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Items: 15

1.

Functionally Biased D2R Antagonists: Targeting the β-Arrestin Pathway to Improve Antipsychotic Treatment.

Weïwer M, Xu Q, Gale JP, Lewis M, Campbell AJ, Schroeder FA, Van de Bittner GC, Walk M, Amaya A, Su P, D Ordevic L, Sacher JR, Skepner A, Fei D, Dennehy K, Nguyen S, Faloon PW, Perez J, Cottrell JR, Liu F, Palmer M, Pan JQ, Hooker JM, Zhang YL, Scolnick E, Wagner FF, Holson EB.

ACS Chem Biol. 2018 Apr 20;13(4):1038-1047. doi: 10.1021/acschembio.8b00168. Epub 2018 Mar 14.

PMID:
29485852
2.

Positron Emission Tomography Assessment of the Intranasal Delivery Route for Orexin A.

Van de Bittner GC, Van de Bittner KC, Wey HY, Rowe W, Dharanipragada R, Ying X, Hurst W, Giovanni A, Alving K, Gupta A, Hoekman J, Hooker JM.

ACS Chem Neurosci. 2018 Feb 21;9(2):358-368. doi: 10.1021/acschemneuro.7b00357. Epub 2017 Nov 7.

PMID:
29035509
3.

Nasal neuron PET imaging quantifies neuron generation and degeneration.

Van de Bittner GC, Riley MM, Cao L, Ehses J, Herrick SP, Ricq EL, Wey HY, O'Neill MJ, Ahmed Z, Murray TK, Smith JE, Wang C, Schroeder FA, Albers MW, Hooker JM.

J Clin Invest. 2017 Feb 1;127(2):681-694. doi: 10.1172/JCI89162. Epub 2017 Jan 23.

4.

In vivo bioluminescence imaging reveals copper deficiency in a murine model of nonalcoholic fatty liver disease.

Heffern MC, Park HM, Au-Yeung HY, Van de Bittner GC, Ackerman CM, Stahl A, Chang CJ.

Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):14219-14224. Epub 2016 Nov 29.

5.

In Vivo Metal Ion Imaging Using Fluorescent Sensors.

Van de Bittner GC, Hirayama T.

Methods Mol Biol. 2016;1444:139-52. doi: 10.1007/978-1-4939-3721-9_13.

PMID:
27283424
6.

A Novel Radiotracer for Imaging Monoacylglycerol Lipase in the Brain Using Positron Emission Tomography.

Wang C, Placzek MS, Van de Bittner GC, Schroeder FA, Hooker JM.

ACS Chem Neurosci. 2016 Apr 20;7(4):484-9. doi: 10.1021/acschemneuro.5b00293. Epub 2016 Jan 6.

PMID:
26694017
7.

Development of a Fluorinated Class-I HDAC Radiotracer Reveals Key Chemical Determinants of Brain Penetrance.

Strebl MG, Wang C, Schroeder FA, Placzek MS, Wey HY, Van de Bittner GC, Neelamegam R, Hooker JM.

ACS Chem Neurosci. 2016 May 18;7(5):528-33. doi: 10.1021/acschemneuro.5b00297. Epub 2015 Dec 21.

8.

Immediate and Persistent Effects of Salvinorin A on the Kappa Opioid Receptor in Rodents, Monitored In Vivo with PET.

Placzek MS, Van de Bittner GC, Wey HY, Lukas SE, Hooker JM.

Neuropsychopharmacology. 2015 Dec;40(13):2865-72. doi: 10.1038/npp.2015.159. Epub 2015 Jun 10.

9.

A philosophy for CNS radiotracer design.

Van de Bittner GC, Ricq EL, Hooker JM.

Acc Chem Res. 2014 Oct 21;47(10):3127-34. doi: 10.1021/ar500233s. Epub 2014 Oct 1. Review.

10.

PET imaging demonstrates histone deacetylase target engagement and clarifies brain penetrance of known and novel small molecule inhibitors in rat.

Schroeder FA, Wang C, Van de Bittner GC, Neelamegam R, Takakura WR, Karunakaran A, Wey HY, Reis SA, Gale J, Zhang YL, Holson EB, Haggarty SJ, Hooker JM.

ACS Chem Neurosci. 2014 Oct 15;5(10):1055-62. doi: 10.1021/cn500162j. Epub 2014 Sep 19.

11.

A chemical strategy for the cell-based detection of HDAC activity.

Diyabalanage HV, Van de Bittner GC, Ricq EL, Hooker JM.

ACS Chem Biol. 2014 Jun 20;9(6):1257-62. doi: 10.1021/cb500248r. Epub 2014 Apr 30.

12.

Strategy for dual-analyte luciferin imaging: in vivo bioluminescence detection of hydrogen peroxide and caspase activity in a murine model of acute inflammation.

Van de Bittner GC, Bertozzi CR, Chang CJ.

J Am Chem Soc. 2013 Feb 6;135(5):1783-95. doi: 10.1021/ja309078t. Epub 2013 Jan 25.

13.

Near-infrared fluorescent sensor for in vivo copper imaging in a murine Wilson disease model.

Hirayama T, Van de Bittner GC, Gray LW, Lutsenko S, Chang CJ.

Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2228-33. doi: 10.1073/pnas.1113729109. Epub 2012 Jan 30.

14.

Boronate oxidation as a bioorthogonal reaction approach for studying the chemistry of hydrogen peroxide in living systems.

Lippert AR, Van de Bittner GC, Chang CJ.

Acc Chem Res. 2011 Sep 20;44(9):793-804. doi: 10.1021/ar200126t. Epub 2011 Aug 11.

15.

In vivo imaging of hydrogen peroxide production in a murine tumor model with a chemoselective bioluminescent reporter.

Van de Bittner GC, Dubikovskaya EA, Bertozzi CR, Chang CJ.

Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21316-21. doi: 10.1073/pnas.1012864107. Epub 2010 Nov 29.

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