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Adipose tissue protects against sepsis-induced muscle weakness in mice: from lipolysis to ketones.

Goossens C, Weckx R, Derde S, Dufour T, Vander Perre S, Pauwels L, Thiessen SE, Van Veldhoven PP, Van den Berghe G, Langouche L.

Crit Care. 2019 Jul 1;23(1):236. doi: 10.1186/s13054-019-2506-6.


Deciphering the potential involvement of PXMP2 and PEX11B in hydrogen peroxide permeation across the peroxisomal membrane reveals a role for PEX11B in protein sorting.

Lismont C, Koster J, Provost S, Baes M, Van Veldhoven PP, Waterham HR, Fransen M.

Biochim Biophys Acta Biomembr. 2019 May 24. pii: S0005-2736(19)30110-5. doi: 10.1016/j.bbamem.2019.05.013. [Epub ahead of print]


Functional peroxisomes are required for β-cell integrity in mice.

Baboota RK, Shinde AB, Lemaire K, Fransen M, Vinckier S, Van Veldhoven PP, Schuit F, Baes M.

Mol Metab. 2019 Apr;22:71-83. doi: 10.1016/j.molmet.2019.02.001. Epub 2019 Feb 8.


Leukodystrophy caused by plasmalogen deficiency rescued by glyceryl 1-myristyl ether treatment.

Malheiro AR, Correia B, Ferreira da Silva T, Bessa-Neto D, Van Veldhoven PP, Brites P.

Brain Pathol. 2019 Jan 22. doi: 10.1111/bpa.12710. [Epub ahead of print]


Differential distribution of peroxisomal proteins points to specific roles of peroxisomes in the murine retina.

Das Y, Roose N, De Groef L, Fransen M, Moons L, Van Veldhoven PP, Baes M.

Mol Cell Biochem. 2019 Jun;456(1-2):53-62. doi: 10.1007/s11010-018-3489-3. Epub 2019 Jan 2.


PPARα-mediated peroxisome induction compensates PPARγ-deficiency in bronchiolar club cells.

Karnati S, Oruqaj G, Janga H, Tumpara S, Colasante C, Van Veldhoven PP, Braverman N, Pilatz A, Mariani TJ, Baumgart-Vogt E.

PLoS One. 2018 Sep 13;13(9):e0203466. doi: 10.1371/journal.pone.0203466. eCollection 2018.


Quantitative lipidomic analysis of mouse lung during postnatal development by electrospray ionization tandem mass spectrometry.

Karnati S, Garikapati V, Liebisch G, Van Veldhoven PP, Spengler B, Schmitz G, Baumgart-Vogt E.

PLoS One. 2018 Sep 7;13(9):e0203464. doi: 10.1371/journal.pone.0203464. eCollection 2018.


Peroxisomal 2-Hydroxyacyl-CoA Lyase Is Involved in Endogenous Biosynthesis of Heptadecanoic Acid.

Jenkins B, de Schryver E, Van Veldhoven PP, Koulman A.

Molecules. 2017 Oct 13;22(10). pii: E1718. doi: 10.3390/molecules22101718.


Lipid homeostasis and inflammatory activation are disturbed in classically activated macrophages with peroxisomal β-oxidation deficiency.

Geric I, Tyurina YY, Krysko O, Krysko DV, De Schryver E, Kagan VE, Van Veldhoven PP, Baes M, Verheijden S.

Immunology. 2018 Mar;153(3):342-356. doi: 10.1111/imm.12844. Epub 2017 Oct 26.


Allostery between two binding sites in the ion channel subunit TRIP8b confers binding specificity to HCN channels.

Lyman KA, Han Y, Heuermann RJ, Cheng X, Kurz JE, Lyman RE, Van Veldhoven PP, Chetkovich DM.

J Biol Chem. 2017 Oct 27;292(43):17718-17730. doi: 10.1074/jbc.M117.802256. Epub 2017 Sep 8.


Mitochondrial disruption in peroxisome deficient cells is hepatocyte selective but is not mediated by common hepatic peroxisomal metabolites.

Shinde AB, Baboota RK, Denis S, Loizides-Mangold U, Peeters A, Espeel M, Malheiro AR, Riezman H, Vinckier S, Vaz FM, Brites P, Ferdinandusse S, Van Veldhoven PP, Baes M.

Mitochondrion. 2018 Mar;39:51-59. doi: 10.1016/j.mito.2017.08.013. Epub 2017 Sep 1.


Cholesterol-Lowering Gene Therapy Counteracts the Development of Non-ischemic Cardiomyopathy in Mice.

Muthuramu I, Amin R, Postnov A, Mishra M, Aboumsallem JP, Dresselaers T, Himmelreich U, Van Veldhoven PP, Gheysens O, Jacobs F, De Geest B.

Mol Ther. 2017 Nov 1;25(11):2513-2525. doi: 10.1016/j.ymthe.2017.07.017. Epub 2017 Aug 1.


Coconut Oil Aggravates Pressure Overload-Induced Cardiomyopathy without Inducing Obesity, Systemic Insulin Resistance, or Cardiac Steatosis.

Muthuramu I, Amin R, Postnov A, Mishra M, Jacobs F, Gheysens O, Van Veldhoven PP, De Geest B.

Int J Mol Sci. 2017 Jul 18;18(7). pii: E1565. doi: 10.3390/ijms18071565.


Phytol-induced pathology in 2-hydroxyacyl-CoA lyase (HACL1) deficient mice. Evidence for a second non-HACL1-related lyase.

Mezzar S, De Schryver E, Asselberghs S, Meyhi E, Morvay PL, Baes M, Van Veldhoven PP.

Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Sep;1862(9):972-990. doi: 10.1016/j.bbalip.2017.06.004. Epub 2017 Jun 17.


Peroxisomes as Modulators of Cellular Protein Thiol Oxidation: A New Model System.

Lismont C, Nordgren M, Brees C, Knoops B, Van Veldhoven PP, Fransen M.

Antioxid Redox Signal. 2019 Jan 1;30(1):22-39. doi: 10.1089/ars.2017.6997. Epub 2017 Jul 14.


Differential activities of peroxisomes along the mouse intestinal epithelium.

Morvay PL, Baes M, Van Veldhoven PP.

Cell Biochem Funct. 2017 Apr;35(3):144-155. doi: 10.1002/cbf.3255. Epub 2017 Mar 29.


Odd Chain Fatty Acids; New Insights of the Relationship Between the Gut Microbiota, Dietary Intake, Biosynthesis and Glucose Intolerance.

Jenkins BJ, Seyssel K, Chiu S, Pan PH, Lin SY, Stanley E, Ament Z, West JA, Summerhill K, Griffin JL, Vetter W, Autio KJ, Hiltunen K, Hazebrouck S, Stepankova R, Chen CJ, Alligier M, Laville M, Moore M, Kraft G, Cherrington A, King S, Krauss RM, de Schryver E, Van Veldhoven PP, Ronis M, Koulman A.

Sci Rep. 2017 Mar 23;7:44845. doi: 10.1038/srep44845.


Sphingosine-1-phosphate lyase mutations cause primary adrenal insufficiency and steroid-resistant nephrotic syndrome.

Prasad R, Hadjidemetriou I, Maharaj A, Meimaridou E, Buonocore F, Saleem M, Hurcombe J, Bierzynska A, Barbagelata E, Bergadá I, Cassinelli H, Das U, Krone R, Hacihamdioglu B, Sari E, Yesilkaya E, Storr HL, Clemente M, Fernandez-Cancio M, Camats N, Ram N, Achermann JC, Van Veldhoven PP, Guasti L, Braslavsky D, Guran T, Metherell LA.

J Clin Invest. 2017 Mar 1;127(3):942-953. doi: 10.1172/JCI90171. Epub 2017 Feb 6.


Localization of 1-deoxysphingolipids to mitochondria induces mitochondrial dysfunction.

Alecu I, Tedeschi A, Behler N, Wunderling K, Lamberz C, Lauterbach MA, Gaebler A, Ernst D, Van Veldhoven PP, Al-Amoudi A, Latz E, Othman A, Kuerschner L, Hornemann T, Bradke F, Thiele C, Penno A.

J Lipid Res. 2017 Jan;58(1):42-59. doi: 10.1194/jlr.M068676. Epub 2016 Nov 23.


Histamine Receptor H1-Mediated Sensitization of TRPV1 Mediates Visceral Hypersensitivity and Symptoms in Patients With Irritable Bowel Syndrome.

Wouters MM, Balemans D, Van Wanrooy S, Dooley J, Cibert-Goton V, Alpizar YA, Valdez-Morales EE, Nasser Y, Van Veldhoven PP, Vanbrabant W, Van der Merwe S, Mols R, Ghesquière B, Cirillo C, Kortekaas I, Carmeliet P, Peetermans WE, Vermeire S, Rutgeerts P, Augustijns P, Hellings PW, Belmans A, Vanner S, Bulmer DC, Talavera K, Vanden Berghe P, Liston A, Boeckxstaens GE.

Gastroenterology. 2016 Apr;150(4):875-87.e9. doi: 10.1053/j.gastro.2015.12.034. Epub 2016 Jan 2.


Bifunctional Sphingosine for Cell-Based Analysis of Protein-Sphingolipid Interactions.

Haberkant P, Stein F, Höglinger D, Gerl MJ, Brügger B, Van Veldhoven PP, Krijgsveld J, Gavin AC, Schultz C.

ACS Chem Biol. 2016 Jan 15;11(1):222-30. doi: 10.1021/acschembio.5b00810. Epub 2015 Nov 25.


Hepatic dysfunction in peroxisomal disorders.

Baes M, Van Veldhoven PP.

Biochim Biophys Acta. 2016 May;1863(5):956-70. doi: 10.1016/j.bbamcr.2015.09.035. Epub 2015 Oct 9. Review.


Corrigendum: Fatty acid carbon is essential for dNTP synthesis in endothelial cells.

Schoors S, Bruning U, Missiaen R, Queiroz KC, Borgers G, Elia I, Zecchin A, Cantelmo AR, Christen S, Goveia J, Heggermont W, Goddë L, Vinckier S, Van Veldhoven PP, Eelen G, Schoonjans L, Gerhardt H, Dewerchin M, Baes M, De Bock K, Ghesquière B, Lunt SY, Fendt SM, Carmeliet P.

Nature. 2015 Oct 1;526(7571):144. doi: 10.1038/nature14624. Epub 2015 Aug 5. No abstract available.


Intellectual disability, muscle weakness and characteristic face in three siblings: A newly described recessive syndrome mapping to 3p24.3-p25.3.

Kariminejad A, Nafissi S, Nilipoor Y, Tavasoli A, Van Veldhoven PP, Bonnard C, Ng YT, Majoie CB, Reversade B, Hennekam RC.

Am J Med Genet A. 2015 Nov;167A(11):2508-15. doi: 10.1002/ajmg.a.37248. Epub 2015 Jul 20.


Export-deficient monoubiquitinated PEX5 triggers peroxisome removal in SV40 large T antigen-transformed mouse embryonic fibroblasts.

Nordgren M, Francisco T, Lismont C, Hennebel L, Brees C, Wang B, Van Veldhoven PP, Azevedo JE, Fransen M.

Autophagy. 2015;11(8):1326-40. doi: 10.1080/15548627.2015.1061846.


Redox interplay between mitochondria and peroxisomes.

Lismont C, Nordgren M, Van Veldhoven PP, Fransen M.

Front Cell Dev Biol. 2015 May 27;3:35. doi: 10.3389/fcell.2015.00035. eCollection 2015. Review.


Verapamil hepatic clearance in four preclinical rat models: towards activity-based scaling.

Nicolaï J, De Bruyn T, Van Veldhoven PP, Keemink J, Augustijns P, Annaert P.

Biopharm Drug Dispos. 2015 Oct;36(7):462-80. doi: 10.1002/bdd.1959. Epub 2015 Jun 11.


Fatty acid carbon is essential for dNTP synthesis in endothelial cells.

Schoors S, Bruning U, Missiaen R, Queiroz KC, Borgers G, Elia I, Zecchin A, Cantelmo AR, Christen S, Goveia J, Heggermont W, Goddé L, Vinckier S, Van Veldhoven PP, Eelen G, Schoonjans L, Gerhardt H, Dewerchin M, Baes M, De Bock K, Ghesquière B, Lunt SY, Fendt SM, Carmeliet P.

Nature. 2015 Apr 9;520(7546):192-197. doi: 10.1038/nature14362. Epub 2015 Apr 1. Erratum in: Nature. 2015 Oct 1;526(7571):144.


The oxysterol and cholestenoic acid profile of mouse cerebrospinal fluid.

Crick PJ, Beckers L, Baes M, Van Veldhoven PP, Wang Y, Griffiths WJ.

Steroids. 2015 Jul;99(Pt B):172-7. doi: 10.1016/j.steroids.2015.02.021. Epub 2015 Mar 7.


Glial β-oxidation regulates Drosophila energy metabolism.

Schulz JG, Laranjeira A, Van Huffel L, Gärtner A, Vilain S, Bastianen J, Van Veldhoven PP, Dotti CG.

Sci Rep. 2015 Jan 15;5:7805. doi: 10.1038/srep07805.


Hematopoietic stem/progenitor cells directly contribute to arteriosclerotic progression via integrin β2.

Wang X, Gao M, Schouteden S, Roebroek A, Eggermont K, van Veldhoven PP, Liu G, Peters T, Scharffetter-Kochanek K, Verfaillie CM, Feng Y.

Stem Cells. 2015 Apr;33(4):1230-40. doi: 10.1002/stem.1939.


Mitochondria in peroxisome-deficient hepatocytes exhibit impaired respiration, depleted DNA, and PGC-1α independent proliferation.

Peeters A, Shinde AB, Dirkx R, Smet J, De Bock K, Espeel M, Vanhorebeek I, Vanlander A, Van Coster R, Carmeliet P, Fransen M, Van Veldhoven PP, Baes M.

Biochim Biophys Acta. 2015 Feb;1853(2):285-98. doi: 10.1016/j.bbamcr.2014.11.017. Epub 2014 Nov 20.


Upregulation of ABC transporters contributes to chemoresistance of sphingosine 1-phosphate lyase-deficient fibroblasts.

Ihlefeld K, Vienken H, Claas RF, Blankenbach K, Rudowski A, ter Braak M, Koch A, Van Veldhoven PP, Pfeilschifter J, Meyer zu Heringdorf D.

J Lipid Res. 2015 Jan;56(1):60-9. doi: 10.1194/jlr.M052761. Epub 2014 Nov 10.


Regulation of high-density lipoprotein on hematopoietic stem/progenitor cells in atherosclerosis requires scavenger receptor type BI expression.

Gao M, Zhao D, Schouteden S, Sorci-Thomas MG, Van Veldhoven PP, Eggermont K, Liu G, Verfaillie CM, Feng Y.

Arterioscler Thromb Vasc Biol. 2014 Sep;34(9):1900-9. doi: 10.1161/ATVBAHA.114.304006. Epub 2014 Jun 26.


Roux-en-y gastric bypass attenuates hepatic mitochondrial dysfunction in mice with non-alcoholic steatohepatitis.

Verbeek J, Lannoo M, Pirinen E, Ryu D, Spincemaille P, Vander Elst I, Windmolders P, Thevissen K, Cammue BP, van Pelt J, Fransis S, Van Eyken P, Ceuterick-De Groote C, Van Veldhoven PP, Bedossa P, Nevens F, Auwerx J, Cassiman D.

Gut. 2015 Apr;64(4):673-83. doi: 10.1136/gutjnl-2014-306748. Epub 2014 Jun 10.


Pharmacological reversion of sphingomyelin-induced dendritic spine anomalies in a Niemann Pick disease type A mouse model.

Arroyo AI, Camoletto PG, Morando L, Sassoe-Pognetto M, Giustetto M, Van Veldhoven PP, Schuchman EH, Ledesma MD.

EMBO Mol Med. 2014 Mar;6(3):398-413. doi: 10.1002/emmm.201302649. Epub 2014 Jan 21.


RP-HPLC-fluorescence analysis of aliphatic aldehydes: application to aldehyde-generating enzymes HACL1 and SGPL1.

Mezzar S, de Schryver E, Van Veldhoven PP.

J Lipid Res. 2014 Mar;55(3):573-82. doi: 10.1194/jlr.D044230. Epub 2013 Dec 9.


Peroxisome deficient invertebrate and vertebrate animal models.

Van Veldhoven PP, Baes M.

Front Physiol. 2013 Nov 22;4:335. doi: 10.3389/fphys.2013.00335. Review.


PEX5, the shuttling import receptor for peroxisomal matrix proteins, is a redox-sensitive protein.

Apanasets O, Grou CP, Van Veldhoven PP, Brees C, Wang B, Nordgren M, Dodt G, Azevedo JE, Fransen M.

Traffic. 2014 Jan;15(1):94-103. doi: 10.1111/tra.12129. Epub 2013 Oct 31.


Abolition of peroxiredoxin-5 mitochondrial targeting during canid evolution.

Van der Eecken V, Clippe A, Dekoninck S, Goemaere J, Walbrecq G, Van Veldhoven PP, Knoops B.

PLoS One. 2013 Sep 2;8(9):e72844. doi: 10.1371/journal.pone.0072844. eCollection 2013.


Mitochondria are targets for peroxisome-derived oxidative stress in cultured mammalian cells.

Wang B, Van Veldhoven PP, Brees C, Rubio N, Nordgren M, Apanasets O, Kunze M, Baes M, Agostinis P, Fransen M.

Free Radic Biol Med. 2013 Dec;65:882-894. doi: 10.1016/j.freeradbiomed.2013.08.173. Epub 2013 Aug 27.


Central nervous system pathology in MFP2 deficiency: insights from general and conditional knockout mouse models.

Verheijden S, Beckers L, De Munter S, Van Veldhoven PP, Baes M.

Biochimie. 2014 Mar;98:119-26. doi: 10.1016/j.biochi.2013.08.009. Epub 2013 Aug 19. Review.


Role of PFKFB3-driven glycolysis in vessel sprouting.

De Bock K, Georgiadou M, Schoors S, Kuchnio A, Wong BW, Cantelmo AR, Quaegebeur A, Ghesquière B, Cauwenberghs S, Eelen G, Phng LK, Betz I, Tembuyser B, Brepoels K, Welti J, Geudens I, Segura I, Cruys B, Bifari F, Decimo I, Blanco R, Wyns S, Vangindertael J, Rocha S, Collins RT, Munck S, Daelemans D, Imamura H, Devlieger R, Rider M, Van Veldhoven PP, Schuit F, Bartrons R, Hofkens J, Fraisl P, Telang S, Deberardinis RJ, Schoonjans L, Vinckier S, Chesney J, Gerhardt H, Dewerchin M, Carmeliet P.

Cell. 2013 Aug 1;154(3):651-63. doi: 10.1016/j.cell.2013.06.037.


Acyl-CoA thioesterase 9 (ACOT9) in mouse may provide a novel link between fatty acid and amino acid metabolism in mitochondria.

Tillander V, Arvidsson Nordström E, Reilly J, Strozyk M, Van Veldhoven PP, Hunt MC, Alexson SE.

Cell Mol Life Sci. 2014 Mar;71(5):933-48. doi: 10.1007/s00018-013-1422-1. Epub 2013 Jul 18.


Aging, age-related diseases and peroxisomes.

Fransen M, Nordgren M, Wang B, Apanasets O, Van Veldhoven PP.

Subcell Biochem. 2013;69:45-65. doi: 10.1007/978-94-007-6889-5_3. Review.


Peroxisomal multifunctional protein-2 deficiency causes neuroinflammation and degeneration of Purkinje cells independent of very long chain fatty acid accumulation.

Verheijden S, Bottelbergs A, Krysko O, Krysko DV, Beckers L, De Munter S, Van Veldhoven PP, Wyns S, Kulik W, Nave KA, Ramer MS, Carmeliet P, Kassmann CM, Baes M.

Neurobiol Dis. 2013 Oct;58:258-69. doi: 10.1016/j.nbd.2013.06.006. Epub 2013 Jun 15.


Hematopoietic sphingosine 1-phosphate lyase deficiency decreases atherosclerotic lesion development in LDL-receptor deficient mice.

Bot M, Van Veldhoven PP, de Jager SC, Johnson J, Nijstad N, Van Santbrink PJ, Westra MM, Van Der Hoeven G, Gijbels MJ, Müller-Tidow C, Varga G, Tietge UJ, Kuiper J, Van Berkel TJ, Nofer JR, Bot I, Biessen EA.

PLoS One. 2013 May 20;8(5):e63360. doi: 10.1371/journal.pone.0063360. Print 2013.


Hematopoietic stem/progenitor cell proliferation and differentiation is differentially regulated by high-density and low-density lipoproteins in mice.

Feng Y, Schouteden S, Geenens R, Van Duppen V, Herijgers P, Holvoet P, Van Veldhoven PP, Verfaillie CM.

PLoS One. 2012;7(11):e47286. doi: 10.1371/journal.pone.0047286. Epub 2012 Nov 7.


Peroxisome deficient aP2-Pex5 knockout mice display impaired white adipocyte and muscle function concomitant with reduced adrenergic tone.

Martens K, Bottelbergs A, Peeters A, Jacobs F, Espeel M, Carmeliet P, Van Veldhoven PP, Baes M.

Mol Genet Metab. 2012 Dec;107(4):735-47. doi: 10.1016/j.ymgme.2012.10.015. Epub 2012 Oct 22.


A Nonradioactive Fluorimetric SPE-Based Ceramide Kinase Assay Using NBD-C(6)-Ceramide.

Van Overloop H, Van der Hoeven G, Van Veldhoven PP.

J Lipids. 2012;2012:404513. doi: 10.1155/2012/404513. Epub 2012 Jul 26.

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