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Gemcitabine-induced epithelial-mesenchymal transition-like changes sustain chemoresistance of pancreatic cancer cells of mesenchymal-like phenotype.

El Amrani M, Corfiotti F, Corvaisier M, Vasseur R, Fulbert M, Skrzypczyk C, Deshorgues AC, Gnemmi V, Tulasne D, Lahdaoui F, Vincent A, Pruvot FR, Van Seuningen I, Huet G, Truant S.

Mol Carcinog. 2019 Nov;58(11):1985-1997. doi: 10.1002/mc.23090. Epub 2019 Aug 2.


Direct and Indirect Targeting of HOXA9 Transcription Factor in Acute Myeloid Leukemia.

Lambert M, Alioui M, Jambon S, Depauw S, Van Seuningen I, David-Cordonnier MH.

Cancers (Basel). 2019 Jun 17;11(6). pii: E837. doi: 10.3390/cancers11060837. Review.


Fine-tuning autophagy in pancreatic adenocarcinoma: full blockage is required.

Jonckheere N, Van Seuningen I.

Ann Transl Med. 2019 Mar;7(Suppl 1):S43. doi: 10.21037/atm.2019.03.01. No abstract available.


Epigenetic Regulation by lncRNAs: An Overview Focused on UCA1 in Colorectal Cancer.

Neve B, Jonckheere N, Vincent A, Van Seuningen I.

Cancers (Basel). 2018 Nov 14;10(11). pii: E440. doi: 10.3390/cancers10110440. Review.


TGF-βRII Knock-down in Pancreatic Cancer Cells Promotes Tumor Growth and Gemcitabine Resistance. Importance of STAT3 Phosphorylation on S727.

Drubay V, Skrypek N, Cordiez L, Vasseur R, Schulz C, Boukrout N, Duchêne B, Coppin L, Van Seuningen I, Jonckheere N.

Cancers (Basel). 2018 Jul 31;10(8). pii: E254. doi: 10.3390/cancers10080254.


Depletion of MUC5B mucin in gastrointestinal cancer cells alters their tumorigenic properties: implication of the Wnt/β-catenin pathway.

Lahdaoui F, Messager M, Vincent A, Hec F, Gandon A, Warlaumont M, Renaud F, Leteurtre E, Piessen G, Jonckheere N, Mariette C, Van Seuningen I.

Biochem J. 2017 Nov 1;474(22):3733-3746. doi: 10.1042/BCJ20170348.


Targeting miR-21 decreases expression of multi-drug resistant genes and promotes chemosensitivity of renal carcinoma.

Gaudelot K, Gibier JB, Pottier N, Hémon B, Van Seuningen I, Glowacki F, Leroy X, Cauffiez C, Gnemmi V, Aubert S, Perrais M.

Tumour Biol. 2017 Jul;39(7):1010428317707372. doi: 10.1177/1010428317707372.


Lepidic predominant adenocarcinoma and invasive mucinous adenocarcinoma of the lung exhibit specific mucin expression in relation with oncogenic drivers.

Duruisseaux M, Antoine M, Rabbe N, Rodenas A, Mc Leer-Florin A, Lacave R, Poulot V, Duchêne B, Van Seuningen I, Cadranel J, Wislez M.

Lung Cancer. 2017 Jul;109:92-100. doi: 10.1016/j.lungcan.2017.05.007. Epub 2017 May 10.


Dual role of MUC1 mucin in kidney ischemia-reperfusion injury: Nephroprotector in early phase, but pro-fibrotic in late phase.

Gibier JB, Hémon B, Fanchon M, Gaudelot K, Pottier N, Ringot B, Van Seuningen I, Glowacki F, Cauffiez C, Blum D, Copin MC, Perrais M, Gnemmi V.

Biochim Biophys Acta Mol Basis Dis. 2017 Jun;1863(6):1336-1349. doi: 10.1016/j.bbadis.2017.03.023. Epub 2017 Mar 31.


Galectin-3 is a non-classic RNA binding protein that stabilizes the mucin MUC4 mRNA in the cytoplasm of cancer cells.

Coppin L, Vincent A, Frénois F, Duchêne B, Lahdaoui F, Stechly L, Renaud F, Villenet C, Van Seuningen I, Leteurtre E, Dion J, Grandjean C, Poirier F, Figeac M, Delacour D, Porchet N, Pigny P.

Sci Rep. 2017 Mar 6;7:43927. doi: 10.1038/srep43927.


The cornerstone K-RAS mutation in pancreatic adenocarcinoma: From cell signaling network, target genes, biological processes to therapeutic targeting.

Jonckheere N, Vasseur R, Van Seuningen I.

Crit Rev Oncol Hematol. 2017 Mar;111:7-19. doi: 10.1016/j.critrevonc.2017.01.002. Epub 2017 Jan 10. Review.


Flagellin-Mediated Protection against Intestinal Yersinia pseudotuberculosis Infection Does Not Require Interleukin-22.

Porte R, Van Maele L, Muñoz-Wolf N, Foligné B, Dumoutier L, Tabareau J, Cayet D, Gosset P, Jonckheere N, Van Seuningen I, Chabalgoity JA, Simonet M, Lamkanfi M, Renauld JC, Sirard JC, Carnoy C.

Infect Immun. 2017 Jan 26;85(2). pii: e00806-16. doi: 10.1128/IAI.00806-16. Print 2017 Feb.


Regulation of cellular quiescence by YAP/TAZ and Cyclin E1 in colon cancer cells: Implication in chemoresistance and cancer relapse.

Corvaisier M, Bauzone M, Corfiotti F, Renaud F, El Amrani M, Monté D, Truant S, Leteurtre E, Formstecher P, Van Seuningen I, Gespach C, Huet G.

Oncotarget. 2016 Aug 30;7(35):56699-56712. doi: 10.18632/oncotarget.11057.


Hemidesmosome integrity protects the colon against colitis and colorectal cancer.

De Arcangelis A, Hamade H, Alpy F, Normand S, Bruyère E, Lefebvre O, Méchine-Neuville A, Siebert S, Pfister V, Lepage P, Laquerriere P, Dembele D, Delanoye-Crespin A, Rodius S, Robine S, Kedinger M, Van Seuningen I, Simon-Assmann P, Chamaillard M, Labouesse M, Georges-Labouesse E.

Gut. 2017 Oct;66(10):1748-1760. doi: 10.1136/gutjnl-2015-310847. Epub 2016 Jul 1.


Targeting MUC4 in pancreatic cancer: miRNAs.

Jonckheere N, Lahdaoui F, Van Seuningen I.

Oncoscience. 2015 Sep 12;2(10):799-800. eCollection 2015. No abstract available.


The mucin MUC4 is a transcriptional and post-transcriptional target of K-ras oncogene in pancreatic cancer. Implication of MAPK/AP-1, NF-κB and RalB signaling pathways.

Vasseur R, Skrypek N, Duchêne B, Renaud F, Martínez-Maqueda D, Vincent A, Porchet N, Van Seuningen I, Jonckheere N.

Biochim Biophys Acta. 2015 Dec;1849(12):1375-84. doi: 10.1016/j.bbagrm.2015.10.014. Epub 2015 Oct 22.


The serrated neoplasia pathway of colorectal tumors: Identification of MUC5AC hypomethylation as an early marker of polyps with malignant potential.

Renaud F, Mariette C, Vincent A, Wacrenier A, Maunoury V, Leclerc J, Coppin L, Crépin M, Van Seuningen I, Leteurtre E, Buisine MP.

Int J Cancer. 2016 Mar 15;138(6):1472-81. doi: 10.1002/ijc.29891. Epub 2015 Oct 30.


Micro-RNAs miR-29a and miR-330-5p function as tumor suppressors by targeting the MUC1 mucin in pancreatic cancer cells.

Tréhoux S, Lahdaoui F, Delpu Y, Renaud F, Leteurtre E, Torrisani J, Jonckheere N, Van Seuningen I.

Biochim Biophys Acta. 2015 Oct;1853(10 Pt A):2392-403. doi: 10.1016/j.bbamcr.2015.05.033. Epub 2015 May 31.


Cryosectioning the intestinal crypt-villus axis: an ex vivo method to study the dynamics of epigenetic modifications from stem cells to differentiated cells.

Vincent A, Kazmierczak C, Duchêne B, Jonckheere N, Leteurtre E, Van Seuningen I.

Stem Cell Res. 2015 Jan;14(1):105-13. doi: 10.1016/j.scr.2014.12.002. Epub 2014 Dec 27.


Overexpression of chemokine receptor CXCR2 and ligand CXCL7 in liver metastases from colon cancer is correlated to shorter disease-free and overall survival.

Desurmont T, Skrypek N, Duhamel A, Jonckheere N, Millet G, Leteurtre E, Gosset P, Duchene B, Ramdane N, Hebbar M, Van Seuningen I, Pruvot FR, Huet G, Truant S.

Cancer Sci. 2015 Mar;106(3):262-9. doi: 10.1111/cas.12603. Epub 2015 Mar 5.


The MUC1 oncomucin regulates pancreatic cancer cell biological properties and chemoresistance. Implication of p42-44 MAPK, Akt, Bcl-2 and MMP13 pathways.

Tréhoux S, Duchêne B, Jonckheere N, Van Seuningen I.

Biochem Biophys Res Commun. 2015 Jan 16;456(3):757-62. doi: 10.1016/j.bbrc.2014.12.025. Epub 2014 Dec 13.


MUC5AC hypomethylation is a predictor of microsatellite instability independently of clinical factors associated with colorectal cancer.

Renaud F, Vincent A, Mariette C, Crépin M, Stechly L, Truant S, Copin MC, Porchet N, Leteurtre E, Van Seuningen I, Buisine MP.

Int J Cancer. 2015 Jun 15;136(12):2811-21. doi: 10.1002/ijc.29342. Epub 2014 Dec 4.


Combined NADPH oxidase 1 and interleukin 10 deficiency induces chronic endoplasmic reticulum stress and causes ulcerative colitis-like disease in mice.

Tréton X, Pedruzzi E, Guichard C, Ladeiro Y, Sedghi S, Vallée M, Fernandez N, Bruyère E, Woerther PL, Ducroc R, Montcuquet N, Freund JN, Van Seuningen I, Barreau F, Marah A, Hugot JP, Cazals-Hatem D, Bouhnik Y, Daniel F, Ogier-Denis E.

PLoS One. 2014 Jul 9;9(7):e101669. doi: 10.1371/journal.pone.0101669. eCollection 2014.


MUC1 expression in papillary thyroid carcinoma is associated with BRAF mutation and lymph node metastasis; the latter is the most important risk factor of relapse.

Renaud F, Gnemmi V, Devos P, Aubert S, Crépin M, Coppin L, Ramdane N, Bouchindhomme B, d'Herbomez M, Van Seuningen I, Do Cao C, Pattou F, Carnaille B, Pigny P, Wémeau JL, Leteurtre E.

Thyroid. 2014 Sep;24(9):1375-84. doi: 10.1089/thy.2013.0594. Epub 2014 Aug 1.


The MUC1 mucin regulates the tumorigenic properties of human esophageal adenocarcinomatous cells.

Gronnier C, Bruyère E, Lahdaoui F, Jonckheere N, Perrais M, Leteurtre E, Piessen G, Mariette C, Van Seuningen I.

Biochim Biophys Acta. 2014 Nov;1843(11):2432-7. doi: 10.1016/j.bbamcr.2014.06.021. Epub 2014 Jul 6.


Of autophagy and in vivo pancreatic carcinogenesis: the p53 status matters!

Jonckheere N, Vincent A, Van Seuningen I.

Clin Res Hepatol Gastroenterol. 2014 Sep;38(4):423-5. doi: 10.1016/j.clinre.2014.04.009. Epub 2014 Jun 14.


Epigenetic silencing of EYA2 in pancreatic adenocarcinomas promotes tumor growth.

Vincent A, Hong SM, Hu C, Omura N, Young A, Kim H, Yu J, Knight S, Ayars M, Griffith M, Van Seuningen I, Maitra A, Goggins M.

Oncotarget. 2014 May 15;5(9):2575-87.


Mucins and tumor resistance to chemotherapeutic drugs.

Jonckheere N, Skrypek N, Van Seuningen I.

Biochim Biophys Acta. 2014 Aug;1846(1):142-51. doi: 10.1016/j.bbcan.2014.04.008. Epub 2014 Apr 29. Review.


miR-219-1-3p is a negative regulator of the mucin MUC4 expression and is a tumor suppressor in pancreatic cancer.

Lahdaoui F, Delpu Y, Vincent A, Renaud F, Messager M, Duchêne B, Leteurtre E, Mariette C, Torrisani J, Jonckheere N, Van Seuningen I.

Oncogene. 2015 Feb 5;34(6):780-8. doi: 10.1038/onc.2014.11. Epub 2014 Mar 10.


MUC1-C nuclear localization drives invasiveness of renal cancer cells through a sheddase/gamma secretase dependent pathway.

Bouillez A, Gnemmi V, Gaudelot K, Hémon B, Ringot B, Pottier N, Glowacki F, Butruille C, Cauffiez C, Hamdane M, Sergeant N, Van Seuningen I, Leroy X, Aubert S, Perrais M.

Oncotarget. 2014 Feb 15;5(3):754-63.


MUC1 drives epithelial-mesenchymal transition in renal carcinoma through Wnt/β-catenin pathway and interaction with SNAIL promoter.

Gnemmi V, Bouillez A, Gaudelot K, Hémon B, Ringot B, Pottier N, Glowacki F, Villers A, Vindrieux D, Cauffiez C, Van Seuningen I, Bernard D, Leroy X, Aubert S, Perrais M.

Cancer Lett. 2014 May 1;346(2):225-36. doi: 10.1016/j.canlet.2013.12.029. Epub 2013 Dec 30.


Suitability of surgically induced chronic reflux in rats for studying esophageal carcinogenesis.

Gronnier C, Piessen G, Leteurtre E, Van Seuningen I, Mariette C.

Ann Surg. 2015 May;261(5):e140-1. doi: 10.1097/SLA.0000000000000474. No abstract available.


Colon cancer cells escape 5FU chemotherapy-induced cell death by entering stemness and quiescence associated with the c-Yes/YAP axis.

Touil Y, Igoudjil W, Corvaisier M, Dessein AF, Vandomme J, Monté D, Stechly L, Skrypek N, Langlois C, Grard G, Millet G, Leteurtre E, Dumont P, Truant S, Pruvot FR, Hebbar M, Fan F, Ellis LM, Formstecher P, Van Seuningen I, Gespach C, Polakowska R, Huet G.

Clin Cancer Res. 2014 Feb 15;20(4):837-46. doi: 10.1158/1078-0432.CCR-13-1854. Epub 2013 Dec 9.


Operatively induced chronic reflux in rats: a suitable model for studying esophageal carcinogenesis?

Gronnier C, Bruyère E, Piessen G, Briez N, Bot J, Buob D, Leteurtre E, Van Seuningen I, Mariette C.

Surgery. 2013 Nov;154(5):955-67. doi: 10.1016/j.surg.2013.05.029. Epub 2013 Sep 29.


Helicobacter pylori urease and flagellin alter mucin gene expression in human gastric cancer cells.

Perrais M, Rousseaux C, Ducourouble MP, Courcol R, Vincent P, Jonckheere N, Van Seuningen I.

Gastric Cancer. 2014 Apr;17(2):235-46. doi: 10.1007/s10120-013-0267-5. Epub 2013 May 24.


Estradiol represses the G(D3) synthase gene ST8SIA1 expression in human breast cancer cells by preventing NFκB binding to ST8SIA1 promoter.

Bobowski M, Vincent A, Steenackers A, Colomb F, Van Seuningen I, Julien S, Delannoy P.

PLoS One. 2013 Apr 23;8(4):e62559. doi: 10.1371/journal.pone.0062559. Print 2013.


Membrane-bound mucin modular domains: from structure to function.

Jonckheere N, Skrypek N, Frénois F, Van Seuningen I.

Biochimie. 2013 Jun;95(6):1077-86. doi: 10.1016/j.biochi.2012.11.005. Epub 2012 Nov 20. Review.


Mucin Muc2 deficiency and weaning influences the expression of the innate defense genes Reg3β, Reg3γ and angiogenin-4.

Burger-van Paassen N, Loonen LM, Witte-Bouma J, Korteland-van Male AM, de Bruijn AC, van der Sluis M, Lu P, Van Goudoever JB, Wells JM, Dekker J, Van Seuningen I, Renes IB.

PLoS One. 2012;7(6):e38798. doi: 10.1371/journal.pone.0038798. Epub 2012 Jun 19.


The MUC4 mucin mediates gemcitabine resistance of human pancreatic cancer cells via the Concentrative Nucleoside Transporter family.

Skrypek N, Duchêne B, Hebbar M, Leteurtre E, van Seuningen I, Jonckheere N.

Oncogene. 2013 Mar 28;32(13):1714-23. doi: 10.1038/onc.2012.179. Epub 2012 May 14.


GATA-4/-6 and HNF-1/-4 families of transcription factors control the transcriptional regulation of the murine Muc5ac mucin during stomach development and in epithelial cancer cells.

Jonckheere N, Vincent A, Franquet-Ansart H, Witte-Bouma J, Korteland-van Male A, Leteurtre E, Renes IB, Van Seuningen I.

Biochim Biophys Acta. 2012 Aug;1819(8):869-76. doi: 10.1016/j.bbagrm.2012.04.003. Epub 2012 Apr 25.


Mucin 16 (cancer antigen 125) expression in human tissues and cell lines and correlation with clinical outcome in adenocarcinomas of the pancreas, esophagus, stomach, and colon.

Streppel MM, Vincent A, Mukherjee R, Campbell NR, Chen SH, Konstantopoulos K, Goggins MG, Van Seuningen I, Maitra A, Montgomery EA.

Hum Pathol. 2012 Oct;43(10):1755-63. doi: 10.1016/j.humpath.2012.01.005. Epub 2012 Apr 26.


On the epigenetic origin of cancer stem cells.

Vincent A, Van Seuningen I.

Biochim Biophys Acta. 2012 Aug;1826(1):83-8. doi: 10.1016/j.bbcan.2012.03.009. Epub 2012 Apr 1. Review.


Tif1γ suppresses murine pancreatic tumoral transformation by a Smad4-independent pathway.

Vincent DF, Gout J, Chuvin N, Arfi V, Pommier RM, Bertolino P, Jonckheere N, Ripoche D, Kaniewski B, Martel S, Langlois JB, Goddard-Léon S, Colombe A, Janier M, Van Seuningen I, Losson R, Valcourt U, Treilleux I, Dubus P, Bardeesy N, Bartholin L.

Am J Pathol. 2012 Jun;180(6):2214-21. doi: 10.1016/j.ajpath.2012.02.006. Epub 2012 Mar 31.


The mucin MUC4 and its membrane partner ErbB2 regulate biological properties of human CAPAN-2 pancreatic cancer cells via different signalling pathways.

Jonckheere N, Skrypek N, Merlin J, Dessein AF, Dumont P, Leteurtre E, Harris A, Desseyn JL, Susini C, Frénois F, Van Seuningen I.

PLoS One. 2012;7(2):e32232. doi: 10.1371/journal.pone.0032232. Epub 2012 Feb 29.


Colonic gene expression patterns of mucin Muc2 knockout mice reveal various phases in colitis development.

Lu P, Burger-van Paassen N, van der Sluis M, Witte-Bouma J, Kerckaert JP, van Goudoever JB, Van Seuningen I, Renes IB.

Inflamm Bowel Dis. 2011 Oct;17(10):2047-57. doi: 10.1002/ibd.21592. Epub 2011 Jan 6.


The MUC4 membrane-bound mucin regulates esophageal cancer cell proliferation and migration properties: Implication for S100A4 protein.

Bruyère E, Jonckheere N, Frénois F, Mariette C, Van Seuningen I.

Biochem Biophys Res Commun. 2011 Sep 23;413(2):325-9. doi: 10.1016/j.bbrc.2011.08.095. Epub 2011 Aug 26.


Colitis development during the suckling-weaning transition in mucin Muc2-deficient mice.

Burger-van Paassen N, van der Sluis M, Bouma J, Korteland-van Male AM, Lu P, Van Seuningen I, Boehm G, van Goudoever JB, Renes IB.

Am J Physiol Gastrointest Liver Physiol. 2011 Oct;301(4):G667-78. doi: 10.1152/ajpgi.00199.2010. Epub 2011 Jun 23.

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