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d-Amino Acid Derivatives as in Situ Probes for Visualizing Bacterial Peptidoglycan Biosynthesis.

Hsu YP, Booher G, Egan A, Vollmer W, VanNieuwenhze MS.

Acc Chem Res. 2019 Sep 17;52(9):2713-2722. doi: 10.1021/acs.accounts.9b00311. Epub 2019 Aug 16.


Spheroplast-Mediated Carbapenem Tolerance in Gram-Negative Pathogens.

Cross T, Ransegnola B, Shin JH, Weaver A, Fauntleroy K, VanNieuwenhze MS, Westblade LF, Dörr T.

Antimicrob Agents Chemother. 2019 Aug 23;63(9). pii: e00756-19. doi: 10.1128/AAC.00756-19. Print 2019 Sep.


SEDS-bPBP pairs direct lateral and septal peptidoglycan synthesis in Staphylococcus aureus.

Reichmann NT, Tavares AC, Saraiva BM, Jousselin A, Reed P, Pereira AR, Monteiro JM, Sobral RG, VanNieuwenhze MS, Fernandes F, Pinho MG.

Nat Microbiol. 2019 Aug;4(8):1368-1377. doi: 10.1038/s41564-019-0437-2. Epub 2019 May 13.


Scalable Synthesis of Orthogonally Protected β-Methyllanthionines by Indium(III)-Mediated Ring Opening of Aziridines.

Li Z, Gentry Z, Murphy B, VanNieuwenhze MS.

Org Lett. 2019 Apr 5;21(7):2200-2203. doi: 10.1021/acs.orglett.9b00125. Epub 2019 Mar 11.


Fluorogenic D-amino acids enable real-time monitoring of peptidoglycan biosynthesis and high-throughput transpeptidation assays.

Hsu YP, Hall E, Booher G, Murphy B, Radkov AD, Yablonowski J, Mulcahey C, Alvarez L, Cava F, Brun YV, Kuru E, VanNieuwenhze MS.

Nat Chem. 2019 Apr;11(4):335-341. doi: 10.1038/s41557-019-0217-x. Epub 2019 Feb 25.


An Acinetobacter baumannii, Zinc-Regulated Peptidase Maintains Cell Wall Integrity during Immune-Mediated Nutrient Sequestration.

Lonergan ZR, Nairn BL, Wang J, Hsu YP, Hesse LE, Beavers WN, Chazin WJ, Trinidad JC, VanNieuwenhze MS, Giedroc DP, Skaar EP.

Cell Rep. 2019 Feb 19;26(8):2009-2018.e6. doi: 10.1016/j.celrep.2019.01.089.


Publisher Correction: Z-ring membrane anchors associate with cell wall synthases to initiate bacterial cell division.

Pazos M, Peters K, Casanova M, Palacios P, VanNieuwenhze M, Breukink E, Vicente M, Vollmer W.

Nat Commun. 2019 Jan 30;10(1):591. doi: 10.1038/s41467-019-08410-y.


Studies toward the Total Synthesis of Nogalamycin: Construction of the Complete ABCDEF-Ring System via a Convergent Hauser Annulation.

Peng R, VanNieuwenhze MS.

J Org Chem. 2019 Jan 18;84(2):760-768. doi: 10.1021/acs.joc.8b02602. Epub 2019 Jan 3.


Construction of the DEF-Benzoxocin Ring System of Nogalamycin and Menogaril via a Reductive Heck Cyclization.

Peng R, VanNieuwenhze MS.

J Org Chem. 2019 Jan 4;84(1):173-180. doi: 10.1021/acs.joc.8b02575. Epub 2018 Dec 24.


Z-ring membrane anchors associate with cell wall synthases to initiate bacterial cell division.

Pazos M, Peters K, Casanova M, Palacios P, VanNieuwenhze M, Breukink E, Vicente M, Vollmer W.

Nat Commun. 2018 Nov 30;9(1):5090. doi: 10.1038/s41467-018-07559-2. Erratum in: Nat Commun. 2019 Jan 30;10(1):591.


Use of a Fluorescent Analogue of a HBV Core Protein-Directed Drug To Interrogate an Antiviral Mechanism.

Nair S, Li L, Francis S, Turner WW, VanNieuwenhze M, Zlotnick A.

J Am Chem Soc. 2018 Nov 14;140(45):15261-15269. doi: 10.1021/jacs.8b07988. Epub 2018 Oct 30.


Copper inhibits peptidoglycan LD-transpeptidases suppressing β-lactam resistance due to bypass of penicillin-binding proteins.

Peters K, Pazos M, Edoo Z, Hugonnet JE, Martorana AM, Polissi A, VanNieuwenhze MS, Arthur M, Vollmer W.

Proc Natl Acad Sci U S A. 2018 Oct 16;115(42):10786-10791. doi: 10.1073/pnas.1809285115. Epub 2018 Oct 1.


The Fluorescent D-Amino Acid NADA as a Tool to Study the Conditional Activity of Transpeptidases in Escherichia coli.

Montón Silva A, Otten C, Biboy J, Breukink E, VanNieuwenhze M, Vollmer W, den Blaauwen T.

Front Microbiol. 2018 Sep 4;9:2101. doi: 10.3389/fmicb.2018.02101. eCollection 2018.


Genetic Determinants of Penicillin Tolerance in Vibrio cholerae.

Weaver AI, Murphy SG, Umans BD, Tallavajhala S, Onyekwere I, Wittels S, Shin JH, VanNieuwenhze M, Waldor MK, Dörr T.

Antimicrob Agents Chemother. 2018 Sep 24;62(10). pii: e01326-18. doi: 10.1128/AAC.01326-18. Print 2018 Oct.


Coupling of polymerase and carrier lipid phosphatase prevents product inhibition in peptidoglycan synthesis.

Hernández-Rocamora VM, Otten CF, Radkov A, Simorre JP, Breukink E, VanNieuwenhze M, Vollmer W.

Cell Surf. 2018 Jun;2:1-13. doi: 10.1016/j.tcsw.2018.04.002.


An Assembly-Activating Site in the Hepatitis B Virus Capsid Protein Can Also Trigger Disassembly.

Qazi S, Schlicksup CJ, Rittichier J, VanNieuwenhze MS, Zlotnick A.

ACS Chem Biol. 2018 Aug 17;13(8):2114-2120. doi: 10.1021/acschembio.8b00283. Epub 2018 Jul 6.


The cell wall hydrolase Pmp23 is important for assembly and stability of the division ring in Streptococcus pneumoniae.

Jacq M, Arthaud C, Manuse S, Mercy C, Bellard L, Peters K, Gallet B, Galindo J, Doan T, Vollmer W, Brun YV, VanNieuwenhze MS, Di Guilmi AM, Vernet T, Grangeasse C, Morlot C.

Sci Rep. 2018 May 15;8(1):7591. doi: 10.1038/s41598-018-25882-y.


Imaging Bacterial Cell Wall Biosynthesis.

Radkov AD, Hsu YP, Booher G, VanNieuwenhze MS.

Annu Rev Biochem. 2018 Jun 20;87:991-1014. doi: 10.1146/annurev-biochem-062917-012921. Epub 2018 Mar 29. Review.


Host-Polarized Cell Growth in Animal Symbionts.

Pende N, Wang J, Weber PM, Verheul J, Kuru E, Rittmann SKR, Leisch N, VanNieuwenhze MS, Brun YV, den Blaauwen T, Bulgheresi S.

Curr Biol. 2018 Apr 2;28(7):1039-1051.e5. doi: 10.1016/j.cub.2018.02.028. Epub 2018 Mar 22.


Peptidoglycan synthesis drives an FtsZ-treadmilling-independent step of cytokinesis.

Monteiro JM, Pereira AR, Reichmann NT, Saraiva BM, Fernandes PB, Veiga H, Tavares AC, Santos M, Ferreira MT, Macário V, VanNieuwenhze MS, Filipe SR, Pinho MG.

Nature. 2018 Feb 22;554(7693):528-532. doi: 10.1038/nature25506. Epub 2018 Feb 14.


Hepatitis B virus core protein allosteric modulators can distort and disrupt intact capsids.

Schlicksup CJ, Wang JC, Francis S, Venkatakrishnan B, Turner WW, VanNieuwenhze M, Zlotnick A.

Elife. 2018 Jan 29;7. pii: e31473. doi: 10.7554/eLife.31473.


Author Correction: Fluorescent D-amino-acids reveal bi-cellular cell wall modifications important for Bdellovibrio bacteriovorus predation.

Kuru E, Lambert C, Rittichier J, Till R, Ducret A, Derouaux A, Gray J, Biboy J, Vollmer W, VanNieuwenhze M, Brun YV, Sockett RE.

Nat Microbiol. 2018 Feb;3(2):254. doi: 10.1038/s41564-017-0087-1.


A programmed cell division delay preserves genome integrity during natural genetic transformation in Streptococcus pneumoniae.

Bergé MJ, Mercy C, Mortier-Barrière I, VanNieuwenhze MS, Brun YV, Grangeasse C, Polard P, Campo N.

Nat Commun. 2017 Nov 20;8(1):1621. doi: 10.1038/s41467-017-01716-9.


Full color palette of fluorescent d-amino acids for in situ labeling of bacterial cell walls.

Hsu YP, Rittichier J, Kuru E, Yablonowski J, Pasciak E, Tekkam S, Hall E, Murphy B, Lee TK, Garner EC, Huang KC, Brun YV, VanNieuwenhze MS.

Chem Sci. 2017 Sep 1;8(9):6313-6321. doi: 10.1039/c7sc01800b. Epub 2017 Jul 7.


Fluorescent D-amino-acids reveal bi-cellular cell wall modifications important for Bdellovibrio bacteriovorus predation.

Kuru E, Lambert C, Rittichier J, Till R, Ducret A, Derouaux A, Gray J, Biboy J, Vollmer W, VanNieuwenhze M, Brun YV, Sockett RE.

Nat Microbiol. 2017 Dec;2(12):1648-1657. doi: 10.1038/s41564-017-0029-y. Epub 2017 Oct 3. Erratum in: Nat Microbiol. 2018 Jan 8;:.


Peptidoglycan O-acetylation is functionally related to cell wall biosynthesis and cell division in Streptococcus pneumoniae.

Bonnet J, Durmort C, Jacq M, Mortier-Barrière I, Campo N, VanNieuwenhze MS, Brun YV, Arthaud C, Gallet B, Moriscot C, Morlot C, Vernet T, Di Guilmi AM.

Mol Microbiol. 2017 Dec;106(5):832-846. doi: 10.1111/mmi.13849. Epub 2017 Oct 26.


Evidence for a peptidoglycan-like structure in Orientia tsutsugamushi.

Atwal S, Giengkam S, Chaemchuen S, Dorling J, Kosaisawe N, VanNieuwenhze M, Sampattavanich S, Schumann P, Salje J.

Mol Microbiol. 2017 Aug;105(3):440-452. doi: 10.1111/mmi.13709. Epub 2017 Jun 19.


Treadmilling by FtsZ filaments drives peptidoglycan synthesis and bacterial cell division.

Bisson-Filho AW, Hsu YP, Squyres GR, Kuru E, Wu F, Jukes C, Sun Y, Dekker C, Holden S, VanNieuwenhze MS, Brun YV, Garner EC.

Science. 2017 Feb 17;355(6326):739-743. doi: 10.1126/science.aak9973.


Dual Mode of Action for Plusbacin A3 in Staphylococcus aureus.

O'Connor RD, Singh M, Chang J, Kim SJ, VanNieuwenhze M, Schaefer J.

J Phys Chem B. 2017 Feb 23;121(7):1499-1505. doi: 10.1021/acs.jpcb.6b11039. Epub 2017 Feb 13.


A Periplasmic Polymer Curves Vibrio cholerae and Promotes Pathogenesis.

Bartlett TM, Bratton BP, Duvshani A, Miguel A, Sheng Y, Martin NR, Nguyen JP, Persat A, Desmarais SM, VanNieuwenhze MS, Huang KC, Zhu J, Shaevitz JW, Gitai Z.

Cell. 2017 Jan 12;168(1-2):172-185.e15. doi: 10.1016/j.cell.2016.12.019. Epub 2017 Jan 12.


FtsZ-Dependent Elongation of a Coccoid Bacterium.

Pereira AR, Hsin J, Król E, Tavares AC, Flores P, Hoiczyk E, Ng N, Dajkovic A, Brun YV, VanNieuwenhze MS, Roemer T, Carballido-Lopez R, Scheffers DJ, Huang KC, Pinho MG.

MBio. 2016 Sep 6;7(5). pii: e00908-16. doi: 10.1128/mBio.00908-16.


Live imaging of the genetically intractable obligate intracellular bacteria Orientia tsutsugamushi using a panel of fluorescent dyes.

Atwal S, Giengkam S, VanNieuwenhze M, Salje J.

J Microbiol Methods. 2016 Nov;130:169-176. doi: 10.1016/j.mimet.2016.08.022. Epub 2016 Aug 28.


Structure-function analysis of the extracellular domain of the pneumococcal cell division site positioning protein MapZ.

Manuse S, Jean NL, Guinot M, Lavergne JP, Laguri C, Bougault CM, VanNieuwenhze MS, Grangeasse C, Simorre JP.

Nat Commun. 2016 Jun 27;7:12071. doi: 10.1038/ncomms12071.


Pathogenic Chlamydia Lack a Classical Sacculus but Synthesize a Narrow, Mid-cell Peptidoglycan Ring, Regulated by MreB, for Cell Division.

Liechti G, Kuru E, Packiam M, Hsu YP, Tekkam S, Hall E, Rittichier JT, VanNieuwenhze M, Brun YV, Maurelli AT.

PLoS Pathog. 2016 May 4;12(5):e1005590. doi: 10.1371/journal.ppat.1005590. eCollection 2016 May.


Minimal Peptidoglycan (PG) Turnover in Wild-Type and PG Hydrolase and Cell Division Mutants of Streptococcus pneumoniae D39 Growing Planktonically and in Host-Relevant Biofilms.

Boersma MJ, Kuru E, Rittichier JT, VanNieuwenhze MS, Brun YV, Winkler ME.

J Bacteriol. 2015 Nov;197(21):3472-85. doi: 10.1128/JB.00541-15. Epub 2015 Aug 24.


Cell shape dynamics during the staphylococcal cell cycle.

Monteiro JM, Fernandes PB, Vaz F, Pereira AR, Tavares AC, Ferreira MT, Pereira PM, Veiga H, Kuru E, VanNieuwenhze MS, Brun YV, Filipe SR, Pinho MG.

Nat Commun. 2015 Aug 17;6:8055. doi: 10.1038/ncomms9055.


Anammox Planctomycetes have a peptidoglycan cell wall.

van Teeseling MC, Mesman RJ, Kuru E, Espaillat A, Cava F, Brun YV, VanNieuwenhze MS, Kartal B, van Niftrik L.

Nat Commun. 2015 May 12;6:6878. doi: 10.1038/ncomms7878.


MapZ marks the division sites and positions FtsZ rings in Streptococcus pneumoniae.

Fleurie A, Lesterlin C, Manuse S, Zhao C, Cluzel C, Lavergne JP, Franz-Wachtel M, Macek B, Combet C, Kuru E, VanNieuwenhze MS, Brun YV, Sherratt D, Grangeasse C.

Nature. 2014 Dec 11;516(7530):259-262. doi: 10.1038/nature13966. Epub 2014 Nov 26.


Electroreductive dimerization of coumarin and coumarin analogues at carbon cathodes.

Pasciak EM, Rittichier JT, Chen CH, Mubarak MS, VanNieuwenhze MS, Peters DG.

J Org Chem. 2015 Jan 2;80(1):274-80. doi: 10.1021/jo502272g. Epub 2014 Dec 5.


Atheroprotective immunization with malondialdehyde-modified LDL is hapten specific and dependent on advanced MDA adducts: implications for development of an atheroprotective vaccine.

Gonen A, Hansen LF, Turner WW, Montano EN, Que X, Rafia A, Chou MY, Wiesner P, Tsiantoulas D, Corr M, VanNieuwenhze MS, Tsimikas S, Binder CJ, Witztum JL, Hartvigsen K.

J Lipid Res. 2014 Oct;55(10):2137-55. doi: 10.1194/jlr.M053256. Epub 2014 Aug 20.


Pbp2x localizes separately from Pbp2b and other peptidoglycan synthesis proteins during later stages of cell division of Streptococcus pneumoniae D39.

Tsui HT, Boersma MJ, Vella SA, Kocaoglu O, Kuru E, Peceny JK, Carlson EE, VanNieuwenhze MS, Brun YV, Shaw SL, Winkler ME.

Mol Microbiol. 2014 Oct;94(1):21-40. doi: 10.1111/mmi.12745. Epub 2014 Aug 21.


Interplay of the serine/threonine-kinase StkP and the paralogs DivIVA and GpsB in pneumococcal cell elongation and division.

Fleurie A, Manuse S, Zhao C, Campo N, Cluzel C, Lavergne JP, Freton C, Combet C, Guiral S, Soufi B, Macek B, Kuru E, VanNieuwenhze MS, Brun YV, Di Guilmi AM, Claverys JP, Galinier A, Grangeasse C.

PLoS Genet. 2014 Apr 10;10(4):e1004275. doi: 10.1371/journal.pgen.1004275. eCollection 2014 Apr.


A new metabolic cell-wall labelling method reveals peptidoglycan in Chlamydia trachomatis.

Liechti GW, Kuru E, Hall E, Kalinda A, Brun YV, VanNieuwenhze M, Maurelli AT.

Nature. 2014 Feb 27;506(7489):507-10. doi: 10.1038/nature12892. Epub 2013 Dec 11.


Discovery of chlamydial peptidoglycan reveals bacteria with murein sacculi but without FtsZ.

Pilhofer M, Aistleitner K, Biboy J, Gray J, Kuru E, Hall E, Brun YV, VanNieuwenhze MS, Vollmer W, Horn M, Jensen GJ.

Nat Commun. 2013;4:2856. doi: 10.1038/ncomms3856.


Peptidoglycan transformations during Bacillus subtilis sporulation.

Tocheva EI, López-Garrido J, Hughes HV, Fredlund J, Kuru E, Vannieuwenhze MS, Brun YV, Pogliano K, Jensen GJ.

Mol Microbiol. 2013 May;88(4):673-86. doi: 10.1111/mmi.12201. Epub 2013 Mar 27.


The isotridecanyl side chain of plusbacin-A3 is essential for the transglycosylase inhibition of peptidoglycan biosynthesis.

Kim SJ, Singh M, Wohlrab A, Yu TY, Patti GJ, O'Connor RD, VanNieuwenhze M, Schaefer J.

Biochemistry. 2013 Mar 19;52(11):1973-9. doi: 10.1021/bi4000222. Epub 2013 Mar 5.


Biomimetic Synthesis of Cbz-(S)-Dolaphenine.

García-Reynaga P, Vannieuwenhze MS.

Tetrahedron Lett. 2012 Sep 12;53(37):4989-4993.


In Situ probing of newly synthesized peptidoglycan in live bacteria with fluorescent D-amino acids.

Kuru E, Hughes HV, Brown PJ, Hall E, Tekkam S, Cava F, de Pedro MA, Brun YV, VanNieuwenhze MS.

Angew Chem Int Ed Engl. 2012 Dec 7;51(50):12519-23. doi: 10.1002/anie.201206749. Epub 2012 Oct 10.


Design and synthesis of a stable oxidized phospholipid mimic with specific binding recognition for macrophage scavenger receptors.

Turner WW, Hartvigsen K, Boullier A, Montano EN, Witztum JL, VanNieuwenhze MS.

J Med Chem. 2012 Sep 27;55(18):8178-82. Epub 2012 Sep 11.


Solid-phase synthesis of lysobactin (katanosin B): insights into structure and function.

Hall EA, Kuru E, VanNieuwenhze MS.

Org Lett. 2012 Jun 1;14(11):2730-3. doi: 10.1021/ol300926d. Epub 2012 May 21.

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