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Items: 21

1.

MYC regulates fatty acid metabolism through a multigenic program in claudin-low triple negative breast cancer.

Casciano JC, Perry C, Cohen-Nowak AJ, Miller KD, Vande Voorde J, Zhang Q, Chalmers S, Sandison ME, Liu Q, Hedley A, McBryan T, Tang HY, Gorman N, Beer T, Speicher DW, Adams PD, Liu X, Schlegel R, McCarron JG, Wakelam MJO, Gottlieb E, Kossenkov AV, Schug ZT.

Br J Cancer. 2020 Jan 16. doi: 10.1038/s41416-019-0711-3. [Epub ahead of print]

PMID:
31942031
2.

Improving the metabolic fidelity of cancer models with a physiological cell culture medium.

Vande Voorde J, Ackermann T, Pfetzer N, Sumpton D, Mackay G, Kalna G, Nixon C, Blyth K, Gottlieb E, Tardito S.

Sci Adv. 2019 Jan 2;5(1):eaau7314. doi: 10.1126/sciadv.aau7314. eCollection 2019 Jan.

3.

Increased formate overflow is a hallmark of oxidative cancer.

Meiser J, Schuster A, Pietzke M, Vande Voorde J, Athineos D, Oizel K, Burgos-Barragan G, Wit N, Dhayade S, Morton JP, Dornier E, Sumpton D, Mackay GM, Blyth K, Patel KJ, Niclou SP, Vazquez A.

Nat Commun. 2018 Apr 10;9(1):1368. doi: 10.1038/s41467-018-03777-w.

4.

Acetate Recapturing by Nuclear Acetyl-CoA Synthetase 2 Prevents Loss of Histone Acetylation during Oxygen and Serum Limitation.

Bulusu V, Tumanov S, Michalopoulou E, van den Broek NJ, MacKay G, Nixon C, Dhayade S, Schug ZT, Vande Voorde J, Blyth K, Gottlieb E, Vazquez A, Kamphorst JJ.

Cell Rep. 2017 Jan 17;18(3):647-658. doi: 10.1016/j.celrep.2016.12.055.

5.

The metabolic fate of acetate in cancer.

Schug ZT, Vande Voorde J, Gottlieb E.

Nat Rev Cancer. 2016 Nov;16(11):708-717. doi: 10.1038/nrc.2016.87. Epub 2016 Aug 26. Review.

PMID:
27562461
6.

The Nurture of Tumors Can Drive Their Metabolic Phenotype.

Schug ZT, Vande Voorde J, Gottlieb E.

Cell Metab. 2016 Mar 8;23(3):391-2. doi: 10.1016/j.cmet.2016.02.016.

7.

Mycoplasma hyorhinis-encoded cytidine deaminase efficiently inactivates cytosine-based anticancer drugs.

Vande Voorde J, Vervaeke P, Liekens S, Balzarini J.

FEBS Open Bio. 2015 Aug 3;5:634-9. doi: 10.1016/j.fob.2015.07.007. eCollection 2015.

8.

Alpha-carboxy nucleoside phosphonates as universal nucleoside triphosphate mimics.

Balzarini J, Das K, Bernatchez JA, Martinez SE, Ngure M, Keane S, Ford A, Maguire N, Mullins N, John J, Kim Y, Dehaen W, Vande Voorde J, Liekens S, Naesens L, Götte M, Maguire AR, Arnold E.

Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):3475-80. doi: 10.1073/pnas.1420233112. Epub 2015 Mar 2.

9.

The pyrimidine nucleoside phosphorylase of Mycoplasma hyorhinis and how it may affect nucleoside-based therapy.

Vande Voorde J, Liekens S, Gago F, Balzarini J.

Nucleosides Nucleotides Nucleic Acids. 2014;33(4-6):394-402. doi: 10.1080/15257770.2013.851394.

PMID:
24940697
10.

Microwave-assisted synthesis of C-8 aryl and heteroaryl inosines and determination of their inhibitory activities against Plasmodium falciparum purine nucleoside phosphorylase.

Gigante A, Priego EM, Sánchez-Carrasco P, Ruiz-Pérez LM, Vande Voorde J, Camarasa MJ, Balzarini J, González-Pacanowska D, Pérez-Pérez MJ.

Eur J Med Chem. 2014 Jul 23;82:459-65. doi: 10.1016/j.ejmech.2014.05.073. Epub 2014 Jun 2.

11.

An emerging understanding of the Janus face of the human microbiome: enhancement versus impairment of cancer therapy.

Vande Voorde J, Balzarini J, Liekens S.

J Antimicrob Chemother. 2014 Oct;69(10):2878-80. doi: 10.1093/jac/dku201. Epub 2014 Jun 12. No abstract available.

PMID:
24925896
12.

Nucleoside-catabolizing enzymes in mycoplasma-infected tumor cell cultures compromise the cytostatic activity of the anticancer drug gemcitabine.

Vande Voorde J, Sabuncuoğlu S, Noppen S, Hofer A, Ranjbarian F, Fieuws S, Balzarini J, Liekens S.

J Biol Chem. 2014 May 9;289(19):13054-65. doi: 10.1074/jbc.M114.558924. Epub 2014 Mar 25.

13.

Mycoplasmas and cancer: focus on nucleoside metabolism.

Vande Voorde J, Balzarini J, Liekens S.

EXCLI J. 2014 Mar 27;13:300-22. eCollection 2014. Review.

14.

Mycoplasma hyorhinis-encoded purine nucleoside phosphorylase: kinetic properties and its effect on the cytostatic potential of purine-based anticancer drugs.

Vande Voorde J, Liekens S, Balzarini J.

Mol Pharmacol. 2013 Dec;84(6):865-75. doi: 10.1124/mol.113.088625. Epub 2013 Sep 25.

PMID:
24068428
15.

Role of human hypoxanthine guanine phosphoribosyltransferase in activation of the antiviral agent T-705 (favipiravir).

Naesens L, Guddat LW, Keough DT, van Kuilenburg AB, Meijer J, Vande Voorde J, Balzarini J.

Mol Pharmacol. 2013 Oct;84(4):615-29. doi: 10.1124/mol.113.087247. Epub 2013 Aug 1.

PMID:
23907213
16.

Characterization of pyrimidine nucleoside phosphorylase of Mycoplasma hyorhinis: implications for the clinical efficacy of nucleoside analogues.

Vande Voorde J, Gago F, Vrancken K, Liekens S, Balzarini J.

Biochem J. 2012 Jul 1;445(1):113-23. doi: 10.1042/BJ20112225.

PMID:
22475552
17.

Inhibition of pyrimidine and purine nucleoside phosphorylases by a 3,5-dichlorobenzoyl-substituted 2-deoxy-D-ribose-1-phosphate derivative.

Vande Voorde J, Quintiliani M, McGuigan C, Liekens S, Balzarini J.

Biochem Pharmacol. 2012 May 15;83(10):1358-63. doi: 10.1016/j.bcp.2012.02.005. Epub 2012 Feb 16.

PMID:
22366108
18.

Phosphoramidate ProTides of the anticancer agent FUDR successfully deliver the preformed bioactive monophosphate in cells and confer advantage over the parent nucleoside.

McGuigan C, Murziani P, Slusarczyk M, Gonczy B, Vande Voorde J, Liekens S, Balzarini J.

J Med Chem. 2011 Oct 27;54(20):7247-58. doi: 10.1021/jm200815w. Epub 2011 Sep 27.

PMID:
21892829
19.

The cytostatic activity of NUC-3073, a phosphoramidate prodrug of 5-fluoro-2'-deoxyuridine, is independent of activation by thymidine kinase and insensitive to degradation by phosphorolytic enzymes.

Vande Voorde J, Liekens S, McGuigan C, Murziani PG, Slusarczyk M, Balzarini J.

Biochem Pharmacol. 2011 Sep 1;82(5):441-52. doi: 10.1016/j.bcp.2011.05.024. Epub 2011 May 31.

PMID:
21658373
20.

Synthesis and biological evaluation of unsaturated keto and exomethylene D-arabinopyranonucleoside analogs: novel 5-fluorouracil analogs that target thymidylate synthase.

Tzioumaki N, Manta S, Tsoukala E, Vande Voorde J, Liekens S, Komiotis D, Balzarini J.

Eur J Med Chem. 2011 Apr;46(4):993-1005. doi: 10.1016/j.ejmech.2011.01.005. Epub 2011 Jan 22.

PMID:
21330014
21.

Evidence for the presence of Legionella bacteriophages in environmental water samples.

Lammertyn E, Vande Voorde J, Meyen E, Maes L, Mast J, Anné J.

Microb Ecol. 2008 Jul;56(1):191-7. Epub 2007 Oct 24.

PMID:
17957402

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