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Improved quantification of muscle insulin sensitivity using oral glucose tolerance test data: the MISI Calculator.

O'Donovan SD, Lenz M, Goossens GH, van der Kallen CJH, Eussen SJMP, Stehouwer CDA, van Greevenbroek MM, Schram MT, Sep SJ, Peeters RLM, Blaak EE, van Riel NAW, de Kok TMCM, Arts ICW.

Sci Rep. 2019 Jun 28;9(1):9388. doi: 10.1038/s41598-019-45858-w.


Computational modelling of energy balance in individuals with Metabolic Syndrome.

Rozendaal YJW, Wang Y, Hilbers PAJ, van Riel NAW.

BMC Syst Biol. 2019 Feb 26;13(1):24. doi: 10.1186/s12918-019-0705-z.


Domain intelligible models.

Imangaliyev S, Prodan A, Nieuwdorp M, Groen AK, van Riel NAW, Levin E.

Methods. 2018 Oct 1;149:69-73. doi: 10.1016/j.ymeth.2018.06.011. Epub 2018 Jul 5.


In Silico Analysis Identifies Intestinal Transit as a Key Determinant of Systemic Bile Acid Metabolism.

Sips FLP, Eggink HM, Hilbers PAJ, Soeters MR, Groen AK, van Riel NAW.

Front Physiol. 2018 Jun 8;9:631. doi: 10.3389/fphys.2018.00631. eCollection 2018.


In vivo and in silico dynamics of the development of Metabolic Syndrome.

Rozendaal YJW, Wang Y, Paalvast Y, Tambyrajah LL, Li Z, Willems van Dijk K, Rensen PCN, Kuivenhoven JA, Groen AK, Hilbers PAJ, van Riel NAW.

PLoS Comput Biol. 2018 Jun 7;14(6):e1006145. doi: 10.1371/journal.pcbi.1006145. eCollection 2018 Jun.


Differential metabolic effects of oral butyrate treatment in lean versus metabolic syndrome subjects.

Bouter K, Bakker GJ, Levin E, Hartstra AV, Kootte RS, Udayappan SD, Katiraei S, Bahler L, Gilijamse PW, Tremaroli V, Stahlman M, Holleman F, van Riel NAW, Verberne HJ, Romijn JA, Dallinga-Thie GM, Serlie MJ, Ackermans MT, Kemper EM, Willems van Dijk K, Backhed F, Groen AK, Nieuwdorp M.

Clin Transl Gastroenterol. 2018 May 25;9(5):155. doi: 10.1038/s41424-018-0025-4.


Physical Activity and Nutrition INfluences In ageing (PANINI): consortium mission statement.

Whittaker AC, Delledonne M, Finni T, Garagnani P, Greig C, Kallen V, Kokko K, Lord J, Maier AB, Meskers CGM, Santos NC, Sipila S, Thompson JL, van Riel N.

Aging Clin Exp Res. 2018 Jun;30(6):685-692. doi: 10.1007/s40520-017-0823-7. Epub 2017 Sep 1. No abstract available.


Identifying User Preferences for a Digital Educational Solution for Young Seniors With Diabetes.

van der Molen P, Maas AH, Chen W, van Pul C, Cottaar EJE, van Riel NAW, Hilbers PAJ, Haak HR.

Diabetes Spectr. 2017 Aug;30(3):182-187. doi: 10.2337/ds16-0023.


Visible Blue Light Therapy: Molecular Mechanisms and Therapeutic Opportunities.

Garza ZCF, Born M, Hilbers PAJ, van Riel NAW, Liebmann J.

Curr Med Chem. 2018;25(40):5564-5577. doi: 10.2174/0929867324666170727112206. Review.


Methodologies for Quantitative Systems Pharmacology (QSP) Models: Design and Estimation.

Ribba B, Grimm HP, Agoram B, Davies MR, Gadkar K, Niederer S, van Riel N, Timmis J, van der Graaf PH.

CPT Pharmacometrics Syst Pharmacol. 2017 Aug;6(8):496-498. doi: 10.1002/psp4.12206. Epub 2017 Jul 11.


The effect of Dr Google on doctor-patient encounters in primary care: a quantitative, observational, cross-sectional study.

Van Riel N, Auwerx K, Debbaut P, Van Hees S, Schoenmakers B.

BJGP Open. 2017 May 17;1(2):bjgpopen17X100833. doi: 10.3399/bjgpopen17X100833.


An In Vivo Magnetic Resonance Spectroscopy Study of the Effects of Caloric and Non-Caloric Sweeteners on Liver Lipid Metabolism in Rats.

Janssens S, Ciapaite J, Wolters JC, van Riel NA, Nicolay K, Prompers JJ.

Nutrients. 2017 May 10;9(5). pii: E476. doi: 10.3390/nu9050476.


A Dynamic Model for Prediction of Psoriasis Management by Blue Light Irradiation.

Félix Garza ZC, Liebmann J, Born M, Hilbers PA, van Riel NA.

Front Physiol. 2017 Jan 26;8:28. doi: 10.3389/fphys.2017.00028. eCollection 2017.


Dietary nitrate does not reduce oxygen cost of exercise or improve muscle mitochondrial function in patients with mitochondrial myopathy.

Nabben M, Schmitz JPJ, Ciapaite J, le Clercq CMP, van Riel NA, Haak HR, Nicolay K, de Coo IFM, Smeets H, Praet SF, van Loon LJ, Prompers JJ.

Am J Physiol Regul Integr Comp Physiol. 2017 May 1;312(5):R689-R701. doi: 10.1152/ajpregu.00264.2016. Epub 2017 Feb 8.


Flux Balance Analysis of Plant Metabolism: The Effect of Biomass Composition and Model Structure on Model Predictions.

Yuan H, Cheung CY, Hilbers PA, van Riel NA.

Front Plant Sci. 2016 Apr 26;7:537. doi: 10.3389/fpls.2016.00537. eCollection 2016.


Requirements for multi-level systems pharmacology models to reach end-usage: the case of type 2 diabetes.

Nyman E, Rozendaal YJ, Helmlinger G, Hamrén B, Kjellsson MC, Strålfors P, van Riel NA, Gennemark P, Cedersund G.

Interface Focus. 2016 Apr 6;6(2):20150075. doi: 10.1098/rsfs.2015.0075. Review.


Altered Energetics of Exercise Explain Risk of Rhabdomyolysis in Very Long-Chain Acyl-CoA Dehydrogenase Deficiency.

Diekman EF, Visser G, Schmitz JP, Nievelstein RA, de Sain-van der Velden M, Wardrop M, Van der Pol WL, Houten SM, van Riel NA, Takken T, Jeneson JA.

PLoS One. 2016 Feb 16;11(2):e0147818. doi: 10.1371/journal.pone.0147818. eCollection 2016.


Concept Development of the Eindhoven Diabetes Education Simulator Project.

Maas AH, van der Molen P, van de Vijver R, Chen W, van Pul C, Cottaar EJ, van Riel NA, Hilbers PA, Haak HR.

Games Health J. 2016 Apr;5(2):120-7. doi: 10.1089/g4h.2015.0037. Epub 2016 Feb 12.


Effects of low-stearate palm oil and high-stearate lard high-fat diets on rat liver lipid metabolism and glucose tolerance.

Janssens S, Heemskerk MM, van den Berg SA, van Riel NA, Nicolay K, Willems van Dijk K, Prompers JJ.

Nutr Metab (Lond). 2015 Dec 18;12:57. doi: 10.1186/s12986-015-0053-y. eCollection 2015.


A genome-scale metabolic network reconstruction of tomato (Solanum lycopersicum L.) and its application to photorespiratory metabolism.

Yuan H, Cheung CY, Poolman MG, Hilbers PA, van Riel NA.

Plant J. 2016 Jan;85(2):289-304. doi: 10.1111/tpj.13075. Epub 2016 Jan 4.


Model-Based Quantification of the Systemic Interplay between Glucose and Fatty Acids in the Postprandial State.

Sips FL, Nyman E, Adiels M, Hilbers PA, Strålfors P, van Riel NA, Cedersund G.

PLoS One. 2015 Sep 10;10(9):e0135665. doi: 10.1371/journal.pone.0135665. eCollection 2015.


A physiology-based model describing heterogeneity in glucose metabolism: the core of the Eindhoven Diabetes Education Simulator (E-DES).

Maas AH, Rozendaal YJ, van Pul C, Hilbers PA, Cottaar WJ, Haak HR, van Riel NA.

J Diabetes Sci Technol. 2015 Mar;9(2):282-92. doi: 10.1177/1932296814562607. Epub 2014 Dec 18.


A systems biology approach reveals the physiological origin of hepatic steatosis induced by liver X receptor activation.

Hijmans BS, Tiemann CA, Grefhorst A, Boesjes M, van Dijk TH, Tietge UJ, Kuipers F, van Riel NA, Groen AK, Oosterveer MH.

FASEB J. 2015 Apr;29(4):1153-64. doi: 10.1096/fj.14-254656. Epub 2014 Dec 4.


Muscle-type specific autophosphorylation of CaMKII isoforms after paced contractions.

Eilers W, Gevers W, van Overbeek D, de Haan A, Jaspers RT, Hilbers PA, van Riel N, Flück M.

Biomed Res Int. 2014;2014:943806. doi: 10.1155/2014/943806. Epub 2014 Jun 26.


A computational model for the analysis of lipoprotein distributions in the mouse: translating FPLC profiles to lipoprotein metabolism.

Sips FL, Tiemann CA, Oosterveer MH, Groen AK, Hilbers PA, van Riel NA.

PLoS Comput Biol. 2014 May 1;10(5):e1003579. doi: 10.1371/journal.pcbi.1003579. eCollection 2014 May.


Optimal experiment design for model selection in biochemical networks.

Vanlier J, Tiemann CA, Hilbers PA, van Riel NA.

BMC Syst Biol. 2014 Feb 20;8:20. doi: 10.1186/1752-0509-8-20.


Parameter trajectory analysis to identify treatment effects of pharmacological interventions.

Tiemann CA, Vanlier J, Oosterveer MH, Groen AK, Hilbers PA, van Riel NA.

PLoS Comput Biol. 2013;9(8):e1003166. doi: 10.1371/journal.pcbi.1003166. Epub 2013 Aug 1.


Applications of analysis of dynamic adaptations in parameter trajectories.

van Riel NA, Tiemann CA, Vanlier J, Hilbers PA.

Interface Focus. 2013 Apr 6;3(2):20120084. doi: 10.1098/rsfs.2012.0084.


Parameter uncertainty in biochemical models described by ordinary differential equations.

Vanlier J, Tiemann CA, Hilbers PA, van Riel NA.

Math Biosci. 2013 Dec;246(2):305-14. doi: 10.1016/j.mbs.2013.03.006. Epub 2013 Mar 25. Review.


Combined in vivo and in silico investigations of activation of glycolysis in contracting skeletal muscle.

Schmitz JP, Groenendaal W, Wessels B, Wiseman RW, Hilbers PA, Nicolay K, Prompers JJ, Jeneson JA, van Riel NA.

Am J Physiol Cell Physiol. 2013 Jan 15;304(2):C180-93. doi: 10.1152/ajpcell.00101.2012. Epub 2012 Oct 31.


Prediction of muscle energy states at low metabolic rates requires feedback control of mitochondrial respiratory chain activity by inorganic phosphate.

Schmitz JP, Jeneson JA, van Oorschot JW, Prompers JJ, Nicolay K, Hilbers PA, van Riel NA.

PLoS One. 2012;7(3):e34118. doi: 10.1371/journal.pone.0034118. Epub 2012 Mar 28.


A Bayesian approach to targeted experiment design.

Vanlier J, Tiemann CA, Hilbers PA, van Riel NA.

Bioinformatics. 2012 Apr 15;28(8):1136-42. doi: 10.1093/bioinformatics/bts092. Epub 2012 Feb 24.


An integrated strategy for prediction uncertainty analysis.

Vanlier J, Tiemann CA, Hilbers PA, van Riel NA.

Bioinformatics. 2012 Apr 15;28(8):1130-5. doi: 10.1093/bioinformatics/bts088. Epub 2012 Feb 21.


Computational modeling of mitochondrial energy transduction.

Schmitz JP, Vanlier J, van Riel NA, Jeneson JA.

Crit Rev Biomed Eng. 2011;39(5):363-77. Review.


Parameter adaptations during phenotype transitions in progressive diseases.

Tiemann CA, Vanlier J, Hilbers PA, van Riel NA.

BMC Syst Biol. 2011 Oct 26;5:174. doi: 10.1186/1752-0509-5-174.


Quantifying the composition of human skin for glucose sensor development.

Groenendaal W, von Basum G, Schmidt KA, Hilbers PA, van Riel NA.

J Diabetes Sci Technol. 2010 Sep 1;4(5):1032-40.


Systems biology from micro-organisms to human metabolic diseases: the role of detailed kinetic models.

Bakker BM, van Eunen K, Jeneson JA, van Riel NA, Bruggeman FJ, Teusink B.

Biochem Soc Trans. 2010 Oct;38(5):1294-301. doi: 10.1042/BST0381294. Review.


The use of a reference tissue arterial input function with low-temporal-resolution DCE-MRI data.

Heisen M, Fan X, Buurman J, van Riel NA, Karczmar GS, ter Haar Romeny BM.

Phys Med Biol. 2010 Aug 21;55(16):4871-83. doi: 10.1088/0031-9155/55/16/016. Epub 2010 Aug 3.


The influence of temporal resolution in determining pharmacokinetic parameters from DCE-MRI data.

Heisen M, Fan X, Buurman J, van Riel NA, Karczmar GS, ter Haar Romeny BM.

Magn Reson Med. 2010 Mar;63(3):811-6. doi: 10.1002/mrm.22171.


Silencing of glycolysis in muscle: experimental observation and numerical analysis.

Schmitz JP, van Riel NA, Nicolay K, Hilbers PA, Jeneson JA.

Exp Physiol. 2010 Feb;95(2):380-97. doi: 10.1113/expphysiol.2009.049841. Epub 2009 Oct 2.


Reliability of pharmacokinetic parameters: small vs. medium-sized contrast agents.

Jaspers K, Aerts HJ, Leiner T, Oostendorp M, van Riel NA, Post MJ, Backes WH.

Magn Reson Med. 2009 Sep;62(3):779-87. doi: 10.1002/mrm.22035.


Magnitude and control of mitochondrial sensitivity to ADP.

Jeneson JA, Schmitz JP, van den Broek NM, van Riel NA, Hilbers PA, Nicolay K, Prompers JJ.

Am J Physiol Endocrinol Metab. 2009 Sep;297(3):E774-84. doi: 10.1152/ajpendo.00370.2009. Epub 2009 Jul 21.


Intra-voxel heterogeneity influences the dose prescription for dose-painting with radiotherapy: a modelling study.

Petit SF, Dekker AL, Seigneuric R, Murrer L, van Riel NA, Nordsmark M, Overgaard J, Lambin P, Wouters BG.

Phys Med Biol. 2009 Apr 7;54(7):2179-96. doi: 10.1088/0031-9155/54/7/022. Epub 2009 Mar 17.


Computational modelling identifies the impact of subtle anatomical variations between amphibian and mammalian skeletal muscle on spatiotemporal calcium dynamics.

Groenendaal W, Jeneson JA, Verhoog PJ, van Riel NA, Ten Eikelder HM, Nicolay K, Hilbers PA.

IET Syst Biol. 2008 Nov;2(6):411-22. doi: 10.1049/iet-syb:20070050.


Modeling glucose and water dynamics in human skin.

Groenendaal W, Schmidt KA, von Basum G, van Riel NA, Hilbers PA.

Diabetes Technol Ther. 2008 Aug;10(4):283-93. doi: 10.1089/dia.2007.0290.


System identification theory in pharmacokinetic modeling of dynamic contrast-enhanced MRI: influence of contrast injection.

Aerts HJ, van Riel NA, Backes WH.

Magn Reson Med. 2008 May;59(5):1111-9. doi: 10.1002/mrm.21575.


Mathematical modelling of the calcium-left ventricular pressure relationship in the intact diabetic rat heart.

Op Den Buijs J, Ligeti L, Ivanics T, Miklós Z, Van Der Vusse GJ, Van Riel NA.

Acta Physiol (Oxf). 2008 Jul;193(3):205-17. doi: 10.1111/j.1748-1716.2008.01831.x. Epub 2008 Feb 18.


Leukocytes of exceptionally old persons display ultra-short telomeres.

Kimura M, Barbieri M, Gardner JP, Skurnick J, Cao X, van Riel N, Rizzo MR, Paoliso G, Aviv A.

Am J Physiol Regul Integr Comp Physiol. 2007 Dec;293(6):R2210-7. Epub 2007 Sep 26.


On the identifiability of pharmacokinetic parameters in dynamic contrast-enhanced imaging.

Lopata RG, Backes WH, van den Bosch PP, van Riel NA.

Magn Reson Med. 2007 Aug;58(2):425-9.


Identifiability analysis of the standard pharmacokinetic models in DCE MR imaging of tumours.

Lopata RG, van Riel NA.

Conf Proc IEEE Eng Med Biol Soc. 2004;2:1040-3.


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