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Items: 28

1.

Genetically Engineered iPSC-Derived FTDP-17 MAPT Neurons Display Mutation-Specific Neurodegenerative and Neurodevelopmental Phenotypes.

Verheyen A, Diels A, Reumers J, Van Hoorde K, Van den Wyngaert I, van Outryve d'Ydewalle C, De Bondt A, Kuijlaars J, De Muynck L, De Hoogt R, Bretteville A, Jaensch S, Buist A, Cabrera-Socorro A, Wray S, Ebneth A, Roevens P, Royaux I, Peeters PJ.

Stem Cell Reports. 2019 Aug 13;13(2):434-435. doi: 10.1016/j.stemcr.2019.07.007. No abstract available.

2.

Role of Kv7.2/Kv7.3 and M1 muscarinic receptors in the regulation of neuronal excitability in hiPSC-derived neurons.

Kreir M, De Bondt A, Van den Wyngaert I, Teuns G, Lu HR, Gallacher DJ.

Eur J Pharmacol. 2019 Sep 5;858:172474. doi: 10.1016/j.ejphar.2019.172474. Epub 2019 Jun 22.

PMID:
31238068
3.

Correction: MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cells.

Beke L, Kig C, Linders JTM, Boens S, Boeckx A, van Heerde E, Parade M, De Bondt A, Van den Wyngaert I, Bashir T, Ogata S, Meerpoel L, Van Eynde A, Johnson CN, Beullens M, Brehmer D, Bollen M.

Biosci Rep. 2018 Nov 30;38(6). pii: BSR-20150194_COR. doi: 10.1042/BSR-20150194_COR. Print 2018 Dec 21. No abstract available.

4.

Genetically Engineered iPSC-Derived FTDP-17 MAPT Neurons Display Mutation-Specific Neurodegenerative and Neurodevelopmental Phenotypes.

Verheyen A, Diels A, Reumers J, Van Hoorde K, Van den Wyngaert I, van Outryve d'Ydewalle C, De Bondt A, Kuijlaars J, De Muynck L, De Hoogt R, Bretteville A, Jaensch S, Buist A, Cabrera-Socorro A, Wray S, Ebneth A, Roevens P, Royaux I, Peeters PJ.

Stem Cell Reports. 2018 Aug 14;11(2):363-379. doi: 10.1016/j.stemcr.2018.06.022. Epub 2018 Jul 26. Erratum in: Stem Cell Reports. 2019 Aug 13;13(2):434-435.

5.

Do in vitro assays in rat primary neurons predict drug-induced seizure liability in humans?

Kreir M, Van Deuren B, Versweyveld S, De Bondt A, Van den Wyngaert I, Van der Linde H, Lu HR, Teuns G, Gallacher DJ.

Toxicol Appl Pharmacol. 2018 May 1;346:45-57. doi: 10.1016/j.taap.2018.03.028. Epub 2018 Mar 26.

PMID:
29596924
6.

Chronic drug-induced effects on contractile motion properties and cardiac biomarkers in human induced pluripotent stem cell-derived cardiomyocytes.

Kopljar I, De Bondt A, Vinken P, Teisman A, Damiano B, Goeminne N, Van den Wyngaert I, Gallacher DJ, Lu HR.

Br J Pharmacol. 2017 Nov;174(21):3766-3779. doi: 10.1111/bph.13713. Epub 2017 Feb 8.

7.

In Vitro Model for Hepatotoxicity Studies Based on Primary Human Hepatocyte Cultivation in a Perfused 3D Bioreactor System.

Knöspel F, Jacobs F, Freyer N, Damm G, De Bondt A, van den Wyngaert I, Snoeys J, Monshouwer M, Richter M, Strahl N, Seehofer D, Zeilinger K.

Int J Mol Sci. 2016 Apr 16;17(4):584. doi: 10.3390/ijms17040584.

8.

Functional and Transcriptional Characterization of Histone Deacetylase Inhibitor-Mediated Cardiac Adverse Effects in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

Kopljar I, Gallacher DJ, De Bondt A, Cougnaud L, Vlaminckx E, Van den Wyngaert I, Lu HR.

Stem Cells Transl Med. 2016 May;5(5):602-12. doi: 10.5966/sctm.2015-0279. Epub 2016 Mar 31.

9.

MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cells.

Beke L, Kig C, Linders JT, Boens S, Boeckx A, van Heerde E, Parade M, De Bondt A, Van den Wyngaert I, Bashir T, Ogata S, Meerpoel L, Van Eynde A, Johnson CN, Beullens M, Brehmer D, Bollen M.

Biosci Rep. 2015 Oct 2;35(6). pii: e00267. doi: 10.1042/BSR20150194. Erratum in: Biosci Rep. 2018 Nov 30;38(6):.

10.

Integrating High-Dimensional Transcriptomics and Image Analysis Tools into Early Safety Screening: Proof of Concept for a New Early Drug Development Strategy.

Verbist BM, Verheyen GR, Vervoort L, Crabbe M, Beerens D, Bosmans C, Jaensch S, Osselaer S, Talloen W, Van den Wyngaert I, Van Hecke G, Wuyts D; QSTAR Consortium, Van Goethem F, Göhlmann HW.

Chem Res Toxicol. 2015 Oct 19;28(10):1914-25. doi: 10.1021/acs.chemrestox.5b00103. Epub 2015 Sep 15.

11.

Evaluation of established human iPSC-derived neurons to model neurodegenerative diseases.

Meneghello G, Verheyen A, Van Ingen M, Kuijlaars J, Tuefferd M, Van Den Wyngaert I, Nuydens R.

Neuroscience. 2015 Aug 20;301:204-12. doi: 10.1016/j.neuroscience.2015.05.071. Epub 2015 Jun 3.

PMID:
26047731
12.

Upregulation of MAPK Negative Feedback Regulators and RET in Mutant ALK Neuroblastoma: Implications for Targeted Treatment.

Lambertz I, Kumps C, Claeys S, Lindner S, Beckers A, Janssens E, Carter DR, Cazes A, Cheung BB, De Mariano M, De Bondt A, De Brouwer S, Delattre O, Gibbons J, Janoueix-Lerosey I, Laureys G, Liang C, Marchall GM, Porcu M, Takita J, Trujillo DC, Van Den Wyngaert I, Van Roy N, Van Goethem A, Van Maerken T, Zabrocki P, Cools J, Schulte JH, Vialard J, Speleman F, De Preter K.

Clin Cancer Res. 2015 Jul 15;21(14):3327-39. doi: 10.1158/1078-0432.CCR-14-2024. Epub 2015 Mar 24.

13.

Microarray profiling of DNA extracted from FFPE tissues using SNP 6.0 Affymetrix platform.

Tuefferd M, de Bondt A, Van den Wyngaert I, Talloen W, Göhlmann H.

Methods Mol Biol. 2011;724:147-60. doi: 10.1007/978-1-61779-055-3_10.

PMID:
21370012
14.

An investigation on performance of Significance Analysis of Microarray (SAM) for the comparisons of several treatments with one control in the presence of small-variance genes.

Lin D, Shkedy Z, Burzykowski T, Ion R, Göhlmann HW, Bondt AD, Perer T, Geerts T, Van den Wyngaert I, Bijnens L.

Biom J. 2008 Oct;50(5):801-23. doi: 10.1002/bimj.200710467.

PMID:
18932139
15.

The ontogeny of drug metabolizing enzymes and transporters in the rat.

de Zwart L, Scholten M, Monbaliu JG, Annaert PP, Van Houdt JM, Van den Wyngaert I, De Schaepdrijver LM, Bailey GP, Coogan TP, Coussement WC, Mannens GS.

Reprod Toxicol. 2008 Nov-Dec;26(3-4):220-30. doi: 10.1016/j.reprotox.2008.09.010. Epub 2008 Oct 7.

PMID:
18926897
16.

Genome-wide copy number alterations detection in fresh frozen and matched FFPE samples using SNP 6.0 arrays.

Tuefferd M, De Bondt A, Van Den Wyngaert I, Talloen W, Verbeke T, Carvalho B, Clevert DA, Alifano M, Raghavan N, Amaratunga D, Göhlmann H, Broët P, Camilleri-Broët S.

Genes Chromosomes Cancer. 2008 Nov;47(11):957-64. doi: 10.1002/gcc.20599.

PMID:
18663747
17.

Diarylquinolines are bactericidal for dormant mycobacteria as a result of disturbed ATP homeostasis.

Koul A, Vranckx L, Dendouga N, Balemans W, Van den Wyngaert I, Vergauwen K, Göhlmann HW, Willebrords R, Poncelet A, Guillemont J, Bald D, Andries K.

J Biol Chem. 2008 Sep 12;283(37):25273-80. doi: 10.1074/jbc.M803899200. Epub 2008 Jul 14.

18.

Alterations in mucosal immunity identified in the colon of patients with irritable bowel syndrome.

Aerssens J, Camilleri M, Talloen W, Thielemans L, Göhlmann HW, Van Den Wyngaert I, Thielemans T, De Hoogt R, Andrews CN, Bharucha AE, Carlson PJ, Busciglio I, Burton DD, Smyrk T, Urrutia R, Coulie B.

Clin Gastroenterol Hepatol. 2008 Feb;6(2):194-205. doi: 10.1016/j.cgh.2007.11.012.

19.

Alterations in the brain-gut axis underlying visceral chemosensitivity in Nippostrongylus brasiliensis-infected mice.

Aerssens J, Hillsley K, Peeters PJ, de Hoogt R, Stanisz A, Lin JH, Van den Wyngaert I, Göhlmann HW, Grundy D, Stead RH, Coulie B.

Gastroenterology. 2007 Apr;132(4):1375-87. Epub 2007 Feb 7.

PMID:
17408648
20.

Alterations in expression of p11 and SERT in mucosal biopsy specimens of patients with irritable bowel syndrome.

Camilleri M, Andrews CN, Bharucha AE, Carlson PJ, Ferber I, Stephens D, Smyrk TC, Urrutia R, Aerssens J, Thielemans L, Göhlmann H, van den Wyngaert I, Coulie B.

Gastroenterology. 2007 Jan;132(1):17-25. Epub 2006 Nov 17.

21.

p53-independent regulation of p21Waf1/Cip1 expression and senescence by Chk2.

Aliouat-Denis CM, Dendouga N, Van den Wyngaert I, Goehlmann H, Steller U, van de Weyer I, Van Slycken N, Andries L, Kass S, Luyten W, Janicot M, Vialard JE.

Mol Cancer Res. 2005 Nov;3(11):627-34.

22.

Gene expression profiles highlight adaptive brain mechanisms in corticotropin releasing factor overexpressing mice.

Peeters PJ, Fierens FL, van den Wyngaert I, Goehlmann HW, Swagemakers SM, Kass SU, Langlois X, Pullan S, Stenzel-Poore MP, Steckler T.

Brain Res Mol Brain Res. 2004 Oct 22;129(1-2):135-50.

PMID:
15469890
23.

Transcriptional response to corticotropin-releasing factor in AtT-20 cells.

Peeters PJ, Göhlmann HW, Van den Wyngaert I, Swagemakers SM, Bijnens L, Kass SU, Steckler T.

Mol Pharmacol. 2004 Nov;66(5):1083-92. Epub 2004 Jul 22.

PMID:
15272051
24.

In vitro methylation of predetermined regions in recombinant DNA constructs.

Van den Wyngaert I, Adams RL, Kass SU.

Methods Mol Biol. 2001;181:243-50.

PMID:
12843455
25.

Characterization of an orphan G protein-coupled receptor localized in the dorsal root ganglia reveals adenine as a signaling molecule.

Bender E, Buist A, Jurzak M, Langlois X, Baggerman G, Verhasselt P, Ercken M, Guo HQ, Wintmolders C, Van den Wyngaert I, Van Oers I, Schoofs L, Luyten W.

Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8573-8.

26.

Cloning and characterization of human histone deacetylase 8.

Van den Wyngaert I, de Vries W, Kremer A, Neefs J, Verhasselt P, Luyten WH, Kass SU.

FEBS Lett. 2000 Jul 28;478(1-2):77-83.

27.

Cloning and analysis of a novel human putative DNA methyltransferase.

Van den Wyngaert I, Sprengel J, Kass SU, Luyten WH.

FEBS Lett. 1998 Apr 17;426(2):283-9.

28.

Cloning and expression of a human serotonin 5-HT4 receptor cDNA.

Van den Wyngaert I, Gommeren W, Verhasselt P, Jurzak M, Leysen J, Luyten W, Bender E.

J Neurochem. 1997 Nov;69(5):1810-9.

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