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Items: 1 to 50 of 250

1.

Chemoprophylaxis vaccination: Phase 1 study to explore stage-specific immunity to Plasmodium falciparum in U.S. adults.

Healy SA, Murphy SC, Hume JCC, Shelton L, Kuntz S, Van Voorhis WC, Moodie Z, Metch B, Wang R, Silver-Brace T, Fishbaugher M, Kennedy M, Finney OC, Chaturvedi R, Hobbs CV, Warner-Lubin M, Talley AK, Wong-Madden S, Stuart K, Wald A, Kappe SH, Kublin JG, Duffy PE.

Clin Infect Dis. 2019 Oct 17. pii: ciz1010. doi: 10.1093/cid/ciz1010. [Epub ahead of print]

PMID:
31621832
2.

P-Glycoprotein-Mediated Efflux Reduces the In Vivo Efficacy of a Therapeutic Targeting the Gastrointestinal Parasite Cryptosporidium.

Arnold SLM, Choi R, Hulverson MA, Whitman GR, Mccloskey MC, Dorr CS, Vidadala RSR, Khatod M, Morada M, Barrett LK, Maly DJ, Yarlett N, Van Voorhis WC.

J Infect Dis. 2019 Aug 30;220(7):1188-1198. doi: 10.1093/infdis/jiz269.

3.

Treatment with Bumped Kinase Inhibitor 1294 Is Safe and Leads to Significant Protection against Abortion and Vertical Transmission in Sheep Experimentally Infected with Toxoplasma gondii during Pregnancy.

Sánchez-Sánchez R, Ferre I, Re M, Ramos JJ, Regidor-Cerrillo J, Pizarro Díaz M, González-Huecas M, Tabanera E, Benavides J, Hemphill A, Hulverson MA, Barrett LK, Choi R, Whitman GR, Ojo KK, Van Voorhis WC, Ortega-Mora LM.

Antimicrob Agents Chemother. 2019 Jun 24;63(7). pii: e02527-18. doi: 10.1128/AAC.02527-18. Print 2019 Jul.

PMID:
31061151
4.

Bumped kinase inhibitor 1369 is effective against Cystoisospora suis in vivo and in vitro.

Shrestha A, Ojo KK, Koston F, Ruttkowski B, Vidadala RSR, Dorr CS, Navaluna ED, Whitman GR, Barrett KF, Barrett LK, Hulverson MA, Choi R, Michaels SA, Maly DJ, Hemphill A, Van Voorhis WC, Joachim A.

Int J Parasitol Drugs Drug Resist. 2019 Aug;10:9-19. doi: 10.1016/j.ijpddr.2019.03.004. Epub 2019 Apr 2.

5.

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.

Baragaña B, Forte B, Choi R, Nakazawa Hewitt S, Bueren-Calabuig JA, Pisco JP, Peet C, Dranow DM, Robinson DA, Jansen C, Norcross NR, Vinayak S, Anderson M, Brooks CF, Cooper CA, Damerow S, Delves M, Dowers K, Duffy J, Edwards TE, Hallyburton I, Horst BG, Hulverson MA, Ferguson L, Jiménez-Díaz MB, Jumani RS, Lorimer DD, Love MS, Maher S, Matthews H, McNamara CW, Miller P, O'Neill S, Ojo KK, Osuna-Cabello M, Pinto E, Post J, Riley J, Rottmann M, Sanz LM, Scullion P, Sharma A, Shepherd SM, Shishikura Y, Simeons FRC, Stebbins EE, Stojanovski L, Straschil U, Tamaki FK, Tamjar J, Torrie LS, Vantaux A, Witkowski B, Wittlin S, Yogavel M, Zuccotto F, Angulo-Barturen I, Sinden R, Baum J, Gamo FJ, Mäser P, Kyle DE, Winzeler EA, Myler PJ, Wyatt PG, Floyd D, Matthews D, Sharma A, Striepen B, Huston CD, Gray DW, Fairlamb AH, Pisliakov AV, Walpole C, Read KD, Van Voorhis WC, Gilbert IH.

Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):7015-7020. doi: 10.1073/pnas.1814685116. Epub 2019 Mar 20.

6.

Development of 5-Aminopyrazole-4-carboxamide-based Bumped-Kinase Inhibitors for Cryptosporidiosis Therapy.

Huang W, Hulverson MA, Choi R, Arnold SLM, Zhang Z, McCloskey MC, Whitman GR, Hackman RC, Rivas KL, Barrett LK, Ojo KK, Van Voorhis WC, Fan E.

J Med Chem. 2019 Mar 28;62(6):3135-3146. doi: 10.1021/acs.jmedchem.9b00069. Epub 2019 Mar 15.

PMID:
30830766
7.

Enzymatic and Structural Characterization of the Naegleria fowleri Glucokinase.

Milanes JE, Suryadi J, Abendroth J, Van Voorhis WC, Barrett KF, Dranow DM, Phan IQ, Patrick SL, Rozema SD, Khalifa MM, Golden JE, Morris JC.

Antimicrob Agents Chemother. 2019 Apr 25;63(5). pii: e02410-18. doi: 10.1128/AAC.02410-18. Print 2019 May.

PMID:
30783001
8.

Optimization of Methionyl tRNA-Synthetase Inhibitors for Treatment of Cryptosporidium Infection.

Buckner FS, Ranade RM, Gillespie JR, Shibata S, Hulverson MA, Zhang Z, Huang W, Choi R, Verlinde CLMJ, Hol WGJ, Ochida A, Akao Y, Choy RKM, Van Voorhis WC, Arnold SLM, Jumani RS, Huston CD, Fan E.

Antimicrob Agents Chemother. 2019 Mar 27;63(4). pii: e02061-18. doi: 10.1128/AAC.02061-18. Print 2019 Apr.

9.

Pharmacokinetics and In Vivo Efficacy of Pyrazolopyrimidine, Pyrrolopyrimidine, and 5-Aminopyrazole-4-Carboxamide Bumped Kinase Inhibitors against Toxoplasmosis.

Hulverson MA, Bruzual I, McConnell EV, Huang W, Vidadala RSR, Choi R, Arnold SLM, Whitman GR, McCloskey MC, Barrett LK, Rivas KL, Scheele S, DeRocher AE, Parsons M, Ojo KK, Maly DJ, Fan E, Van Voorhis WC, Doggett JS.

J Infect Dis. 2019 Apr 16;219(9):1464-1473. doi: 10.1093/infdis/jiy664.

PMID:
30423128
10.

Evaluating the safety, tolerability, pharmacokinetics and efficacy of clofazimine in cryptosporidiosis (CRYPTOFAZ): study protocol for a randomized controlled trial.

Nachipo P, Hermann D, Quinnan G, Gordon MA, Van Voorhis WC, Iroh Tam PY.

Trials. 2018 Aug 23;19(1):456. doi: 10.1186/s13063-018-2846-6.

11.

Structure and analysis of nucleoside diphosphate kinase from Borrelia burgdorferi prepared in a transition-state complex with ADP and vanadate moieties.

Dumais M, Davies DR, Lin T, Staker BL, Myler PJ, Van Voorhis WC.

Acta Crystallogr F Struct Biol Commun. 2018 Jun 1;74(Pt 6):373-384. doi: 10.1107/S2053230X18007392. Epub 2018 May 31.

12.

Kinome chemoproteomics characterization of pyrrolo[3,4-c]pyrazoles as potent and selective inhibitors of glycogen synthase kinase 3.

Golkowski M, Perera GK, Vidadala VN, Ojo KK, Van Voorhis WC, Maly DJ, Ong SE.

Mol Omics. 2018 Feb 12;14(1):26-36. doi: 10.1039/c7mo00006e.

13.

Therapeutic Efficacy of Bumped Kinase Inhibitor 1369 in a Pig Model of Acute Diarrhea Caused by Cryptosporidium hominis.

Lee S, Ginese M, Beamer G, Danz HR, Girouard DJ, Chapman-Bonofiglio SP, Lee M, Hulverson MA, Choi R, Whitman GR, Ojo KK, Arnold SLM, Van Voorhis WC, Tzipori S.

Antimicrob Agents Chemother. 2018 Jun 26;62(7). pii: e00147-18. doi: 10.1128/AAC.00147-18. Print 2018 Jul.

14.

Toxoplasma Calcium-Dependent Protein Kinase 1 Inhibitors: Probing Activity and Resistance Using Cellular Thermal Shift Assays.

Scheele S, Geiger JA, DeRocher AE, Choi R, Smith TR, Hulverson MA, Vidadala RSR, Barrett LK, Maly DJ, Merritt EA, Ojo KK, Van Voorhis WC, Parsons M.

Antimicrob Agents Chemother. 2018 May 25;62(6). pii: e00051-18. doi: 10.1128/AAC.00051-18. Print 2018 Jun.

15.

7 H-Pyrrolo[2,3- d]pyrimidin-4-amine-Based Inhibitors of Calcium-Dependent Protein Kinase 1 Have Distinct Inhibitory and Oral Pharmacokinetic Characteristics Compared with 1 H-Pyrazolo[3,4- d]pyrimidin-4-amine-Based Inhibitors.

Vidadala RSR, Golkowski M, Hulverson MA, Choi R, McCloskey MC, Whitman GR, Huang W, Arnold SLM, Barrett LK, Fan E, Merritt EA, Van Voorhis WC, Ojo KK, Maly DJ.

ACS Infect Dis. 2018 Apr 13;4(4):516-522. doi: 10.1021/acsinfecdis.7b00224. Epub 2018 Mar 16.

16.

Safety and efficacy of the bumped kinase inhibitor BKI-1553 in pregnant sheep experimentally infected with Neospora caninum tachyzoites.

Sánchez-Sánchez R, Ferre I, Re M, Vázquez P, Ferrer LM, Blanco-Murcia J, Regidor-Cerrillo J, Pizarro Díaz M, González-Huecas M, Tabanera E, García-Lunar P, Benavides J, Castaño P, Hemphill A, Hulverson MA, Whitman GR, Rivas KL, Choi R, Ojo KK, Barrett LK, Van Voorhis WC, Ortega-Mora LM.

Int J Parasitol Drugs Drug Resist. 2018 Apr;8(1):112-124. doi: 10.1016/j.ijpddr.2018.02.003. Epub 2018 Mar 2.

17.

Fragment-Based Screening of a Natural Product Library against 62 Potential Malaria Drug Targets Employing Native Mass Spectrometry.

Vu H, Pedro L, Mak T, McCormick B, Rowley J, Liu M, Di Capua A, Williams-Noonan B, Pham NB, Pouwer R, Nguyen B, Andrews KT, Skinner-Adams T, Kim J, Hol WGJ, Hui R, Crowther GJ, Van Voorhis WC, Quinn RJ.

ACS Infect Dis. 2018 Apr 13;4(4):431-444. doi: 10.1021/acsinfecdis.7b00197. Epub 2018 Mar 3.

18.

In vitro growth inhibition of Theileria equi by bumped kinase inhibitors.

Gimenez F, Hines SA, Evanoff R, Ojo KK, Van Voorhis WC, Maly DJ, Vidadala RSR, Mealey RH.

Vet Parasitol. 2018 Feb 15;251:90-94. doi: 10.1016/j.vetpar.2017.12.024. Epub 2018 Jan 1.

19.

Solution NMR structures of oxidized and reduced Ehrlichia chaffeensis thioredoxin: NMR-invisible structure owing to backbone dynamics.

Buchko GW, Hewitt SN, Van Voorhis WC, Myler PJ.

Acta Crystallogr F Struct Biol Commun. 2018 Jan 1;74(Pt 1):46-56. doi: 10.1107/S2053230X1701799X. Epub 2018 Jan 1.

20.

In vitro efficacy of bumped kinase inhibitors against Besnoitia besnoiti tachyzoites.

Jiménez-Meléndez A, Ojo KK, Wallace AM, Smith TR, Hemphill A, Balmer V, Regidor-Cerrillo J, Ortega-Mora LM, Hehl AB, Fan E, Maly DJ, Van Voorhis WC, Álvarez-García G.

Int J Parasitol. 2017 Oct;47(12):811-821. doi: 10.1016/j.ijpara.2017.08.005. Epub 2017 Sep 9.

PMID:
28899692
21.

Advances in bumped kinase inhibitors for human and animal therapy for cryptosporidiosis.

Hulverson MA, Choi R, Arnold SLM, Schaefer DA, Hemphill A, McCloskey MC, Betzer DP, Müller J, Vidadala RSR, Whitman GR, Rivas KL, Barrett LK, Hackman RC, Love MS, McNamara CW, Shaughnessy TK, Kondratiuk A, Kurnick M, Banfor PN, Lynch JJ, Freiberg GM, Kempf DJ, Maly DJ, Riggs MW, Ojo KK, Van Voorhis WC.

Int J Parasitol. 2017 Oct;47(12):753-763. doi: 10.1016/j.ijpara.2017.08.006. Epub 2017 Sep 9.

22.

Malaria.

Phillips MA, Burrows JN, Manyando C, van Huijsduijnen RH, Van Voorhis WC, Wells TNC.

Nat Rev Dis Primers. 2017 Aug 3;3:17050. doi: 10.1038/nrdp.2017.50. Review.

PMID:
28770814
23.

Recombinant human G6PD for quality control and quality assurance of novel point-of-care diagnostics for G6PD deficiency.

Kahn M, LaRue N, Zhu C, Pal S, Mo JS, Barrett LK, Hewitt SN, Dumais M, Hemmington S, Walker A, Joynson J, Leader BT, Van Voorhis WC, Domingo GJ.

PLoS One. 2017 May 26;12(5):e0177885. doi: 10.1371/journal.pone.0177885. eCollection 2017.

24.

Necessity of Bumped Kinase Inhibitor Gastrointestinal Exposure in Treating Cryptosporidium Infection.

Arnold SLM, Choi R, Hulverson MA, Schaefer DA, Vinayak S, Vidadala RSR, McCloskey MC, Whitman GR, Huang W, Barrett LK, Ojo KK, Fan E, Maly DJ, Riggs MW, Striepen B, Van Voorhis WC.

J Infect Dis. 2017 Jul 1;216(1):55-63. doi: 10.1093/infdis/jix247.

25.

5-Aminopyrazole-4-Carboxamide-Based Compounds Prevent the Growth of Cryptosporidium parvum.

Huang W, Choi R, Hulverson MA, Zhang Z, McCloskey MC, Schaefer DA, Whitman GR, Barrett LK, Vidadala RSR, Riggs MW, Maly DJ, Van Voorhis WC, Ojo KK, Fan E.

Antimicrob Agents Chemother. 2017 Jul 25;61(8). pii: e00020-17. doi: 10.1128/AAC.00020-17. Print 2017 Aug.

26.

Susceptibility Testing of Medically Important Parasites.

Genetu Bayih A, Debnath A, Mitre E, Huston CD, Laleu B, Leroy D, Blasco B, Campo B, Wells TNC, Willis PA, Sjö P, Van Voorhis WC, Pillai DR.

Clin Microbiol Rev. 2017 Jul;30(3):647-669. doi: 10.1128/CMR.00111-16. Review.

27.

Bumped-Kinase Inhibitors for Cryptosporidiosis Therapy.

Hulverson MA, Vinayak S, Choi R, Schaefer DA, Castellanos-Gonzalez A, Vidadala RSR, Brooks CF, Herbert GT, Betzer DP, Whitman GR, Sparks HN, Arnold SLM, Rivas KL, Barrett LK, White AC Jr, Maly DJ, Riggs MW, Striepen B, Van Voorhis WC, Ojo KK.

J Infect Dis. 2017 Apr 15;215(8):1275-1284. doi: 10.1093/infdis/jix120. Erratum in: J Infect Dis. 2018 Jan 4;217(2):340.

28.

Ligand co-crystallization of aminoacyl-tRNA synthetases from infectious disease organisms.

Moen SO, Edwards TE, Dranow DM, Clifton MC, Sankaran B, Van Voorhis WC, Sharma A, Manoil C, Staker BL, Myler PJ, Lorimer DD.

Sci Rep. 2017 Mar 16;7(1):223. doi: 10.1038/s41598-017-00367-6.

29.

Two Novel Calcium-Dependent Protein Kinase 1 Inhibitors Interfere with Vertical Transmission in Mice Infected with Neospora caninum Tachyzoites.

Müller J, Aguado-Martínez A, Balmer V, Maly DJ, Fan E, Ortega-Mora LM, Ojo KK, Van Voorhis WC, Hemphill A.

Antimicrob Agents Chemother. 2017 Mar 24;61(4). pii: e02324-16. doi: 10.1128/AAC.02324-16. Print 2017 Apr.

30.

Extended-spectrum antiprotozoal bumped kinase inhibitors: A review.

Van Voorhis WC, Doggett JS, Parsons M, Hulverson MA, Choi R, Arnold SLM, Riggs MW, Hemphill A, Howe DK, Mealey RH, Lau AOT, Merritt EA, Maly DJ, Fan E, Ojo KK.

Exp Parasitol. 2017 Sep;180:71-83. doi: 10.1016/j.exppara.2017.01.001. Epub 2017 Jan 5. Review.

31.

Novel Bumped Kinase Inhibitors Are Safe and Effective Therapeutics in the Calf Clinical Model for Cryptosporidiosis.

Schaefer DA, Betzer DP, Smith KD, Millman ZG, Michalski HC, Menchaca SE, Zambriski JA, Ojo KK, Hulverson MA, Arnold SL, Rivas KL, Vidadala RS, Huang W, Barrett LK, Maly DJ, Fan E, Van Voorhis WC, Riggs MW.

J Infect Dis. 2016 Dec 15;214(12):1856-1864. Epub 2016 Oct 17.

32.

Reduced Activity of Mutant Calcium-Dependent Protein Kinase 1 Is Compensated in Plasmodium falciparum through the Action of Protein Kinase G.

Bansal A, Ojo KK, Mu J, Maly DJ, Van Voorhis WC, Miller LH.

MBio. 2016 Dec 6;7(6). pii: e02011-16. doi: 10.1128/mBio.02011-16.

33.

Seymour J. Klebanoff: Discoverer of WBC killing mechanisms.

Rosen H, Liles WC, Van Voorhis WC.

Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):12891-12892. Epub 2016 Nov 4. No abstract available.

34.

Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase.

Hewitt SN, Dranow DM, Horst BG, Abendroth JA, Forte B, Hallyburton I, Jansen C, Baragaña B, Choi R, Rivas KL, Hulverson MA, Dumais M, Edwards TE, Lorimer DD, Fairlamb AH, Gray DW, Read KD, Lehane AM, Kirk K, Myler PJ, Wernimont A, Walpole C, Stacy R, Barrett LK, Gilbert IH, Van Voorhis WC.

ACS Infect Dis. 2017 Jan 13;3(1):34-44. doi: 10.1021/acsinfecdis.6b00078. Epub 2016 Nov 16.

35.

5-Aminopyrazole-4-carboxamide analogues are selective inhibitors of Plasmodium falciparum microgametocyte exflagellation and potential malaria transmission blocking agents.

Huang W, Hulverson MA, Zhang Z, Choi R, Hart KJ, Kennedy M, Vidadala RSR, Maly DJ, Van Voorhis WC, Lindner SE, Fan E, Ojo KK.

Bioorg Med Chem Lett. 2016 Nov 15;26(22):5487-5491. doi: 10.1016/j.bmcl.2016.10.014. Epub 2016 Oct 10.

36.

A Novel Calcium-Dependent Kinase Inhibitor, Bumped Kinase Inhibitor 1517, Cures Cryptosporidiosis in Immunosuppressed Mice.

Castellanos-Gonzalez A, Sparks H, Nava S, Huang W, Zhang Z, Rivas K, Hulverson MA, Barrett LK, Ojo KK, Fan E, Van Voorhis WC, White AC Jr.

J Infect Dis. 2016 Dec 15;214(12):1850-1855. Epub 2016 Oct 12.

37.

Selective inhibition of Sarcocystis neurona calcium-dependent protein kinase 1 for equine protozoal myeloencephalitis therapy.

Ojo KK, Dangoudoubiyam S, Verma SK, Scheele S, DeRocher AE, Yeargan M, Choi R, Smith TR, Rivas KL, Hulverson MA, Barrett LK, Fan E, Maly DJ, Parsons M, Dubey JP, Howe DK, Van Voorhis WC.

Int J Parasitol. 2016 Dec;46(13-14):871-880. doi: 10.1016/j.ijpara.2016.08.003. Epub 2016 Oct 8.

38.

Correction: Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis.

Ojo KK, Ranade RM, Zhang Z, Dranow DM, Myers JB, Choi R, Nakazawa Hewitt S, Edwards TE, Davies DR, Lorimer D, Boyle SM, Barrett LK, Buckner FS, Fan E, Van Voorhis WC.

PLoS One. 2016 Sep 22;11(9):e0163641. doi: 10.1371/journal.pone.0163641. eCollection 2016.

39.

Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis.

Ojo KK, Ranade RM, Zhang Z, Dranow DM, Myers JB, Choi R, Nakazawa Hewitt S, Edwards TE, Davies DR, Lorimer D, Boyle SM, Barrett LK, Buckner FS, Fan E, Van Voorhis WC.

PLoS One. 2016 Aug 8;11(8):e0160350. doi: 10.1371/journal.pone.0160350. eCollection 2016. Erratum in: PLoS One. 2016;11(9):e0163641.

40.

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.

Van Voorhis WC, Adams JH, Adelfio R, Ahyong V, Akabas MH, Alano P, Alday A, Alemán Resto Y, Alsibaee A, Alzualde A, Andrews KT, Avery SV, Avery VM, Ayong L, Baker M, Baker S, Ben Mamoun C, Bhatia S, Bickle Q, Bounaadja L, Bowling T, Bosch J, Boucher LE, Boyom FF, Brea J, Brennan M, Burton A, Caffrey CR, Camarda G, Carrasquilla M, Carter D, Belen Cassera M, Chih-Chien Cheng K, Chindaudomsate W, Chubb A, Colon BL, Colón-López DD, Corbett Y, Crowther GJ, Cowan N, D'Alessandro S, Le Dang N, Delves M, DeRisi JL, Du AY, Duffy S, Abd El-Salam El-Sayed S, Ferdig MT, Fernández Robledo JA, Fidock DA, Florent I, Fokou PV, Galstian A, Gamo FJ, Gokool S, Gold B, Golub T, Goldgof GM, Guha R, Guiguemde WA, Gural N, Guy RK, Hansen MA, Hanson KK, Hemphill A, Hooft van Huijsduijnen R, Horii T, Horrocks P, Hughes TB, Huston C, Igarashi I, Ingram-Sieber K, Itoe MA, Jadhav A, Naranuntarat Jensen A, Jensen LT, Jiang RH, Kaiser A, Keiser J, Ketas T, Kicka S, Kim S, Kirk K, Kumar VP, Kyle DE, Lafuente MJ, Landfear S, Lee N, Lee S, Lehane AM, Li F, Little D, Liu L, Llinás M, Loza MI, Lubar A, Lucantoni L, Lucet I, Maes L, Mancama D, Mansour NR, March S, McGowan S, Medina Vera I, Meister S, Mercer L, Mestres J, Mfopa AN, Misra RN, Moon S, Moore JP, Morais Rodrigues da Costa F, Müller J, Muriana A, Nakazawa Hewitt S, Nare B, Nathan C, Narraidoo N, Nawaratna S, Ojo KK, Ortiz D, Panic G, Papadatos G, Parapini S, Patra K, Pham N, Prats S, Plouffe DM, Poulsen SA, Pradhan A, Quevedo C, Quinn RJ, Rice CA, Abdo Rizk M, Ruecker A, St Onge R, Salgado Ferreira R, Samra J, Robinett NG, Schlecht U, Schmitt M, Silva Villela F, Silvestrini F, Sinden R, Smith DA, Soldati T, Spitzmüller A, Stamm SM, Sullivan DJ, Sullivan W, Suresh S, Suzuki BM, Suzuki Y, Swamidass SJ, Taramelli D, Tchokouaha LR, Theron A, Thomas D, Tonissen KF, Townson S, Tripathi AK, Trofimov V, Udenze KO, Ullah I, Vallieres C, Vigil E, Vinetz JM, Voong Vinh P, Vu H, Watanabe NA, Weatherby K, White PM, Wilks AF, Winzeler EA, Wojcik E, Wree M, Wu W, Yokoyama N, Zollo PH, Abla N, Blasco B, Burrows J, Laleu B, Leroy D, Spangenberg T, Wells T, Willis PA.

PLoS Pathog. 2016 Jul 28;12(7):e1005763. doi: 10.1371/journal.ppat.1005763. eCollection 2016 Jul.

41.

Invasion of hepatocytes by Plasmodium sporozoites requires cGMP-dependent protein kinase and calcium dependent protein kinase 4.

Govindasamy K, Jebiwott S, Jaijyan DK, Davidow A, Ojo KK, Van Voorhis WC, Brochet M, Billker O, Bhanot P.

Mol Microbiol. 2016 Oct;102(2):349-363. doi: 10.1111/mmi.13466. Epub 2016 Aug 9.

42.

Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis.

Vidadala RS, Rivas KL, Ojo KK, Hulverson MA, Zambriski JA, Bruzual I, Schultz TL, Huang W, Zhang Z, Scheele S, DeRocher AE, Choi R, Barrett LK, Siddaramaiah LK, Hol WG, Fan E, Merritt EA, Parsons M, Freiberg G, Marsh K, Kempf DJ, Carruthers VB, Isoherranen N, Doggett JS, Van Voorhis WC, Maly DJ.

J Med Chem. 2016 Jul 14;59(13):6531-46. doi: 10.1021/acs.jmedchem.6b00760. Epub 2016 Jul 1.

43.

Optimization of Electrospray Ionization by Statistical Design of Experiments and Response Surface Methodology: Protein-Ligand Equilibrium Dissociation Constant Determinations.

Pedro L, Van Voorhis WC, Quinn RJ.

J Am Soc Mass Spectrom. 2016 Sep;27(9):1520-30. doi: 10.1007/s13361-016-1417-x. Epub 2016 May 25.

44.

Mycobacterium Cytidylate Kinase Appears to Be an Undruggable Target.

Craig JK, Risler JK, Loesch KA, Dong W, Baker D, Barrett LK, Subramanian S, Samudrala R, Van Voorhis WC.

J Biomol Screen. 2016 Aug;21(7):695-700. doi: 10.1177/1087057116646702. Epub 2016 May 4.

PMID:
27146385
45.

Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds.

Crowther GJ, Hillesland HK, Keyloun KR, Reid MC, Lafuente-Monasterio MJ, Ghidelli-Disse S, Leonard SE, He P, Jones JC, Krahn MM, Mo JS, Dasari KS, Fox AM, Boesche M, El Bakkouri M, Rivas KL, Leroy D, Hui R, Drewes G, Maly DJ, Van Voorhis WC, Ojo KK.

PLoS One. 2016 Mar 2;11(3):e0149996. doi: 10.1371/journal.pone.0149996. eCollection 2016.

46.

Bumped kinase inhibitor prohibits egression in Babesia bovis.

Pedroni MJ, Vidadala RS, Choi R, Keyloun KR, Reid MC, Murphy RC, Barrett LK, Van Voorhis WC, Maly DJ, Ojo KK, Lau AO.

Vet Parasitol. 2016 Jan 15;215:22-8. doi: 10.1016/j.vetpar.2015.10.023. Epub 2015 Nov 5.

47.

Bioaffinity Mass Spectrometry Screening.

Yang B, Feng YJ, Vu H, McCormick B, Rowley J, Pedro L, Crowther GJ, Van Voorhis WC, Forster PI, Quinn RJ.

J Biomol Screen. 2016 Feb;21(2):194-200. doi: 10.1177/1087057115622605.

PMID:
26773071
48.

Profile of William C. Campbell, Satoshi Ōmura, and Youyou Tu, 2015 Nobel Laureates in Physiology or Medicine.

Van Voorhis WC, Hooft van Huijsduijnen R, Wells TN.

Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):15773-6. doi: 10.1073/pnas.1520952112. Epub 2015 Dec 22. No abstract available.

49.

SAR Studies of 5-Aminopyrazole-4-carboxamide Analogues as Potent and Selective Inhibitors of Toxoplasma gondii CDPK1.

Huang W, Ojo KK, Zhang Z, Rivas K, Vidadala RS, Scheele S, DeRocher AE, Choi R, Hulverson MA, Barrett LK, Bruzual I, Siddaramaiah LK, Kerchner KM, Kurnick MD, Freiberg GM, Kempf D, Hol WG, Merritt EA, Neckermann G, de Hostos EL, Isoherranen N, Maly DJ, Parsons M, Doggett JS, Van Voorhis WC, Fan E.

ACS Med Chem Lett. 2015 Oct 22;6(12):1184-1189. eCollection 2015 Dec 10.

50.

High-throughput screening against thioredoxin glutathione reductase identifies novel inhibitors with potential therapeutic value for schistosomiasis.

Li T, Ziniel PD, He PQ, Kommer VP, Crowther GJ, He M, Liu Q, Van Voorhis WC, Williams DL, Wang MW.

Infect Dis Poverty. 2015 Aug 31;4:40. doi: 10.1186/s40249-015-0071-z.

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