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Items: 9

1.

Elucidating the active δ-opioid receptor crystal structure with peptide and small-molecule agonists.

Claff T, Yu J, Blais V, Patel N, Martin C, Wu L, Han GW, Holleran BJ, Van der Poorten O, White KL, Hanson MA, Sarret P, Gendron L, Cherezov V, Katritch V, Ballet S, Liu ZJ, Müller CE, Stevens RC.

Sci Adv. 2019 Nov 27;5(11):eaax9115. doi: 10.1126/sciadv.aax9115. eCollection 2019 Nov.

2.

Rapid construction of substituted 3-amino-1,5-benzothiazepin-4(5H)-one dipeptide scaffolds through an Ugi-4CR - Ullmann cross-coupling sequence.

Van der Poorten O, Van Den Hauwe R, Hollanders K, Maes BUW, Tourwé D, Jida M, Ballet S.

Org Biomol Chem. 2018 Feb 21;16(8):1242-1246. doi: 10.1039/c7ob03094k.

PMID:
29379930
3.

Indoloazepinone-Constrained Oligomers as Cell-Penetrating and Blood-Brain-Barrier-Permeating Compounds.

Van der Poorten O, Legrand B, Vezenkov LL, García-Pindado J, Bettache N, Knuhtsen A, Pedersen DS, Sánchez-Navarro M, Martinez J, Teixidó M, Garcia M, Tourwé D, Amblard M, Ballet S.

Chembiochem. 2018 Apr 4;19(7):696-705. doi: 10.1002/cbic.201700678. Epub 2018 Feb 28.

PMID:
29377388
4.

χ-Space Screening of Dermorphin-Based Tetrapeptides through Use of Constrained Arylazepinone and Quinolinone Scaffolds.

Van der Poorten O, Van Den Hauwe R, Eiselt E, Betti C, Guillemyn K, Chung NN, Hallé F, Bihel F, Schiller PW, Tourwé D, Sarret P, Gendron L, Ballet S.

ACS Med Chem Lett. 2017 Oct 4;8(11):1177-1182. doi: 10.1021/acsmedchemlett.7b00347. eCollection 2017 Nov 9.

5.

Side Chain Cyclized Aromatic Amino Acids: Great Tools as Local Constraints in Peptide and Peptidomimetic Design.

Van der Poorten O, Knuhtsen A, Sejer Pedersen D, Ballet S, Tourwé D.

J Med Chem. 2016 Dec 22;59(24):10865-10890. doi: 10.1021/acs.jmedchem.6b01029. Epub 2016 Oct 12. Review.

PMID:
27690430
6.

Conformationally Constrained Peptidomimetics as Inhibitors of the Protein Arginine Methyl Transferases.

Knuhtsen A, Legrand B, Van der Poorten O, Amblard M, Martinez J, Ballet S, Kristensen JL, Pedersen DS.

Chemistry. 2016 Sep 19;22(39):14022-14028. doi: 10.1002/chem.201602518. Epub 2016 Aug 12.

PMID:
27515561
7.

T3P-Promoted, Mild, One-Pot Syntheses of Constrained Polycyclic Lactam Dipeptide Analogues via Stereoselective Pictet-Spengler and Meyers Lactamization Reactions.

Jida M, Van der Poorten O, Guillemyn K, Urbanczyk-Lipkowska Z, Tourwé D, Ballet S.

Org Lett. 2015 Sep 18;17(18):4482-5. doi: 10.1021/acs.orglett.5b02145. Epub 2015 Aug 31.

PMID:
26322913
8.

Azepinone-Containing Tetrapeptide Analogues of Melanotropin Lead to Selective hMC4R Agonists and hMC5R Antagonist.

Van der Poorten O, Fehér K, Buysse K, Feytens D, Zoi I, Schwartz SD, Martins JC, Tourwé D, Cai M, Hruby VJ, Ballet S.

ACS Med Chem Lett. 2014 Dec 3;6(2):192-7. doi: 10.1021/ml500436s. eCollection 2015 Feb 12.

9.

Synthesis and biological evaluation of compact, conformationally constrained bifunctional opioid agonist - neurokinin-1 antagonist peptidomimetics.

Guillemyn K, Kleczkowska P, Lesniak A, Dyniewicz J, Van der Poorten O, Van den Eynde I, Keresztes A, Varga E, Lai J, Porreca F, Chung NN, Lemieux C, Mika J, Rojewska E, Makuch W, Van Duppen J, Przewlocka B, Vanden Broeck J, Lipkowski AW, Schiller PW, Tourwé D, Ballet S.

Eur J Med Chem. 2015 Mar 6;92:64-77. doi: 10.1016/j.ejmech.2014.12.033. Epub 2014 Dec 19.

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