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Items: 1 to 50 of 78

1.

Slaying a giant: Structures of calmodulin and protein kinase a bound to the cardiac ryanodine receptor.

Van Petegem F.

Cell Calcium. 2019 Sep 6;83:102079. doi: 10.1016/j.ceca.2019.102079. [Epub ahead of print]

PMID:
31522075
2.

Binding and structural asymmetry governs ligand sensitivity in a cyclic nucleotide-gated ion channel.

Ng LCT, Zhuang M, Van Petegem F, Li YX, Accili EA.

J Gen Physiol. 2019 Sep 3. pii: jgp.201812162. doi: 10.1085/jgp.201812162. [Epub ahead of print]

PMID:
31481514
3.

Type 8 long QT syndrome: pathogenic variants in CACNA1C-encoded Cav1.2 cluster in STAC protein binding site.

Mellor GJ, Panwar P, Lee AK, Steinberg C, Hathaway JA, Bartels K, Christian S, Balaji S, Roberts JD, Simpson CS, Boczek NJ, Tester DJ, Radbill AE, Mok NS, Hamilton RM, Kaufman ES, Eugenio PL, Weiss R, January C, McDaniel GM, Leather RA, Erickson C, Falik S, Behr ER, Wilde AAM, Sanatani S, Ackerman MJ, Van Petegem F, Krahn AD, Laksman Z.

Europace. 2019 Aug 13. pii: euz215. doi: 10.1093/europace/euz215. [Epub ahead of print]

PMID:
31408100
4.

The Cardiac Ryanodine Receptor Phosphorylation Hotspot Embraces PKA in a Phosphorylation-Dependent Manner.

Haji-Ghassemi O, Yuchi Z, Van Petegem F.

Mol Cell. 2019 Jul 11;75(1):39-52.e4. doi: 10.1016/j.molcel.2019.04.019. Epub 2019 May 8.

PMID:
31078384
5.

Crystal structures of Ca2+-calmodulin bound to NaV C-terminal regions suggest role for EF-hand domain in binding and inactivation.

Gardill BR, Rivera-Acevedo RE, Tung CC, Van Petegem F.

Proc Natl Acad Sci U S A. 2019 May 28;116(22):10763-10772. doi: 10.1073/pnas.1818618116. Epub 2019 May 9.

PMID:
31072926
6.

Surface glycan-binding proteins are essential for cereal beta-glucan utilization by the human gut symbiont Bacteroides ovatus.

Tamura K, Foley MH, Gardill BR, Dejean G, Schnizlein M, Bahr CME, Louise Creagh A, van Petegem F, Koropatkin NM, Brumer H.

Cell Mol Life Sci. 2019 May 6. doi: 10.1007/s00018-019-03115-3. [Epub ahead of print]

PMID:
31062073
7.

In vitro analyses of suspected arrhythmogenic thin filament variants as a cause of sudden cardiac death in infants.

Shafaattalab S, Li AY, Lin E, Stevens CM, Dewar LJ, Lynn FC, Sanatani S, Laksman Z, Morin RD, van Petegem F, Hove-Madsen L, Tieleman DP, Davis JP, Tibbits GF.

Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):6969-6974. doi: 10.1073/pnas.1819023116. Epub 2019 Mar 18.

PMID:
30886088
8.

Cardiac hypertrophy and arrhythmia in mice induced by a mutation in ryanodine receptor 2.

Alvarado FJ, Bos JM, Yuchi Z, Valdivia CR, Hernández JJ, Zhao YT, Henderlong DS, Chen Y, Booher TR, Marcou CA, Van Petegem F, Ackerman MJ, Valdivia HH.

JCI Insight. 2019 Mar 5;5. pii: 126544. doi: 10.1172/jci.insight.126544.

9.

Subtle Changes in the Combining Site of the Chlamydiaceae-Specific mAb S25-23 Increase the Antibody-Carbohydrate Binding Affinity by an Order of Magnitude.

Haji-Ghassemi O, Müller-Loennies S, Brooks CL, MacKenzie CR, Caveney N, Van Petegem F, Brade L, Kosma P, Brade H, Evans SV.

Biochemistry. 2019 Feb 12;58(6):714-726. doi: 10.1021/acs.biochem.8b00318. Epub 2019 Jan 10.

PMID:
30571096
10.

Ca2+-dependent calmodulin binding to cardiac ryanodine receptor (RyR2) calmodulin-binding domains.

Brohus M, Søndergaard MT, Wayne Chen SR, van Petegem F, Overgaard MT.

Biochem J. 2019 Jan 18;476(2):193-209. doi: 10.1042/BCJ20180545.

11.

Catecholaminergic polymorphic ventricular tachycardia patients with multiple genetic variants in the PACES CPVT Registry.

Roston TM, Haji-Ghassemi O, LaPage MJ, Batra AS, Bar-Cohen Y, Anderson C, Lau YR, Maginot K, Gebauer RA, Etheridge SP, Potts JE, Van Petegem F, Sanatani S.

PLoS One. 2018 Nov 7;13(11):e0205925. doi: 10.1371/journal.pone.0205925. eCollection 2018.

12.

Arrhythmia mutations in calmodulin cause conformational changes that affect interactions with the cardiac voltage-gated calcium channel.

Wang K, Holt C, Lu J, Brohus M, Larsen KT, Overgaard MT, Wimmer R, Van Petegem F.

Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10556-E10565. doi: 10.1073/pnas.1808733115. Epub 2018 Oct 22.

13.

Calcium Channelopathies: Structural Insights into Disorders of the Muscle Excitation-Contraction Complex.

Pancaroglu R, Van Petegem F.

Annu Rev Genet. 2018 Nov 23;52:373-396. doi: 10.1146/annurev-genet-120417-031311. Epub 2018 Sep 12.

PMID:
30208288
14.

The voltage-gated sodium channel EF-hands form an interaction with the III-IV linker that is disturbed by disease-causing mutations.

Gardill BR, Rivera-Acevedo RE, Tung CC, Okon M, McIntosh LP, Van Petegem F.

Sci Rep. 2018 Mar 14;8(1):4483. doi: 10.1038/s41598-018-22713-y.

15.

STAC proteins associate to the IQ domain of CaV1.2 and inhibit calcium-dependent inactivation.

Campiglio M, Costé de Bagneaux P, Ortner NJ, Tuluc P, Van Petegem F, Flucher BE.

Proc Natl Acad Sci U S A. 2018 Feb 6;115(6):1376-1381. doi: 10.1073/pnas.1715997115. Epub 2018 Jan 23.

16.

Structural insights into binding of STAC proteins to voltage-gated calcium channels.

Wong King Yuen SM, Campiglio M, Tung CC, Flucher BE, Van Petegem F.

Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):E9520-E9528. doi: 10.1073/pnas.1708852114. Epub 2017 Oct 23.

17.

CPVT-associated cardiac ryanodine receptor mutation G357S with reduced penetrance impairs Ca2+ release termination and diminishes protein expression.

Liu Y, Wei J, Wong King Yuen SM, Sun B, Tang Y, Wang R, Van Petegem F, Chen SRW.

PLoS One. 2017 Sep 29;12(9):e0184177. doi: 10.1371/journal.pone.0184177. eCollection 2017.

18.

The clinical and genetic spectrum of catecholaminergic polymorphic ventricular tachycardia: findings from an international multicentre registry.

Roston TM, Yuchi Z, Kannankeril PJ, Hathaway J, Vinocur JM, Etheridge SP, Potts JE, Maginot KR, Salerno JC, Cohen MI, Hamilton RM, Pflaumer A, Mohammed S, Kimlicka L, Kanter RJ, LaPage MJ, Collins KK, Gebauer RA, Temple JD, Batra AS, Erickson C, Miszczak-Knecht M, Kubuš P, Bar-Cohen Y, Kantoch M, Thomas VC, Hessling G, Anderson C, Young ML, Choi SHJ, Cabrera Ortega M, Lau YR, Johnsrude CL, Fournier A, Van Petegem F, Sanatani S.

Europace. 2018 Mar 1;20(3):541-547. doi: 10.1093/europace/euw389.

19.

The Arrhythmogenic Calmodulin p.Phe142Leu Mutation Impairs C-domain Ca2+ Binding but Not Calmodulin-dependent Inhibition of the Cardiac Ryanodine Receptor.

Søndergaard MT, Liu Y, Larsen KT, Nani A, Tian X, Holt C, Wang R, Wimmer R, Van Petegem F, Fill M, Chen SR, Overgaard MT.

J Biol Chem. 2017 Jan 27;292(4):1385-1395. doi: 10.1074/jbc.M116.766253. Epub 2016 Dec 7.

20.

Ligand binding to Ryanodine Receptors revealed through cryo-electron microscopy.

Van Petegem F.

Cell Calcium. 2017 Jan;61:50-52. doi: 10.1016/j.ceca.2016.10.004. Epub 2016 Nov 4. No abstract available.

PMID:
27865558
21.

Catecholaminergic polymorphic ventricular tachycardia: a model for genotype-specific therapy.

Roston TM, Van Petegem F, Sanatani S.

Curr Opin Cardiol. 2017 Jan;32(1):78-85. Review.

PMID:
27861184
22.

Crystallographic insight into the evolutionary origins of xyloglucan endotransglycosylases and endohydrolases.

McGregor N, Yin V, Tung CC, Van Petegem F, Brumer H.

Plant J. 2017 Feb;89(4):651-670. doi: 10.1111/tpj.13421. Epub 2017 Feb 11.

23.

A novel RYR2 loss-of-function mutation (I4855M) is associated with left ventricular non-compaction and atypical catecholaminergic polymorphic ventricular tachycardia.

Roston TM, Guo W, Krahn AD, Wang R, Van Petegem F, Sanatani S, Chen SR, Lehman A.

J Electrocardiol. 2017 Mar - Apr;50(2):227-233. doi: 10.1016/j.jelectrocard.2016.09.006. Epub 2016 Sep 8.

PMID:
27646203
24.

How to open a Ryanodine Receptor.

Van Petegem F.

Cell Res. 2016 Oct;26(10):1073-1074. doi: 10.1038/cr.2016.106. Epub 2016 Sep 9.

25.

Cyclic Purine and Pyrimidine Nucleotides Bind to the HCN2 Ion Channel and Variably Promote C-Terminal Domain Interactions and Opening.

Ng LCT, Putrenko I, Baronas V, Van Petegem F, Accili EA.

Structure. 2016 Oct 4;24(10):1629-1642. doi: 10.1016/j.str.2016.06.024. Epub 2016 Aug 25.

26.

Characterization of Zebrafish Cardiac and Slow Skeletal Troponin C Paralogs by MD Simulation and ITC.

Stevens CM, Rayani K, Genge CE, Singh G, Liang B, Roller JM, Li C, Li AY, Tieleman DP, van Petegem F, Tibbits GF.

Biophys J. 2016 Jul 12;111(1):38-49. doi: 10.1016/j.bpj.2016.05.029.

27.

Ryanodine receptors under the magnifying lens: Insights and limitations of cryo-electron microscopy and X-ray crystallography studies.

Yuchi Z, Van Petegem F.

Cell Calcium. 2016 May;59(5):209-27. doi: 10.1016/j.ceca.2016.04.003. Epub 2016 Apr 12. Review.

PMID:
27103405
28.

Defining the stoichiometry of inositol 1,4,5-trisphosphate binding required to initiate Ca2+ release.

Alzayady KJ, Wang L, Chandrasekhar R, Wagner LE 2nd, Van Petegem F, Yule DI.

Sci Signal. 2016 Apr 5;9(422):ra35. doi: 10.1126/scisignal.aad6281.

29.

Identification of Avian Corticosteroid-binding Globulin (SerpinA6) Reveals the Molecular Basis of Evolutionary Adaptations in SerpinA6 Structure and Function as a Steroid-binding Protein.

Vashchenko G, Das S, Moon KM, Rogalski JC, Taves MD, Soma KK, Van Petegem F, Foster LJ, Hammond GL.

J Biol Chem. 2016 May 20;291(21):11300-12. doi: 10.1074/jbc.M116.714378. Epub 2016 Mar 29.

30.

Binary architecture of the Nav1.2-β2 signaling complex.

Das S, Gilchrist J, Bosmans F, Van Petegem F.

Elife. 2016 Feb 19;5. pii: e10960. doi: 10.7554/eLife.10960.

31.

The H29D Mutation Does Not Enhance Cytosolic Ca2+ Activation of the Cardiac Ryanodine Receptor.

Xiao Z, Guo W, Yuen SM, Wang R, Zhang L, Van Petegem F, Chen SR.

PLoS One. 2015 Sep 25;10(9):e0139058. doi: 10.1371/journal.pone.0139058. eCollection 2015.

32.

Paramagnetic Ligand Tagging To Identify Protein Binding Sites.

Brath U, Swamy SI, Veiga AX, Tung CC, Van Petegem F, Erdélyi M.

J Am Chem Soc. 2015 Sep 9;137(35):11391-8. doi: 10.1021/jacs.5b06220. Epub 2015 Aug 27.

33.

Crystal structures of ryanodine receptor SPRY1 and tandem-repeat domains reveal a critical FKBP12 binding determinant.

Yuchi Z, Yuen SM, Lau K, Underhill AQ, Cornea RL, Fessenden JD, Van Petegem F.

Nat Commun. 2015 Aug 6;6:7947. doi: 10.1038/ncomms8947.

34.

Roles of the NH2-terminal domains of cardiac ryanodine receptor in Ca2+ release activation and termination.

Liu Y, Sun B, Xiao Z, Wang R, Guo W, Zhang JZ, Mi T, Wang Y, Jones PP, Van Petegem F, Chen SR.

J Biol Chem. 2015 Mar 20;290(12):7736-46. doi: 10.1074/jbc.M114.618827. Epub 2015 Jan 27.

35.

Mapping the sevoflurane-binding sites of calmodulin.

Brath U, Lau K, Van Petegem F, Erdélyi M.

Pharmacol Res Perspect. 2014 Feb;2(1):5. doi: 10.1002/prp2.25. Epub 2014 Feb 12.

36.

Crystal structures of wild type and disease mutant forms of the ryanodine receptor SPRY2 domain.

Lau K, Van Petegem F.

Nat Commun. 2014 Nov 5;5:5397. doi: 10.1038/ncomms6397.

PMID:
25370123
37.

Ryanodine receptors: allosteric ion channel giants.

Van Petegem F.

J Mol Biol. 2015 Jan 16;427(1):31-53. doi: 10.1016/j.jmb.2014.08.004. Epub 2014 Aug 15. Review.

PMID:
25134758
38.

Deciphering the binding of caveolin-1 to client protein endothelial nitric-oxide synthase (eNOS): scaffolding subdomain identification, interaction modeling, and biological significance.

Trane AE, Pavlov D, Sharma A, Saqib U, Lau K, van Petegem F, Minshall RD, Roman LJ, Bernatchez PN.

J Biol Chem. 2014 May 9;289(19):13273-83. doi: 10.1074/jbc.M113.528695. Epub 2014 Mar 19.

39.

Lobe-specific calmodulin binding to different ryanodine receptor isoforms.

Lau K, Chan MM, Van Petegem F.

Biochemistry. 2014 Feb 11;53(5):932-46. doi: 10.1021/bi401502x. Epub 2014 Jan 30.

PMID:
24447242
40.

Crystallographic insights into sodium-channel modulation by the β4 subunit.

Gilchrist J, Das S, Van Petegem F, Bosmans F.

Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):E5016-24. doi: 10.1073/pnas.1314557110. Epub 2013 Dec 2.

41.

Conformational dynamics inside amino-terminal disease hotspot of ryanodine receptor.

Zhong X, Liu Y, Zhu L, Meng X, Wang R, Van Petegem F, Wagenknecht T, Chen SR, Liu Z.

Structure. 2013 Nov 5;21(11):2051-60. doi: 10.1016/j.str.2013.09.004. Epub 2013 Oct 17.

42.

Talin autoinhibition is required for morphogenesis.

Ellis SJ, Goult BT, Fairchild MJ, Harris NJ, Long J, Lobo P, Czerniecki S, Van Petegem F, Schöck F, Peifer M, Tanentzapf G.

Curr Biol. 2013 Sep 23;23(18):1825-33. doi: 10.1016/j.cub.2013.07.054. Epub 2013 Sep 5.

43.

Type 2 ryanodine receptor domain A contains a unique and dynamic α-helix that transitions to a β-strand in a mutant linked with a heritable cardiomyopathy.

Amador FJ, Kimlicka L, Stathopulos PB, Gasmi-Seabrook GM, Maclennan DH, Van Petegem F, Ikura M.

J Mol Biol. 2013 Nov 1;425(21):4034-46. doi: 10.1016/j.jmb.2013.08.015. Epub 2013 Aug 23.

PMID:
23978697
44.

The cardiac ryanodine receptor N-terminal region contains an anion binding site that is targeted by disease mutations.

Kimlicka L, Tung CC, Carlsson AC, Lobo PA, Yuchi Z, Van Petegem F.

Structure. 2013 Aug 6;21(8):1440-9. doi: 10.1016/j.str.2013.06.012. Epub 2013 Jul 18.

45.

The CPVT-associated RyR2 mutation G230C enhances store overload-induced Ca2+ release and destabilizes the N-terminal domains.

Liu Y, Kimlicka L, Hiess F, Tian X, Wang R, Zhang L, Jones PP, Van Petegem F, Chen SR.

Biochem J. 2013 Aug 15;454(1):123-31. doi: 10.1042/BJ20130594.

PMID:
23746327
46.

Disease mutations in the ryanodine receptor N-terminal region couple to a mobile intersubunit interface.

Kimlicka L, Lau K, Tung CC, Van Petegem F.

Nat Commun. 2013;4:1506. doi: 10.1038/ncomms2501.

47.

Seeing the forest through the trees: towards a unified view on physiological calcium regulation of voltage-gated sodium channels.

Van Petegem F, Lobo PA, Ahern CA.

Biophys J. 2012 Dec 5;103(11):2243-51. doi: 10.1016/j.bpj.2012.10.020. Review.

48.

Ryanodine receptors: structure and function.

Van Petegem F.

J Biol Chem. 2012 Sep 14;287(38):31624-32. doi: 10.1074/jbc.R112.349068. Epub 2012 Jul 20. Review.

49.

Disease mutations in the ryanodine receptor central region: crystal structures of a phosphorylation hot spot domain.

Yuchi Z, Lau K, Van Petegem F.

Structure. 2012 Jul 3;20(7):1201-11. doi: 10.1016/j.str.2012.04.015. Epub 2012 Jun 14.

50.

Molecular and structural characterization of the SH3 domain of AHI-1 in regulation of cellular resistance of BCR-ABL(+) chronic myeloid leukemia cells to tyrosine kinase inhibitors.

Liu X, Chen M, Lobo P, An J, Grace Cheng SW, Moradian A, Morin GB, Van Petegem F, Jiang X.

Proteomics. 2012 Jul;12(13):2094-106. doi: 10.1002/pmic.201100553.

PMID:
22623184

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