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Items: 1 to 50 of 472

1.

The ubiquitin-editing enzyme A20 controls NK cell homeostasis through regulation of mTOR activity and TNF.

Vetters J, van Helden MJ, Wahlen S, Tavernier SJ, Martens A, Fayazpour F, Vergote K, Vanheerswynghels M, Deswarte K, Van Moorleghem J, De Prijck S, Takahashi N, Vandenabeele P, Boon L, van Loo G, Vivier E, Lambrecht BN, Janssens S.

J Exp Med. 2019 Jul 11. pii: jem.20182164. doi: 10.1084/jem.20182164. [Epub ahead of print]

PMID:
31296735
2.

Targeting Ferroptosis to Iron Out Cancer.

Hassannia B, Vandenabeele P, Vanden Berghe T.

Cancer Cell. 2019 Jun 10;35(6):830-849. doi: 10.1016/j.ccell.2019.04.002. Epub 2019 May 16. Review.

PMID:
31105042
3.

Caspase-3 probes for PET imaging of apoptotic tumor response to anticancer therapy.

Elvas F, Vanden Berghe T, Adriaenssens Y, Vandenabeele P, Augustyns K, Staelens S, Stroobants S, Van der Veken P, Wyffels L.

Org Biomol Chem. 2019 May 15;17(19):4801-4824. doi: 10.1039/c9ob00657e.

PMID:
31033991
4.

Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation.

Dondelinger Y, Delanghe T, Priem D, Wynosky-Dolfi MA, Sorobetea D, Rojas-Rivera D, Giansanti P, Roelandt R, Gropengiesser J, Ruckdeschel K, Savvides SN, Heck AJR, Vandenabeele P, Brodsky IE, Bertrand MJM.

Nat Commun. 2019 Apr 15;10(1):1729. doi: 10.1038/s41467-019-09690-0.

5.

The molecular machinery of regulated cell death.

Tang D, Kang R, Berghe TV, Vandenabeele P, Kroemer G.

Cell Res. 2019 May;29(5):347-364. doi: 10.1038/s41422-019-0164-5. Epub 2019 Apr 4. Review.

PMID:
30948788
6.

Survival of Single Positive Thymocytes Depends upon Developmental Control of RIPK1 Kinase Signaling by the IKK Complex Independent of NF-κB.

Webb LV, Barbarulo A, Huysentruyt J, Vanden Berghe T, Takahashi N, Ley S, Vandenabeele P, Seddon B.

Immunity. 2019 Feb 19;50(2):348-361.e4. doi: 10.1016/j.immuni.2019.01.004. Epub 2019 Feb 5.

7.

A Micro-Analytical Study of the Scarabs of the Necropolis of Vinha das Caliças (Portugal).

Costa M, Arruda AM, Barbosa R, Barrulas P, Vandenabeele P, Mirão J.

Microsc Microanal. 2019 Feb;25(1):214-220. doi: 10.1017/S143192761801560X. Epub 2019 Jan 31.

PMID:
30702056
8.

Intersections between Regulated Cell Death and Autophagy.

Napoletano F, Baron O, Vandenabeele P, Mollereau B, Fanto M.

Trends Cell Biol. 2019 Apr;29(4):323-338. doi: 10.1016/j.tcb.2018.12.007. Epub 2019 Jan 18. Review.

PMID:
30665736
9.

To NET or not to NET:current opinions and state of the science regarding the formation of neutrophil extracellular traps.

Boeltz S, Amini P, Anders HJ, Andrade F, Bilyy R, Chatfield S, Cichon I, Clancy DM, Desai J, Dumych T, Dwivedi N, Gordon RA, Hahn J, Hidalgo A, Hoffmann MH, Kaplan MJ, Knight JS, Kolaczkowska E, Kubes P, Leppkes M, Manfredi AA, Martin SJ, Maueröder C, Maugeri N, Mitroulis I, Munoz LE, Nakazawa D, Neeli I, Nizet V, Pieterse E, Radic MZ, Reinwald C, Ritis K, Rovere-Querini P, Santocki M, Schauer C, Schett G, Shlomchik MJ, Simon HU, Skendros P, Stojkov D, Vandenabeele P, Berghe TV, van der Vlag J, Vitkov L, von Köckritz-Blickwede M, Yousefi S, Zarbock A, Herrmann M.

Cell Death Differ. 2019 Mar;26(3):395-408. doi: 10.1038/s41418-018-0261-x. Epub 2019 Jan 8. Review.

PMID:
30622307
10.

Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis.

Saavedra PHV, Huang L, Ghazavi F, Kourula S, Vanden Berghe T, Takahashi N, Vandenabeele P, Lamkanfi M.

Nat Commun. 2018 Nov 19;9(1):4846. doi: 10.1038/s41467-018-07386-5.

11.

Therapeutic Targeting of Connexin Channels: New Views and Challenges.

Delvaeye T, Vandenabeele P, Bultynck G, Leybaert L, Krysko DV.

Trends Mol Med. 2018 Dec;24(12):1036-1053. doi: 10.1016/j.molmed.2018.10.005. Epub 2018 Nov 10. Review.

PMID:
30424929
12.

Macrophages regulate the clearance of living cells by calreticulin.

Krysko DV, Ravichandran KS, Vandenabeele P.

Nat Commun. 2018 Nov 7;9(1):4644. doi: 10.1038/s41467-018-06807-9. No abstract available.

13.

MLKL Reveals Its Friendly Face: A Role in Nerve Regeneration.

Vandenabeele P, Declercq W, Roelandt R, Vanden Berghe T.

Mol Cell. 2018 Nov 1;72(3):397-399. doi: 10.1016/j.molcel.2018.10.025.

PMID:
30388406
14.

Discovery of Novel, Drug-Like Ferroptosis Inhibitors with in Vivo Efficacy.

Devisscher L, Van Coillie S, Hofmans S, Van Rompaey D, Goossens K, Meul E, Maes L, De Winter H, Van Der Veken P, Vandenabeele P, Berghe TV, Augustyns K.

J Med Chem. 2018 Nov 21;61(22):10126-10140. doi: 10.1021/acs.jmedchem.8b01299. Epub 2018 Nov 6.

PMID:
30354101
15.

Nuclear RIPK3 and MLKL contribute to cytosolic necrosome formation and necroptosis.

Weber K, Roelandt R, Bruggeman I, Estornes Y, Vandenabeele P.

Commun Biol. 2018 Jan 22;1:6. doi: 10.1038/s42003-017-0007-1. eCollection 2018.

16.

Treatment with mRNA coding for the necroptosis mediator MLKL induces antitumor immunity directed against neo-epitopes.

Van Hoecke L, Van Lint S, Roose K, Van Parys A, Vandenabeele P, Grooten J, Tavernier J, De Koker S, Saelens X.

Nat Commun. 2018 Aug 24;9(1):3417. doi: 10.1038/s41467-018-05979-8.

17.

Keratinocyte Expression of A20/TNFAIP3 Controls Skin Inflammation Associated with Atopic Dermatitis and Psoriasis.

Devos M, Mogilenko DA, Fleury S, Gilbert B, Becquart C, Quemener S, Dehondt H, Tougaard P, Staels B, Bachert C, Vandenabeele P, Van Loo G, Staumont-Salle D, Declercq W, Dombrowicz D.

J Invest Dermatol. 2019 Jan;139(1):135-145. doi: 10.1016/j.jid.2018.06.191. Epub 2018 Aug 14.

PMID:
30118730
18.

The Transcription Factor ZEB2 Is Required to Maintain the Tissue-Specific Identities of Macrophages.

Scott CL, T'Jonck W, Martens L, Todorov H, Sichien D, Soen B, Bonnardel J, De Prijck S, Vandamme N, Cannoodt R, Saelens W, Vanneste B, Toussaint W, De Bleser P, Takahashi N, Vandenabeele P, Henri S, Pridans C, Hume DA, Lambrecht BN, De Baetselier P, Milling SWF, Van Ginderachter JA, Malissen B, Berx G, Beschin A, Saeys Y, Guilliams M.

Immunity. 2018 Aug 21;49(2):312-325.e5. doi: 10.1016/j.immuni.2018.07.004. Epub 2018 Jul 31.

19.

Comparative study of the differential cell death protecting effect of various ROS scavengers.

Kavčič N, Pegan K, Vandenabeele P, Turk B.

Biol Chem. 2019 Jan 28;400(2):149-160. doi: 10.1515/hsz-2017-0317.

PMID:
30052510
20.

Correction: Resistance to anticancer vaccination effect is controlled by a cancer cell-autonomous phenotype that disrupts immunogenic phagocytic removal.

Garg AD, Elsen S, Krysko DV, Vandenabeele P, de Witte P, Agostinis P.

Oncotarget. 2018 Jun 26;9(49):29284. doi: 10.18632/oncotarget.25721. eCollection 2018 Jun 26.

21.

Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma.

Hassannia B, Wiernicki B, Ingold I, Qu F, Van Herck S, Tyurina YY, Bayır H, Abhari BA, Angeli JPF, Choi SM, Meul E, Heyninck K, Declerck K, Chirumamilla CS, Lahtela-Kakkonen M, Van Camp G, Krysko DV, Ekert PG, Fulda S, De Geest BG, Conrad M, Kagan VE, Vanden Berghe W, Vandenabeele P, Vanden Berghe T.

J Clin Invest. 2018 Aug 1;128(8):3341-3355. doi: 10.1172/JCI99032. Epub 2018 Jun 25.

22.

Glucocorticoid receptor dimers control intestinal STAT1 and TNF-induced inflammation in mice.

Ballegeer M, Van Looveren K, Timmermans S, Eggermont M, Vandevyver S, Thery F, Dendoncker K, Souffriau J, Vandewalle J, Van Wyngene L, De Rycke R, Takahashi N, Vandenabeele P, Tuckermann J, Reichardt HM, Impens F, Beyaert R, De Bosscher K, Vandenbroucke RE, Libert C.

J Clin Invest. 2018 Aug 1;128(8):3265-3279. doi: 10.1172/JCI96636. Epub 2018 Jun 25.

23.

Author Correction: Hypericin-based photodynamic therapy induces surface exposure of damage-associated molecular patterns like HSP70 and calreticulin.

Garg AD, Krysko DV, Vandenabeele P, Agostinis P.

Cancer Immunol Immunother. 2018 Jul;67(7):1179-1180. doi: 10.1007/s00262-018-2162-8.

PMID:
29737376
24.

N-glycosylation of mouse TRAIL-R restrains TRAIL-induced apoptosis.

Estornes Y, Dondelinger Y, Weber K, Bruggeman I, Peall A, MacFarlane M, Lebecque S, Vandenabeele P, Bertrand MJM.

Cell Death Dis. 2018 May 1;9(5):494. doi: 10.1038/s41419-018-0544-7.

25.

Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2.

Annibaldi A, Wicky John S, Vanden Berghe T, Swatek KN, Ruan J, Liccardi G, Bianchi K, Elliott PR, Choi SM, Van Coillie S, Bertin J, Wu H, Komander D, Vandenabeele P, Silke J, Meier P.

Mol Cell. 2018 Feb 15;69(4):566-580.e5. doi: 10.1016/j.molcel.2018.01.027.

26.

Tozasertib Analogues as Inhibitors of Necroptotic Cell Death.

Hofmans S, Devisscher L, Martens S, Van Rompaey D, Goossens K, Divert T, Nerinckx W, Takahashi N, De Winter H, Van Der Veken P, Goossens V, Vandenabeele P, Augustyns K.

J Med Chem. 2018 Mar 8;61(5):1895-1920. doi: 10.1021/acs.jmedchem.7b01449. Epub 2018 Feb 20.

PMID:
29437386
27.

RIPK4 activity in keratinocytes is controlled by the SCFβ-TrCP ubiquitin ligase to maintain cortical actin organization.

Tanghe G, Urwyler-Rösselet C, De Groote P, Dejardin E, De Bock PJ, Gevaert K, Vandenabeele P, Declercq W.

Cell Mol Life Sci. 2018 Aug;75(15):2827-2841. doi: 10.1007/s00018-018-2763-6. Epub 2018 Feb 12.

PMID:
29435596
28.

RIPK1-dependent cell death: a novel target of the Aurora kinase inhibitor Tozasertib (VX-680).

Martens S, Goossens V, Devisscher L, Hofmans S, Claeys P, Vuylsteke M, Takahashi N, Augustyns K, Vandenabeele P.

Cell Death Dis. 2018 Feb 12;9(2):211. doi: 10.1038/s41419-017-0245-7.

29.

Noninvasive Whole-Body Imaging of Phosphatidylethanolamine as a Cell Death Marker Using 99mTc-Duramycin During TNF-Induced SIRS.

Delvaeye T, Wyffels L, Deleye S, Lemeire K, Gonçalves A, Decrock E, Staelens S, Leybaert L, Vandenabeele P, Krysko DV.

J Nucl Med. 2018 Jul;59(7):1140-1145. doi: 10.2967/jnumed.117.205815. Epub 2018 Feb 1.

30.

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, Bazan NG, Bernassola F, Bertrand MJM, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Boya P, Brenner C, Campanella M, Candi E, Carmona-Gutierrez D, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Cohen GM, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, DeBerardinis RJ, Deshmukh M, Di Daniele N, Di Virgilio F, Dixit VM, Dixon SJ, Duckett CS, Dynlacht BD, El-Deiry WS, Elrod JW, Fimia GM, Fulda S, García-Sáez AJ, Garg AD, Garrido C, Gavathiotis E, Golstein P, Gottlieb E, Green DR, Greene LA, Gronemeyer H, Gross A, Hajnoczky G, Hardwick JM, Harris IS, Hengartner MO, Hetz C, Ichijo H, Jäättelä M, Joseph B, Jost PJ, Juin PP, Kaiser WJ, Karin M, Kaufmann T, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Knight RA, Kumar S, Lee SW, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lowe SW, Luedde T, Lugli E, MacFarlane M, Madeo F, Malewicz M, Malorni W, Manic G, Marine JC, Martin SJ, Martinou JC, Medema JP, Mehlen P, Meier P, Melino S, Miao EA, Molkentin JD, Moll UM, Muñoz-Pinedo C, Nagata S, Nuñez G, Oberst A, Oren M, Overholtzer M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pereira DM, Pervaiz S, Peter ME, Piacentini M, Pinton P, Prehn JHM, Puthalakath H, Rabinovich GA, Rehm M, Rizzuto R, Rodrigues CMP, Rubinsztein DC, Rudel T, Ryan KM, Sayan E, Scorrano L, Shao F, Shi Y, Silke J, Simon HU, Sistigu A, Stockwell BR, Strasser A, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Thorburn A, Tsujimoto Y, Turk B, Vanden Berghe T, Vandenabeele P, Vander Heiden MG, Villunger A, Virgin HW, Vousden KH, Vucic D, Wagner EF, Walczak H, Wallach D, Wang Y, Wells JA, Wood W, Yuan J, Zakeri Z, Zhivotovsky B, Zitvogel L, Melino G, Kroemer G.

Cell Death Differ. 2018 Mar;25(3):486-541. doi: 10.1038/s41418-017-0012-4. Epub 2018 Jan 23. Review.

31.

Nanoscopic X-ray fluorescence imaging and quantification of intracellular key-elements in cryofrozen Friedreich's ataxia fibroblasts.

De Samber B, Meul E, Laforce B, De Paepe B, Smet J, De Bruyne M, De Rycke R, Bohic S, Cloetens P, Van Coster R, Vandenabeele P, Vanden Berghe T.

PLoS One. 2018 Jan 17;13(1):e0190495. doi: 10.1371/journal.pone.0190495. eCollection 2018. Erratum in: PLoS One. 2018 Apr 30;13(4):e0194850.

32.

Keratinocyte-Specific Ablation of RIPK4 Allows Epidermal Cornification but Impairs Skin Barrier Formation.

Urwyler-Rösselet C, Tanghe G, Leurs K, Gilbert B, De Rycke R, De Bruyne M, Lippens S, Bartunkova S, De Groote P, Niessen C, Haftek M, Vandenabeele P, Declercq W.

J Invest Dermatol. 2018 Jun;138(6):1268-1278. doi: 10.1016/j.jid.2017.12.031. Epub 2018 Jan 6.

33.

Necroptotic cell death in anti-cancer therapy.

Krysko O, Aaes TL, Kagan VE, D'Herde K, Bachert C, Leybaert L, Vandenabeele P, Krysko DV.

Immunol Rev. 2017 Nov;280(1):207-219. doi: 10.1111/imr.12583. Review.

PMID:
29027225
34.

6E11, a highly selective inhibitor of Receptor-Interacting Protein Kinase 1, protects cells against cold hypoxia-reoxygenation injury.

Delehouzé C, Leverrier-Penna S, Le Cann F, Comte A, Jacquard-Fevai M, Delalande O, Desban N, Baratte B, Gallais I, Faurez F, Bonnet MC, Hauteville M, Goekjian PG, Thuillier R, Favreau F, Vandenabeele P, Hauet T, Dimanche-Boitrel MT, Bach S.

Sci Rep. 2017 Oct 10;7(1):12931. doi: 10.1038/s41598-017-12788-4.

35.

How do we fit ferroptosis in the family of regulated cell death?

Fearnhead HO, Vandenabeele P, Vanden Berghe T.

Cell Death Differ. 2017 Dec;24(12):1991-1998. doi: 10.1038/cdd.2017.149. Epub 2017 Oct 6. Review.

36.

Sorafenib inhibits therapeutic induction of necroptosis in acute leukemia cells.

Feldmann F, Schenk B, Martens S, Vandenabeele P, Fulda S.

Oncotarget. 2017 Aug 4;8(40):68208-68220. doi: 10.18632/oncotarget.19919. eCollection 2017 Sep 15.

37.

Heme Oxygenase Activity and Heme Binding in a Neonatal Mouse Model.

Kourula S, Ang J, Zhao H, Kalish F, Vandenabeele P, Sylvester KG, Wong RJ, Stevenson DK.

Neonatology. 2017;112(4):376-383. doi: 10.1159/000479493. Epub 2017 Sep 20.

PMID:
28926834
38.

MK2 phosphorylation of RIPK1 regulates TNF-mediated cell death.

Dondelinger Y, Delanghe T, Rojas-Rivera D, Priem D, Delvaeye T, Bruggeman I, Van Herreweghe F, Vandenabeele P, Bertrand MJM.

Nat Cell Biol. 2017 Oct;19(10):1237-1247. doi: 10.1038/ncb3608. Epub 2017 Sep 18.

PMID:
28920952
39.

RIPK1 protects hepatocytes from death in Fas-induced hepatitis.

Filliol A, Farooq M, Piquet-Pellorce C, Genet V, Dimanche-Boitrel MT, Vandenabeele P, Bertrand MJM, Samson M, Le Seyec J.

Sci Rep. 2017 Aug 23;7(1):9205. doi: 10.1038/s41598-017-09789-8.

40.

Development of a Fiber-Optics Microspatially Offset Raman Spectroscopy Sensor for Probing Layered Materials.

Vandenabeele P, Conti C, Rousaki A, Moens L, Realini M, Matousek P.

Anal Chem. 2017 Sep 5;89(17):9218-9223. doi: 10.1021/acs.analchem.7b01978. Epub 2017 Aug 11.

PMID:
28753322
41.

Necroptosis: (Last) Message in a Bubble.

Vandenabeele P, Riquet F, Cappe B.

Immunity. 2017 Jul 18;47(1):1-3. doi: 10.1016/j.immuni.2017.07.002.

42.

Sibiriline, a new small chemical inhibitor of receptor-interacting protein kinase 1, prevents immune-dependent hepatitis.

Le Cann F, Delehouzé C, Leverrier-Penna S, Filliol A, Comte A, Delalande O, Desban N, Baratte B, Gallais I, Piquet-Pellorce C, Faurez F, Bonnet M, Mettey Y, Goekjian P, Samson M, Vandenabeele P, Bach S, Dimanche-Boitrel MT.

FEBS J. 2017 Sep;284(18):3050-3068. doi: 10.1111/febs.14176. Epub 2017 Aug 11.

43.

Sorafenib tosylate inhibits directly necrosome complex formation and protects in mouse models of inflammation and tissue injury.

Martens S, Jeong M, Tonnus W, Feldmann F, Hofmans S, Goossens V, Takahashi N, Bräsen JH, Lee EW, Van der Veken P, Joossens J, Augustyns K, Fulda S, Linkermann A, Song J, Vandenabeele P.

Cell Death Dis. 2017 Jun 29;8(6):e2904. doi: 10.1038/cddis.2017.298.

44.

The IL-33/ST2 axis is crucial in type 2 airway responses induced by Staphylococcus aureus-derived serine protease-like protein D.

Teufelberger AR, Nordengrün M, Braun H, Maes T, De Grove K, Holtappels G, O'Brien C, Provoost S, Hammad H, Gonçalves A, Beyaert R, Declercq W, Vandenabeele P, Krysko DV, Bröker BM, Bachert C, Krysko O.

J Allergy Clin Immunol. 2018 Feb;141(2):549-559.e7. doi: 10.1016/j.jaci.2017.05.004. Epub 2017 May 19.

PMID:
28532656
45.

Initiation and execution mechanisms of necroptosis: an overview.

Grootjans S, Vanden Berghe T, Vandenabeele P.

Cell Death Differ. 2017 Jul;24(7):1184-1195. doi: 10.1038/cdd.2017.65. Epub 2017 May 12. Review.

46.

When PERK inhibitors turn out to be new potent RIPK1 inhibitors: critical issues on the specificity and use of GSK2606414 and GSK2656157.

Rojas-Rivera D, Delvaeye T, Roelandt R, Nerinckx W, Augustyns K, Vandenabeele P, Bertrand MJM.

Cell Death Differ. 2017 Jun;24(6):1100-1110. doi: 10.1038/cdd.2017.58. Epub 2017 Apr 28.

47.

Impact of caspase-1/11, -3, -7, or IL-1β/IL-18 deficiency on rabies virus-induced macrophage cell death and onset of disease.

Kip E, Nazé F, Suin V, Vanden Berghe T, Francart A, Lamoral S, Vandenabeele P, Beyaert R, Van Gucht S, Kalai M.

Cell Death Discov. 2017 Mar 6;3:17012. doi: 10.1038/cddiscovery.2017.12. eCollection 2017.

48.

RIPK1 protects hepatocytes from Kupffer cells-mediated TNF-induced apoptosis in mouse models of PAMP-induced hepatitis.

Filliol A, Piquet-Pellorce C, Raguénès-Nicol C, Dion S, Farooq M, Lucas-Clerc C, Vandenabeele P, Bertrand MJM, Le Seyec J, Samson M.

J Hepatol. 2017 Jun;66(6):1205-1213. doi: 10.1016/j.jhep.2017.01.005. Epub 2017 Jan 11.

49.

RIPK1 protects from TNF-α-mediated liver damage during hepatitis.

Filliol A, Piquet-Pellorce C, Le Seyec J, Farooq M, Genet V, Lucas-Clerc C, Bertin J, Gough PJ, Dimanche-Boitrel MT, Vandenabeele P, Bertrand MJ, Samson M.

Cell Death Dis. 2016 Nov 10;7(11):e2462. doi: 10.1038/cddis.2016.362.

50.

Raman spectroscopy in art and archaeology.

Edwards HG, Vandenabeele P.

Philos Trans A Math Phys Eng Sci. 2016 Dec 13;374(2082). pii: 20160052. No abstract available.

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