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Items: 1 to 50 of 93

1.

Gasdermin-D and Caspase-7 are the key Caspase-1/8 substrates downstream of the NAIP5/NLRC4 inflammasome required for restriction of Legionella pneumophila.

Gonçalves AV, Margolis SR, Quirino GFS, Mascarenhas DPA, Rauch I, Nichols RD, Ansaldo E, Fontana MF, Vance RE, Zamboni DS.

PLoS Pathog. 2019 Jun 28;15(6):e1007886. doi: 10.1371/journal.ppat.1007886. eCollection 2019 Jun.

2.

The NLRP1 inflammasome: new mechanistic insights and unresolved mysteries.

Mitchell PS, Sandstrom A, Vance RE.

Curr Opin Immunol. 2019 May 20;60:37-45. doi: 10.1016/j.coi.2019.04.015. [Epub ahead of print] Review.

PMID:
31121538
3.

Functional degradation: A mechanism of NLRP1 inflammasome activation by diverse pathogen enzymes.

Sandstrom A, Mitchell PS, Goers L, Mu EW, Lesser CF, Vance RE.

Science. 2019 Apr 5;364(6435). pii: eaau1330. doi: 10.1126/science.aau1330. Epub 2019 Mar 14.

PMID:
30872533
4.

Tumor-Derived cGAMP Triggers a STING-Mediated Interferon Response in Non-tumor Cells to Activate the NK Cell Response.

Marcus A, Mao AJ, Lensink-Vasan M, Wang L, Vance RE, Raulet DH.

Immunity. 2018 Oct 16;49(4):754-763.e4. doi: 10.1016/j.immuni.2018.09.016.

PMID:
30332631
5.

Legionella pneumophila Is Directly Sensitive to 2-Deoxyglucose-Phosphate via Its UhpC Transporter but Is Indifferent to Shifts in Host Cell Glycolytic Metabolism.

Price JV, Jiang K, Galantowicz A, Freifeld A, Vance RE.

J Bacteriol. 2018 Jul 25;200(16). pii: e00176-18. doi: 10.1128/JB.00176-18. Print 2018 Aug 15.

6.

Defusing inflammasomes.

Sandstrom A, Vance RE.

J Exp Med. 2018 Mar 5;215(3):723-724. doi: 10.1084/jem.20180241. Epub 2018 Feb 12.

7.

NAIP/NLRC4 inflammasome activation in MRP8+ cells is sufficient to cause systemic inflammatory disease.

Nichols RD, von Moltke J, Vance RE.

Nat Commun. 2017 Dec 20;8(1):2209. doi: 10.1038/s41467-017-02266-w.

8.

Positive and Negative Regulation of the Master Metabolic Regulator mTORC1 by Two Families of Legionella pneumophila Effectors.

De Leon JA, Qiu J, Nicolai CJ, Counihan JL, Barry KC, Xu L, Lawrence RE, Castellano BM, Zoncu R, Nomura DK, Luo ZQ, Vance RE.

Cell Rep. 2017 Nov 21;21(8):2031-2038. doi: 10.1016/j.celrep.2017.10.088.

9.

Cell death and cell lysis are separable events during pyroptosis.

DiPeso L, Ji DX, Vance RE, Price JV.

Cell Death Discov. 2017 Nov 13;3:17070. doi: 10.1038/cddiscovery.2017.70. eCollection 2017.

10.

The structural basis of flagellin detection by NAIP5: A strategy to limit pathogen immune evasion.

Tenthorey JL, Haloupek N, López-Blanco JR, Grob P, Adamson E, Hartenian E, Lind NA, Bourgeois NM, Chacón P, Nogales E, Vance RE.

Science. 2017 Nov 17;358(6365):888-893. doi: 10.1126/science.aao1140.

11.

Listening to each other: Infectious disease and cancer immunology.

Vance RE, Eichberg MJ, Portnoy DA, Raulet DH.

Sci Immunol. 2017 Jan 13;2(7). pii: eaai9339. doi: 10.1126/sciimmunol.aai9339. Review.

12.

Evolutionary Origins of cGAS-STING Signaling.

Margolis SR, Wilson SC, Vance RE.

Trends Immunol. 2017 Oct;38(10):733-743. doi: 10.1016/j.it.2017.03.004. Epub 2017 Apr 14. Review.

PMID:
28416447
13.

NAIP-NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL-18 Release via Activation of Caspase-1 and -8.

Rauch I, Deets KA, Ji DX, von Moltke J, Tenthorey JL, Lee AY, Philip NH, Ayres JS, Brodsky IE, Gronert K, Vance RE.

Immunity. 2017 Apr 18;46(4):649-659. doi: 10.1016/j.immuni.2017.03.016. Epub 2017 Apr 11.

14.
15.

Intracellular innate immune surveillance devices in plants and animals.

Jones JD, Vance RE, Dangl JL.

Science. 2016 Dec 2;354(6316). pii: aaf6395. Review.

PMID:
27934708
16.

Functional and Evolutionary Analyses Identify Proteolysis as a General Mechanism for NLRP1 Inflammasome Activation.

Chavarría-Smith J, Mitchell PS, Ho AM, Daugherty MD, Vance RE.

PLoS Pathog. 2016 Dec 7;12(12):e1006052. doi: 10.1371/journal.ppat.1006052. eCollection 2016 Dec.

17.

Cytosolic DNA Sensing: The Field Narrows.

Vance RE.

Immunity. 2016 Aug 16;45(2):227-8. doi: 10.1016/j.immuni.2016.08.006.

18.

NAIP proteins are required for cytosolic detection of specific bacterial ligands in vivo.

Rauch I, Tenthorey JL, Nichols RD, Al Moussawi K, Kang JJ, Kang C, Kazmierczak BI, Vance RE.

J Exp Med. 2016 May 2;213(5):657-65. doi: 10.1084/jem.20151809. Epub 2016 Apr 4.

19.

Radical Sabbaticals.

Clevers H, Firestein S, Ringrose L, Bernards R, Darwin KH, Vance RE.

Cell. 2015 Nov 5;163(4):788-9. doi: 10.1016/j.cell.2015.10.058. No abstract available.

20.

Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling.

Kranzusch PJ, Wilson SC, Lee AS, Berger JM, Doudna JA, Vance RE.

Mol Cell. 2015 Sep 17;59(6):891-903. doi: 10.1016/j.molcel.2015.07.022. Epub 2015 Aug 20.

21.

The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy.

Watson RO, Bell SL, MacDuff DA, Kimmey JM, Diner EJ, Olivas J, Vance RE, Stallings CL, Virgin HW, Cox JS.

Cell Host Microbe. 2015 Jun 10;17(6):811-819. doi: 10.1016/j.chom.2015.05.004. Epub 2015 Jun 2.

22.

The NLRP1 inflammasomes.

Chavarría-Smith J, Vance RE.

Immunol Rev. 2015 May;265(1):22-34. doi: 10.1111/imr.12283. Review.

PMID:
25879281
23.

The NAIP/NLRC4 inflammasomes.

Vance RE.

Curr Opin Immunol. 2015 Feb;32:84-9. doi: 10.1016/j.coi.2015.01.010. Epub 2015 Jan 24. Review.

24.

The macrophage paradox.

Price JV, Vance RE.

Immunity. 2014 Nov 20;41(5):685-93. doi: 10.1016/j.immuni.2014.10.015. Epub 2014 Nov 1.

25.

Gastrointestinal helminths may affect host susceptibility to anthrax through seasonal immune trade-offs.

Cizauskas CA, Turner WC, Wagner B, Küsters M, Vance RE, Getz WM.

BMC Ecol. 2014 Nov 12;14:27. doi: 10.1186/s12898-014-0027-3.

26.

Structure-guided reprogramming of human cGAS dinucleotide linkage specificity.

Kranzusch PJ, Lee ASY, Wilson SC, Solovykh MS, Vance RE, Berger JM, Doudna JA.

Cell. 2014 Aug 28;158(5):1011-1021. doi: 10.1016/j.cell.2014.07.028. Epub 2014 Aug 14.

27.

Molecular basis for specific recognition of bacterial ligands by NAIP/NLRC4 inflammasomes.

Tenthorey JL, Kofoed EM, Daugherty MD, Malik HS, Vance RE.

Mol Cell. 2014 Apr 10;54(1):17-29. doi: 10.1016/j.molcel.2014.02.018. Epub 2014 Mar 20.

28.

Frequent and seasonally variable sublethal anthrax infections are accompanied by short-lived immunity in an endemic system.

Cizauskas CA, Bellan SE, Turner WC, Vance RE, Getz WM.

J Anim Ecol. 2014 Sep;83(5):1078-90. doi: 10.1111/1365-2656.12207. Epub 2014 Mar 14.

29.

cGAS dimerization entangles DNA recognition.

Kranzusch PJ, Vance RE.

Immunity. 2013 Dec 12;39(6):992-4. doi: 10.1016/j.immuni.2013.11.012.

30.

Taking the STING out of cytosolic DNA sensing.

Diner EJ, Vance RE.

Trends Immunol. 2014 Jan;35(1):1-2. doi: 10.1016/j.it.2013.10.011. Epub 2013 Nov 11.

PMID:
24231656
31.

Cutting edge: Mouse NAIP1 detects the type III secretion system needle protein.

Rayamajhi M, Zak DE, Chavarria-Smith J, Vance RE, Miao EA.

J Immunol. 2013 Oct 15;191(8):3986-9. doi: 10.4049/jimmunol.1301549. Epub 2013 Sep 16.

32.

Blue native polyacrylamide gel electrophoresis to monitor inflammasome assembly and composition.

Kofoed EM, Vance RE.

Methods Mol Biol. 2013;1040:169-83. doi: 10.1007/978-1-62703-523-1_13.

PMID:
23852604
33.

Direct proteolytic cleavage of NLRP1B is necessary and sufficient for inflammasome activation by anthrax lethal factor.

Chavarría-Smith J, Vance RE.

PLoS Pathog. 2013;9(6):e1003452. doi: 10.1371/journal.ppat.1003452. Epub 2013 Jun 20.

34.

The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING.

Diner EJ, Burdette DL, Wilson SC, Monroe KM, Kellenberger CA, Hyodo M, Hayakawa Y, Hammond MC, Vance RE.

Cell Rep. 2013 May 30;3(5):1355-61. doi: 10.1016/j.celrep.2013.05.009. Epub 2013 May 23.

35.

IL-1α signaling initiates the inflammatory response to virulent Legionella pneumophila in vivo.

Barry KC, Fontana MF, Portman JL, Dugan AS, Vance RE.

J Immunol. 2013 Jun 15;190(12):6329-39. doi: 10.4049/jimmunol.1300100. Epub 2013 May 17.

36.

STING-dependent recognition of cyclic di-AMP mediates type I interferon responses during Chlamydia trachomatis infection.

Barker JR, Koestler BJ, Carpenter VK, Burdette DL, Waters CM, Vance RE, Valdivia RH.

MBio. 2013 Apr 30;4(3):e00018-13. doi: 10.1128/mBio.00018-13.

37.

Mouse, but not human STING, binds and signals in response to the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid.

Conlon J, Burdette DL, Sharma S, Bhat N, Thompson M, Jiang Z, Rathinam VA, Monks B, Jin T, Xiao TS, Vogel SN, Vance RE, Fitzgerald KA.

J Immunol. 2013 May 15;190(10):5216-25. doi: 10.4049/jimmunol.1300097. Epub 2013 Apr 12.

38.

Caspase-11 protects against bacteria that escape the vacuole.

Aachoui Y, Leaf IA, Hagar JA, Fontana MF, Campos CG, Zak DE, Tan MH, Cotter PA, Vance RE, Aderem A, Miao EA.

Science. 2013 Feb 22;339(6122):975-8. doi: 10.1126/science.1230751. Epub 2013 Jan 24.

39.

STING and the innate immune response to nucleic acids in the cytosol.

Burdette DL, Vance RE.

Nat Immunol. 2013 Jan;14(1):19-26. doi: 10.1038/ni.2491. Review.

PMID:
23238760
40.

Recognition of bacteria by inflammasomes.

von Moltke J, Ayres JS, Kofoed EM, Chavarría-Smith J, Vance RE.

Annu Rev Immunol. 2013;31:73-106. doi: 10.1146/annurev-immunol-032712-095944. Epub 2012 Nov 26. Review.

PMID:
23215645
41.

Rapid induction of inflammatory lipid mediators by the inflammasome in vivo.

von Moltke J, Trinidad NJ, Moayeri M, Kintzer AF, Wang SB, van Rooijen N, Brown CR, Krantz BA, Leppla SH, Gronert K, Vance RE.

Nature. 2012 Oct 4;490(7418):107-11. doi: 10.1038/nature11351. Epub 2012 Aug 19.

42.

Activation of host mitogen-activated protein kinases by secreted Legionella pneumophila effectors that inhibit host protein translation.

Fontana MF, Shin S, Vance RE.

Infect Immun. 2012 Oct;80(10):3570-5. doi: 10.1128/IAI.00557-12. Epub 2012 Jul 30.

43.

Lethal inflammasome activation by a multidrug-resistant pathobiont upon antibiotic disruption of the microbiota.

Ayres JS, Trinidad NJ, Vance RE.

Nat Med. 2012 May;18(5):799-806. doi: 10.1038/nm.2729.

44.
45.

Cellular teamwork in antibacterial innate immunity.

Ayres JS, Vance RE.

Nat Immunol. 2012 Jan 19;13(2):115-7. doi: 10.1038/ni.2212. No abstract available.

PMID:
22261960
46.

STING is a direct innate immune sensor of cyclic di-GMP.

Burdette DL, Monroe KM, Sotelo-Troha K, Iwig JS, Eckert B, Hyodo M, Hayakawa Y, Vance RE.

Nature. 2011 Sep 25;478(7370):515-8. doi: 10.1038/nature10429.

47.

Two signal models in innate immunity.

Fontana MF, Vance RE.

Immunol Rev. 2011 Sep;243(1):26-39. doi: 10.1111/j.1600-065X.2011.01037.x.

PMID:
21884165
48.

Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity.

Kofoed EM, Vance RE.

Nature. 2011 Aug 28;477(7366):592-5. doi: 10.1038/nature10394.

49.

A biomechanical analysis of a tensioned suture device in the fixation of the ligamentous Lisfranc injury.

Pelt CE, Bachus KN, Vance RE, Beals TC.

Foot Ankle Int. 2011 Apr;32(4):422-31. doi: 10.3113/FAI.2011.0422.

PMID:
21733447
50.

Secreted bacterial effectors that inhibit host protein synthesis are critical for induction of the innate immune response to virulent Legionella pneumophila.

Fontana MF, Banga S, Barry KC, Shen X, Tan Y, Luo ZQ, Vance RE.

PLoS Pathog. 2011 Feb;7(2):e1001289. doi: 10.1371/journal.ppat.1001289. Epub 2011 Feb 17.

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