitlles M, Casanova C, Cosio BG, de Lucas-Ramos P, Marin JM, Martinez C, Mir I, Soriano JB, de Torres JP, Agusti A, Atalay NB, Billington J, Boutou AK, Brighenti-Zogg S, Chaplin E, Coster S, Dodd JW, Dürr S, Fernandez-Villar A, Groenen MTJ, Guimarães M, Hejduk K, Higgins V, Hopkinson NS, Horita N, Houben-Wilke S, Janssen DJA, Jehn M, Joerres R, Karch A, Kelly JL, Kim YI, Kimura H, Koblizek V, Kocks JH, Kon SSC, Kwon N, Ladeira I, Lee SD, Leuppi JD, Locantore N, Lopez-Campos JL, D-C Man W, Maricic L, Mendoza L, Miedinger D, Mihaltan F, Minami S, van der Molen T, Murrells TJ, Nakken N, Nishijima Y, Norman IJ, Novotna B, O'Donnell DE, Ogata Y, Pereira ED, Piercy J, Price D, Pothirat C, Raghavan N, Ringbaek T, Sajkov D, Sigari N, Singh S, Small M, da Silva GF, Tanner RJ, Tsiligianni IG, Tulek B, Tzanakis N, Vanfleteren LEGW, Watz H, Webb KA, Wouters EFM, Xie GG, Yoshikawa M, Spruit MA.

J Am Med Dir Assoc. 2017 Dec 1;18(12):1097.e11-1097.e24. doi: 10.1016/j.jamda.2017.09.003. Review.


The patient with a complex chronic respiratory disease: a specialist of his own life?

Houben-Wilke S, Augustin IM, Wouters BB, Stevens RA, Janssen DJ, Spruit MA, Vanfleteren LE, Franssen FM, Wouters EF.

Expert Rev Respir Med. 2017 Dec;11(12):919-924. doi: 10.1080/17476348.2017.1392242. Epub 2017 Oct 25.


Endothelial function in patients with chronic obstructive pulmonary disease: a systematic review of studies using flow mediated dilatation.

Vaes AW, Spruit MA, Theunis J, Goswami N, Vanfleteren LE, Franssen FME, Wouters EFM, De Boever P.

Expert Rev Respir Med. 2017 Dec;11(12):1021-1031. doi: 10.1080/17476348.2017.1389277. Epub 2017 Oct 12. Review.


Increased exercise tolerance using daytime mouthpiece ventilation for patients with diaphragm paralysis.

Koopman M, Vanfleteren LEGW, Steijns S, Wouters EFM, Sprooten R.

Breathe (Sheff). 2017 Sep;13(3):225-229. doi: 10.1183/20734735.005817.


Altitude and COPD prevalence: analysis of the PREPOCOL-PLATINO-BOLD-EPI-SCAN study.

Horner A, Soriano JB, Puhan MA, Studnicka M, Kaiser B, Vanfleteren LEGW, Gnatiuc L, Burney P, Miravitlles M, García-Rio F, Ancochea J, Menezes AM, Perez-Padilla R, Montes de Oca M, Torres-Duque CA, Caballero A, González-García M, Buist S, Flamm M, Lamprecht B; BOLD Collaborative Research Group; EPI-SCAN Team; PLATINO Team; PREPOCOL Study Group.

Respir Res. 2017 Aug 23;18(1):162. doi: 10.1186/s12931-017-0643-5.


Cognitive impairment and clinical characteristics in patients with chronic obstructive pulmonary disease.

Cleutjens FAHM, Spruit MA, Ponds RWHM, Vanfleteren LEGW, Franssen FME, Gijsen C, Dijkstra JB, Wouters EFM, Janssen DJA.

Chron Respir Dis. 2018 May;15(2):91-102. doi: 10.1177/1479972317709651. Epub 2017 May 29.


The Relationship between Cerebral Small Vessel Disease, Hippocampal Volume and Cognitive Functioning in Patients with COPD: An MRI Study.

Cleutjens FAHM, Ponds RWHM, Spruit MA, Burgmans S, Jacobs HIL, Gronenschild EHBM, Staals J, Franssen FME, Dijkstra JB, Vanfleteren LEGW, Hofman PA, Wouters EFM, Janssen DJA.

Front Aging Neurosci. 2017 Mar 30;9:88. doi: 10.3389/fnagi.2017.00088. eCollection 2017.


Lower-limb muscle function is a determinant of exercise tolerance after lung resection surgery in patients with lung cancer.

Burtin C, Franssen FME, Vanfleteren LEGW, Groenen MTJ, Wouters EFM, Spruit MA.

Respirology. 2017 Aug;22(6):1185-1189. doi: 10.1111/resp.13041. Epub 2017 Mar 30.


[Oxygen therapy not required for all COPD patients].

Vanfleteren LE.

Ned Tijdschr Geneeskd. 2017;161:D1367. Dutch.


Tailoring the approach to multimorbidity in adults with respiratory disease: the NICE guideline.

Vanfleteren LE, Spruit MA, Franssen FM.

Eur Respir J. 2017 Feb 8;49(2). pii: 1601696. doi: 10.1183/13993003.01696-2016. Print 2017 Feb. No abstract available.


The Impact of Cognitive Impairment on Efficacy of Pulmonary Rehabilitation in Patients With COPD.

Cleutjens FAHM, Spruit MA, Ponds RWHM, Vanfleteren LEGW, Franssen FME, Dijkstra JB, Gijsen C, Wouters EFM, Janssen DJA.

J Am Med Dir Assoc. 2017 May 1;18(5):420-426. doi: 10.1016/j.jamda.2016.11.016. Epub 2017 Jan 17.


Domain-specific cognitive impairment in patients with COPD and control subjects.

Cleutjens FA, Franssen FM, Spruit MA, Vanfleteren LE, Gijsen C, Dijkstra JB, Ponds RW, Wouters EF, Janssen DJ.

Int J Chron Obstruct Pulmon Dis. 2016 Dec 19;12:1-11. doi: 10.2147/COPD.S119633. eCollection 2017.


Echocardiographic abnormalities and their impact on health status in patients with COPD referred for pulmonary rehabilitation.

Houben-Wilke S, Spruit MA, Uszko-Lencer NHMK, Otkinska G, Vanfleteren LEGW, Jones PW, Wouters EFM, Franssen FME.

Respirology. 2017 Jul;22(5):928-934. doi: 10.1111/resp.12968. Epub 2016 Dec 21.


Management of chronic obstructive pulmonary disease beyond the lungs.

Vanfleteren LEGW, Spruit MA, Wouters EFM, Franssen FME.

Lancet Respir Med. 2016 Nov;4(11):911-924. doi: 10.1016/S2213-2600(16)00097-7. Epub 2016 Jun 2. Review.


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