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Items: 20


Sustained SREBP-1-dependent lipogenesis as a key mediator of resistance to BRAF-targeted therapy.

Talebi A, Dehairs J, Rambow F, Rogiers A, Nittner D, Derua R, Vanderhoydonc F, Duarte JAG, Bosisio F, Van den Eynde K, Nys K, Pérez MV, Agostinis P, Waelkens E, Van den Oord J, Fendt SM, Marine JC, Swinnen JV.

Nat Commun. 2018 Jun 27;9(1):2500. doi: 10.1038/s41467-018-04664-0.


Longitudinal microcomputed tomography-derived biomarkers for lung metastasis detection in a syngeneic mouse model: added value to bioluminescence imaging.

Marien E, Hillen A, Vanderhoydonc F, Swinnen JV, Vande Velde G.

Lab Invest. 2017 Jan;97(1):24-33. doi: 10.1038/labinvest.2016.114. Epub 2016 Nov 21.


Phospholipid profiling identifies acyl chain elongation as a ubiquitous trait and potential target for the treatment of lung squamous cell carcinoma.

Marien E, Meister M, Muley T, Gomez Del Pulgar T, Derua R, Spraggins JM, Van de Plas R, Vanderhoydonc F, Machiels J, Binda MM, Dehairs J, Willette-Brown J, Hu Y, Dienemann H, Thomas M, Schnabel PA, Caprioli RM, Lacal JC, Waelkens E, Swinnen JV.

Oncotarget. 2016 Mar 15;7(11):12582-97. doi: 10.18632/oncotarget.7179.


Identification of drugs that restore primary cilium expression in cancer cells.

Khan NA, Willemarck N, Talebi A, Marchand A, Binda MM, Dehairs J, Rueda-Rincon N, Daniels VW, Bagadi M, Thimiri Govinda Raj DB, Vanderhoydonc F, Munck S, Chaltin P, Swinnen JV.

Oncotarget. 2016 Mar 1;7(9):9975-92. doi: 10.18632/oncotarget.7198.


Primary cilium suppression by SREBP1c involves distortion of vesicular trafficking by PLA2G3.

Gijs HL, Willemarck N, Vanderhoydonc F, Khan NA, Dehairs J, Derua R, Waelkens E, Taketomi Y, Murakami M, Agostinis P, Annaert W, Swinnen JV.

Mol Biol Cell. 2015 Jun 15;26(12):2321-32. doi: 10.1091/mbc.E14-10-1472. Epub 2015 Apr 22.


Do androgens control the uptake of 18F-FDG, 11C-choline and 11C-acetate in human prostate cancer cell lines?

Emonds KM, Swinnen JV, van Weerden WM, Vanderhoydonc F, Nuyts J, Mortelmans L, Mottaghy FM.

Eur J Nucl Med Mol Imaging. 2011 Oct;38(10):1842-53. doi: 10.1007/s00259-011-1861-6. Epub 2011 Jul 6.


Aberrant activation of fatty acid synthesis suppresses primary cilium formation and distorts tissue development.

Willemarck N, Rysman E, Brusselmans K, Van Imschoot G, Vanderhoydonc F, Moerloose K, Lerut E, Verhoeven G, van Roy F, Vleminckx K, Swinnen JV.

Cancer Res. 2010 Nov 15;70(22):9453-62. doi: 10.1158/0008-5472.CAN-10-2324. Epub 2010 Oct 1.


De novo lipogenesis protects cancer cells from free radicals and chemotherapeutics by promoting membrane lipid saturation.

Rysman E, Brusselmans K, Scheys K, Timmermans L, Derua R, Munck S, Van Veldhoven PP, Waltregny D, Daniëls VW, Machiels J, Vanderhoydonc F, Smans K, Waelkens E, Verhoeven G, Swinnen JV.

Cancer Res. 2010 Oct 15;70(20):8117-26. doi: 10.1158/0008-5472.CAN-09-3871. Epub 2010 Sep 28.


Methotrexate enhances the antianabolic and antiproliferative effects of 5-aminoimidazole-4-carboxamide riboside.

Beckers A, Organe S, Timmermans L, Vanderhoydonc F, Deboel L, Derua R, Waelkens E, Brusselmans K, Verhoeven G, Swinnen JV.

Mol Cancer Ther. 2006 Sep;5(9):2211-7.


Mimicry of a cellular low energy status blocks tumor cell anabolism and suppresses the malignant phenotype.

Swinnen JV, Beckers A, Brusselmans K, Organe S, Segers J, Timmermans L, Vanderhoydonc F, Deboel L, Derua R, Waelkens E, De Schrijver E, Van de Sande T, Noël A, Foufelle F, Verhoeven G.

Cancer Res. 2005 Mar 15;65(6):2441-8.


Contribution of circulating lipids to the improved outcome of critical illness by glycemic control with intensive insulin therapy.

Mesotten D, Swinnen JV, Vanderhoydonc F, Wouters PJ, Van den Berghe G.

J Clin Endocrinol Metab. 2004 Jan;89(1):219-26.


Androgens stimulate coordinated lipogenic gene expression in normal target tissues in vivo.

Heemers H, Vanderhoydonc F, Roskams T, Shechter I, Heyns W, Verhoeven G, Swinnen JV.

Mol Cell Endocrinol. 2003 Jul 31;205(1-2):21-31.


Fatty acid synthase drives the synthesis of phospholipids partitioning into detergent-resistant membrane microdomains.

Swinnen JV, Van Veldhoven PP, Timmermans L, De Schrijver E, Brusselmans K, Vanderhoydonc F, Van de Sande T, Heemers H, Heyns W, Verhoeven G.

Biochem Biophys Res Commun. 2003 Mar 21;302(4):898-903.


Regulation of insulin-like growth factor binding protein-1 during protracted critical illness.

Mesotten D, Delhanty PJ, Vanderhoydonc F, Hardman KV, Weekers F, Baxter RC, Van Den Berghe G.

J Clin Endocrinol Metab. 2002 Dec;87(12):5516-23.


Selective activation of the fatty acid synthesis pathway in human prostate cancer.

Swinnen JV, Vanderhoydonc F, Elgamal AA, Eelen M, Vercaeren I, Joniau S, Van Poppel H, Baert L, Goossens K, Heyns W, Verhoeven G.

Int J Cancer. 2000 Oct 15;88(2):176-9.


Progestins and androgens increase expression of Spot 14 in T47-D breast tumor cells.

Heemers H, Vanderhoydonc F, Heyns W, Verhoeven G, Swinnen JV.

Biochem Biophys Res Commun. 2000 Mar 5;269(1):209-12.


Nandrolone decanoate does not enhance training effects but increases IGF-I mRNA in rat diaphragm.

Gayan-Ramirez G, Rollier H, Vanderhoydonc F, Verhoeven G, Gosselink R, Decramer M.

J Appl Physiol (1985). 2000 Jan;88(1):26-34.


Acute treatment with corticosteroids decreases IGF-1 and IGF-2 expression in the rat diaphragm and gastrocnemius.

Gayan-Ramirez G, Vanderhoydonc F, Verhoeven G, Decramer M.

Am J Respir Crit Care Med. 1999 Jan;159(1):283-9.


Biliary cirrhosis induces type IIx/b fiber atrophy in rat diaphragm and skeletal muscle, and decreases IGF-I mRNA in the liver but not in muscle.

Gayan-Ramirez G, van de Casteele M, Rollier H, Fevery J, Vanderhoydonc F, Verhoeven G, Decramer M.

J Hepatol. 1998 Aug;29(2):241-9.


Effect of androgens on the germ cell-depleted testes of prenatally irradiated rats.

Verhoeven G, Deboel L, Swinnen J, Rombauts L, Vanderhoydonc F, Rosseels J, Hoeben E, Heyns W.

Int J Androl. 1995 Feb;18(1):23-34.


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