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Items: 1 to 50 of 104

1.

Activation of anti-oxidant Nrf2 signaling by enone analogues of curcumin.

Deck LM, Hunsaker LA, Vander Jagt TA, Whalen LJ, Royer RE, Vander Jagt DL.

Eur J Med Chem. 2018 Jan 1;143:854-865. doi: 10.1016/j.ejmech.2017.11.048. Epub 2017 Nov 21.

PMID:
29223100
2.

Activation of anti-oxidant Nrf2 signaling by substituted trans stilbenes.

Deck LM, Whalen LJ, Hunsaker LA, Royer RE, Vander Jagt DL.

Bioorg Med Chem. 2017 Feb 15;25(4):1423-1430. doi: 10.1016/j.bmc.2017.01.005. Epub 2017 Jan 6.

PMID:
28126440
3.

Optical and SPION-enhanced MR imaging shows that trans-stilbene inhibitors of NF-κB concomitantly lower Alzheimer's disease plaque formation and microglial activation in AβPP/PS-1 transgenic mouse brain.

Solberg NO, Chamberlin R, Vigil JR, Deck LM, Heidrich JE, Brown DC, Brady CI, Vander Jagt TA, Garwood M, Bisoffi M, Severns V, Vander Jagt DL, Sillerud LO.

J Alzheimers Dis. 2014;40(1):191-212. doi: 10.3233/JAD-131031.

4.

Evaluation of LDH-A and glutaminase inhibition in vivo by hyperpolarized 13C-pyruvate magnetic resonance spectroscopy of tumors.

Dutta P, Le A, Vander Jagt DL, Tsukamoto T, Martinez GV, Dang CV, Gillies RJ.

Cancer Res. 2013 Jul 15;73(14):4190-5. doi: 10.1158/0008-5472.CAN-13-0465. Epub 2013 May 30.

5.

SPION-enhanced magnetic resonance imaging of Alzheimer's disease plaques in AβPP/PS-1 transgenic mouse brain.

Sillerud LO, Solberg NO, Chamberlain R, Orlando RA, Heidrich JE, Brown DC, Brady CI, Vander Jagt TA, Garwood M, Vander Jagt DL.

J Alzheimers Dis. 2013;34(2):349-65. doi: 10.3233/JAD-121171.

6.

Plasma metabolomic profiles in different stages of CKD.

Shah VO, Townsend RR, Feldman HI, Pappan KL, Kensicki E, Vander Jagt DL.

Clin J Am Soc Nephrol. 2013 Mar;8(3):363-70. doi: 10.2215/CJN.05540512. Epub 2012 Dec 6.

7.

A chemical analog of curcumin as an improved inhibitor of amyloid Abeta oligomerization.

Orlando RA, Gonzales AM, Royer RE, Deck LM, Vander Jagt DL.

PLoS One. 2012;7(3):e31869. doi: 10.1371/journal.pone.0031869. Epub 2012 Mar 19.

8.

Synthesis of benzyl substituted naphthalenes from benzylidene tetralones.

Deck LM, Mgani Q, Martinez A, Martinic A, Whalen LJ, Vander Jagt DL, Royer RE.

Tetrahedron Lett. 2012 Jan 25;53(4):373-376.

9.

The curcumin analog ca27 down-regulates androgen receptor through an oxidative stress mediated mechanism in human prostate cancer cells.

Fajardo AM, MacKenzie DA, Ji M, Deck LM, Vander Jagt DL, Thompson TA, Bisoffi M.

Prostate. 2012 May 1;72(6):612-25. doi: 10.1002/pros.21464. Epub 2011 Jul 27.

10.

Synthesis of Hemigossypol and its Derivatives.

Wei J, Vander Jagt DL, Royer RE, Deck LM.

Tetrahedron Lett. 2010 Oct 3;51(44):5757-5760. Epub 2010 Aug 30.

11.

Natural products inhibit LPS-induced activation of pro-inflammatory cytokines in peripheral blood mononuclear cells.

Shah VO, Ferguson JE, Hunsaker LA, Deck LM, Vander Jagt DL.

Nat Prod Res. 2010 Jul;24(12):1177-88. doi: 10.1080/14786410903112680.

PMID:
20582811
12.

Inhibition of nuclear factor kappaB activation and cyclooxygenase-2 expression by aqueous extracts of Hispanic medicinal herbs.

Orlando RA, Gonzales AM, Hunsaker LA, Franco CR, Royer RE, Vander Jagt DL, Vander Jagt DJ.

J Med Food. 2010 Aug;13(4):888-95. doi: 10.1089/jmf.2009.1128.

13.

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression.

Le A, Cooper CR, Gouw AM, Dinavahi R, Maitra A, Deck LM, Royer RE, Vander Jagt DL, Semenza GL, Dang CV.

Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2037-42. doi: 10.1073/pnas.0914433107. Epub 2010 Jan 19.

14.

Substituted trans-stilbenes can inhibit or enhance the TPA-induced up-regulation of activator protein-1.

Deck LM, Hunsaker LA, Gonzales AM, Orlando RA, Vander Jagt DL.

BMC Pharmacol. 2008 Nov 10;8:19. doi: 10.1186/1471-2210-8-19.

15.

Efficient calculation of molecular properties from simulation using kernel molecular dynamics.

Brown WM, Sasson A, Bellew DR, Hunsaker LA, Martin S, Leitao A, Deck LM, Vander Jagt DL, Oprea TI.

J Chem Inf Model. 2008 Aug;48(8):1626-37. doi: 10.1021/ci8001233. Epub 2008 Aug 2.

PMID:
18672870
16.

Methylglyoxal, diabetes mellitus and diabetic complications.

Vander Jagt DL.

Drug Metabol Drug Interact. 2008;23(1-2):93-124. Review.

PMID:
18533366
17.

Distribution of glyoxalase I polymorphism among Zuni Indians: the Zuni Kidney Project.

Degaffe GH, Vander Jagt DL, Bobelu A, Bobelu J, Neha D, Waikaniwa M, Zager P, Shah VO.

J Diabetes Complications. 2008 Jul-Aug;22(4):267-72. doi: 10.1016/j.jdiacomp.2007.06.010. Epub 2008 Apr 16.

18.

Isocoumarin-based inhibitors of pancreatic cholesterol esterase.

Heynekamp JJ, Hunsaker LA, Vander Jagt TA, Royer RE, Deck LM, Vander Jagt DL.

Bioorg Med Chem. 2008 May 1;16(9):5285-94. doi: 10.1016/j.bmc.2008.03.016. Epub 2008 Mar 6.

19.

TPA-induced up-regulation of activator protein-1 can be inhibited or enhanced by analogs of the natural product curcumin.

Weber WM, Hunsaker LA, Gonzales AM, Heynekamp JJ, Orlando RA, Deck LM, Vander Jagt DL.

Biochem Pharmacol. 2006 Oct 16;72(8):928-40. Epub 2006 Aug 28.

PMID:
16934760
20.

Uncharged isocoumarin-based inhibitors of urokinase-type plasminogen activator.

Heynekamp JJ, Hunsaker LA, Vander Jagt TA, Deck LM, Vander Jagt DL.

BMC Chem Biol. 2006 Feb 8;6:1.

21.

Activation of NFkappaB is inhibited by curcumin and related enones.

Weber WM, Hunsaker LA, Roybal CN, Bobrovnikova-Marjon EV, Abcouwer SF, Royer RE, Deck LM, Vander Jagt DL.

Bioorg Med Chem. 2006 Apr 1;14(7):2450-61. Epub 2005 Dec 7.

PMID:
16338138
22.

Aberrant accumulation of fibulin-3 in the endoplasmic reticulum leads to activation of the unfolded protein response and VEGF expression.

Roybal CN, Marmorstein LY, Vander Jagt DL, Abcouwer SF.

Invest Ophthalmol Vis Sci. 2005 Nov;46(11):3973-9.

PMID:
16249470
23.

Anti-oxidant activities of curcumin and related enones.

Weber WM, Hunsaker LA, Abcouwer SF, Deck LM, Vander Jagt DL.

Bioorg Med Chem. 2005 Jun 1;13(11):3811-20.

PMID:
15863007
24.

The oxidative stressor arsenite activates vascular endothelial growth factor mRNA transcription by an ATF4-dependent mechanism.

Roybal CN, Hunsaker LA, Barbash O, Vander Jagt DL, Abcouwer SF.

J Biol Chem. 2005 May 27;280(21):20331-9. Epub 2005 Mar 23.

25.

Creating artificial binding pocket boundaries to improve the efficiency of flexible ligand docking.

Brown WM, Vander Jagt DL.

J Chem Inf Comput Sci. 2004 Jul-Aug;44(4):1412-22.

PMID:
15272849
27.

Comparative structural analysis and kinetic properties of lactate dehydrogenases from the four species of human malarial parasites.

Brown WM, Yowell CA, Hoard A, Vander Jagt TA, Hunsaker LA, Deck LM, Royer RE, Piper RC, Dame JB, Makler MT, Vander Jagt DL.

Biochemistry. 2004 May 25;43(20):6219-29.

PMID:
15147206
28.

Inhibition of pancreatic cholesterol esterase reduces cholesterol absorption in the hamster.

Heidrich JE, Contos LM, Hunsaker LA, Deck LM, Vander Jagt DL.

BMC Pharmacol. 2004 Apr 19;4:5.

29.

Homocysteine increases the expression of vascular endothelial growth factor by a mechanism involving endoplasmic reticulum stress and transcription factor ATF4.

Roybal CN, Yang S, Sun CW, Hurtado D, Vander Jagt DL, Townes TM, Abcouwer SF.

J Biol Chem. 2004 Apr 9;279(15):14844-52. Epub 2004 Jan 26.

30.

17-beta-Hydroxysteroid dehydrogenase type 1: computational design of active site inhibitors targeted to the Rossmann fold.

Brown WM, Metzger LE, Barlow JP, Hunsaker LA, Deck LM, Royer RE, Vander Jagt DL.

Chem Biol Interact. 2003 Feb 1;143-144:481-91.

PMID:
12604234
32.

Response of VEGF expression to amino acid deprivation and inducers of endoplasmic reticulum stress.

Abcouwer SF, Marjon PL, Loper RK, Vander Jagt DL.

Invest Ophthalmol Vis Sci. 2002 Aug;43(8):2791-8.

PMID:
12147617
33.

Inhibition of yeast lipase (CRL1) and cholesterol esterase (CRL3) by 6-chloro-2-pyrones: comparison with porcine cholesterol esterase.

Stoddard Hatch M, Brown WM, Deck JA, Hunsaker LA, Deck LM, Vander Jagt DL.

Biochim Biophys Acta. 2002 Apr 29;1596(2):381-91.

PMID:
12007617
34.

The kinetic properties and sensitivities to inhibitors of lactate dehydrogenases (LDH1 and LDH2) from Toxoplasma gondii: comparisons with pLDH from Plasmodium falciparum.

Dando C, Schroeder ER, Hunsaker LA, Deck LM, Royer RE, Zhou X, Parmley SF, Vander Jagt DL.

Mol Biochem Parasitol. 2001 Nov;118(1):23-32.

PMID:
11704270
35.

Oxidative stress indices in IDDM subjects with and without long-term diabetic complications.

VanderJagt DJ, Harrison JM, Ratliff DM, Hunsaker LA, Vander Jagt DL.

Clin Biochem. 2001 Jun;34(4):265-70.

PMID:
11440725
36.

Selective active site inhibitors of human lactate dehydrogenases A4, B4, and C4.

Yu Y, Deck JA, Hunsaker LA, Deck LM, Royer RE, Goldberg E, Vander Jagt DL.

Biochem Pharmacol. 2001 Jul 1;62(1):81-9.

PMID:
11377399
37.

Metabolism of the 2-oxoaldehyde methylglyoxal by aldose reductase and by glyoxalase-I: roles for glutathione in both enzymes and implications for diabetic complications.

Vander Jagt DL, Hassebrook RK, Hunsaker LA, Brown WM, Royer RE.

Chem Biol Interact. 2001 Jan 30;130-132(1-3):549-62.

PMID:
11306074
38.

Relationship of oxidative stress indices to decreased LDL-cholesterol after acute myocardial infarction.

Chamblee BB, Timm TC, Hunsaker LA, Vander Jagt DL.

Clin Biochem. 2000 Jul;33(5):423-6. No abstract available.

PMID:
11018697
39.

Gossypol: prototype of inhibitors targeted to dinucleotide folds.

Vander Jagt DL, Deck LM, Royer RE.

Curr Med Chem. 2000 Apr;7(4):479-98. Review.

PMID:
10702620
40.

3-Alkyl-6-chloro-2-pyrones: selective inhibitors of pancreatic cholesterol esterase.

Deck LM, Baca ML, Salas SL, Hunsaker LA, Vander Jagt DL.

J Med Chem. 1999 Oct 7;42(20):4250-6.

PMID:
10514295
41.

Inhibition of human aldose and aldehyde reductases by non-steroidal anti-inflammatory drugs.

Ratliff DM, Martinez FJ, Vander Jagt TJ, Schimandle CM, Robinson B, Hunsaker LA, Vander Jagt DL.

Adv Exp Med Biol. 1999;463:493-9. No abstract available.

PMID:
10352724
42.

Inhibition of aldose reductase by gossypol and gossypol-related compounds.

Deck LM, Chamblee BB, Royer RE, Hunsaker LA, Vander Jagt DL.

Adv Exp Med Biol. 1999;463:487-92. No abstract available.

PMID:
10352723
43.

Selective inhibitors of human lactate dehydrogenases and lactate dehydrogenase from the malarial parasite Plasmodium falciparum.

Deck LM, Royer RE, Chamblee BB, Hernandez VM, Malone RR, Torres JE, Hunsaker LA, Piper RC, Makler MT, Vander Jagt DL.

J Med Chem. 1998 Sep 24;41(20):3879-87.

PMID:
9748363
44.

Z-2 microsatellite allele is linked to increased expression of the aldose reductase gene in diabetic nephropathy.

Shah VO, Scavini M, Nikolic J, Sun Y, Vai S, Griffith JK, Dorin RI, Stidley C, Yacoub M, Vander Jagt DL, Eaton RP, Zager PG.

J Clin Endocrinol Metab. 1998 Aug;83(8):2886-91.

PMID:
9709964
45.

Substrate and cofactor specificity and selective inhibition of lactate dehydrogenase from the malarial parasite P. falciparum.

Gomez MS, Piper RC, Hunsaker LA, Royer RE, Deck LM, Makler MT, Vander Jagt DL.

Mol Biochem Parasitol. 1997 Dec 1;90(1):235-46.

PMID:
9497046
46.

Inactivation of glutathione reductase by 4-hydroxynonenal and other endogenous aldehydes.

Vander Jagt DL, Hunsaker LA, Vander Jagt TJ, Gomez MS, Gonzales DM, Deck LM, Royer RE.

Biochem Pharmacol. 1997 Apr 25;53(8):1133-40.

PMID:
9175718
47.

Physiological substrates of human aldose and aldehyde reductases.

Vander Jagt DL, Torres JE, Hunsaker LA, Deck LM, Royer RE.

Adv Exp Med Biol. 1997;414:491-7. No abstract available.

PMID:
9059654
49.

Synthesis and anti-HIV activity of 1,1'-dideoxygossypol and related compounds.

Royer RE, Deck LM, Vander Jagt TJ, Martinez FJ, Mills RG, Young SA, Vander Jagt DL.

J Med Chem. 1995 Jun 23;38(13):2427-32.

PMID:
7608907
50.

Substrate specificity of human aldose reductase: identification of 4-hydroxynonenal as an endogenous substrate.

Vander Jagt DL, Kolb NS, Vander Jagt TJ, Chino J, Martinez FJ, Hunsaker LA, Royer RE.

Biochim Biophys Acta. 1995 Jun 12;1249(2):117-26.

PMID:
7599164

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