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Items: 1 to 50 of 99

1.

Design and synthesis of orally active inhibitors of TNF synthesis as anti-rheumatoid arthritis drugs.

Chen JJ, Dewdney N, Lin X, Martin RL, Walker KA, Huang J, Chu F, Eugui E, Mirkovich A, Kim Y, Sarma K, Arzeno H, Van Wart HE.

Bioorg Med Chem Lett. 2003 Nov 17;13(22):3951-4.

PMID:
14592482
2.

Novel inhibitors of procollagen C-proteinase. Part 2: glutamic acid hydroxamates.

Robinson LA, Wilson DM, Delaet NG, Bradley EK, Dankwardt SM, Campbell JA, Martin RL, Van Wart HE, Walker KA, Sullivan RW.

Bioorg Med Chem Lett. 2003 Jul 21;13(14):2381-4.

PMID:
12824039
3.

Novel inhibitors of procollagen C-terminal proteinase. Part 1: diamino Acid hydroxamates.

Delaet NG, Robinson LA, Wilson DM, Sullivan RW, Bradley EK, Dankwardt SM, Martin RL, Van Wart HE, Walker KA.

Bioorg Med Chem Lett. 2003 Jul 7;13(13):2101-4.

PMID:
12798313
4.

Amino acid derived sulfonamide hydroxamates as inhibitors of procollagen C-proteinase. Part 2: Solid-phase optimization of side chains.

Dankwardt SM, Abbot SC, Broka CA, Martin RL, Chan CS, Springman EB, Van Wart HE, Walker KA.

Bioorg Med Chem Lett. 2002 Apr 22;12(8):1233-5.

PMID:
11934595
5.

Proteolysis involving matrix metalloproteinase 13 (collagenase-3) is required for chondrocyte differentiation that is associated with matrix mineralization.

Wu CW, Tchetina EV, Mwale F, Hasty K, Pidoux I, Reiner A, Chen J, Van Wart HE, Poole AR.

J Bone Miner Res. 2002 Apr;17(4):639-51.

6.

Amino acid derived sulfonamide hydroxamates as inhibitors of procollagen C-proteinase: solid-phase synthesis of ornithine analogues.

Dankwardt SM, Martin RL, Chan CS, Van Wart HE, Walker KA, Delaet NG, Robinson LA.

Bioorg Med Chem Lett. 2001 Aug 20;11(16):2085-8. Erratum in: Bioorg Med Chem Lett 2001 Nov 5;11(21):2891.

PMID:
11514144
7.

Solid-phase synthesis of di- and tripeptidic hydroxamic acids as inhibitors of procollagen C-proteinase.

Dankwardt SM, Billedeau RJ, Lawley LK, Abbot SC, Martin RL, Chan CS, Van Wart HE, Walker KA.

Bioorg Med Chem Lett. 2000 Nov 20;10(22):2513-6.

PMID:
11086718
8.

Selective enhancement of collagenase-mediated cleavage of resident type II collagen in cultured osteoarthritic cartilage and arrest with a synthetic inhibitor that spares collagenase 1 (matrix metalloproteinase 1).

Dahlberg L, Billinghurst RC, Manner P, Nelson F, Webb G, Ionescu M, Reiner A, Tanzer M, Zukor D, Chen J, van Wart HE, Poole AR.

Arthritis Rheum. 2000 Mar;43(3):673-82.

9.

Comparison of the peroxidase reaction kinetics of prostaglandin H synthase-1 and -2.

Lu G, Tsai AL, Van Wart HE, Kulmacz RJ.

J Biol Chem. 1999 Jun 4;274(23):16162-7.

10.

Role of His-224 in the anomalous pH dependence of human stromelysin-1.

Holman CM, Kan CC, Gehring MR, Van Wart HE.

Biochemistry. 1999 Jan 12;38(2):677-81.

PMID:
9888808
11.

Hydrolysis of a broad spectrum of extracellular matrix proteins by human macrophage elastase.

Gronski TJ Jr, Martin RL, Kobayashi DK, Walsh BC, Holman MC, Huber M, Van Wart HE, Shapiro SD.

J Biol Chem. 1997 May 2;272(18):12189-94.

12.

Comparison of peroxidase reaction mechanisms of prostaglandin H synthase-1 containing heme and mangano protoporphyrin IX.

Tsai Al, Wei C, Baek HK, Kulmacz RJ, Van Wart HE.

J Biol Chem. 1997 Apr 4;272(14):8885-94.

13.

Understanding the P1' specificity of the matrix metalloproteinases: effect of S1' pocket mutations in matrilysin and stromelysin-1.

Welch AR, Holman CM, Huber M, Brenner MC, Browner MF, Van Wart HE.

Biochemistry. 1996 Aug 6;35(31):10103-9.

PMID:
8756473
14.

Zinc content and function in human fibroblast collagenase.

Springman EB, Nagase H, Birkedal-Hansen H, Van Wart HE.

Biochemistry. 1995 Dec 5;34(48):15713-20.

PMID:
7495802
15.

Purification of human matrilysin produced in Escherichia coli and characterization using a new optimized fluorogenic peptide substrate.

Welch AR, Holman CM, Browner MF, Gehring MR, Kan CC, Van Wart HE.

Arch Biochem Biophys. 1995 Dec 1;324(1):59-64.

PMID:
7503560
16.

Proteolytic and non-proteolytic activation of human neutrophil progelatinase B.

Sang QX, Birkedal-Hansen H, Van Wart HE.

Biochim Biophys Acta. 1995 Sep 6;1251(2):99-108.

PMID:
7669817
17.

Vertebrate collagenases.

Dioszegi M, Cannon P, Van Wart HE.

Methods Enzymol. 1995;248:413-31. No abstract available.

PMID:
7674935
18.

Evidence for a triple helix recognition site in the hemopexin-like domains of human fibroblast and neutrophil interstitial collagenases.

Netzel-Arnett S, Salari A, Goli UB, Van Wart HE.

Ann N Y Acad Sci. 1994 Sep 6;732:22-30. No abstract available.

PMID:
7978794
19.

Zinc content of promatrilysin, matrilysin and the stromelysin catalytic domain.

Soler D, Nomizu T, Brown WE, Chen M, Ye QZ, Van Wart HE, Auld DS.

Biochem Biophys Res Commun. 1994 Jun 15;201(2):917-23.

PMID:
8003031
20.

Differential effect of halide anions on the hydrolysis of different dansyl substrates by thermolysin.

Yang JJ, Artis DR, Van Wart HE.

Biochemistry. 1994 May 31;33(21):6516-23.

PMID:
8204586
22.

Comparative sequence specificities of human 72- and 92-kDa gelatinases (type IV collagenases) and PUMP (matrilysin).

Netzel-Arnett S, Sang QX, Moore WG, Navre M, Birkedal-Hansen H, Van Wart HE.

Biochemistry. 1993 Jun 29;32(25):6427-32.

PMID:
8390857
23.

Heme coordination of prostaglandin H synthase.

Tsai AL, Kulmacz RJ, Wang JS, Wang Y, Van Wart HE, Palmer G.

J Biol Chem. 1993 Apr 25;268(12):8554-63.

24.

Raman and resonance Raman spectroscopy.

Wang Y, Van Wart HE.

Methods Enzymol. 1993;226:319-73. Review. No abstract available.

PMID:
8277871
25.

Structure and expression of neutrophil gelatinase cDNA. Identity with type IV collagenase from HT1080 cells.

Devarajan P, Johnston JJ, Ginsberg SS, Van Wart HE, Berliner N.

J Biol Chem. 1992 Dec 15;267(35):25228-32.

26.
28.
29.

Kinetics of hydrolysis of type I, II, and III collagens by the class I and II Clostridium histolyticum collagenases.

Mallya SK, Mookhtiar KA, Van Wart HE.

J Protein Chem. 1992 Feb;11(1):99-107.

PMID:
1325155
31.

Fluorogenic peptide substrates optimized for five human matrix metalloproteinases.

Angleton EL, Nagase H, Birkedal-Hansen H, Van Wart HE.

Matrix Suppl. 1992;1:89-90. No abstract available.

PMID:
1480101
32.

The glycoprotein nature of human neutrophil collagenase.

Gao Y, Mookhtiar KA, Van Wart HE.

Matrix Suppl. 1992;1:78-9. No abstract available.

PMID:
1480095
33.

Biochemical basis for multiple modes of activation of human fibroblast collagenase.

Springman EB, Angleton EL, Birkedal-Hansen H, Van Wart HE.

Matrix Suppl. 1992;1:76-7. No abstract available.

PMID:
1480094
34.

Comparative sequence specificities of human fibroblast and neutrophil matrix metalloproteinases.

Netzel-Arnett SJ, Fields GB, Nagase H, Suzuki K, Moore WG, Birkedal-Hansen H, Van Wart HE.

Matrix Suppl. 1992;1:74-5. No abstract available.

PMID:
1480093
35.

Synthetic triple helical models for the collagen cleavage site in interstitial collagens.

Goli UB, Fields GB, Van Wart HE.

Matrix Suppl. 1992;1:71-2. No abstract available.

PMID:
1480091
36.

Unique features of the tissue collagenase cleavage site in interstitial collagens.

Fields GB, Van Wart HE.

Matrix Suppl. 1992;1:68-70. No abstract available.

PMID:
1480090
37.

Human neutrophil collagenase.

Van Wart HE.

Matrix Suppl. 1992;1:31-6.

PMID:
1480044
38.

Sulfur-based inhibitors for matrix metalloproteinases.

Schwartz MA, Venkataraman S, Libby A, Mookhtiar K, Mallya S, Van Wart HE, Birkedal-Hansen H.

Matrix Suppl. 1992;1:309-10. No abstract available.

PMID:
1480043
39.

Limited proteolysis of types I, II and III collagens at hyper-reactive sites by Clostridium histolyticum collagenase.

French MF, Bhown A, Van Wart HE.

Matrix Suppl. 1992;1:134-5. No abstract available.

PMID:
1480013
40.

Synthetic inhibitors of bacterial and mammalian interstitial collagenases.

Schwartz MA, Van Wart HE.

Prog Med Chem. 1992;29:271-334. Review. No abstract available.

PMID:
1475372
41.

Clostridium histolyticum collagenases: a new look at some old enzymes.

Mookhtiar KA, Van Wart HE.

Matrix Suppl. 1992;1:116-26.

PMID:
1336107
42.
43.

Continuously recording fluorescent assays optimized for five human matrix metalloproteinases.

Netzel-Arnett S, Mallya SK, Nagase H, Birkedal-Hansen H, Van Wart HE.

Anal Biochem. 1991 May 15;195(1):86-92.

PMID:
1888020
44.

Inhibition of human collagenases by sulfur-based substrate analogs.

Schwartz MA, Venkataraman S, Ghaffari MA, Libby A, Mookhtiar KA, Mallya SK, Birkedal-Hansen H, Van Wart HE.

Biochem Biophys Res Commun. 1991 Apr 15;176(1):173-9.

PMID:
1850255
45.

Sequence specificities of human fibroblast and neutrophil collagenases.

Netzel-Arnett S, Fields GB, Birkedal-Hansen H, Van Wart HE.

J Biol Chem. 1991 Apr 15;266(11):6747-55. Erratum in: J Biol Chem 1991 Nov 5;266(31):21326. Fields G [corrected to Fields GB].

46.

Characterization of 58-kilodalton human neutrophil collagenase: comparison with human fibroblast collagenase.

Mallya SK, Mookhtiar KA, Gao Y, Brew K, Dioszegi M, Birkedal-Hansen H, Van Wart HE.

Biochemistry. 1990 Nov 27;29(47):10628-34.

PMID:
2176876
47.

Purification to homogeneity of latent and active 58-kilodalton forms of human neutrophil collagenase.

Mookhtiar KA, Van Wart HE.

Biochemistry. 1990 Nov 27;29(47):10620-7.

PMID:
2176875
48.

Construction of a fast, inexpensive rapid-scanning diode-array detector and spectrometer.

Carter TP, Baek HK, Bonninghausen L, Morris RJ, van Wart HE.

Anal Biochem. 1990 Oct;190(1):134-40.

PMID:
2285140
49.

Proteolytic activities of human fibroblast collagenase: hydrolysis of a broad range of substrates at a single active site.

Fields GB, Netzel-Arnett SJ, Windsor LJ, Engler JA, Birkedal-Hansen H, Van Wart HE.

Biochemistry. 1990 Jul 17;29(28):6670-7.

PMID:
2168739

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