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Items: 17

1.

Novel Potent Capsid Assembly Modulators Regulate Multiple Steps of the Hepatitis B Virus Life Cycle.

Lahlali T, Berke JM, Vergauwen K, Foca A, Vandyck K, Pauwels F, Zoulim F, Durantel D.

Antimicrob Agents Chemother. 2018 Sep 24;62(10). pii: e00835-18. doi: 10.1128/AAC.00835-18. Print 2018 Oct.

2.

Synthesis and Evaluation of N-Phenyl-3-sulfamoyl-benzamide Derivatives as Capsid Assembly Modulators Inhibiting Hepatitis B Virus (HBV).

Vandyck K, Rombouts G, Stoops B, Tahri A, Vos A, Verschueren W, Wu Y, Yang J, Hou F, Huang B, Vergauwen K, Dehertogh P, Berke JM, Raboisson P.

J Med Chem. 2018 Jul 26;61(14):6247-6260. doi: 10.1021/acs.jmedchem.8b00654. Epub 2018 Jul 3.

PMID:
29906396
3.

Severe aortic stenosis in a parturient with triplets: multidisciplinary approach for cesarean delivery.

Shah T, Vandyck K.

Int J Obstet Anesth. 2018 Nov;36:135-137. doi: 10.1016/j.ijoa.2018.04.006. Epub 2018 Apr 25. No abstract available.

PMID:
29747996
4.

Characterization of a dengue NS4B inhibitor originating from an HCV small molecule library.

Hernandez-Morales I, Geluykens P, Clynhens M, Strijbos R, Goethals O, Megens S, Verheyen N, Last S, McGowan D, Coesemans E, De Boeck B, Stoops B, Devogelaere B, Pauwels F, Vandyck K, Berke JM, Raboisson P, Simmen K, Lory P, Van Loock M.

Antiviral Res. 2017 Nov;147:149-158. doi: 10.1016/j.antiviral.2017.10.011. Epub 2017 Oct 14.

PMID:
29037976
5.

Capsid Assembly Modulators Have a Dual Mechanism of Action in Primary Human Hepatocytes Infected with Hepatitis B Virus.

Berke JM, Dehertogh P, Vergauwen K, Van Damme E, Mostmans W, Vandyck K, Pauwels F.

Antimicrob Agents Chemother. 2017 Jul 25;61(8). pii: e00560-17. doi: 10.1128/AAC.00560-17. Print 2017 Aug.

6.

The use of high-dose hydroxocobalamin for vasoplegic syndrome.

Roderique JD, VanDyck K, Holman B, Tang D, Chui B, Spiess BD.

Ann Thorac Surg. 2014 May;97(5):1785-6. doi: 10.1016/j.athoracsur.2013.08.050.

PMID:
24792267
7.

Nucleotide prodrugs of 2'-deoxy-2'-spirooxetane ribonucleosides as novel inhibitors of the HCV NS5B polymerase.

Jonckers TH, Vandyck K, Vandekerckhove L, Hu L, Tahri A, Van Hoof S, Lin TI, Vijgen L, Berke JM, Lachau-Durand S, Stoops B, Leclercq L, Fanning G, Samuelsson B, Nilsson M, Rosenquist Å, Simmen K, Raboisson P.

J Med Chem. 2014 Mar 13;57(5):1836-44. doi: 10.1021/jm4015422. Epub 2014 Jan 6.

PMID:
24345201
8.

Discovery of 4'-azido-2'-deoxy-2'-C-methyl cytidine and prodrugs thereof: a potent inhibitor of Hepatitis C virus replication.

Nilsson M, Kalayanov G, Winqvist A, Pinho P, Sund C, Zhou XX, Wähling H, Belfrage AK, Pelcman M, Agback T, Benckestock K, Wikström K, Boothee M, Lindqvist A, Rydegård C, Jonckers TH, Vandyck K, Raboisson P, Lin TI, Lachau-Durand S, de Kock H, Smith DB, Martin JA, Klumpp K, Simmen K, Vrang L, Terelius Y, Samuelsson B, Rosenquist S, Johansson NG.

Bioorg Med Chem Lett. 2012 May 1;22(9):3265-8. doi: 10.1016/j.bmcl.2012.03.021. Epub 2012 Mar 16.

PMID:
22472694
9.

Practical synthesis of (2'R)-2'-deoxy-2'-C-methyluridine by highly diastereoselective homogeneous hydrogenation.

Lemaire S, Houpis I, Wechselberger R, Langens J, Vermeulen WA, Smets N, Nettekoven U, Wang Y, Xiao T, Qu H, Liu R, Jonckers TH, Raboisson P, Vandyck K, Nilsson KM, Farina V.

J Org Chem. 2011 Jan 7;76(1):297-300. doi: 10.1021/jo101822j. Epub 2010 Dec 6.

PMID:
21133352
10.

2'-Deoxy-2'-spirocyclopropylcytidine revisited: a new and selective inhibitor of the hepatitis C virus NS5B polymerase.

Jonckers TH, Lin TI, Buyck C, Lachau-Durand S, Vandyck K, Van Hoof S, Vandekerckhove LA, Hu L, Berke JM, Vijgen L, Dillen LL, Cummings MD, de Kock H, Nilsson M, Sund C, Rydegård C, Samuelsson B, Rosenquist A, Fanning G, Van Emelen K, Simmen K, Raboisson P.

J Med Chem. 2010 Nov 25;53(22):8150-60. doi: 10.1021/jm101050a. Epub 2010 Oct 29.

PMID:
21033671
11.

1a/1b subtype profiling of nonnucleoside polymerase inhibitors of hepatitis C virus.

Nyanguile O, Devogelaere B, Vijgen L, Van den Broeck W, Pauwels F, Cummings MD, De Bondt HL, Vos AM, Berke JM, Lenz O, Vandercruyssen G, Vermeiren K, Mostmans W, Dehertogh P, Delouvroy F, Vendeville S, VanDyck K, Dockx K, Cleiren E, Raboisson P, Simmen KA, Fanning GC.

J Virol. 2010 Mar;84(6):2923-34. doi: 10.1128/JVI.01980-09. Epub 2010 Jan 13.

12.

Structure-based design of a benzodiazepine scaffold yields a potent allosteric inhibitor of hepatitis C NS5B RNA polymerase.

Vandyck K, Cummings MD, Nyanguile O, Boutton CW, Vendeville S, McGowan D, Devogelaere B, Amssoms K, Last S, Rombauts K, Tahri A, Lory P, Hu L, Beauchamp DA, Simmen K, Raboisson P.

J Med Chem. 2009 Jul 23;52(14):4099-102. doi: 10.1021/jm9005548.

PMID:
19507864
13.

1,5-Benzodiazepine inhibitors of HCV NS5B polymerase.

McGowan D, Nyanguile O, Cummings MD, Vendeville S, Vandyck K, Van den Broeck W, Boutton CW, De Bondt H, Quirynen L, Amssoms K, Bonfanti JF, Last S, Rombauts K, Tahri A, Hu L, Delouvroy F, Vermeiren K, Vandercruyssen G, Van der Helm L, Cleiren E, Mostmans W, Lory P, Pille G, Van Emelen K, Fanning G, Pauwels F, Lin TI, Simmen K, Raboisson P.

Bioorg Med Chem Lett. 2009 May 1;19(9):2492-6. doi: 10.1016/j.bmcl.2009.03.035. Epub 2009 Mar 14.

PMID:
19342234
14.

A DFT conformational analysis and VCD study on methyl tetrahydrofuran-2-carboxylate.

Kuppens T, Vandyck K, van der Eycken J, Herrebout W, van der Veken B, Bultinck P.

Spectrochim Acta A Mol Biomol Spectrosc. 2007 Jun;67(2):402-11. Epub 2006 Jul 29.

PMID:
17045521
15.

Rhodium-Catalyzed Asymmetric Conjugate Additions of Boronic Acids to enones using DIPHONANE: a novel chiral bisphosphine ligand.

Vandyck K, Matthys B, Willen M, Robeyns K, Van Meervelt L, Van der Eycken J.

Org Lett. 2006 Feb 2;8(3):363-6.

PMID:
16435835
16.

Determination of the absolute configuration of three as-hydrindacene compounds by vibrational circular dichroism.

Kuppens T, Vandyck K, Van der Eycken J, Herrebout W, van der Veken BJ, Bultinck P.

J Org Chem. 2005 Nov 11;70(23):9103-14.

PMID:
16268579
17.

Increased lymphocyte replicative index following 2,4-dichlorophenoxyacetic acid herbicide exposure.

Figgs LW, Holland NT, Rothmann N, Zahm SH, Tarone RE, Hill R, Vogt RF, Smith MT, Boysen CD, Holmes FF, VanDyck K, Blair A.

Cancer Causes Control. 2000 Apr;11(4):373-80.

PMID:
10843448

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