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Seeing the Wood for the Trees - Household Air Pollution and Lung Disease.

van Zyl-Smit RN, Balmes JR.

Am J Respir Crit Care Med. 2018 Sep 25. doi: 10.1164/rccm.201808-1554ED. [Epub ahead of print] No abstract available.


Erratum to South African guideline for the management of community-acquired pneumonia in adults.

Boyles TH, Brink A, Calligaro GL, Cohen C, Dheda K, Maartens G, Richards GA, van Zyl Smit R, Smith C, Wasserman S, Whitelaw AC, Feldman C; South African Thoracic Society; Federation of Infectious Diseases Societies of Southern Africa.

J Thorac Dis. 2018 Aug;10(8):E673-E675. doi: 10.21037/jtd.2018.07.137.


Questionnaires for Lung Health in Africa across the Life Course.

Saleh S, van Zyl-Smit R, Allwood B, Lawin H, Mbatchou Ngahane BH, Ayakaka I, Moyo E, El-Sony A, Mortimer K, Rylance J.

Int J Environ Res Public Health. 2018 Jul 31;15(8). pii: E1615. doi: 10.3390/ijerph15081615.


Priority areas for cannabis and cannabinoid product research in South Africa.

Augustine TN, Cairns CJ, Chetty S, Dannatt LG, Gravett N, Grey G, Grobler G, Jafta Z, Kamerman P, Lopes J, Matsabisa MG, Mugabo P, Mulder M, Parry C, Rataemane S, Siegfried N, Steenkamp V, Thomas E, Van Zyl-Smit R.

Afr J Prim Health Care Fam Med. 2018 Jun 21;10(1):e1-e3. doi: 10.4102/phcfm.v10i1.1711.


E-cigarette vapour enhances pneumococcal adherence to airway epithelial cells.

Miyashita L, Suri R, Dearing E, Mudway I, Dove RE, Neill DR, Van Zyl-Smit R, Kadioglu A, Grigg J.

Eur Respir J. 2018 Feb 7;51(2). pii: 1701592. doi: 10.1183/13993003.01592-2017. Print 2018 Feb.


Five-year follow-up of participants diagnosed with chronic airflow obstruction in a South African Burden of Obstructive Lung Disease (BOLD) survey.

Allwood BW, Gillespie R, Bateman M, Olckers H, Taborda-Barata L, Calligaro GL, Van Zyl-Smit R, Cooper CB, Beyers N, Bateman ED.

S Afr Med J. 2018 Feb 1;108(2):138-143. doi: 10.7196/SAMJ.2017.v108i2.12688.


Tuberculosis, chronic obstructive pulmonary disease and inhaled corticosteroids: a complex web.

Allwood BW, van Zyl-Smit R.

Int J Tuberc Lung Dis. 2017 Dec 1;21(12):1317-1318. doi: 10.5588/ijtld.17.0496. No abstract available.


South African guideline for the management of community-acquired pneumonia in adults.

Boyles TH, Brink A, Calligaro GL, Cohen C, Dheda K, Maartens G, Richards GA, van Zyl Smit R, Smith C, Wasserman S, Whitelaw AC, Feldman C; South African Thoracic Society; Federation of Infectious Diseases Societies of Southern Africa.

J Thorac Dis. 2017 Jun;9(6):1469-1502. doi: 10.21037/jtd.2017.05.31. Review. No abstract available. Erratum in: J Thorac Dis. 2018 Aug;10(8):E673-E675.


Obstructive pulmonary disease in patients with previous tuberculosis: Pathophysiology of a community-based cohort.

Allwood BW, Gillespie R, Galperin-Aizenberg M, Bateman M, Olckers H, Taborda-Barata L, Calligaro GL, Said-Hartley Q, Van Zyl-Smit R, Cooper CB, Van Rikxoort E, Goldin J, Beyers N, Bateman ED.

S Afr Med J. 2017 Apr 25;107(5):440-445. doi: 10.7196/SAMJ.2017.v107i5.12118.


Anaerobic Bacterial Fermentation Products Increase Tuberculosis Risk in Antiretroviral-Drug-Treated HIV Patients.

Segal LN, Clemente JC, Li Y, Ruan C, Cao J, Danckers M, Morris A, Tapyrik S, Wu BG, Diaz P, Calligaro G, Dawson R, van Zyl-Smit RN, Dheda K, Rom WN, Weiden MD.

Cell Host Microbe. 2017 Apr 12;21(4):530-537.e4. doi: 10.1016/j.chom.2017.03.003. Epub 2017 Mar 30.


Safety and Immunogenicity of Adenovirus 35 Tuberculosis Vaccine Candidate in Adults with Active or Previous Tuberculosis. A Randomized Trial.

van Zyl-Smit RN, Esmail A, Bateman ME, Dawson R, Goldin J, van Rikxoort E, Douoguih M, Pau MG, Sadoff JC, McClain JB, Snowden MA, Benko J, Hokey DA, Rutkowski KT, Graves A, Shepherd B, Ishmukhamedov S, Kagina BMN, Abel B, Hanekom WA, Scriba TJ, Bateman ED.

Am J Respir Crit Care Med. 2017 May 1;195(9):1171-1180. doi: 10.1164/rccm.201603-0654OC.


The Intention to Test for Latent Tuberculosis Should Be a Targeted Intention to Trust and Treat the Result.

van Zyl-Smit RN, van Hest R.

Ann Am Thorac Soc. 2016 May;13(5):591-2. doi: 10.1513/AnnalsATS.201511-734ED. No abstract available.


Chronic obstructive pulmonary disease--diagnosis and classification of severity.

Viviers PJ, van Zyl-Smit RN.

S Afr Med J. 2015 Sep;105(9):786-8. Review.


Chronic obstructive pulmonary disease in South Africa: under-recognized and undertreated.

Allwood B, van Zyl-Smit RN.

S Afr Med J. 2015 Sep;105(9):785. No abstract available.


Assessment of previous tuberculosis status using questionnaires, chest X-rays and computed tomography scans.

Allwood BW, Goldin J, Said-Hartley Q, van Zyl-Smit RN, Calligaro G, Esmail A, Beyers N, Bateman ED.

Int J Tuberc Lung Dis. 2015 Dec;19(12):1435-40. doi: 10.5588/ijtld.14.0992.


The asthma-COPD overlap syndrome: towards a revised taxonomy of chronic airways diseases?

Bateman ED, Reddel HK, van Zyl-Smit RN, Agusti A.

Lancet Respir Med. 2015 Sep;3(9):719-728. doi: 10.1016/S2213-2600(15)00254-4. Epub 2015 Aug 5. Review.


HIV associated Lymphocytic Interstitial Pneumonia: a clinical, histological and radiographic study from an HIV endemic resource-poor setting.

van Zyl-Smit RN, Naidoo J, Wainwright H, Said-Hartley Q, Davids M, Goodman H, Rogers S, Dheda K.

BMC Pulm Med. 2015 Apr 22;15:38. doi: 10.1186/s12890-015-0030-2.


Incidence of occupational latent tuberculosis infection in South African healthcare workers.

Adams S, Ehrlich R, Baatjies R, van Zyl-Smit RN, Said-Hartley Q, Dawson R, Dheda K.

Eur Respir J. 2015 May;45(5):1364-73. doi: 10.1183/09031936.00138414. Epub 2015 Feb 19.


Reproducibility of interferon gamma (IFN-γ) release Assays. A systematic review.

Tagmouti S, Slater M, Benedetti A, Kik SV, Banaei N, Cattamanchi A, Metcalfe J, Dowdy D, van Zyl Smit R, Dendukuri N, Pai M, Denkinger C.

Ann Am Thorac Soc. 2014 Oct;11(8):1267-76. doi: 10.1513/AnnalsATS.201405-188OC. Review.


Electronic cigarettes. A position statement of the forum of international respiratory societies.

Schraufnagel DE, Blasi F, Drummond MB, Lam DC, Latif E, Rosen MJ, Sansores R, Van Zyl-Smit R; Forum of International Respiratory Societies.

Am J Respir Crit Care Med. 2014 Sep 15;190(6):611-8. doi: 10.1164/rccm.201407-1198PP.


Efficacy of varenicline combined with nicotine replacement therapy vs varenicline alone for smoking cessation: a randomized clinical trial.

Koegelenberg CF, Noor F, Bateman ED, van Zyl-Smit RN, Bruning A, O'Brien JA, Smith C, Abdool-Gaffar MS, Emanuel S, Esterhuizen TM, Irusen EM.

JAMA. 2014 Jul;312(2):155-61. doi: 10.1001/jama.2014.7195.


Comparison of same day diagnostic tools including Gene Xpert and unstimulated IFN-γ for the evaluation of pleural tuberculosis: a prospective cohort study.

Meldau R, Peter J, Theron G, Calligaro G, Allwood B, Symons G, Khalfey H, Ntombenhle G, Govender U, Binder A, van Zyl-Smit R, Dheda K.

BMC Pulm Med. 2014 Apr 8;14:58. doi: 10.1186/1471-2466-14-58.


Cigarette smoke impairs cytokine responses and BCG containment in alveolar macrophages.

van Zyl-Smit RN, Binder A, Meldau R, Semple PL, Evans A, Smith P, Bateman ED, Dheda K.

Thorax. 2014 Apr;69(4):363-70. doi: 10.1136/thoraxjnl-2013-204229. Epub 2013 Nov 28.


Electronic cigarettes: the potential risks outweigh the benefits.

van Zyl-Smit RN.

S Afr Med J. 2013 Sep 30;103(11):833. doi: 10.7196/samj.7435. No abstract available.


South African tobacco smoking cessation clinical practice guideline.

van Zyl-Smit RN, Allwood B, Stickells D, Symons G, Abdool-Gaffar S, Murphy K, Lalloo U, Vanker A, Dheda K, Richards G.

S Afr Med J. 2013 Sep 30;103(11):869-76. doi: 10.7196/samj.7484.


Smoking and tuberculous infection: chasing associations with imperfect exposure and outcome measures.

van Zyl-Smit RN, Pai M.

Int J Tuberc Lung Dis. 2013 Nov;17(11):1375-6. doi: 10.5588/ijtld.13.0559. No abstract available.


Drug-associated adverse events and their relationship with outcomes in patients receiving treatment for extensively drug-resistant tuberculosis in South Africa.

Shean K, Streicher E, Pieterson E, Symons G, van Zyl Smit R, Theron G, Lehloenya R, Padanilam X, Wilcox P, Victor TC, van Helden P, Grobusch MP, Warren R, Badri M, Dheda K.

PLoS One. 2013 May 7;8(5):e63057. doi: 10.1371/journal.pone.0063057. Print 2013. Erratum in: PLoS One. 2013;8(5). doi:10.1371/annotation/644591a8-8ae6-450e-974e-1cd1f08f52c7. Groubusch, Martin [corrected to Grobusch, Martin P].


Regulatory T cells attenuate mycobacterial stasis in alveolar and blood-derived macrophages from patients with tuberculosis.

Semple PL, Binder AB, Davids M, Maredza A, van Zyl-Smit RN, Dheda K.

Am J Respir Crit Care Med. 2013 Jun 1;187(11):1249-58. doi: 10.1164/rccm.201210-1934OC.


Development of a simple reliable radiographic scoring system to aid the diagnosis of pulmonary tuberculosis.

Pinto LM, Dheda K, Theron G, Allwood B, Calligaro G, van Zyl-Smit R, Peter J, Schwartzman K, Menzies D, Bateman E, Pai M, Dawson R.

PLoS One. 2013;8(1):e54235. doi: 10.1371/journal.pone.0054235. Epub 2013 Jan 18.


Diagnostic accuracy of induced sputum LAM ELISA for tuberculosis diagnosis in sputum-scarce patients.

Peter JG, Cashmore TJ, Meldau R, Theron G, van Zyl-Smit R, Dheda K.

Int J Tuberc Lung Dis. 2012 Aug;16(8):1108-12. doi: 10.5588/ijtld.11.0614. Epub 2012 Jun 14.


Correlation of mycobacterium tuberculosis specific and non-specific quantitative Th1 T-cell responses with bacillary load in a high burden setting.

Theron G, Peter J, Lenders L, van Zyl-Smit R, Meldau R, Govender U, Dheda K.

PLoS One. 2012;7(5):e37436. doi: 10.1371/journal.pone.0037436. Epub 2012 May 22.


Diagnostic accuracy of a urine lipoarabinomannan strip-test for TB detection in HIV-infected hospitalised patients.

Peter JG, Theron G, van Zyl-Smit R, Haripersad A, Mottay L, Kraus S, Binder A, Meldau R, Hardy A, Dheda K.

Eur Respir J. 2012 Nov;40(5):1211-20. doi: 10.1183/09031936.00201711. Epub 2012 Feb 23.


Comparison of quantitative techniques including Xpert MTB/RIF to evaluate mycobacterial burden.

van Zyl-Smit RN, Binder A, Meldau R, Mishra H, Semple PL, Theron G, Peter J, Whitelaw A, Sharma SK, Warren R, Bateman ED, Dheda K.

PLoS One. 2011;6(12):e28815. doi: 10.1371/journal.pone.0028815. Epub 2011 Dec 22.


The use of an automated quantitative polymerase chain reaction (Xpert MTB/RIF) to predict the sputum smear status of tuberculosis patients.

Theron G, Pinto L, Peter J, Mishra HK, Mishra HK, van Zyl-Smit R, Sharma SK, Dheda K.

Clin Infect Dis. 2012 Feb 1;54(3):384-8. doi: 10.1093/cid/cir824. Epub 2011 Dec 1.


Do adjunct tuberculosis tests, when combined with Xpert MTB/RIF, improve accuracy and the cost of diagnosis in a resource-poor setting?

Theron G, Pooran A, Peter J, van Zyl-Smit R, Kumar Mishra H, Meldau R, Calligaro G, Allwood B, Sharma SK, Dawson R, Dheda K.

Eur Respir J. 2012 Jul;40(1):161-8. doi: 10.1183/09031936.00145511. Epub 2011 Nov 10.


A historical review of XDR tuberculosis in the Western Cape province of South Africa.

Symons G, Shean K, Pietersen E, Van Zyl Smit R, Pool L, Davids M, Willcox P, Dheda K.

S Afr Med J. 2011 Sep 5;101(9):636-8.


Evaluation of the Xpert MTB/RIF assay for the diagnosis of pulmonary tuberculosis in a high HIV prevalence setting.

Theron G, Peter J, van Zyl-Smit R, Mishra H, Streicher E, Murray S, Dawson R, Whitelaw A, Hoelscher M, Sharma S, Pai M, Warren R, Dheda K.

Am J Respir Crit Care Med. 2011 Jul 1;184(1):132-40. doi: 10.1164/rccm.201101-0056OC. Epub 2011 Apr 14.


Are interferon-γ release assays useful for diagnosing active tuberculosis in a high-burden setting?

Ling DI, Pai M, Davids V, Brunet L, Lenders L, Meldau R, Calligaro G, Allwood B, van Zyl-Smit R, Peter J, Bateman E, Dawson R, Dheda K.

Eur Respir J. 2011 Sep;38(3):649-56. doi: 10.1183/09031936.00181610. Epub 2011 Feb 24.


High prevalence of smoking among patients with suspected tuberculosis in South Africa.

Brunet L, Pai M, Davids V, Ling D, Paradis G, Lenders L, Meldau R, van Zyl Smit R, Calligaro G, Allwood B, Dawson R, Dheda K.

Eur Respir J. 2011 Jul;38(1):139-46. doi: 10.1183/09031936.00137710. Epub 2010 Dec 9.


The convergence of the global smoking, COPD, tuberculosis, HIV, and respiratory infection epidemics.

van Zyl-Smit RN, Brunet L, Pai M, Yew WW.

Infect Dis Clin North Am. 2010 Sep;24(3):693-703. doi: 10.1016/j.idc.2010.04.012. Review.


Feasibility and diagnostic utility of antigen-specific interferon-gamma responses for rapid immunodiagnosis of tuberculosis using induced sputum.

Cashmore TJ, Peter JG, van Zyl-Smit RN, Semple PL, Maredza A, Meldau R, Zumla A, Nurse B, Dheda K.

PLoS One. 2010 Apr 28;5(4):e10389. doi: 10.1371/journal.pone.0010389.


The immunology of tuberculosis: from bench to bedside.

Dheda K, Schwander SK, Zhu B, van Zyl-Smit RN, Zhang Y.

Respirology. 2010 Apr;15(3):433-50. doi: 10.1111/j.1440-1843.2010.01739.x. Review.


Clinical utility of a commercial LAM-ELISA assay for TB diagnosis in HIV-infected patients using urine and sputum samples.

Dheda K, Davids V, Lenders L, Roberts T, Meldau R, Ling D, Brunet L, van Zyl Smit R, Peter J, Green C, Badri M, Sechi L, Sharma S, Hoelscher M, Dawson R, Whitelaw A, Blackburn J, Pai M, Zumla A.

PLoS One. 2010 Mar 24;5(3):e9848. doi: 10.1371/journal.pone.0009848.


Comparison of same day versus delayed enumeration of TB-specific T cell responses.

Lenders LM, Meldau R, van Zyl-Smit RN, Woodburne V, Maredza A, Cashmore TJ, Semple PL, Badri M, Zumla A, Dheda K.

J Infect. 2010 May;60(5):344-50. doi: 10.1016/j.jinf.2010.01.012. Epub 2010 Feb 10.


Quantitative pulmonary T-cell responses for the diagnosis of active tuberculosis.

van Zyl-Smit R, Meldau R, Dheda K.

Am J Respir Crit Care Med. 2010 Feb 1;181(3):289; author reply 289-90. No abstract available.


Global lung health: the colliding epidemics of tuberculosis, tobacco smoking, HIV and COPD.

van Zyl Smit RN, Pai M, Yew WW, Leung CC, Zumla A, Bateman ED, Dheda K.

Eur Respir J. 2010 Jan;35(1):27-33. doi: 10.1183/09031936.00072909. Review.


Within-subject variability of interferon-g assay results for tuberculosis and boosting effect of tuberculin skin testing: a systematic review.

van Zyl-Smit RN, Zwerling A, Dheda K, Pai M.

PLoS One. 2009 Dec 30;4(12):e8517. doi: 10.1371/journal.pone.0008517. Review.


Quantitative lung T cell responses aid the rapid diagnosis of pulmonary tuberculosis.

Dheda K, van Zyl-Smit RN, Meldau R, Meldau S, Symons G, Khalfey H, Govender N, Rosu V, Sechi LA, Maredza A, Semple P, Whitelaw A, Wainwright H, Badri M, Dawson R, Bateman ED, Zumla A.

Thorax. 2009 Oct;64(10):847-53. doi: 10.1136/thx.2009.116376. Epub 2009 Jul 9.


T-cell interferon-gamma release assays for the rapid immunodiagnosis of tuberculosis: clinical utility in high-burden vs. low-burden settings.

Dheda K, van Zyl Smit R, Badri M, Pai M.

Curr Opin Pulm Med. 2009 May;15(3):188-200. doi: 10.1097/MCP.0b013e32832a0adc. Review.


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