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Items: 34


The Rad51 paralogs facilitate a novel DNA strand specific damage tolerance pathway.

Rosenbaum JC, Bonilla B, Hengel SR, Mertz TM, Herken BW, Kazemier HG, Pressimone CA, Ratterman TC, MacNary E, De Magis A, Kwon Y, Godin SK, Van Houten B, Normolle DP, Sung P, Das SR, Paeschke K, Roberts SA, VanDemark AP, Bernstein KA.

Nat Commun. 2019 Aug 5;10(1):3515. doi: 10.1038/s41467-019-11374-8.


Missense variant in TPI1 (Arg189Gln) causes neurologic deficits through structural changes in the triosephosphate isomerase catalytic site and reduced enzyme levels in vivo.

Roland BP, Richards KR, Hrizo SL, Eicher S, Barile ZJ, Chang TC, Savon G, Bianchi P, Fermo E, Ricerca BM, Tortorolo L, Vockley J, VanDemark AP, Palladino MJ.

Biochim Biophys Acta Mol Basis Dis. 2019 Sep 1;1865(9):2257-2266. doi: 10.1016/j.bbadis.2019.05.002. Epub 2019 May 7.


Characterization of Differential Dynamics, Specificity, and Allostery of Lipoxygenase Family Members.

Mikulska-Ruminska K, Shrivastava I, Krieger J, Zhang S, Li H, Bayır H, Wenzel SE, VanDemark AP, Kagan VE, Bahar I.

J Chem Inf Model. 2019 May 28;59(5):2496-2508. doi: 10.1021/acs.jcim.9b00006. Epub 2019 Feb 28.


Empowerment of 15-Lipoxygenase Catalytic Competence in Selective Oxidation of Membrane ETE-PE to Ferroptotic Death Signals, HpETE-PE.

Anthonymuthu TS, Kenny EM, Shrivastava I, Tyurina YY, Hier ZE, Ting HC, Dar HH, Tyurin VA, Nesterova A, Amoscato AA, Mikulska-Ruminska K, Rosenbaum JC, Mao G, Zhao J, Conrad M, Kellum JA, Wenzel SE, VanDemark AP, Bahar I, Kagan VE, Bayır H.

J Am Chem Soc. 2018 Dec 26;140(51):17835-17839. doi: 10.1021/jacs.8b09913. Epub 2018 Dec 17.


PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals.

Wenzel SE, Tyurina YY, Zhao J, St Croix CM, Dar HH, Mao G, Tyurin VA, Anthonymuthu TS, Kapralov AA, Amoscato AA, Mikulska-Ruminska K, Shrivastava IH, Kenny EM, Yang Q, Rosenbaum JC, Sparvero LJ, Emlet DR, Wen X, Minami Y, Qu F, Watkins SC, Holman TR, VanDemark AP, Kellum JA, Bahar I, Bayır H, Kagan VE.

Cell. 2017 Oct 19;171(3):628-641.e26. doi: 10.1016/j.cell.2017.09.044.


Combining Wet and Dry Lab Techniques to Guide the Crystallization of Large Coiled-coil Containing Proteins.

Zalewski JK, Heber S, Mo JH, O'Conor K, Hildebrand JD, VanDemark AP.

J Vis Exp. 2017 Jan 6;(119). doi: 10.3791/54886.


The Histone Modification Domain of Paf1 Complex Subunit Rtf1 Directly Stimulates H2B Ubiquitylation through an Interaction with Rad6.

Van Oss SB, Shirra MK, Bataille AR, Wier AD, Yen K, Vinayachandran V, Byeon IL, Cucinotta CE, Héroux A, Jeon J, Kim J, VanDemark AP, Pugh BF, Arndt KM.

Mol Cell. 2016 Nov 17;64(4):815-825. doi: 10.1016/j.molcel.2016.10.008. Epub 2016 Nov 10.


Structure of the Shroom-Rho Kinase Complex Reveals a Binding Interface with Monomeric Shroom That Regulates Cell Morphology and Stimulates Kinase Activity.

Zalewski JK, Mo JH, Heber S, Heroux A, Gardner RG, Hildebrand JD, VanDemark AP.

J Biol Chem. 2016 Dec 2;291(49):25364-25374. Epub 2016 Oct 10.


Structural and Genetic Studies Demonstrate Neurologic Dysfunction in Triosephosphate Isomerase Deficiency Is Associated with Impaired Synaptic Vesicle Dynamics.

Roland BP, Zeccola AM, Larsen SB, Amrich CG, Talsma AD, Stuchul KA, Heroux A, Levitan ES, VanDemark AP, Palladino MJ.

PLoS Genet. 2016 Mar 31;12(3):e1005941. doi: 10.1371/journal.pgen.1005941. eCollection 2016 Mar.


Promotion of presynaptic filament assembly by the ensemble of S. cerevisiae Rad51 paralogues with Rad52.

Gaines WA, Godin SK, Kabbinavar FF, Rao T, VanDemark AP, Sung P, Bernstein KA.

Nat Commun. 2015 Jul 28;6:7834. doi: 10.1038/ncomms8834.


Triosephosphate isomerase I170V alters catalytic site, enhances stability and induces pathology in a Drosophila model of TPI deficiency.

Roland BP, Amrich CG, Kammerer CJ, Stuchul KA, Larsen SB, Rode S, Aslam AA, Heroux A, Wetzel R, VanDemark AP, Palladino MJ.

Biochim Biophys Acta. 2015 Jan;1852(1):61-9. doi: 10.1016/j.bbadis.2014.10.010. Epub 2014 Oct 16.


The interaction between Shroom3 and Rho-kinase is required for neural tube morphogenesis in mice.

Das D, Zalewski JK, Mohan S, Plageman TF, VanDemark AP, Hildebrand JD.

Biol Open. 2014 Aug 29;3(9):850-60. doi: 10.1242/bio.20147450.


Structure of a highly conserved domain of Rock1 required for Shroom-mediated regulation of cell morphology.

Mohan S, Das D, Bauer RJ, Heroux A, Zalewski JK, Heber S, Dosunmu-Ogunbi AM, Trakselis MA, Hildebrand JD, Vandemark AP.

PLoS One. 2013 Dec 9;8(12):e81075. doi: 10.1371/journal.pone.0081075. eCollection 2013.


Cross-talk between diverse serine integrases.

Singh S, Rockenbach K, Dedrick RM, VanDemark AP, Hatfull GF.

J Mol Biol. 2014 Jan 23;426(2):318-31. doi: 10.1016/j.jmb.2013.10.013. Epub 2013 Oct 22.


The structure of Xis reveals the basis for filament formation and insight into DNA bending within a mycobacteriophage intasome.

Singh S, Plaks JG, Homa NJ, Amrich CG, Héroux A, Hatfull GF, VanDemark AP.

J Mol Biol. 2014 Jan 23;426(2):412-22. doi: 10.1016/j.jmb.2013.10.002. Epub 2013 Oct 7.


Structural basis for Spt5-mediated recruitment of the Paf1 complex to chromatin.

Wier AD, Mayekar MK, Héroux A, Arndt KM, VanDemark AP.

Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17290-5. doi: 10.1073/pnas.1314754110. Epub 2013 Oct 7.


Evidence of a triosephosphate isomerase non-catalytic function crucial to behavior and longevity.

Roland BP, Stuchul KA, Larsen SB, Amrich CG, Vandemark AP, Celotto AM, Palladino MJ.

J Cell Sci. 2013 Jul 15;126(Pt 14):3151-8. doi: 10.1242/jcs.124586. Epub 2013 May 2.


The Shu complex interacts with Rad51 through the Rad51 paralogues Rad55-Rad57 to mediate error-free recombination.

Godin S, Wier A, Kabbinavar F, Bratton-Palmer DS, Ghodke H, Van Houten B, VanDemark AP, Bernstein KA.

Nucleic Acids Res. 2013 Apr;41(8):4525-34. doi: 10.1093/nar/gkt138. Epub 2013 Mar 4.


A novel Drosophila SOD2 mutant demonstrates a role for mitochondrial ROS in neurodevelopment and disease.

Celotto AM, Liu Z, Vandemark AP, Palladino MJ.

Brain Behav. 2012 Jul;2(4):424-34. doi: 10.1002/brb3.73. Epub 2012 Jun 25.


Structure of Shroom domain 2 reveals a three-segmented coiled-coil required for dimerization, Rock binding, and apical constriction.

Mohan S, Rizaldy R, Das D, Bauer RJ, Heroux A, Trakselis MA, Hildebrand JD, VanDemark AP.

Mol Biol Cell. 2012 Jun;23(11):2131-42. doi: 10.1091/mbc.E11-11-0937. Epub 2012 Apr 4.


Cdc73 subunit of Paf1 complex contains C-terminal Ras-like domain that promotes association of Paf1 complex with chromatin.

Amrich CG, Davis CP, Rogal WP, Shirra MK, Heroux A, Gardner RG, Arndt KM, VanDemark AP.

J Biol Chem. 2012 Mar 30;287(14):10863-75. doi: 10.1074/jbc.M111.325647. Epub 2012 Feb 8.


Structural and functional analysis of the Spt16p N-terminal domain reveals overlapping roles of yFACT subunits.

VanDemark AP, Xin H, McCullough L, Rawlins R, Bentley S, Heroux A, Stillman DJ, Hill CP, Formosa T.

J Biol Chem. 2008 Feb 22;283(8):5058-68. Epub 2007 Dec 18.


Potent D-peptide inhibitors of HIV-1 entry.

Welch BD, VanDemark AP, Heroux A, Hill CP, Kay MS.

Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):16828-33. Epub 2007 Oct 17.


Autoregulation of the rsc4 tandem bromodomain by gcn5 acetylation.

VanDemark AP, Kasten MM, Ferris E, Heroux A, Hill CP, Cairns BR.

Mol Cell. 2007 Sep 7;27(5):817-28.


The structure of the yFACT Pob3-M domain, its interaction with the DNA replication factor RPA, and a potential role in nucleosome deposition.

VanDemark AP, Blanksma M, Ferris E, Heroux A, Hill CP, Formosa T.

Mol Cell. 2006 May 5;22(3):363-74. Erratum in: Mol Cell. 2007 Jul 6;27(1):171-2.


Inositol hexakisphosphate is bound in the ADAR2 core and required for RNA editing.

Macbeth MR, Schubert HL, Vandemark AP, Lingam AT, Hill CP, Bass BL.

Science. 2005 Sep 2;309(5740):1534-9.


E1 on the move.

VanDemark AP, Hill CP.

Mol Cell. 2005 Feb 18;17(4):474-5. Review.


Grabbing E2 by the tail.

VanDemark AP, Hill CP.

Nat Struct Mol Biol. 2004 Oct;11(10):908-9. No abstract available.


Two-stepping with E1.

VanDemark AP, Hill CP.

Nat Struct Biol. 2003 Apr;10(4):244-6. No abstract available.


Structural basis of ubiquitylation.

VanDemark AP, Hill CP.

Curr Opin Struct Biol. 2002 Dec;12(6):822-30. Review.


SUMO wrestling with specificity.

VanDemark AP, Hill CP.

Structure. 2002 Mar;10(3):281-2.


Molecular insights into polyubiquitin chain assembly: crystal structure of the Mms2/Ubc13 heterodimer.

VanDemark AP, Hofmann RM, Tsui C, Pickart CM, Wolberger C.

Cell. 2001 Jun 15;105(6):711-20.


Opening doors into the proteasome.

Pickart CM, VanDemark AP.

Nat Struct Biol. 2000 Nov;7(11):999-1001. No abstract available.


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