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Items: 20


A Collection of Single-Domain Antibodies that Crowd Ricin Toxin's Active Site.

Angalakurthi SK, Vance DJ, Rong Y, Nguyen CMT, Rudolph MJ, Volkin D, Middaugh CR, Weis DD, Mantis NJ.

Antibodies (Basel). 2018 Dec;7(4). pii: 45. doi: 10.3390/antib7040045. Epub 2018 Dec 17.


Fine-Specificity Epitope Analysis Identifies Contact Points on Ricin Toxin Recognized by Protective Monoclonal Antibodies.

Van Slyke G, Angalakurthi SK, Toth RT 4th, Vance DJ, Rong Y, Ehrbar D, Shi Y, Middaugh CR, Volkin DB, Weis DD, Mantis NJ.

Immunohorizons. 2018 Sep;2(8):262-273. doi: 10.4049/immunohorizons.1800042.


Contribution of an unusual CDR2 element of a single domain antibody in ricin toxin binding affinity and neutralizing activity.

Rudolph MJ, Vance DJ, Kelow S, Angalakurthi SK, Nguyen S, Davis SA, Rong Y, Middaugh CR, Weis DD, Dunbrack R Jr, Karanicolas J, Mantis NJ.

Protein Eng Des Sel. 2018 Jul 1;31(7-8):277-287. doi: 10.1093/protein/gzy022.


A Supercluster of Neutralizing Epitopes at the Interface of Ricin's Enzymatic (RTA) and Binding (RTB) Subunits.

Poon AY, Vance DJ, Rong Y, Ehrbar D, Mantis NJ.

Toxins (Basel). 2017 Nov 23;9(12). pii: E378. doi: 10.3390/toxins9120378.


High-Definition Mapping of Four Spatially Distinct Neutralizing Epitope Clusters on RiVax, a Candidate Ricin Toxin Subunit Vaccine.

Toth RT 4th, Angalakurthi SK, Van Slyke G, Vance DJ, Hickey JM, Joshi SB, Middaugh CR, Volkin DB, Weis DD, Mantis NJ.

Clin Vaccine Immunol. 2017 Dec 5;24(12). pii: e00237-17. doi: 10.1128/CVI.00237-17. Print 2017 Dec.


High-Resolution Epitope Positioning of a Large Collection of Neutralizing and Nonneutralizing Single-Domain Antibodies on the Enzymatic and Binding Subunits of Ricin Toxin.

Vance DJ, Tremblay JM, Rong Y, Angalakurthi SK, Volkin DB, Middaugh CR, Weis DD, Shoemaker CB, Mantis NJ.

Clin Vaccine Immunol. 2017 Dec 5;24(12). pii: e00236-17. doi: 10.1128/CVI.00236-17. Print 2017 Dec.


Using homology modeling to interrogate binding affinity in neutralization of ricin toxin by a family of single domain antibodies.

Bazzoli A, Vance DJ, Rudolph MJ, Rong Y, Angalakurthi SK, Toth RT 4th, Middaugh CR, Volkin DB, Weis DD, Karanicolas J, Mantis NJ.

Proteins. 2017 Nov;85(11):1994-2008. doi: 10.1002/prot.25353. Epub 2017 Aug 4.


Spatial location of neutralizing and non-neutralizing B cell epitopes on domain 1 of ricin toxin's binding subunit.

Rong Y, Van Slyke G, Vance DJ, Westfall J, Ehrbar D, Mantis NJ.

PLoS One. 2017 Jul 10;12(7):e0180999. doi: 10.1371/journal.pone.0180999. eCollection 2017.


Structural Analysis of Single Domain Antibodies Bound to a Second Neutralizing Hot Spot on Ricin Toxin's Enzymatic Subunit.

Rudolph MJ, Vance DJ, Cassidy MS, Rong Y, Mantis NJ.

J Biol Chem. 2017 Jan 20;292(3):872-883. doi: 10.1074/jbc.M116.758102. Epub 2016 Nov 30.


Structural analysis of nested neutralizing and non-neutralizing B cell epitopes on ricin toxin's enzymatic subunit.

Rudolph MJ, Vance DJ, Cassidy MS, Rong Y, Shoemaker CB, Mantis NJ.

Proteins. 2016 Aug;84(8):1162-72. doi: 10.1002/prot.25062. Epub 2016 Jun 15.


Enhancement of humoral immunity by the type II heat-labile enterotoxin LT-IIb is dependent upon IL-6 and neutrophils.

Greene CJ, Hu JC, Vance DJ, Rong Y, Mandell L, King-Lyons N, Masso-Welch P, Mantis NJ, Connell TD.

J Leukoc Biol. 2016 Aug;100(2):361-9. doi: 10.1189/jlb.3A0415-153RR. Epub 2016 Apr 8.


Progress and challenges associated with the development of ricin toxin subunit vaccines.

Vance DJ, Mantis NJ.

Expert Rev Vaccines. 2016 Sep;15(9):1213-22. doi: 10.1586/14760584.2016.1168701. Epub 2016 Apr 6. Review.


Comparative Adjuvant Effects of Type II Heat-Labile Enterotoxins in Combination with Two Different Candidate Ricin Toxin Vaccine Antigens.

Vance DJ, Greene CJ, Rong Y, Mandell LM, Connell TD, Mantis NJ.

Clin Vaccine Immunol. 2015 Dec;22(12):1285-93. doi: 10.1128/CVI.00402-15. Epub 2015 Oct 21.


Glassy-state stabilization of a dominant negative inhibitor anthrax vaccine containing aluminum hydroxide and glycopyranoside lipid A adjuvants.

Hassett KJ, Vance DJ, Jain NK, Sahni N, Rabia LA, Cousins MC, Joshi S, Volkin DB, Middaugh CR, Mantis NJ, Carpenter JF, Randolph TW.

J Pharm Sci. 2015 Feb;104(2):627-39. doi: 10.1002/jps.24295. Epub 2015 Jan 11.


Combination of two candidate subunit vaccine antigens elicits protective immunity to ricin and anthrax toxin in mice.

Vance DJ, Rong Y, Brey RN 3rd, Mantis NJ.

Vaccine. 2015 Jan 9;33(3):417-21. doi: 10.1016/j.vaccine.2014.11.036. Epub 2014 Dec 2.


Differential neutralizing activities of a single domain camelid antibody (VHH) specific for ricin toxin's binding subunit (RTB).

Herrera C, Vance DJ, Eisele LE, Shoemaker CB, Mantis NJ.

PLoS One. 2014 Jun 11;9(6):e99788. doi: 10.1371/journal.pone.0099788. eCollection 2014.


Crystal structures of ricin toxin's enzymatic subunit (RTA) in complex with neutralizing and non-neutralizing single-chain antibodies.

Rudolph MJ, Vance DJ, Cheung J, Franklin MC, Burshteyn F, Cassidy MS, Gary EN, Herrera C, Shoemaker CB, Mantis NJ.

J Mol Biol. 2014 Aug 26;426(17):3057-68. doi: 10.1016/j.jmb.2014.05.026. Epub 2014 Jun 4.


Stepwise engineering of heterodimeric single domain camelid VHH antibodies that passively protect mice from ricin toxin.

Vance DJ, Tremblay JM, Mantis NJ, Shoemaker CB.

J Biol Chem. 2013 Dec 20;288(51):36538-47. doi: 10.1074/jbc.M113.519207. Epub 2013 Nov 7.


Sub-domains of ricin's B subunit as targets of toxin neutralizing and non-neutralizing monoclonal antibodies.

Yermakova A, Vance DJ, Mantis NJ.

PLoS One. 2012;7(9):e44317. doi: 10.1371/journal.pone.0044317. Epub 2012 Sep 11.


Resolution of two overlapping neutralizing B cell epitopes within a solvent exposed, immunodominant α-helix in ricin toxin's enzymatic subunit.

Vance DJ, Mantis NJ.

Toxicon. 2012 Oct;60(5):874-7. doi: 10.1016/j.toxicon.2012.06.014. Epub 2012 Jun 29.

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