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High enantiomeric excess D-[methyl-11C]methionine for use as a diagnostic PET radiotracer in bacterial infection.

Stewart M, Parker MFL, Jivan S, Luu J, Huynh T, Schulte B, Seo Y, Blecha J, Villanueva-Meyer J, Flavell RR, VanBrocklin HF, Ohliger M, Rosenberg O, Wilson DM.

ACS Infect Dis. 2019 Nov 7. doi: 10.1021/acsinfecdis.9b00196. [Epub ahead of print]


Seeing Is Believing: Nuclear Imaging of HIV Persistence.

Henrich TJ, Hsue PY, VanBrocklin H.

Front Immunol. 2019 Sep 12;10:2077. doi: 10.3389/fimmu.2019.02077. eCollection 2019. Review.


Synthesis and Initial Biological Evaluation of Boron-Containing Prostate-Specific Membrane Antigen Ligands for Treatment of Prostate Cancer Using Boron Neutron Capture Therapy.

Wang S, Blaha C, Santos R, Huynh T, Hayes TR, Beckford-Vera DR, Blecha JE, Hong AS, Fogarty M, Hope TA, Raleigh DR, Wilson DM, Evans MJ, VanBrocklin HF, Ozawa T, Flavell RR.

Mol Pharm. 2019 Sep 3;16(9):3831-3841. doi: 10.1021/acs.molpharmaceut.9b00464. Epub 2019 Aug 16.


Enzymatically Catalyzed Radiofluorination of Biomolecules.

Drake CR, Evans MJ, VanBrocklin HF.

Methods Mol Biol. 2019;2033:191-205. doi: 10.1007/978-1-4939-9654-4_13.


Divergent synthesis of organophosphate [11C]VX- and [11C]Sarin-surrogates from a common set of starting materials.

Hayes TR, Blecha JE, Thompson CM, Gerdes JM, VanBrocklin HF.

Appl Radiat Isot. 2019 Sep;151:182-186. doi: 10.1016/j.apradiso.2019.05.033. Epub 2019 May 24.


PET/CT Imaging of Human TNFα Using [89Zr]Certolizumab Pegol in a Transgenic Preclinical Model of Rheumatoid Arthritis.

Beckford-Vera DR, Gonzalez-Junca A, Janneck JS, Huynh TL, Blecha JE, Seo Y, Li X, VanBrocklin HF, Franc BL.

Mol Imaging Biol. 2019 May 7. doi: 10.1007/s11307-019-01363-0. [Epub ahead of print]


Imaging of Activated T Cells as an Early Predictor of Immune Response to Anti-PD-1 Therapy.

Levi J, Lam T, Goth SR, Yaghoubi S, Bates J, Ren G, Jivan S, Huynh TL, Blecha JE, Khattri R, Schmidt KF, Jennings D, VanBrocklin H.

Cancer Res. 2019 Jul 1;79(13):3455-3465. doi: 10.1158/0008-5472.CAN-19-0267. Epub 2019 May 7.


Positron emission tomography studies of organophosphate chemical threats and oxime countermeasures.

Thompson CM, Gerdes JM, VanBrocklin HF.

Neurobiol Dis. 2019 Apr 22:104455. doi: 10.1016/j.nbd.2019.04.011. [Epub ahead of print] Review.


Phase I Study of CTT1057, an 18F-Labeled Imaging Agent with Phosphoramidate Core Targeting Prostate-Specific Membrane Antigen in Prostate Cancer.

Behr SC, Aggarwal R, VanBrocklin HF, Flavell RR, Gao K, Small EJ, Blecha J, Jivan S, Hope TA, Simko JP, Kurhanewicz J, Noworolski SM, Korn NJ, De Los Santos R, Cooperberg MR, Carroll PR, Nguyen HG, Greene KL, Langton-Webster B, Berkman CE, Seo Y.

J Nucl Med. 2019 Jul;60(7):910-916. doi: 10.2967/jnumed.118.220715. Epub 2018 Nov 21.


Radiosynthesis of O-(1-[18 F]fluoropropan-2-yl)-O-(4-nitrophenyl)methylphosphonate: A novel PET tracer surrogate of sarin.

Hayes TR, Thompson CM, Blecha JE, Gerdes JM, VanBrocklin HF.

J Labelled Comp Radiopharm. 2018 Dec;61(14):1089-1094. doi: 10.1002/jlcr.3688. Epub 2018 Nov 4.


A Patient-derived Xenograft Model of Pancreatic Neuroendocrine Tumors Identifies Sapanisertib as a Possible New Treatment for Everolimus-resistant Tumors.

Chamberlain CE, German MS, Yang K, Wang J, VanBrocklin H, Regan M, Shokat KM, Ducker GS, Kim GE, Hann B, Donner DB, Warren RS, Venook AP, Bergsland EK, Lee D, Wang Y, Nakakura EK.

Mol Cancer Ther. 2018 Dec;17(12):2702-2709. doi: 10.1158/1535-7163.MCT-17-1204. Epub 2018 Sep 25.


Radiosynthesis, ex Vivo Biodistribution, and in Vivo Positron Emission Tomography Imaging Evaluations of [11C]2-Pyridinealdoxime Methiodide ([11C]2-PAM): A First-In-Class Antidote Tracer for Organophosphate Intoxication.

Neumann KD, Blecha JE, Hayes TR, Huynh T, Chao CK, Guilloteau N, Zinn KR, VanBrocklin HF, Thompson CM, Gerdes JM.

ACS Chem Neurosci. 2018 Dec 19;9(12):3007-3014. doi: 10.1021/acschemneuro.8b00212. Epub 2018 Aug 20.


Quantification of 89 Zr-Iron oxide nanoparticle biodistribution using PET-MR and ultrashort TE sequences.

Jordan CD, Han M, Kondapavulur S, Vera DB, Neumann KD, Moore T, Stillson C, Krug R, Behr S, Seo Y, VanBrocklin HF, Larson PEZ, Wilson M, Martin AJ, Hetts SW.

J Magn Reson Imaging. 2018 Dec;48(6):1717-1720. doi: 10.1002/jmri.26193. Epub 2018 May 14. No abstract available.


Late-stage deuteration of 13C-enriched substrates for T1 prolongation in hyperpolarized 13C MRI.

Taglang C, Korenchan DE, von Morze C, Yu J, Najac C, Wang S, Blecha JE, Subramaniam S, Bok R, VanBrocklin HF, Vigneron DB, Ronen SM, Sriram R, Kurhanewicz J, Wilson DM, Flavell RR.

Chem Commun (Camb). 2018 May 17;54(41):5233-5236. doi: 10.1039/c8cc02246a.


[11C]Para-Aminobenzoic Acid: A Positron Emission Tomography Tracer Targeting Bacteria-Specific Metabolism.

Mutch CA, Ordonez AA, Qin H, Parker M, Bambarger LE, Villanueva-Meyer JE, Blecha J, Carroll V, Taglang C, Flavell R, Sriram R, VanBrocklin H, Rosenberg O, Ohliger MA, Jain SK, Neumann KD, Wilson DM.

ACS Infect Dis. 2018 Jul 13;4(7):1067-1072. doi: 10.1021/acsinfecdis.8b00061. Epub 2018 May 8.


Imaging Active Infection in vivo Using D-Amino Acid Derived PET Radiotracers.

Neumann KD, Villanueva-Meyer JE, Mutch CA, Flavell RR, Blecha JE, Kwak T, Sriram R, VanBrocklin HF, Rosenberg OS, Ohliger MA, Wilson DM.

Sci Rep. 2017 Aug 11;7(1):7903. doi: 10.1038/s41598-017-08415-x.


In Vivo PET Imaging of the Activated Immune Environment in a Small Animal Model of Inflammatory Arthritis.

Franc BL, Goth S, MacKenzie J, Li X, Blecha J, Lam T, Jivan S, Hawkins RA, VanBrocklin H.

Mol Imaging. 2017 Jan 1;16:1536012117712638. doi: 10.1177/1536012117712638.


A PET Imaging Strategy to Visualize Activated T Cells in Acute Graft-versus-Host Disease Elicited by Allogenic Hematopoietic Cell Transplant.

Ronald JA, Kim BS, Gowrishankar G, Namavari M, Alam IS, D'Souza A, Nishikii H, Chuang HY, Ilovich O, Lin CF, Reeves R, Shuhendler A, Hoehne A, Chan CT, Baker J, Yaghoubi SS, VanBrocklin HF, Hawkins R, Franc BL, Jivan S, Slater JB, Verdin EF, Gao KT, Benjamin J, Negrin R, Gambhir SS.

Cancer Res. 2017 Jun 1;77(11):2893-2902. doi: 10.1158/0008-5472.CAN-16-2953.


An updated synthesis of [11 C]carfentanil for positron emission tomography (PET) imaging of the μ-opioid receptor.

Blecha JE, Henderson BD, Hockley BG, VanBrocklin HF, Zubieta JK, DaSilva AF, Kilbourn MR, Koeppe RA, Scott PJH, Shao X.

J Labelled Comp Radiopharm. 2017 Jun 30;60(8):375-380. doi: 10.1002/jlcr.3513. Epub 2017 May 12.


An improved radiosynthesis of O-(2-[18 F]fluoroethyl)-O-(p-nitrophenyl)methylphosphonate: A first-in-class cholinesterase PET tracer.

Neumann KD, Thompson CM, Blecha JE, Gerdes JM, VanBrocklin HF.

J Labelled Comp Radiopharm. 2017 Jun 15;60(7):337-342. doi: 10.1002/jlcr.3511. Epub 2017 May 15.


Dicarboxylic acids as pH sensors for hyperpolarized 13C magnetic resonance spectroscopic imaging.

Korenchan DE, Taglang C, von Morze C, Blecha JE, Gordon JW, Sriram R, Larson PEZ, Vigneron DB, VanBrocklin HF, Kurhanewicz J, Wilson DM, Flavell RR.

Analyst. 2017 May 2;142(9):1429-1433. doi: 10.1039/c7an00076f.


11C-L-methyl methionine dynamic PET/CT of skeletal muscle: response to protein supplementation compared to L-[ring 13C6] phenylalanine infusion with serial muscle biopsy.

Arentson-Lantz EJ, Saeed IH, Frassetto LA, Masharani U, Harnish RJ, Seo Y, VanBrocklin HF, Hawkins RA, Mari-Aparici C, Pampaloni MH, Slater J, Paddon-Jones D, Lang TF.

Ann Nucl Med. 2017 May;31(4):295-303. doi: 10.1007/s12149-017-1157-4. Epub 2017 Mar 4.


Optimization of an endovascular magnetic filter for maximized capture of magnetic nanoparticles.

Kondapavulur S, Cote AM, Neumann KD, Jordan CD, McCoy D, Mabray MC, Liu D, Sze CH, Gautam A, VanBrocklin HF, Wilson M, Hetts SW.

Biomed Microdevices. 2016 Dec;18(6):109.


Ictal lack of binding to brain parenchyma suggests integrity of the blood-brain barrier for 11C-dihydroergotamine during glyceryl trinitrate-induced migraine.

Schankin CJ, Maniyar FH, Seo Y, Kori S, Eller M, Chou DE, Blecha J, Murphy ST, Hawkins RA, Sprenger T, VanBrocklin HF, Goadsby PJ.

Brain. 2016 Jul;139(Pt 7):1994-2001. doi: 10.1093/brain/aww096. Epub 2016 May 27.


Structure-Activity Relationship of (18)F-Labeled Phosphoramidate Peptidomimetic Prostate-Specific Membrane Antigen (PSMA)-Targeted Inhibitor Analogues for PET Imaging of Prostate Cancer.

Dannoon S, Ganguly T, Cahaya H, Geruntho JJ, Galliher MS, Beyer SK, Choy CJ, Hopkins MR, Regan M, Blecha JE, Skultetyova L, Drake CR, Jivan S, Barinka C, Jones EF, Berkman CE, VanBrocklin HF.

J Med Chem. 2016 Jun 23;59(12):5684-94. doi: 10.1021/acs.jmedchem.5b01850. Epub 2016 Jun 13.


Site-Specific Radiofluorination of Biomolecules with 8-[(18)F]-Fluorooctanoic Acid Catalyzed by Lipoic Acid Ligase.

Drake CR, Sevillano N, Truillet C, Craik CS, VanBrocklin HF, Evans MJ.

ACS Chem Biol. 2016 Jun 17;11(6):1587-94. doi: 10.1021/acschembio.6b00172. Epub 2016 Mar 31.


[(11)C]Ascorbic and [(11)C]dehydroascorbic acid, an endogenous redox pair for sensing reactive oxygen species using positron emission tomography.

Carroll VN, Truillet C, Shen B, Flavell RR, Shao X, Evans MJ, VanBrocklin HF, Scott PJ, Chin FT, Wilson DM.

Chem Commun (Camb). 2016 Apr 7;52(27):4888-90. doi: 10.1039/c6cc00895j. Epub 2016 Mar 10.


Dynamic nuclear polarization of biocompatible (13)C-enriched carbonates for in vivo pH imaging.

Korenchan DE, Flavell RR, Baligand C, Sriram R, Neumann K, Sukumar S, VanBrocklin H, Vigneron DB, Wilson DM, Kurhanewicz J.

Chem Commun (Camb). 2016 Feb 18;52(14):3030-3. doi: 10.1039/c5cc09724j.


Caged [(18)F]FDG Glycosylamines for Imaging Acidic Tumor Microenvironments Using Positron Emission Tomography.

Flavell RR, Truillet C, Regan MK, Ganguly T, Blecha JE, Kurhanewicz J, VanBrocklin HF, Keshari KR, Chang CJ, Evans MJ, Wilson DM.

Bioconjug Chem. 2016 Jan 20;27(1):170-8. doi: 10.1021/acs.bioconjchem.5b00584. Epub 2015 Dec 22.


[(11)C]acetate PET Imaging is not Always Associated with Increased Lipogenesis in Hepatocellular Carcinoma in Mice.

Li L, Che L, Wang C, Blecha JE, Li X, VanBrocklin HF, Calvisi DF, Puchowicz M, Chen X, Seo Y.

Mol Imaging Biol. 2016 Jun;18(3):360-7. doi: 10.1007/s11307-015-0915-8.


Non-invasive imaging and cellular tracking of pulmonary emboli by near-infrared fluorescence and positron-emission tomography.

Page MJ, Lourenço AL, David T, LeBeau AM, Cattaruzza F, Castro HC, VanBrocklin HF, Coughlin SR, Craik CS.

Nat Commun. 2015 Oct 1;6:8448. doi: 10.1038/ncomms9448.


Metabolic response of prostate cancer to nicotinamide phophoribosyltransferase inhibition in a hyperpolarized MR/PET compatible bioreactor.

Keshari KR, Wilson DM, Van Criekinge M, Sriram R, Koelsch BL, Wang ZJ, VanBrocklin HF, Peehl DM, O'Brien T, Sampath D, Carano RA, Kurhanewicz J.

Prostate. 2015 Oct;75(14):1601-9. doi: 10.1002/pros.23036. Epub 2015 Jul 14.


A high-affinity [(18)F]-labeled phosphoramidate peptidomimetic PSMA-targeted inhibitor for PET imaging of prostate cancer.

Ganguly T, Dannoon S, Hopkins MR, Murphy S, Cahaya H, Blecha JE, Jivan S, Drake CR, Barinka C, Jones EF, VanBrocklin HF, Berkman CE.

Nucl Med Biol. 2015 Oct;42(10):780-7. doi: 10.1016/j.nucmedbio.2015.06.003. Epub 2015 Jun 9.


Synthesis and evaluation of constrained phosphoramidate inhibitors of prostate-specific membrane antigen.

Ley CR, Beattie NR, Dannoon S, Regan M, VanBrocklin H, Berkman CE.

Bioorg Med Chem Lett. 2015 Jun 15;25(12):2536-9. doi: 10.1016/j.bmcl.2015.04.047. Epub 2015 Apr 29.


Simultaneous (68)Ga-DOTA-TOC PET/MRI with gadoxetate disodium in patients with neuroendocrine tumor.

Hope TA, Pampaloni MH, Nakakura E, VanBrocklin H, Slater J, Jivan S, Aparici CM, Yee J, Bergsland E.

Abdom Imaging. 2015 Aug;40(6):1432-40. doi: 10.1007/s00261-015-0409-9.


Somatostatin imaging of neuroendocrine-differentiated prostate cancer.

Hope TA, Aggarwal R, Simko JP, VanBrocklin HF, Ryan CJ.

Clin Nucl Med. 2015 Jun;40(6):540-1. doi: 10.1097/RLU.0000000000000776.


Imaging active urokinase plasminogen activator in prostate cancer.

LeBeau AM, Sevillano N, Markham K, Winter MB, Murphy ST, Hostetter DR, West J, Lowman H, Craik CS, VanBrocklin HF.

Cancer Res. 2015 Apr 1;75(7):1225-35. doi: 10.1158/0008-5472.CAN-14-2185. Epub 2015 Feb 11.


A boronate-caged [¹⁸F]FLT probe for hydrogen peroxide detection using positron emission tomography.

Carroll V, Michel BW, Blecha J, VanBrocklin H, Keshari K, Wilson D, Chang CJ.

J Am Chem Soc. 2014 Oct 22;136(42):14742-5. doi: 10.1021/ja509198w. Epub 2014 Oct 13.


Regulatory Requirements for PET Drug Production.

Schwarz SW, Dick D, VanBrocklin HF, Hoffman JM.

J Nucl Med. 2014 Jul;55(7):1132-7. doi: 10.2967/jnumed.113.132472. Epub 2014 Jun 9. Review.


A novel fluorine-18 β-fluoroethoxy organophosphate positron emission tomography imaging tracer targeted to central nervous system acetylcholinesterase.

James SL, Ahmed SK, Murphy S, Braden MR, Belabassi Y, VanBrocklin HF, Thompson CM, Gerdes JM.

ACS Chem Neurosci. 2014 Jul 16;5(7):519-24. doi: 10.1021/cn500024c. Epub 2014 Apr 23.


Imaging the urokinase plasminongen activator receptor in preclinical breast cancer models of acquired drug resistance.

LeBeau AM, Sevillano N, King ML, Duriseti S, Murphy ST, Craik CS, Murphy LL, VanBrocklin HF.

Theranostics. 2014 Jan 18;4(3):267-79. doi: 10.7150/thno.7323. eCollection 2014.


Photons across medicine: relating optical and nuclear imaging.

Nordstrom R, Cherry S, Azhdarinia A, Sevick-Muraca E, Vanbrocklin H.

Biomed Opt Express. 2013 Nov 5;4(12):2751-62. doi: 10.1364/BOE.4.002751. eCollection 2013.


Hyperpolarized [1-13C]dehydroascorbate MR spectroscopy in a murine model of prostate cancer: comparison with 18F-FDG PET.

Keshari KR, Sai V, Wang ZJ, Vanbrocklin HF, Kurhanewicz J, Wilson DM.

J Nucl Med. 2013 Jun;54(6):922-8. doi: 10.2967/jnumed.112.115402. Epub 2013 Apr 10.


Targeting uPAR with antagonistic recombinant human antibodies in aggressive breast cancer.

LeBeau AM, Duriseti S, Murphy ST, Pepin F, Hann B, Gray JW, VanBrocklin HF, Craik CS.

Cancer Res. 2013 Apr 1;73(7):2070-81. doi: 10.1158/0008-5472.CAN-12-3526. Epub 2013 Feb 11.


Imaging a functional tumorigenic biomarker in the transformed epithelium.

LeBeau AM, Lee M, Murphy ST, Hann BC, Warren RS, Delos Santos R, Kurhanewicz J, Hanash SM, VanBrocklin HF, Craik CS.

Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):93-8. doi: 10.1073/pnas.1218694110. Epub 2012 Dec 17.


In memoriam: Michael John Welch, Ph.D 1939-2012.

McCarthy TJ, Vanbrocklin HF.

Mol Imaging Biol. 2012 Aug;14(4):393-4. doi: 10.1007/s11307-012-0570-2. No abstract available.


Accepting the torch.

VanBrocklin H.

Mol Imaging. 2012 Feb;11(1):1. No abstract available.


Tumor dosimetry using [124I]m-iodobenzylguanidine microPET/CT for [131I]m-iodobenzylguanidine treatment of neuroblastoma in a murine xenograft model.

Seo Y, Gustafson WC, Dannoon SF, Nekritz EA, Lee CL, Murphy ST, VanBrocklin HF, Hernandez-Pampaloni M, Haas-Kogan DA, Weiss WA, Matthay KK.

Mol Imaging Biol. 2012 Dec;14(6):735-42. doi: 10.1007/s11307-012-0552-4.


Approach to assessing myocardial perfusion in rats using static [13N]-ammonia images and a small-animal PET.

Vaquero JJ, Gao DW, García-Villaba C, Bacharach S, Vanbrocklin H, Fang Q, Desco M, Lee R, Dae M.

Mol Imaging Biol. 2012 Oct;14(5):541-5. doi: 10.1007/s11307-011-0538-7.


The Q43L mutant of neuregulin 2β is a pan-ErbB receptor antagonist.

Wilson KJ, Mill CP, Gallo RM, Cameron EM, VanBrocklin H, Settleman J, Riese DJ.

Biochem J. 2012 Apr 1;443(1):133-44. doi: 10.1042/BJ20110921.

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