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Items: 1 to 50 of 59

1.

A TCR β-Chain Motif Biases toward Recognition of Human CD1 Proteins.

Reinink P, Shahine A, Gras S, Cheng TY, Farquhar R, Lopez K, Suliman SA, Reijneveld JF, Le Nours J, Tan LL, León SR, Jimenez J, Calderon R, Lecca L, Murray MB, Rossjohn J, Moody DB, Van Rhijn I.

J Immunol. 2019 Dec 15;203(12):3395-3406. doi: 10.4049/jimmunol.1900872. Epub 2019 Nov 6.

PMID:
31694911
2.

Total Synthesis of an Immunogenic Trehalose Phospholipid from Salmonella Typhi and Elucidation of Its sn-Regiochemistry by Mass Spectrometry.

Mishra VK, Buter J, Blevins MS, Witte MD, Van Rhijn I, Moody DB, Brodbelt JS, Minnaard AJ.

Org Lett. 2019 Jul 5;21(13):5126-5131. doi: 10.1021/acs.orglett.9b01725. Epub 2019 Jun 20.

3.

CD1b presents self and Borrelia burgdorferi diacylglycerols to human T cells.

Reinink P, Souter MNT, Cheng TY, van Gorkom T, Lenz S, Kubler-Kielb J, Strle K, Kremer K, Thijsen SFT, Steere AC, Godfrey DI, Pellicci DG, Moody DB, Van Rhijn I.

Eur J Immunol. 2019 May;49(5):737-746. doi: 10.1002/eji.201847949. Epub 2019 Mar 20.

4.

Discovery of Salmonella trehalose phospholipids reveals functional convergence with mycobacteria.

Reinink P, Buter J, Mishra VK, Ishikawa E, Cheng TY, Willemsen PTJ, Porwollik S, Brennan PJ, Heinz E, Mayfield JA, Dougan G, van Els CA, Cerundolo V, Napolitani G, Yamasaki S, Minnaard AJ, McClelland M, Moody DB, Van Rhijn I.

J Exp Med. 2019 Apr 1;216(4):757-771. doi: 10.1084/jem.20181812. Epub 2019 Feb 25.

5.

A T-cell receptor escape channel allows broad T-cell response to CD1b and membrane phospholipids.

Shahine A, Reinink P, Reijneveld JF, Gras S, Holzheimer M, Cheng TY, Minnaard AJ, Altman JD, Lenz S, Prandi J, Kubler-Kielb J, Moody DB, Rossjohn J, Van Rhijn I.

Nat Commun. 2019 Jan 4;10(1):56. doi: 10.1038/s41467-018-07898-0.

6.

T cell autoreactivity directed toward CD1c itself rather than toward carried self lipids.

Wun KS, Reijneveld JF, Cheng TY, Ladell K, Uldrich AP, Le Nours J, Miners KL, McLaren JE, Grant EJ, Haigh OL, Watkins TS, Suliman S, Iwany S, Jimenez J, Calderon R, Tamara KL, Leon SR, Murray MB, Mayfield JA, Altman JD, Purcell AW, Miles JJ, Godfrey DI, Gras S, Price DA, Van Rhijn I, Moody DB, Rossjohn J.

Nat Immunol. 2018 Apr;19(4):397-406. doi: 10.1038/s41590-018-0065-7. Epub 2018 Mar 12.

7.

CD1b Tetramers Identify T Cells that Recognize Natural and Synthetic Diacylated Sulfoglycolipids from Mycobacterium tuberculosis.

James CA, Yu KKQ, Gilleron M, Prandi J, Yedulla VR, Moleda ZZ, Diamanti E, Khan M, Aggarwal VK, Reijneveld JF, Reinink P, Lenz S, Emerson RO, Scriba TJ, Souter MNT, Godfrey DI, Pellicci DG, Moody DB, Minnaard AJ, Seshadri C, Van Rhijn I.

Cell Chem Biol. 2018 Apr 19;25(4):392-402.e14. doi: 10.1016/j.chembiol.2018.01.006. Epub 2018 Feb 1.

8.

Molecular recognition of microbial lipid-based antigens by T cells.

Gras S, Van Rhijn I, Shahine A, Le Nours J.

Cell Mol Life Sci. 2018 May;75(9):1623-1639. doi: 10.1007/s00018-018-2749-4. Epub 2018 Jan 16. Review.

9.

A molecular basis of human T cell receptor autoreactivity toward self-phospholipids.

Shahine A, Van Rhijn I, Cheng TY, Iwany S, Gras S, Moody DB, Rossjohn J.

Sci Immunol. 2017 Oct 20;2(16). pii: eaao1384. doi: 10.1126/sciimmunol.aao1384.

10.

CD1b-mycolic acid tetramers demonstrate T-cell fine specificity for mycobacterial lipid tails.

Van Rhijn I, Iwany SK, Fodran P, Cheng TY, Gapin L, Minnaard AJ, Moody DB.

Eur J Immunol. 2017 Sep;47(9):1525-1534. doi: 10.1002/eji.201747062. Epub 2017 Jul 31.

11.

CD1b-autoreactive T cells contribute to hyperlipidemia-induced skin inflammation in mice.

Bagchi S, He Y, Zhang H, Cao L, Van Rhijn I, Moody DB, Gudjonsson JE, Wang CR.

J Clin Invest. 2017 Jun 1;127(6):2339-2352. doi: 10.1172/JCI92217. Epub 2017 May 2.

12.

Total Synthesis of Mycobacterium tuberculosis Dideoxymycobactin-838 and Stereoisomers: Diverse CD1a-Restricted T Cells Display a Common Hierarchy of Lipopeptide Recognition.

Cheng JM, Liu L, Pellicci DG, Reddiex SJ, Cotton RN, Cheng TY, Young DC, Van Rhijn I, Moody DB, Rossjohn J, Fairlie DP, Godfrey DI, Williams SJ.

Chemistry. 2017 Jan 31;23(7):1694-1701. doi: 10.1002/chem.201605287. Epub 2017 Jan 18.

13.

T cell receptor recognition of CD1b presenting a mycobacterial glycolipid.

Gras S, Van Rhijn I, Shahine A, Cheng TY, Bhati M, Tan LL, Halim H, Tuttle KD, Gapin L, Le Nours J, Moody DB, Rossjohn J.

Nat Commun. 2016 Oct 27;7:13257. doi: 10.1038/ncomms13257.

14.

Mammalian CD1 and MR1 genes.

Reinink P, Van Rhijn I.

Immunogenetics. 2016 Aug;68(8):515-23. doi: 10.1007/s00251-016-0926-x. Epub 2016 Jul 28. Review.

15.

Human autoreactive T cells recognize CD1b and phospholipids.

Van Rhijn I, van Berlo T, Hilmenyuk T, Cheng TY, Wolf BJ, Tatituri RV, Uldrich AP, Napolitani G, Cerundolo V, Altman JD, Willemsen P, Huang S, Rossjohn J, Besra GS, Brenner MB, Godfrey DI, Moody DB.

Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):380-5. doi: 10.1073/pnas.1520947112. Epub 2015 Nov 30.

16.

Lipid and small-molecule display by CD1 and MR1.

Van Rhijn I, Godfrey DI, Rossjohn J, Moody DB.

Nat Rev Immunol. 2015 Oct;15(10):643-54. doi: 10.1038/nri3889. Epub 2015 Sep 21. Review.

PMID:
26388332
17.

Donor Unrestricted T Cells: A Shared Human T Cell Response.

Van Rhijn I, Moody DB.

J Immunol. 2015 Sep 1;195(5):1927-32. doi: 10.4049/jimmunol.1500943. Review.

18.

Correction: Expression Patterns of Bovine CD1 In Vivo and Assessment of the Specificities of the Anti-Bovine CD1 Antibodies.

Nguyen TK, Reinink P, El Messlaki C, Im JS, Ercan A, Porcelli SA, Van Rhijn I.

PLoS One. 2015 Jun 5;10(6):e0129755. doi: 10.1371/journal.pone.0129755. eCollection 2015. No abstract available.

19.

Expression patterns of bovine CD1 in vivo and assessment of the specificities of the anti-bovine CD1 antibodies.

Nguyen TK, Reinink P, El Messlaki C, Im JS, Ercan A, Porcelli SA, Van Rhijn I.

PLoS One. 2015 Mar 27;10(3):e0121923. doi: 10.1371/journal.pone.0121923. eCollection 2015. Erratum in: PLoS One. 2015;10(6):e0129755.

20.

CD1 and mycobacterial lipids activate human T cells.

Van Rhijn I, Moody DB.

Immunol Rev. 2015 Mar;264(1):138-53. doi: 10.1111/imr.12253. Review.

21.

Discovery of invariant T cells by next-generation sequencing of the human TCR α-chain repertoire.

van Schaik B, Klarenbeek P, Doorenspleet M, van Kampen A, Moody DB, de Vries N, Van Rhijn I.

J Immunol. 2014 Nov 15;193(10):5338-44. doi: 10.4049/jimmunol.1401380. Epub 2014 Oct 22.

22.

Targeted delivery of mycobacterial antigens to human dendritic cells via Siglec-7 induces robust T cell activation.

Kawasaki N, Rillahan CD, Cheng TY, Van Rhijn I, Macauley MS, Moody DB, Paulson JC.

J Immunol. 2014 Aug 15;193(4):1560-6. doi: 10.4049/jimmunol.1303278. Epub 2014 Jul 7.

23.

TCR bias and affinity define two compartments of the CD1b-glycolipid-specific T Cell repertoire.

Van Rhijn I, Gherardin NA, Kasmar A, de Jager W, Pellicci DG, Kostenko L, Tan LL, Bhati M, Gras S, Godfrey DI, Rossjohn J, Moody DB.

J Immunol. 2014 May 1;192(9):4054-60. doi: 10.4049/jimmunol.1400158. Epub 2014 Mar 28.

24.

CD1a-autoreactive T cells recognize natural skin oils that function as headless antigens.

de Jong A, Cheng TY, Huang S, Gras S, Birkinshaw RW, Kasmar AG, Van Rhijn I, Peña-Cruz V, Ruan DT, Altman JD, Rossjohn J, Moody DB.

Nat Immunol. 2014 Feb;15(2):177-85. doi: 10.1038/ni.2790. Epub 2013 Dec 22.

25.

Cutting Edge: CD1a tetramers and dextramers identify human lipopeptide-specific T cells ex vivo.

Kasmar AG, Van Rhijn I, Magalhaes KG, Young DC, Cheng TY, Turner MT, Schiefner A, Kalathur RC, Wilson IA, Bhati M, Gras S, Birkinshaw RW, Tan LL, Rossjohn J, Shires J, Jakobsen S, Altman JD, Moody DB.

J Immunol. 2013 Nov 1;191(9):4499-503. doi: 10.4049/jimmunol.1301660. Epub 2013 Oct 2.

26.

A conserved human T cell population targets mycobacterial antigens presented by CD1b.

Van Rhijn I, Kasmar A, de Jong A, Gras S, Bhati M, Doorenspleet ME, de Vries N, Godfrey DI, Altman JD, de Jager W, Rossjohn J, Moody DB.

Nat Immunol. 2013 Jul;14(7):706-13. doi: 10.1038/ni.2630. Epub 2013 Jun 2.

27.

The molecular basis for Mucosal-Associated Invariant T cell recognition of MR1 proteins.

López-Sagaseta J, Dulberger CL, Crooks JE, Parks CD, Luoma AM, McFedries A, Van Rhijn I, Saghatelian A, Adams EJ.

Proc Natl Acad Sci U S A. 2013 May 7;110(19):E1771-8. doi: 10.1073/pnas.1222678110. Epub 2013 Apr 23.

28.

CD1a, CD1b, and CD1c in immunity against mycobacteria.

Van Rhijn I, Ly D, Moody DB.

Adv Exp Med Biol. 2013;783:181-97. doi: 10.1007/978-1-4614-6111-1_10. Review.

PMID:
23468110
29.

Lipoproteins are major targets of the polyclonal human T cell response to Mycobacterium tuberculosis.

Seshadri C, Turner MT, Lewinsohn DM, Moody DB, Van Rhijn I.

J Immunol. 2013 Jan 1;190(1):278-84. doi: 10.4049/jimmunol.1201667. Epub 2012 Nov 28.

30.

Crystal structures of bovine CD1d reveal altered αGalCer presentation and a restricted A' pocket unable to bind long-chain glycolipids.

Wang J, Guillaume J, Pauwels N, Van Calenbergh S, Van Rhijn I, Zajonc DM.

PLoS One. 2012;7(10):e47989. doi: 10.1371/journal.pone.0047989. Epub 2012 Oct 23.

31.

Tandem repeats modify the structure of the canine CD1D gene.

Looringh van Beeck FA, Leegwater PA, Herrmann T, Broere F, Rutten VP, Willemse T, Van Rhijn I.

Anim Genet. 2013 Jun;44(3):352-5. doi: 10.1111/age.12002. Epub 2012 Sep 19.

PMID:
22988997
32.

The bovine CD1D gene has an unusual gene structure and is expressed but cannot present α-galactosylceramide with a C26 fatty acid.

Nguyen TK, Koets AP, Vordermeier M, Jervis PJ, Cox LR, Graham SP, Santema WJ, Moody DB, van Calenbergh S, Zajonc DM, Besra GS, Van Rhijn I.

Int Immunol. 2013 Feb;25(2):91-8. doi: 10.1093/intimm/dxs092. Epub 2012 Sep 11.

33.

γδ T cell homing to skin and migration to skin-draining lymph nodes is CCR7 independent.

Vrieling M, Santema W, Van Rhijn I, Rutten V, Koets A.

J Immunol. 2012 Jan 15;188(2):578-84. doi: 10.4049/jimmunol.1101972. Epub 2011 Dec 12.

34.

CD1b tetramers bind αβ T cell receptors to identify a mycobacterial glycolipid-reactive T cell repertoire in humans.

Kasmar AG, van Rhijn I, Cheng TY, Turner M, Seshadri C, Schiefner A, Kalathur RC, Annand JW, de Jong A, Shires J, Leon L, Brenner M, Wilson IA, Altman JD, Moody DB.

J Exp Med. 2011 Aug 29;208(9):1741-7. doi: 10.1084/jem.20110665. Epub 2011 Aug 1.

35.

Immune response of cattle immunized with a conjugate of the glycolipid glucose monomycolate and protein.

Nguyen TK, Wieland W, Santema W, Hoeboer J, van Eden W, Rutten V, Koets A, Van Rhijn I.

Vet Immunol Immunopathol. 2011 Aug 15;142(3-4):265-70. doi: 10.1016/j.vetimm.2011.05.016. Epub 2011 May 13.

PMID:
21640388
36.

CD1a-autoreactive T cells are a normal component of the human αβ T cell repertoire.

de Jong A, Peña-Cruz V, Cheng TY, Clark RA, Van Rhijn I, Moody DB.

Nat Immunol. 2010 Dec;11(12):1102-9. doi: 10.1038/ni.1956. Epub 2010 Oct 31.

37.

Crystal structure of bovine CD1b3 with endogenously bound ligands.

Girardi E, Wang J, Mac TT, Versluis C, Bhowruth V, Besra G, Heck AJ, Van Rhijn I, Zajonc DM.

J Immunol. 2010 Jul 1;185(1):376-86. doi: 10.4049/jimmunol.1000042. Epub 2010 Jun 2.

38.

Conservation of mucosal associated invariant T (MAIT) cells and the MR1 restriction element in ruminants, and abundance of MAIT cells in spleen.

Goldfinch N, Reinink P, Connelley T, Koets A, Morrison I, Van Rhijn I.

Vet Res. 2010 Sep-Oct;41(5):62. doi: 10.1051/vetres/2010034. Epub 2010 May 31.

39.

Lion (Panthera leo) and cheetah (Acinonyx jubatus) IFN-gamma sequences.

Maas M, Van Rhijn I, Allsopp MT, Rutten VP.

Vet Immunol Immunopathol. 2010 Apr 15;134(3-4):296-8. doi: 10.1016/j.vetimm.2009.10.001. Epub 2009 Oct 12.

PMID:
19913304
40.

Low cross-reactivity of T-cell responses against lipids from Mycobacterium bovis and M. avium paratuberculosis during natural infection.

Van Rhijn I, Nguyen TK, Michel A, Cooper D, Govaerts M, Cheng TY, van Eden W, Moody DB, Coetzer JA, Rutten V, Koets AP.

Eur J Immunol. 2009 Nov;39(11):3031-41. doi: 10.1002/eji.200939619.

41.

The bovine T cell receptor alpha/delta locus contains over 400 V genes and encodes V genes without CDR2.

Reinink P, Van Rhijn I.

Immunogenetics. 2009 Jul;61(7):541-9. doi: 10.1007/s00251-009-0384-9. Epub 2009 Jul 2.

42.

The evolved functions of CD1 during infection.

Kasmar A, Van Rhijn I, Moody DB.

Curr Opin Immunol. 2009 Aug;21(4):397-403. doi: 10.1016/j.coi.2009.05.022. Epub 2009 Jun 21. Review.

43.

The mycobacterial glycolipid glucose monomycolate induces a memory T cell response comparable to a model protein antigen and no B cell response upon experimental vaccination of cattle.

Nguyen TK, Koets AP, Santema WJ, van Eden W, Rutten VP, Van Rhijn I.

Vaccine. 2009 Jul 30;27(35):4818-25. doi: 10.1016/j.vaccine.2009.05.078. Epub 2009 Jun 16.

44.

CD1c bypasses lysosomes to present a lipopeptide antigen with 12 amino acids.

Van Rhijn I, Young DC, De Jong A, Vazquez J, Cheng TY, Talekar R, Barral DC, León L, Brenner MB, Katz JT, Riese R, Ruprecht RM, O'Connor PB, Costello CE, Porcelli SA, Briken V, Moody DB.

J Exp Med. 2009 Jun 8;206(6):1409-22. doi: 10.1084/jem.20082480. Epub 2009 May 25. Erratum in: J Exp Med. 2009 Aug 3;206(8):1831. Barral, Duarte [corrected to Barral, Duarte C].

45.

Functional CD1d and/or NKT cell invariant chain transcript in horse, pig, African elephant and guinea pig, but not in ruminants.

Looringh van Beeck FA, Reinink P, Hermsen R, Zajonc DM, Laven MJ, Fun A, Troskie M, Schoemaker NJ, Morar D, Lenstra JA, Vervelde L, Rutten VP, van Eden W, Van Rhijn I.

Mol Immunol. 2009 Apr;46(7):1424-31. doi: 10.1016/j.molimm.2008.12.009. Epub 2009 Jan 30.

46.

Subpopulations of bovine WC1(+) gammadelta T cells rather than CD4(+)CD25(high) Foxp3(+) T cells act as immune regulatory cells ex vivo.

Hoek A, Rutten VP, Kool J, Arkesteijn GJ, Bouwstra RJ, Van Rhijn I, Koets AP.

Vet Res. 2009 Jan-Feb;40(1):6. doi: 10.1051/vetres:2008044. Epub 2008 Oct 18.

47.

Bovine tuberculosis as a model for human tuberculosis: advantages over small animal models.

Van Rhijn I, Godfroid J, Michel A, Rutten V.

Microbes Infect. 2008 Jun;10(7):711-5. doi: 10.1016/j.micinf.2008.04.005. Epub 2008 Apr 22. Review.

PMID:
18538612
48.

Two canine CD1a proteins are differentially expressed in skin.

Looringh van Beeck FA, Zajonc DM, Moore PF, Schlotter YM, Broere F, Rutten VP, Willemse T, Van Rhijn I.

Immunogenetics. 2008 Jun;60(6):315-24. doi: 10.1007/s00251-008-0297-z. Epub 2008 May 17.

49.

Highly diverse TCR delta chain repertoire in bovine tissues due to the use of up to four D segments per delta chain.

Van Rhijn I, Spiering R, Smits M, van Blokland MT, de Weger R, van Eden W, Rutten VP, Koets AP.

Mol Immunol. 2007 May;44(12):3155-61. Epub 2007 Apr 6.

PMID:
17418895
50.

Massive, sustained γδ T cell migration from the bovine skin in vivo.

Van Rhijn I, Rutten VPMG, Charleston B, Smits M, van Eden W, Koets AP.

J Leukoc Biol. 2007 Apr;81(4):968-973. doi: 10.1189/jlb.0506331.

PMID:
29350847

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