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Preclinical evaluation of topically-administered PEGylated Fab' lung toxicity.

Freches D, Rocks N, Patil HP, Perin F, Van Snick J, Vanbever R, Cataldo D.

Int J Pharm X. 2019 Jun 21;1:100019. doi: 10.1016/j.ijpx.2019.100019. eCollection 2019 Dec.


Interlesional Heterogeneity of Metastatic Neuroendocrine Tumors Based on 18F-DOPA PET/CT.

de Hosson LD, van der Loo-van der Schaaf AM, Boellaard R, van Snick JH, de Vries EGE, Brouwers AH, Walenkamp AME.

Clin Nucl Med. 2019 Aug;44(8):612-619. doi: 10.1097/RLU.0000000000002640.


Interlesional Heterogeneity of Metastatic Neuroendocrine Tumors Based on 18F-DOPA PET/CT.

de Hosson LD, van der Loo-van der Schaaf AM, Boellaard R, van Snick JH, de Vries EGE, Brouwers AH, Walenkamp AME.

Clin Nucl Med. 2019 Jun 13. doi: 10.1097/RLU.0000000000002640. [Epub ahead of print]


Prophylactic treatment against GM-CSF, but not IL-17, abolishes relapses in a chronic murine model of multiple sclerosis.

Uyttenhove C, Gaignage M, Donckers D, Nasr Z, Cheou P, van Snick J, D'Auria L, van Pesch V.

Eur J Immunol. 2018 Nov;48(11):1883-1891. doi: 10.1002/eji.201847580. Epub 2018 Sep 25.


The TLR7 ligand R848 prevents mouse graft-versus-host disease and cooperates with anti-interleukin-27 antibody for maximal protection and regulatory T-cell upregulation.

Gaignage M, Marillier RG, Cochez PM, Dumoutier L, Uyttenhove C, Coutelier JP, Van Snick J.

Haematologica. 2019 Feb;104(2):392-402. doi: 10.3324/haematol.2018.195628. Epub 2018 Sep 13.


GM-CSF targeted immunomodulation affects host response to M. tuberculosis infection.

Benmerzoug S, Marinho FV, Rose S, Mackowiak C, Gosset D, Sedda D, Poisson E, Uyttenhove C, Van Snick J, Jacobs M, Garcia I, Ryffel B, Quesniaux VFJ.

Sci Rep. 2018 Jun 5;8(1):8652. doi: 10.1038/s41598-018-26984-3.


Effects of interleukin 17A (IL-17A) neutralization on murine hepatitis virus (MHV-A59) infection.

Aparicio JL, Ottobre M, Duhalde Vega M, Coutelier JP, Van Snick J, Retegui LA.

Eur Cytokine Netw. 2017 Sep 1;28(3):111-119. doi: 10.1684/ecn.2017.0399.


Neutralization of either IL-17A or IL-17F is sufficient to inhibit house dust mite induced allergic asthma in mice.

Chenuet P, Fauconnier L, Madouri F, Marchiol T, Rouxel N, Ledru A, Mauny P, Lory R, Uttenhove C, van Snick J, Iwakura Y, di Padova F, Quesniaux V, Togbe D, Ryffel B.

Clin Sci (Lond). 2017 Oct 12;131(20):2533-2548. doi: 10.1042/CS20171034. Print 2017 Oct 15.


Mouse nidovirus LDV infection alleviates graft versus host disease and induces type I IFN-dependent inhibition of dendritic cells and allo-responsive T cells.

Gaignage M, Marillier RG, Uyttenhove C, Dauguet N, Saxena A, Ryffel B, Michiels T, Coutelier JP, Van Snick J.

Immun Inflamm Dis. 2017 Jun;5(2):200-213. doi: 10.1002/iid3.157. Epub 2017 Apr 4.


Blockade of interleukin-27 signaling reduces GVHD in mice by augmenting Treg reconstitution and stabilizing Foxp3 expression.

Belle L, Agle K, Zhou V, Yin-Yuan C, Komorowski R, Eastwood D, Logan B, Sun J, Ghilardi N, Cua D, Williams CB, Gaignage M, Marillier R, van Snick J, Drobyski WR.

Blood. 2016 Oct 20;128(16):2068-2082. doi: 10.1182/blood-2016-02-698241. Epub 2016 Aug 3.


Structure and Expression of Different Serum Amyloid A (SAA) Variants and their Concentration-Dependent Functions During Host Insults.

De Buck M, Gouwy M, Wang JM, Van Snick J, Opdenakker G, Struyf S, Van Damme J.

Curr Med Chem. 2016;23(17):1725-55. Review.


The cytokine-serum amyloid A-chemokine network.

De Buck M, Gouwy M, Wang JM, Van Snick J, Proost P, Struyf S, Van Damme J.

Cytokine Growth Factor Rev. 2016 Aug;30:55-69. doi: 10.1016/j.cytogfr.2015.12.010. Epub 2015 Dec 28. Review.


Novel highly specific anti-periostin antibodies uncover the functional importance of the fascilin 1-1 domain and highlight preferential expression of periostin in aggressive breast cancer.

Field S, Uyttenhove C, Stroobant V, Cheou P, Donckers D, Coutelier JP, Simpson PT, Cummings MC, Saunus JM, Reid LE, Kutasovic JR, McNicol AM, Kim BR, Kim JH, Lakhani SR, Neville AM, Van Snick J, Jat PS.

Int J Cancer. 2016 Apr 15;138(8):1959-70. doi: 10.1002/ijc.29946. Epub 2015 Dec 21.


Increased IgA production by B-cells in COPD via lung epithelial interleukin-6 and TACI pathways.

Ladjemi MZ, Lecocq M, Weynand B, Bowen H, Gould HJ, Van Snick J, Detry B, Pilette C.

Eur Respir J. 2015 Apr;45(4):980-93. doi: 10.1183/09031936.00063914. Epub 2014 Dec 23.


Myeloid dendritic cells are primed in allergic asthma for thymic stromal lymphopoietin-mediated induction of Th2 and Th9 responses.

Froidure A, Shen C, Gras D, Van Snick J, Chanez P, Pilette C.

Allergy. 2014 Aug;69(8):1068-76. doi: 10.1111/all.12435. Epub 2014 Jun 3.


PEGylation of antibody fragments greatly increases their local residence time following delivery to the respiratory tract.

Koussoroplis SJ, Paulissen G, Tyteca D, Goldansaz H, Todoroff J, Barilly C, Uyttenhove C, Van Snick J, Cataldo D, Vanbever R.

J Control Release. 2014 Aug 10;187:91-100. doi: 10.1016/j.jconrel.2014.05.021. Epub 2014 May 17.


Modulation of the host microenvironment by a common non-oncolytic mouse virus leads to inhibition of plasmacytoma development through NK cell activation.

Thirion G, Saxena A, Hulhoven X, Markine-Goriaynoff D, Van Snick J, Coutelier JP.

J Gen Virol. 2014 Jul;95(Pt 7):1504-9. doi: 10.1099/vir.0.063990-0. Epub 2014 Apr 16.


IL-27p28 is essential for parent-to-F1 acute graft-versus-host disease.

Marillier RG, Uyttenhove C, Goriely S, Marbaix E, Van Snick J.

Eur J Immunol. 2014 Jul;44(7):2064-73. doi: 10.1002/eji.201444491. Epub 2014 Apr 27.


Local immunostimulation leading to rejection of accepted male skin grafts by female mice as a model for cancer immunotherapy.

Bourdeaux C, Lurquin C, Jacquemart I, Lethé B, Brasseur F, van Baren N, Baurain JF, Dyson J, Van Snick J, Uyttenhove C, Boon T.

Proc Natl Acad Sci U S A. 2014 Mar 4;111(9):3502-7. doi: 10.1073/pnas.1401115111. Epub 2014 Feb 18.


Systemic juvenile idiopathic arthritis-like syndrome in mice following stimulation of the immune system with Freund's complete adjuvant: regulation by interferon-γ.

Avau A, Mitera T, Put S, Put K, Brisse E, Filtjens J, Uyttenhove C, Van Snick J, Liston A, Leclercq G, Billiau AD, Wouters CH, Matthys P.

Arthritis Rheumatol. 2014 May;66(5):1340-51. doi: 10.1002/art.38359.


CXCL6 antibody neutralization prevents lung inflammation and fibrosis in mice in the bleomycin model.

Besnard AG, Struyf S, Guabiraba R, Fauconnier L, Rouxel N, Proost P, Uyttenhove C, Van Snick J, Couillin I, Ryffel B.

J Leukoc Biol. 2013 Dec;94(6):1317-23. doi: 10.1189/jlb.0313140. Epub 2013 Aug 23.


T cell-derived IL-17 mediates epithelial changes in the airway and drives pulmonary neutrophilia.

Fogli LK, Sundrud MS, Goel S, Bajwa S, Jensen K, Derudder E, Sun A, Coffre M, Uyttenhove C, Van Snick J, Schmidt-Supprian M, Rao A, Grunig G, Durbin J, Casola S, Rajewsky K, Koralov SB.

J Immunol. 2013 Sep 15;191(6):3100-11. doi: 10.4049/jimmunol.1301360. Epub 2013 Aug 21. Erratum in: J Immunol. 2013 Nov 15;191(10):5318. Casola, Stefano S [corrected to Casola, Stefano].


Production, purification and biological characterization of mono-PEGylated anti-IL-17A antibody fragments.

Koussoroplis SJ, Heywood S, Uyttenhove C, Barilly C, Van Snick J, Vanbever R.

Int J Pharm. 2013 Sep 15;454(1):107-15. doi: 10.1016/j.ijpharm.2013.06.077. Epub 2013 Jul 9.


[Auto-vaccines: an immunological alternative to gene silencing].

Uyttenhove C, van Snick J.

Med Sci (Paris). 2013 Apr;29(4):425-9. doi: 10.1051/medsci/2013294017. Epub 2013 Apr 26. Review. French.


Changes in antibody specificities and cytokine release after infection with lactate dehydrogenase-elevating virus.

Aparicio JL, Saxena A, Coutelier JP, Van Snick J, Retegui LA.

Int Immunopharmacol. 2013 Mar;15(3):544-9. doi: 10.1016/j.intimp.2013.01.016. Epub 2013 Feb 5.


Programmed cell death ligand 2 regulates TH9 differentiation and induction of chronic airway hyperreactivity.

Kerzerho J, Maazi H, Speak AO, Szely N, Lombardi V, Khoo B, Geryak S, Lam J, Soroosh P, Van Snick J, Akbari O.

J Allergy Clin Immunol. 2013 Apr;131(4):1048-57, 1057.e1-2. doi: 10.1016/j.jaci.2012.09.027. Epub 2012 Nov 20.


The many lives of IL-9: a question of survival?

Wilhelm C, Turner JE, Van Snick J, Stockinger B.

Nat Immunol. 2012 Jun 19;13(7):637-41. doi: 10.1038/ni.2303.


Distinct subunit pairing criteria within the heterodimeric IL-12 cytokine family.

Jones LL, Chaturvedi V, Uyttenhove C, Van Snick J, Vignali DA.

Mol Immunol. 2012 Jun;51(2):234-44. doi: 10.1016/j.molimm.2012.03.025. Epub 2012 Apr 7.


Upregulation of IL-17, but not of IL-9, in circulating cells of CIS and relapsing MS patients. Impact of corticosteroid therapy on the cytokine network.

Muls N, Jnaoui K, Dang HA, Wauters A, Van Snick J, Sindic CJ, van Pesch V.

J Neuroimmunol. 2012 Feb 29;243(1-2):73-80. doi: 10.1016/j.jneuroim.2011.12.010. Epub 2012 Jan 14.


Anti-cytokine auto-vaccinations as tools for the analysis of cytokine function in vivo.

Uyttenhove C, Van Snick J.

Cytokine Growth Factor Rev. 2012 Feb-Apr;23(1-2):1-6. doi: 10.1016/j.cytogfr.2011.12.001. Epub 2012 Jan 10. Review.


An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation.

Wilhelm C, Hirota K, Stieglitz B, Van Snick J, Tolaini M, Lahl K, Sparwasser T, Helmby H, Stockinger B.

Nat Immunol. 2011 Oct 9;12(11):1071-7. doi: 10.1038/ni.2133.


Dual TCR expression biases lung inflammation in DO11.10 transgenic mice and promotes neutrophilia via microbiota-induced Th17 differentiation.

Lemaire MM, Dumoutier L, Warnier G, Uyttenhove C, Van Snick J, de Heusch M, Stevens M, Renauld JC.

J Immunol. 2011 Oct 1;187(7):3530-7. doi: 10.4049/jimmunol.1101720. Epub 2011 Aug 22.


Signals through 4-1BB inhibit T regulatory cells by blocking IL-9 production enhancing antitumor responses.

Smith SE, Hoelzinger DB, Dominguez AL, Van Snick J, Lustgarten J.

Cancer Immunol Immunother. 2011 Dec;60(12):1775-87. doi: 10.1007/s00262-011-1075-6. Epub 2011 Jul 26.


In vivo maturation of T(H) cells in relation to atopy.

Bullens DM, Kasran A, Dilissen E, De Swert K, Coorevits L, Van Snick J, Ceuppens JL.

J Allergy Clin Immunol. 2011 Jul;128(1):234-237.e7. doi: 10.1016/j.jaci.2011.02.033. Epub 2011 Mar 24. No abstract available.


Characterization of the T-lymphocyte response elicited by mouse immunization with rat platelets.

Detalle L, Saxena A, Haddou NO, Uyttenhove C, Van Snick J, Coutelier JP.

Exp Hematol. 2011 Jun;39(6):676-85. doi: 10.1016/j.exphem.2011.03.002. Epub 2011 Mar 11.


Amine-reactive OVA multimers for auto-vaccination against cytokines and other mediators: perspectives illustrated for GCP-2 in L. major infection.

Uyttenhove C, Marillier RG, Tacchini-Cottier F, Charmoy M, Caspi RR, Damsker JM, Goriely S, Su D, Van Damme J, Struyf S, Opdenakker G, Van Snick J.

J Leukoc Biol. 2011 Jun;89(6):1001-7. doi: 10.1189/jlb.1210699. Epub 2011 Mar 8.


Interferon-γ orchestrates the number and function of Th17 cells in experimental autoimmune encephalomyelitis.

Berghmans N, Nuyts A, Uyttenhove C, Van Snick J, Opdenakker G, Heremans H.

J Interferon Cytokine Res. 2011 Jul;31(7):575-87. doi: 10.1089/jir.2010.0137. Epub 2011 Feb 25.


Isotypic neutralizing antibodies against mouse GCP-2/CXCL6 inhibit melanoma growth and metastasis.

Verbeke H, Struyf S, Berghmans N, Van Coillie E, Opdenakker G, Uyttenhove C, Van Snick J, Van Damme J.

Cancer Lett. 2011 Mar 1;302(1):54-62. doi: 10.1016/j.canlet.2010.12.013. Epub 2011 Jan 13.


Increased pulmonary tumor necrosis factor alpha, interleukin-6 (IL-6), and IL-17A responses compensate for decreased gamma interferon production in anti-IL-12 autovaccine-treated, Mycobacterium bovis BCG-vaccinated mice.

Freches D, Romano M, Korf H, Renauld JC, Van Snick J, Uyttenhove C, Huygen K.

Clin Vaccine Immunol. 2011 Jan;18(1):95-104. doi: 10.1128/CVI.00352-10. Epub 2010 Nov 17.


B cell depletion reduces the development of atherosclerosis in mice.

Ait-Oufella H, Herbin O, Bouaziz JD, Binder CJ, Uyttenhove C, Laurans L, Taleb S, Van Vré E, Esposito B, Vilar J, Sirvent J, Van Snick J, Tedgui A, Tedder TF, Mallat Z.

J Exp Med. 2010 Aug 2;207(8):1579-87. doi: 10.1084/jem.20100155. Epub 2010 Jul 5.


TGF-β interactions with IL-1 family members trigger IL-4-independent IL-9 production by mouse CD4(+) T cells.

Uyttenhove C, Brombacher F, Van Snick J.

Eur J Immunol. 2010 Aug;40(8):2230-5. doi: 10.1002/eji.200940281.


IL-17A-producing gammadelta T and Th17 lymphocytes mediate lung inflammation but not fibrosis in experimental silicosis.

Lo Re S, Dumoutier L, Couillin I, Van Vyve C, Yakoub Y, Uwambayinema F, Marien B, van den Brûle S, Van Snick J, Uyttenhove C, Ryffel B, Renauld JC, Lison D, Huaux F.

J Immunol. 2010 Jun 1;184(11):6367-77. doi: 10.4049/jimmunol.0900459. Epub 2010 Apr 26.


IL-9 regulates pathology during primary and memory responses to respiratory syncytial virus infection.

Dodd JS, Lum E, Goulding J, Muir R, Van Snick J, Openshaw PJ.

J Immunol. 2009 Dec 1;183(11):7006-13. doi: 10.4049/jimmunol.0900085. Epub 2009 Nov 13.


Interleukin 17 is not required for autoimmune-mediated pathologic damage during chronic graft-versus-host disease.

Chen X, Das R, Komorowski R, van Snick J, Uyttenhove C, Drobyski WR.

Biol Blood Marrow Transplant. 2010 Jan;16(1):123-8. doi: 10.1016/j.bbmt.2009.09.008. Epub 2009 Sep 17.


Loss of SOCS3 expression in T cells reveals a regulatory role for interleukin-17 in atherosclerosis.

Taleb S, Romain M, Ramkhelawon B, Uyttenhove C, Pasterkamp G, Herbin O, Esposito B, Perez N, Yasukawa H, Van Snick J, Yoshimura A, Tedgui A, Mallat Z.

J Exp Med. 2009 Sep 28;206(10):2067-77. doi: 10.1084/jem.20090545. Epub 2009 Sep 8.


Effector mechanisms of interleukin-17 in collagen-induced arthritis in the absence of interferon-gamma and counteraction by interferon-gamma.

Kelchtermans H, Schurgers E, Geboes L, Mitera T, Van Damme J, Van Snick J, Uyttenhove C, Matthys P.

Arthritis Res Ther. 2009;11(4):R122. doi: 10.1186/ar2787. Epub 2009 Aug 17.


IL-9 induces differentiation of TH17 cells and enhances function of FoxP3+ natural regulatory T cells.

Elyaman W, Bradshaw EM, Uyttenhove C, Dardalhon V, Awasthi A, Imitola J, Bettelli E, Oukka M, van Snick J, Renauld JC, Kuchroo VK, Khoury SJ.

Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12885-90. doi: 10.1073/pnas.0812530106. Epub 2009 May 11.


IL-9 promotes IL-13-dependent paneth cell hyperplasia and up-regulation of innate immunity mediators in intestinal mucosa.

Steenwinckel V, Louahed J, Lemaire MM, Sommereyns C, Warnier G, McKenzie A, Brombacher F, Van Snick J, Renauld JC.

J Immunol. 2009 Apr 15;182(8):4737-43. doi: 10.4049/jimmunol.0801941.


ICOS deficiency results in exacerbated IL-17 mediated experimental autoimmune encephalomyelitis.

Galicia G, Kasran A, Uyttenhove C, De Swert K, Van Snick J, Ceuppens JL.

J Clin Immunol. 2009 Jul;29(4):426-33. doi: 10.1007/s10875-009-9287-7. Epub 2009 Mar 17.


Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset.

Veldhoen M, Uyttenhove C, van Snick J, Helmby H, Westendorf A, Buer J, Martin B, Wilhelm C, Stockinger B.

Nat Immunol. 2008 Dec;9(12):1341-6. doi: 10.1038/ni.1659. Epub 2008 Oct 19.


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