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Items: 37


Placebo Effects in Clinical Trials Evaluating Patients with Uncontrolled Persistent Asthma.

Luc F, Prieur E, Whitmore GA, Gibson PG, Vandemheen KL, Aaron SD.

Ann Am Thorac Soc. 2019 Sep;16(9):1124-1130. doi: 10.1513/AnnalsATS.201901-071OC.


Between-Visit Variability in FEV1 as a Diagnostic Test for Asthma in Adults.

Dean BW, Birnie EE, Whitmore GA, Vandemheen KL, Boulet LP, FitzGerald JM, Ainslie M, Gupta S, Lemiere C, Field SK, McIvor RA, Hernandez P, Mayers I, Aaron SD; Canadian Respiratory Research Network.

Ann Am Thorac Soc. 2018 Sep;15(9):1039-1046. doi: 10.1513/AnnalsATS.201803-211OC.


Reevaluation of Diagnosis in Adults With Physician-Diagnosed Asthma.

Aaron SD, Vandemheen KL, FitzGerald JM, Ainslie M, Gupta S, Lemière C, Field SK, McIvor RA, Hernandez P, Mayers I, Mulpuru S, Alvarez GG, Pakhale S, Mallick R, Boulet LP; Canadian Respiratory Research Network.

JAMA. 2017 Jan 17;317(3):269-279. doi: 10.1001/jama.2016.19627.


COPD Exacerbation Biomarkers Validated Using Multiple Reaction Monitoring Mass Spectrometry.

Leung JM, Chen V, Hollander Z, Dai D, Tebbutt SJ, Aaron SD, Vandemheen KL, Rennard SI, FitzGerald JM, Woodruff PG, Lazarus SC, Connett JE, Coxson HO, Miller B, Borchers C, McManus BM, Ng RT, Sin DD.

PLoS One. 2016 Aug 15;11(8):e0161129. doi: 10.1371/journal.pone.0161129. eCollection 2016.


Implementation of a cystic fibrosis lung transplant referral patient decision aid in routine clinical practice: an observational study.

Stacey D, Vandemheen KL, Hennessey R, Gooyers T, Gaudet E, Mallick R, Salgado J, Freitag A, Berthiaume Y, Brown N, Aaron SD.

Implement Sci. 2015 Feb 7;10:17. doi: 10.1186/s13012-015-0206-4.


Acute effects of viral respiratory tract infections on sputum bacterial density during CF pulmonary exacerbations.

Chin M, De Zoysa M, Slinger R, Gaudet E, Vandemheen KL, Chan F, Hyde L, Mah TF, Ferris W, Mallick R, Aaron SD.

J Cyst Fibros. 2015 Jul;14(4):482-9. doi: 10.1016/j.jcf.2014.11.009. Epub 2014 Dec 18.


TNFα antagonists for acute exacerbations of COPD: a randomised double-blind controlled trial.

Aaron SD, Vandemheen KL, Maltais F, Field SK, Sin DD, Bourbeau J, Marciniuk DD, FitzGerald JM, Nair P, Mallick R.

Thorax. 2013 Feb;68(2):142-8. doi: 10.1136/thoraxjnl-2012-202432. Epub 2012 Nov 17.


Treatment of Aspergillus fumigatus in patients with cystic fibrosis: a randomized, placebo-controlled pilot study.

Aaron SD, Vandemheen KL, Freitag A, Pedder L, Cameron W, Lavoie A, Paterson N, Wilcox P, Rabin H, Tullis E, Morrison N, Ratjen F.

PLoS One. 2012;7(4):e36077. doi: 10.1371/journal.pone.0036077. Epub 2012 Apr 30.


Persistency of Pseudomonas aeruginosa in sputum cultures and clinical outcomes in adult patients with cystic fibrosis.

Burkett A, Vandemheen KL, Giesbrecht-Lewis T, Ramotar K, Ferris W, Chan F, Doucette S, Fergusson D, Aaron SD.

Eur J Clin Microbiol Infect Dis. 2012 Jul;31(7):1603-10. doi: 10.1007/s10096-011-1483-8. Epub 2011 Nov 23.


Exacerbation frequency and clinical outcomes in adult patients with cystic fibrosis.

de Boer K, Vandemheen KL, Tullis E, Doucette S, Fergusson D, Freitag A, Paterson N, Jackson M, Lougheed MD, Kumar V, Aaron SD.

Thorax. 2011 Aug;66(8):680-5. doi: 10.1136/thx.2011.161117. Epub 2011 Jun 15.


Infection with transmissible strains of Pseudomonas aeruginosa and clinical outcomes in adults with cystic fibrosis.

Aaron SD, Vandemheen KL, Ramotar K, Giesbrecht-Lewis T, Tullis E, Freitag A, Paterson N, Jackson M, Lougheed MD, Dowson C, Kumar V, Ferris W, Chan F, Doucette S, Fergusson D.

JAMA. 2010 Nov 17;304(19):2145-53. doi: 10.1001/jama.2010.1665.


Multi analyte profiling and variability of inflammatory markers in blood and induced sputum in patients with stable COPD.

Aaron SD, Vandemheen KL, Ramsay T, Zhang C, Avnur Z, Nikolcheva T, Quinn A.

Respir Res. 2010 Apr 22;11:41. doi: 10.1186/1465-9921-11-41.


Development of a decision aid for adult cystic fibrosis patients considering referral for lung transplantation.

Vandemheen KL, Aaron SD, Poirier C, Tullis E, O'Connor A.

Prog Transplant. 2010 Mar;20(1):81-7.


Confirmation of asthma in an era of overdiagnosis.

Luks VP, Vandemheen KL, Aaron SD.

Eur Respir J. 2010 Aug;36(2):255-60. doi: 10.1183/09031936.00165109. Epub 2010 Jan 14.


Randomized trial of a decision aid for patients with cystic fibrosis considering lung transplantation.

Vandemheen KL, O'Connor A, Bell SC, Freitag A, Bye P, Jeanneret A, Berthiaume Y, Brown N, Wilcox P, Ryan G, Brager N, Rabin H, Morrison N, Gibson P, Jackson M, Paterson N, Middleton P, Aaron SD.

Am J Respir Crit Care Med. 2009 Oct 15;180(8):761-8. doi: 10.1164/rccm.200903-0421OC. Epub 2009 Jul 9.


A retrospective analysis of biofilm antibiotic susceptibility testing: a better predictor of clinical response in cystic fibrosis exacerbations.

Keays T, Ferris W, Vandemheen KL, Chan F, Yeung SW, Mah TF, Ramotar K, Saginur R, Aaron SD.

J Cyst Fibros. 2009 Mar;8(2):122-7. doi: 10.1016/j.jcf.2008.10.005. Epub 2008 Dec 7.


Overdiagnosis of asthma in obese and nonobese adults.

Aaron SD, Vandemheen KL, Boulet LP, McIvor RA, Fitzgerald JM, Hernandez P, Lemiere C, Sharma S, Field SK, Alvarez GG, Dales RE, Doucette S, Fergusson D; Canadian Respiratory Clinical Research Consortium.

CMAJ. 2008 Nov 18;179(11):1121-31. doi: 10.1503/cmaj.081332. Erratum in: CMAJ. 2008 Dec 2;179(12):1301.


Epidemiological investigation and glycotyping of clinical Pseudomonas aeruginosa isolates from patients with cystic fibrosis by mass spectrometry: association with multiple drug resistance.

Altman E, Wang Z, Aaron SD, Liu X, Vandemheen KL, Ferris W, Giesbrecht T, Li J.

J Microbiol Methods. 2009 Feb;76(2):204-8. doi: 10.1016/j.mimet.2008.10.008. Epub 2008 Oct 28.


Cost effectiveness of therapy with combinations of long acting bronchodilators and inhaled steroids for treatment of COPD.

Najafzadeh M, Marra CA, Sadatsafavi M, Aaron SD, Sullivan SD, Vandemheen KL, Jones PW, Fitzgerald JM.

Thorax. 2008 Nov;63(11):962-7. doi: 10.1136/thx.2007.089557. Epub 2008 Jul 11.


Methodological issues in therapeutic trials of COPD.

Suissa S, Ernst P, Vandemheen KL, Aaron SD.

Eur Respir J. 2008 May;31(5):927-33. doi: 10.1183/09031936.00098307. Epub 2008 Jan 23. Review.


Counting, analysing and reporting exacerbations of COPD in randomised controlled trials.

Aaron SD, Fergusson D, Marks GB, Suissa S, Vandemheen KL, Doucette S, Maltais F, Bourbeau JF, Goldstein RS, Balter M, O'Donnell D, Fitzgerald M; Canadian Thoracic Society/Canadian Respiratory Clinical Research Consortium.

Thorax. 2008 Feb;63(2):122-8. Epub 2007 Aug 16. Review.


Tiotropium in combination with placebo, salmeterol, or fluticasone-salmeterol for treatment of chronic obstructive pulmonary disease: a randomized trial.

Aaron SD, Vandemheen KL, Fergusson D, Maltais F, Bourbeau J, Goldstein R, Balter M, O'Donnell D, McIvor A, Sharma S, Bishop G, Anthony J, Cowie R, Field S, Hirsch A, Hernandez P, Rivington R, Road J, Hoffstein V, Hodder R, Marciniuk D, McCormack D, Fox G, Cox G, Prins HB, Ford G, Bleskie D, Doucette S, Mayers I, Chapman K, Zamel N, FitzGerald M; Canadian Thoracic Society/Canadian Respiratory Clinical Research Consortium.

Ann Intern Med. 2007 Apr 17;146(8):545-55. Epub 2007 Feb 19.


Sex differences in the clinical presentation and management of airflow obstruction.

Dales RE, Mehdizadeh A, Aaron SD, Vandemheen KL, Clinch J.

Eur Respir J. 2006 Aug;28(2):319-22.


Predictors of pulmonary exacerbations in patients with cystic fibrosis infected with multi-resistant bacteria.

Block JK, Vandemheen KL, Tullis E, Fergusson D, Doucette S, Haase D, Berthiaume Y, Brown N, Wilcox P, Bye P, Bell S, Noseworthy M, Pedder L, Freitag A, Paterson N, Aaron SD.

Thorax. 2006 Nov;61(11):969-74. Epub 2006 Jul 14.


Spirometry in the primary care setting: influence on clinical diagnosis and management of airflow obstruction.

Dales RE, Vandemheen KL, Clinch J, Aaron SD.

Chest. 2005 Oct;128(4):2443-7.


The prevalence of airflow obstruction in rural primary care.

Dales RE, Aaron SD, Vandemheen KL, Mehdizadeh A, Clinch J.

Respir Med. 2006 Apr;100(4):754-9. Epub 2005 Aug 24.


Combination antibiotic susceptibility testing to treat exacerbations of cystic fibrosis associated with multiresistant bacteria: a randomised, double-blind, controlled clinical trial.

Aaron SD, Vandemheen KL, Ferris W, Fergusson D, Tullis E, Haase D, Berthiaume Y, Brown N, Wilcox P, Yozghatlian V, Bye P, Bell S, Chan F, Rose B, Jeanneret A, Stephenson A, Noseworthy M, Freitag A, Paterson N, Doucette S, Harbour C, Ruel M, MacDonald N.

Lancet. 2005 Aug 6-12;366(9484):463-71.


Evaluation of a decision aid for making choices about intubation and mechanical ventilation in chronic obstructive pulmonary disease.

Wilson KG, Aaron SD, Vandemheen KL, Hébert PC, McKim DA, Fiset V, Graham ID, Sevigny E, O'Connor AM.

Patient Educ Couns. 2005 Apr;57(1):88-95.


Sputum versus bronchoscopy for diagnosis of Pseudomonas aeruginosa biofilms in cystic fibrosis.

Aaron SD, Kottachchi D, Ferris WJ, Vandemheen KL, St Denis ML, Plouffe A, Doucette SP, Saginur R, Chan FT, Ramotar K.

Eur Respir J. 2004 Oct;24(4):631-7.


Effect of weight reduction on respiratory function and airway reactivity in obese women.

Aaron SD, Fergusson D, Dent R, Chen Y, Vandemheen KL, Dales RE.

Chest. 2004 Jun;125(6):2046-52.


Retrospective application of the NEXUS low-risk criteria for cervical spine radiography in Canadian emergency departments.

Dickinson G, Stiell IG, Schull M, Brison R, Clement CM, Vandemheen KL, Cass D, McKnight D, Greenberg G, Worthington JR, Reardon M, Morrison L, Eisenhauer MA, Dreyer J, Wells GA.

Ann Emerg Med. 2004 Apr;43(4):507-14.


Topical tetracaine prior to arterial puncture: a randomized, placebo-controlled clinical trial.

Aaron SD, Vandemheen KL, Naftel SA, Lewis MJ, Rodger MA.

Respir Med. 2003 Nov;97(11):1195-9.


The Canadian C-spine rule performs better than unstructured physician judgment.

Bandiera G, Stiell IG, Wells GA, Clement C, De Maio V, Vandemheen KL, Greenberg GH, Lesiuk H, Brison R, Cass D, Dreyer J, Eisenhauer MA, Macphail I, McKnight RD, Morrison L, Reardon M, Schull M, Worthington J; Canadian C-Spine and CT Head Study Group.

Ann Emerg Med. 2003 Sep;42(3):395-402.


Outpatient oral prednisone after emergency treatment of chronic obstructive pulmonary disease.

Aaron SD, Vandemheen KL, Hebert P, Dales R, Stiell IG, Ahuja J, Dickinson G, Brison R, Rowe BH, Dreyer J, Yetisir E, Cass D, Wells G.

N Engl J Med. 2003 Jun 26;348(26):2618-25.


Measurement of short-term changes in dyspnea and disease-specific quality of life following an acute COPD exacerbation.

Aaron SD, Vandemheen KL, Clinch JJ, Ahuja J, Brison RJ, Dickinson G, Hébert PC.

Chest. 2002 Mar;121(3):688-96.


The Canadian C-spine rule for radiography in alert and stable trauma patients.

Stiell IG, Wells GA, Vandemheen KL, Clement CM, Lesiuk H, De Maio VJ, Laupacis A, Schull M, McKnight RD, Verbeek R, Brison R, Cass D, Dreyer J, Eisenhauer MA, Greenberg GH, MacPhail I, Morrison L, Reardon M, Worthington J.

JAMA. 2001 Oct 17;286(15):1841-8.


Vasopressin versus epinephrine for inhospital cardiac arrest: a randomised controlled trial.

Stiell IG, Hébert PC, Wells GA, Vandemheen KL, Tang AS, Higginson LA, Dreyer JF, Clement C, Battram E, Watpool I, Mason S, Klassen T, Weitzman BN.

Lancet. 2001 Jul 14;358(9276):105-9.


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