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Metabolic and Stress Response Changes Precede Disease Onset in the Spinal Cord of Mutant SOD1 ALS Mice.

Pharaoh G, Sataranatarajan K, Street K, Hill S, Gregston J, Ahn B, Kinter C, Kinter M, Van Remmen H.

Front Neurosci. 2019 May 31;13:487. doi: 10.3389/fnins.2019.00487. eCollection 2019.


Mitochondrial oxidative stress impairs contractile function but paradoxically increases muscle mass via fibre branching.

Ahn B, Ranjit R, Premkumar P, Pharaoh G, Piekarz KM, Matsuzaki S, Claflin DR, Riddle K, Judge J, Bhaskaran S, Satara Natarajan K, Barboza E, Wronowski B, Kinter M, Humphries KM, Griffin TM, Freeman WM, Richardson A, Brooks SV, Van Remmen H.

J Cachexia Sarcopenia Muscle. 2019 Apr;10(2):411-428. doi: 10.1002/jcsm.12375. Epub 2019 Feb 1.


Accelerated sarcopenia in Cu/Zn superoxide dismutase knockout mice.

Deepa SS, Van Remmen H, Brooks SV, Faulkner JA, Larkin L, McArdle A, Jackson MJ, Vasilaki A, Richardson A.

Free Radic Biol Med. 2019 Feb 20;132:19-23. doi: 10.1016/j.freeradbiomed.2018.06.032. Epub 2018 Jul 2. Review.


Continuous overexpression of thioredoxin 1 enhances cancer development and does not extend maximum lifespan in male C57BL/6 mice.

Flores LC, Roman MG, Cunningham GM, Cheng C, Dube S, Allen C, Van Remmen H, Hubbard GB, Saunders TL, Ikeno Y.

Pathobiol Aging Age Relat Dis. 2018 Oct 23;8(1):1533754. doi: 10.1080/20010001.2018.1533754. eCollection 2018.


Protein imbalance in the development of skeletal muscle wasting in tumour-bearing mice.

Brown JL, Lee DE, Rosa-Caldwell ME, Brown LA, Perry RA, Haynie WS, Huseman K, Sataranatarajan K, Van Remmen H, Washington TA, Wiggs MP, Greene NP.

J Cachexia Sarcopenia Muscle. 2018 Oct;9(5):987-1002. doi: 10.1002/jcsm.12354. Epub 2018 Oct 16. Erratum in: J Cachexia Sarcopenia Muscle. 2019 Jun;10(3):712.


Restoration of SERCA ATPase prevents oxidative stress-related muscle atrophy and weakness.

Qaisar R, Bhaskaran S, Ranjit R, Sataranatarajan K, Premkumar P, Huseman K, Van Remmen H.

Redox Biol. 2019 Jan;20:68-74. doi: 10.1016/j.redox.2018.09.018. Epub 2018 Sep 27.


Oxidative stress-induced dysregulation of excitation-contraction coupling contributes to muscle weakness.

Qaisar R, Bhaskaran S, Premkumar P, Ranjit R, Natarajan KS, Ahn B, Riddle K, Claflin DR, Richardson A, Brooks SV, Van Remmen H.

J Cachexia Sarcopenia Muscle. 2018 Oct;9(5):1003-1017. doi: 10.1002/jcsm.12339. Epub 2018 Aug 2.


G protein-coupled estrogen receptor (GPER) deficiency induces cardiac remodeling through oxidative stress.

Wang H, Sun X, Lin MS, Ferrario CM, Van Remmen H, Groban L.

Transl Res. 2018 Sep;199:39-51. doi: 10.1016/j.trsl.2018.04.005. Epub 2018 Apr 25.


Lifelong reduction in complex IV induces tissue-specific metabolic effects but does not reduce lifespan or healthspan in mice.

Deepa SS, Pharaoh G, Kinter M, Diaz V, Fok WC, Riddle K, Pulliam D, Hill S, Fischer KE, Soto V, Georgescu C, Wren JD, Viscomi C, Richardson A, Van Remmen H.

Aging Cell. 2018 Aug;17(4):e12769. doi: 10.1111/acel.12769. Epub 2018 Apr 25.


Nrf2 deficiency exacerbates age-related contractile dysfunction and loss of skeletal muscle mass.

Ahn B, Pharaoh G, Premkumar P, Huseman K, Ranjit R, Kinter M, Szweda L, Kiss T, Fulop G, Tarantini S, Csiszar A, Ungvari Z, Van Remmen H.

Redox Biol. 2018 Jul;17:47-58. doi: 10.1016/j.redox.2018.04.004. Epub 2018 Apr 6. No abstract available.


Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-β uptake in astrocytes.

Logan S, Pharaoh GA, Marlin MC, Masser DR, Matsuzaki S, Wronowski B, Yeganeh A, Parks EE, Premkumar P, Farley JA, Owen DB, Humphries KM, Kinter M, Freeman WM, Szweda LI, Van Remmen H, Sonntag WE.

Mol Metab. 2018 Mar;9:141-155. doi: 10.1016/j.molmet.2018.01.013. Epub 2018 Feb 2.


Comparison of Whole Body SOD1 Knockout with Muscle-Specific SOD1 Knockout Mice Reveals a Role for Nerve Redox Signaling in Regulation of Degenerative Pathways in Skeletal Muscle.

Sakellariou GK, McDonagh B, Porter H, Giakoumaki II, Earl KE, Nye GA, Vasilaki A, Brooks SV, Richardson A, Van Remmen H, McArdle A, Jackson MJ.

Antioxid Redox Signal. 2018 Feb 1;28(4):275-295. doi: 10.1089/ars.2017.7249. Epub 2017 Dec 12.


Role of nerve-muscle interactions and reactive oxygen species in regulation of muscle proteostasis with ageing.

Vasilaki A, Richardson A, Van Remmen H, Brooks SV, Larkin L, McArdle A, Jackson MJ.

J Physiol. 2017 Oct 15;595(20):6409-6415. doi: 10.1113/JP274336. Epub 2017 Sep 10. Review.


Sustained NFκB inhibition improves insulin sensitivity but is detrimental to muscle health.

Zhang N, Valentine JM, Zhou Y, Li ME, Zhang Y, Bhattacharya A, Walsh ME, Fischer KE, Austad SN, Osmulski P, Gaczynska M, Shoelson SE, Van Remmen H, Chen HI, Chen Y, Liang H, Musi N.

Aging Cell. 2017 Aug;16(4):847-858. doi: 10.1111/acel.12613. Epub 2017 May 29.


Sco2 deficient mice develop increased adiposity and insulin resistance.

Hill S, Deepa SS, Sataranatarajan K, Premkumar P, Pulliam D, Liu Y, Soto VY, Fischer KE, Van Remmen H.

Mol Cell Endocrinol. 2017 Nov 5;455:103-114. doi: 10.1016/j.mce.2017.03.019. Epub 2017 Apr 18.


A new mouse model of frailty: the Cu/Zn superoxide dismutase knockout mouse.

Deepa SS, Bhaskaran S, Espinoza S, Brooks SV, McArdle A, Jackson MJ, Van Remmen H, Richardson A.

Geroscience. 2017 Apr;39(2):187-198. doi: 10.1007/s11357-017-9975-9. Epub 2017 Apr 13.


Emerging roles for histone deacetylases in age-related muscle atrophy.

Walsh ME, Van Remmen H.

Nutr Healthy Aging. 2016 Oct 27;4(1):17-30. doi: 10.3233/NHA-160005. Review.


A new role for oxidative stress in aging: The accelerated aging phenotype in Sod1-/- mice is correlated to increased cellular senescence.

Zhang Y, Unnikrishnan A, Deepa SS, Liu Y, Li Y, Ikeno Y, Sosnowska D, Van Remmen H, Richardson A.

Redox Biol. 2017 Apr;11:30-37. doi: 10.1016/j.redox.2016.10.014. Epub 2016 Nov 2.


Enhanced GLUT4-Dependent Glucose Transport Relieves Nutrient Stress in Obese Mice Through Changes in Lipid and Amino Acid Metabolism.

Gurley JM, Ilkayeva O, Jackson RM, Griesel BA, White P, Matsuzaki S, Qaisar R, Van Remmen H, Humphries KM, Newgard CB, Olson AL.

Diabetes. 2016 Dec;65(12):3585-3597. Epub 2016 Sep 27.


Loss of the antioxidant enzyme CuZnSOD (Sod1) mimics an age-related increase in absolute mitochondrial DNA copy number in the skeletal muscle.

Masser DR, Clark NW, Van Remmen H, Freeman WM.

Age (Dordr). 2016 Aug;38(4):323-333. doi: 10.1007/s11357-016-9930-1. Epub 2016 Jul 21.


Ablation of the mitochondrial complex IV assembly protein Surf1 leads to increased expression of the UPR(MT) and increased resistance to oxidative stress in primary cultures of fibroblasts.

Pharaoh G, Pulliam D, Hill S, Sataranatarajan K, Van Remmen H.

Redox Biol. 2016 Aug;8:430-8. doi: 10.1016/j.redox.2016.05.001. Epub 2016 May 9.


Reactive Oxygen Species Differentially Regulate Bone Turnover in an Age-Specific Manner in Catalase Transgenic Female Mice.

Alund AW, Mercer KE, Suva LJ, Pulliam CF, Chen JR, Badger TM, Van Remmen H, Ronis MJ.

J Pharmacol Exp Ther. 2016 Jul;358(1):50-60. doi: 10.1124/jpet.116.233213. Epub 2016 May 12.


Moderate modulation of disease in the G93A model of ALS by the compound 2-(2-hydroxyphenyl)-benzoxazole (HBX).

Evans TM, Bhattacharya A, Shi Y, Qi W, Block TJ, Chaudhuri A, Chaudhuri AR, Hawker K, Van Remmen H.

Neurosci Lett. 2016 Jun 15;624:1-7. doi: 10.1016/j.neulet.2016.04.035. Epub 2016 Apr 29.


Muscle fiber type diversification during exercise and regeneration.

Qaisar R, Bhaskaran S, Van Remmen H.

Free Radic Biol Med. 2016 Sep;98:56-67. doi: 10.1016/j.freeradbiomed.2016.03.025. Epub 2016 Mar 29. Review.


Liver specific expression of Cu/ZnSOD extends the lifespan of Sod1 null mice.

Zhang Y, Liu Y, Walsh M, Bokov A, Ikeno Y, Jang YC, Perez VI, Van Remmen H, Richardson A.

Mech Ageing Dev. 2016 Mar;154:1-8. doi: 10.1016/j.mad.2016.01.005. Epub 2016 Feb 1.


Down-regulation of the mitochondrial matrix peptidase ClpP in muscle cells causes mitochondrial dysfunction and decreases cell proliferation.

Deepa SS, Bhaskaran S, Ranjit R, Qaisar R, Nair BC, Liu Y, Walsh ME, Fok WC, Van Remmen H.

Free Radic Biol Med. 2016 Feb;91:281-92. doi: 10.1016/j.freeradbiomed.2015.12.021. Epub 2015 Dec 23.


The histone deacetylase inhibitor butyrate improves metabolism and reduces muscle atrophy during aging.

Walsh ME, Bhattacharya A, Sataranatarajan K, Qaisar R, Sloane L, Rahman MM, Kinter M, Van Remmen H.

Aging Cell. 2015 Dec;14(6):957-70. doi: 10.1111/acel.12387. Epub 2015 Aug 20.


Metabolic Damage and Premature Thymus Aging Caused by Stromal Catalase Deficiency.

Griffith AV, Venables T, Shi J, Farr A, van Remmen H, Szweda L, Fallahi M, Rabinovitch P, Petrie HT.

Cell Rep. 2015 Aug 18;12(7):1071-9. doi: 10.1016/j.celrep.2015.07.008. Epub 2015 Aug 6.


Microwave & Magnetic (M2) Proteomics of a Mouse Model of Mild Traumatic Brain Injury.

Evans TM, Van Remmen H, Purkar A, Mahesula S, Gelfond JA, Sabia M, Qi W, Lin AL, Jaramillo CA, Haskins WE.

Transl Proteom. 2014 Jun 1;3:10-21.


The effect of mild traumatic brain injury on peripheral nervous system pathology in wild-type mice and the G93A mutant mouse model of motor neuron disease.

Evans TM, Jaramillo CA, Sataranatarajan K, Watts L, Sabia M, Qi W, Van Remmen H.

Neuroscience. 2015 Jul 9;298:410-23. doi: 10.1016/j.neuroscience.2015.04.041. Epub 2015 Apr 25.


Neuron specific reduction in CuZnSOD is not sufficient to initiate a full sarcopenia phenotype.

Sataranatarajan K, Qaisar R, Davis C, Sakellariou GK, Vasilaki A, Zhang Y, Liu Y, Bhaskaran S, McArdle A, Jackson M, Brooks SV, Richardson A, Van Remmen H.

Redox Biol. 2015 Aug;5:140-148. doi: 10.1016/j.redox.2015.04.005. Epub 2015 Apr 15.


Sod1 gene ablation in adult mice leads to physiological changes at the neuromuscular junction similar to changes that occur in old wild-type mice.

Ivannikov MV, Van Remmen H.

Free Radic Biol Med. 2015 Jul;84:254-262. doi: 10.1016/j.freeradbiomed.2015.03.021. Epub 2015 Apr 2.


Butyrate prevents muscle atrophy after sciatic nerve crush.

Walsh ME, Bhattacharya A, Liu Y, Van Remmen H.

Muscle Nerve. 2015 Nov;52(5):859-68. doi: 10.1002/mus.24622. Epub 2015 Jun 3.


Reduced expression of MYC increases longevity and enhances healthspan.

Hofmann JW, Zhao X, De Cecco M, Peterson AL, Pagliaroli L, Manivannan J, Hubbard GB, Ikeno Y, Zhang Y, Feng B, Li X, Serre T, Qi W, Van Remmen H, Miller RA, Bath KG, de Cabo R, Xu H, Neretti N, Sedivy JM.

Cell. 2015 Jan 29;160(3):477-88. doi: 10.1016/j.cell.2014.12.016. Epub 2015 Jan 22.


Use of Nerve Conduction Velocity to Assess Peripheral Nerve Health in Aging Mice.

Walsh ME, Sloane LB, Fischer KE, Austad SN, Richardson A, Van Remmen H.

J Gerontol A Biol Sci Med Sci. 2015 Nov;70(11):1312-9. doi: 10.1093/gerona/glu208. Epub 2014 Dec 3.


Skeletal muscle mitochondrial DNA deletions are not increased in CuZn-superoxide dismutase deficient mice.

Wanagat J, Ahmadieh N, Bielas JH, Ericson NG, Van Remmen H.

Exp Gerontol. 2015 Jan;61:15-9. doi: 10.1016/j.exger.2014.11.012. Epub 2014 Nov 20.


Mitochondrial stress signaling in longevity: a new role for mitochondrial function in aging.

Hill S, Van Remmen H.

Redox Biol. 2014 Jul 27;2:936-44. doi: 10.1016/j.redox.2014.07.005. eCollection 2014. Review.


MnSOD overexpression reduces fibrosis and pro-apoptotic signaling in the aging mouse heart.

Kwak HB, Lee Y, Kim JH, Van Remmen H, Richardson AG, Lawler JM.

J Gerontol A Biol Sci Med Sci. 2015 May;70(5):533-44. doi: 10.1093/gerona/glu090. Epub 2014 Jul 11.


The lack of CuZnSOD leads to impaired neurotransmitter release, neuromuscular junction destabilization and reduced muscle strength in mice.

Shi Y, Ivannikov MV, Walsh ME, Liu Y, Zhang Y, Jaramillo CA, Macleod GT, Van Remmen H.

PLoS One. 2014 Jun 27;9(6):e100834. doi: 10.1371/journal.pone.0100834. eCollection 2014.


Complex IV-deficient Surf1(-/-) mice initiate mitochondrial stress responses.

Pulliam DA, Deepa SS, Liu Y, Hill S, Lin AL, Bhattacharya A, Shi Y, Sloane L, Viscomi C, Zeviani M, Van Remmen H.

Biochem J. 2014 Sep 1;462(2):359-71. doi: 10.1042/BJ20140291.


Neuron-specific expression of CuZnSOD prevents the loss of muscle mass and function that occurs in homozygous CuZnSOD-knockout mice.

Sakellariou GK, Davis CS, Shi Y, Ivannikov MV, Zhang Y, Vasilaki A, Macleod GT, Richardson A, Van Remmen H, Jackson MJ, McArdle A, Brooks SV.

FASEB J. 2014 Apr;28(4):1666-81. doi: 10.1096/fj.13-240390. Epub 2013 Dec 30.


Effect of oxygen tension on bioenergetics and proteostasis in young and old myoblast precursor cells.

Konigsberg M, Pérez VI, Ríos C, Liu Y, Lee S, Shi Y, Van Remmen H.

Redox Biol. 2013 Sep 27;1:475-82. doi: 10.1016/j.redox.2013.09.004. eCollection 2013.


Genetic ablation of 12/15-lipoxygenase but not 5-lipoxygenase protects against denervation-induced muscle atrophy.

Bhattacharya A, Hamilton R, Jernigan A, Zhang Y, Sabia M, Rahman MM, Li Y, Wei R, Chaudhuri A, Van Remmen H.

Free Radic Biol Med. 2014 Feb;67:30-40. doi: 10.1016/j.freeradbiomed.2013.10.002. Epub 2013 Oct 8.


Rapamycin Modulates Markers of Mitochondrial Biogenesis and Fatty Acid Oxidation in the Adipose Tissue of db/db Mice.

Deepa SS, Walsh ME, Hamilton RT, Pulliam D, Shi Y, Hill S, Li Y, Van Remmen H.

J Biochem Pharmacol Res. 2013 Jun;1(2):114-123.


Genetic disruption of SOD1 gene causes glucose intolerance and impairs β-cell function.

Muscogiuri G, Salmon AB, Aguayo-Mazzucato C, Li M, Balas B, Guardado-Mendoza R, Giaccari A, Reddick RL, Reyna SM, Weir G, Defronzo RA, Van Remmen H, Musi N.

Diabetes. 2013 Dec;62(12):4201-7. doi: 10.2337/db13-0314. Epub 2013 Sep 5.


Oxidative damage associated with obesity is prevented by overexpression of CuZn- or Mn-superoxide dismutase.

Liu Y, Qi W, Richardson A, Van Remmen H, Ikeno Y, Salmon AB.

Biochem Biophys Res Commun. 2013 Aug 16;438(1):78-83. doi: 10.1016/j.bbrc.2013.07.029. Epub 2013 Jul 18.


Decreased in vitro mitochondrial function is associated with enhanced brain metabolism, blood flow, and memory in Surf1-deficient mice.

Lin AL, Pulliam DA, Deepa SS, Halloran JJ, Hussong SA, Burbank RR, Bresnen A, Liu Y, Podlutskaya N, Soundararajan A, Muir E, Duong TQ, Bokov AF, Viscomi C, Zeviani M, Richardson AG, Van Remmen H, Fox PT, Galvan V.

J Cereb Blood Flow Metab. 2013 Oct;33(10):1605-11. doi: 10.1038/jcbfm.2013.116. Epub 2013 Jul 10.


Reduced mammalian target of rapamycin activity facilitates mitochondrial retrograde signaling and increases life span in normal human fibroblasts.

Lerner C, Bitto A, Pulliam D, Nacarelli T, Konigsberg M, Van Remmen H, Torres C, Sell C.

Aging Cell. 2013 Dec;12(6):966-77. doi: 10.1111/acel.12122. Epub 2013 Jul 30.


Elevated protein carbonylation, and misfolding in sciatic nerve from db/db and Sod1(-/-) mice: plausible link between oxidative stress and demyelination.

Hamilton RT, Bhattacharya A, Walsh ME, Shi Y, Wei R, Zhang Y, Rodriguez KA, Buffenstein R, Chaudhuri AR, Van Remmen H.

PLoS One. 2013 Jun 4;8(6):e65725. doi: 10.1371/journal.pone.0065725. Print 2013.


The effects of dietary restriction on oxidative stress in rodents.

Walsh ME, Shi Y, Van Remmen H.

Free Radic Biol Med. 2014 Jan;66:88-99. doi: 10.1016/j.freeradbiomed.2013.05.037. Epub 2013 Jun 4. Review.

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