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Items: 20


Dusp3 deletion in mice promotes experimental lung tumour metastasis in a macrophage dependent manner.

Vandereyken M, Jacques S, Van Overmeire E, Amand M, Rocks N, Delierneux C, Singh P, Singh M, Ghuysen C, Wathieu C, Zurashvili T, Sounni NE, Moutschen M, Gilles C, Oury C, Cataldo D, Van Ginderachter JA, Rahmouni S.

PLoS One. 2017 Oct 11;12(10):e0185786. doi: 10.1371/journal.pone.0185786. eCollection 2017.


The tumour microenvironment harbours ontogenically distinct dendritic cell populations with opposing effects on tumour immunity.

Laoui D, Keirsse J, Morias Y, Van Overmeire E, Geeraerts X, Elkrim Y, Kiss M, Bolli E, Lahmar Q, Sichien D, Serneels J, Scott CL, Boon L, De Baetselier P, Mazzone M, Guilliams M, Van Ginderachter JA.

Nat Commun. 2016 Dec 23;7:13720. doi: 10.1038/ncomms13720.


M-CSF and GM-CSF Receptor Signaling Differentially Regulate Monocyte Maturation and Macrophage Polarization in the Tumor Microenvironment.

Van Overmeire E, Stijlemans B, Heymann F, Keirsse J, Morias Y, Elkrim Y, Brys L, Abels C, Lahmar Q, Ergen C, Vereecke L, Tacke F, De Baetselier P, Van Ginderachter JA, Laoui D.

Cancer Res. 2016 Jan 1;76(1):35-42. doi: 10.1158/0008-5472.CAN-15-0869. Epub 2015 Nov 16.


The timing of surgery after neoadjuvant radiotherapy influences tumor dissemination in a preclinical model.

Leroi N, Sounni NE, Van Overmeire E, Blacher S, Marée R, Van Ginderachter J, Lallemand F, Lenaerts E, Coucke P, Noel A, Martinive P.

Oncotarget. 2015 Nov 3;6(34):36825-37. doi: 10.18632/oncotarget.5931.


Tissue-resident versus monocyte-derived macrophages in the tumor microenvironment.

Lahmar Q, Keirsse J, Laoui D, Movahedi K, Van Overmeire E, Van Ginderachter JA.

Biochim Biophys Acta. 2016 Jan;1865(1):23-34. doi: 10.1016/j.bbcan.2015.06.009. Epub 2015 Jul 2. Review.


Ly6C- Monocytes Regulate Parasite-Induced Liver Inflammation by Inducing the Differentiation of Pathogenic Ly6C+ Monocytes into Macrophages.

Morias Y, Abels C, Laoui D, Van Overmeire E, Guilliams M, Schouppe E, Tacke F, deVries CJ, De Baetselier P, Beschin A.

PLoS Pathog. 2015 May 28;11(5):e1004873. doi: 10.1371/journal.ppat.1004873. eCollection 2015 May.


Estrogen Receptor α Regulates β-Cell Formation During Pancreas Development and Following Injury.

Yuchi Y, Cai Y, Legein B, De Groef S, Leuckx G, Coppens V, Van Overmeire E, Staels W, De Leu N, Martens G, Van Ginderachter JA, Heimberg H, Van de Casteele M.

Diabetes. 2015 Sep;64(9):3218-28. doi: 10.2337/db14-1798. Epub 2015 May 26.


Concise Review: Macrophages: Versatile Gatekeepers During Pancreatic β-Cell Development, Injury, and Regeneration.

Van Gassen N, Staels W, Van Overmeire E, De Groef S, Sojoodi M, Heremans Y, Leuckx G, Van de Casteele M, Van Ginderachter JA, Heimberg H, De Leu N.

Stem Cells Transl Med. 2015 Jun;4(6):555-63. doi: 10.5966/sctm.2014-0272. Epub 2015 Apr 6. Review.


Macrophage dynamics are regulated by local macrophage proliferation and monocyte recruitment in injured pancreas.

Van Gassen N, Van Overmeire E, Leuckx G, Heremans Y, De Groef S, Cai Y, Elkrim Y, Gysemans C, Stijlemans B, Van de Casteele M, De Baetselier P, De Leu N, Heimberg H, Van Ginderachter JA.

Eur J Immunol. 2015 May;45(5):1482-93. doi: 10.1002/eji.201445013. Epub 2015 Mar 19.


Targeting cell-intrinsic and cell-extrinsic mechanisms of intravasation in invasive breast cancer.

Keirsse J, Laoui D, Van Overmeire E, Van Ginderachter JA.

Sci Signal. 2014 Nov 25;7(353):pe28. doi: 10.1126/scisignal.aaa2104.


Functional Relationship between Tumor-Associated Macrophages and Macrophage Colony-Stimulating Factor as Contributors to Cancer Progression.

Laoui D, Van Overmeire E, De Baetselier P, Van Ginderachter JA, Raes G.

Front Immunol. 2014 Oct 7;5:489. doi: 10.3389/fimmu.2014.00489. eCollection 2014. Review.


STAT of the union: dynamics of distinct tumor-associated macrophage subsets governed by STAT1.

Van Overmeire E, Laoui D, Keirsse J, Bonelli S, Lahmar Q, Van Ginderachter JA.

Eur J Immunol. 2014 Aug;44(8):2238-42. doi: 10.1002/eji.201444870.


Hypoxia and tumor-associated macrophages: A deadly alliance in support of tumor progression.

Van Overmeire E, Laoui D, Keirsse J, Van Ginderachter JA.

Oncoimmunology. 2014 Jan 1;3(1):e27561. Epub 2014 Jan 3.


Mechanisms driving macrophage diversity and specialization in distinct tumor microenvironments and parallelisms with other tissues.

Van Overmeire E, Laoui D, Keirsse J, Van Ginderachter JA, Sarukhan A.

Front Immunol. 2014 Mar 26;5:127. doi: 10.3389/fimmu.2014.00127. eCollection 2014. Review.


Tumor hypoxia does not drive differentiation of tumor-associated macrophages but rather fine-tunes the M2-like macrophage population.

Laoui D, Van Overmeire E, Di Conza G, Aldeni C, Keirsse J, Morias Y, Movahedi K, Houbracken I, Schouppe E, Elkrim Y, Karroum O, Jordan B, Carmeliet P, Gysemans C, De Baetselier P, Mazzone M, Van Ginderachter JA.

Cancer Res. 2014 Jan 1;74(1):24-30. doi: 10.1158/0008-5472.CAN-13-1196. Epub 2013 Nov 12.


Unsuspected allies: chemotherapy teams up with immunity to fight cancer.

Laoui D, Van Overmeire E, Van Ginderachter JA.

Eur J Immunol. 2013 Oct;43(10):2538-42. doi: 10.1002/eji.201344042.


Modulation of CD8(+) T-cell activation events by monocytic and granulocytic myeloid-derived suppressor cells.

Schouppe E, Van Overmeire E, Laoui D, Keirsse J, Van Ginderachter JA.

Immunobiology. 2013 Nov;218(11):1385-91. doi: 10.1016/j.imbio.2013.07.003. Epub 2013 Jul 15. Review.


Pivotal Advance: Arginase-1-independent polyamine production stimulates the expression of IL-4-induced alternatively activated macrophage markers while inhibiting LPS-induced expression of inflammatory genes.

Van den Bossche J, Lamers WH, Koehler ES, Geuns JM, Alhonen L, Uimari A, Pirnes-Karhu S, Van Overmeire E, Morias Y, Brys L, Vereecke L, De Baetselier P, Van Ginderachter JA.

J Leukoc Biol. 2012 May;91(5):685-99. doi: 10.1189/jlb.0911453. Epub 2012 Mar 13.


Tumor-associated macrophages in breast cancer: distinct subsets, distinct functions.

Laoui D, Movahedi K, Van Overmeire E, Van den Bossche J, Schouppe E, Mommer C, Nikolaou A, Morias Y, De Baetselier P, Van Ginderachter JA.

Int J Dev Biol. 2011;55(7-9):861-7. doi: 10.1387/ijdb.113371dl. Review.


Mononuclear phagocyte heterogeneity in cancer: different subsets and activation states reaching out at the tumor site.

Laoui D, Van Overmeire E, Movahedi K, Van den Bossche J, Schouppe E, Mommer C, Nikolaou A, Morias Y, De Baetselier P, Van Ginderachter JA.

Immunobiology. 2011 Nov;216(11):1192-202. doi: 10.1016/j.imbio.2011.06.007. Epub 2011 Jun 30. Review.


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