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Items: 30


Hyperthermia induced by transient receptor potential vanilloid-1 (TRPV1) antagonists in human clinical trials: Insights from mathematical modeling and meta-analysis.

Garami A, Shimansky YP, Rumbus Z, Vizin RCL, Farkas N, Hegyi J, Szakacs Z, Solymar M, Csenkey A, Chiche DA, Kapil R, Kyle DJ, Van Horn WD, Hegyi P, Romanovsky AA.

Pharmacol Ther. 2020 Jan 9:107474. doi: 10.1016/j.pharmthera.2020.107474. [Epub ahead of print] Review.


Structure-Based Design of Novel Biphenyl Amide Antagonists of Human Transient Receptor Potential Cation Channel Subfamily M Member 8 Channels with Potential Implications in the Treatment of Sensory Neuropathies.

Journigan VB, Feng Z, Rahman S, Wang Y, Amin ARMR, Heffner CE, Bachtel N, Wang S, Gonzalez-Rodriguez S, Fernández-Carvajal A, Fernández-Ballester G, Hilton JK, Van Horn WD, Ferrer-Montiel A, Xie XQ, Rahman T.

ACS Chem Neurosci. 2020 Jan 9. doi: 10.1021/acschemneuro.9b00404. [Epub ahead of print]


Competitive Interactions between PIRT, the Cold Sensing Ion Channel TRPM8, and PIP2 Suggest a Mechanism for Regulation.

Sisco NJ, Helsell CVM, Van Horn WD.

Sci Rep. 2019 Oct 1;9(1):14128. doi: 10.1038/s41598-019-49912-5.


Structural and Evolutionary Insights Point to Allosteric Regulation of TRP Ion Channels.

Hilton JK, Kim M, Van Horn WD.

Acc Chem Res. 2019 Jun 18;52(6):1643-1652. doi: 10.1021/acs.accounts.9b00075. Epub 2019 May 31.


Phosphoinositide-interacting regulator of TRP (PIRT) has opposing effects on human and mouse TRPM8 ion channels.

Hilton JK, Salehpour T, Sisco NJ, Rath P, Van Horn WD.

J Biol Chem. 2018 Jun 15;293(24):9423-9434. doi: 10.1074/jbc.RA118.003563. Epub 2018 May 3.


New pieces to an old puzzle: identifying the warfarin-binding site that prevents clotting.

Hilton JK, Van Horn WD.

Nat Struct Mol Biol. 2017 Jan 5;24(1):5-6. doi: 10.1038/nsmb.3356. No abstract available.


A parallel stranded G-quadruplex composed of threose nucleic acid (TNA).

Liao JY, Anosova I, Bala S, Van Horn WD, Chaput JC.

Biopolymers. 2017 Mar;107(3). doi: 10.1002/bip.22999.


Structural basis for KCNE3 modulation of potassium recycling in epithelia.

Kroncke BM, Van Horn WD, Smith J, Kang C, Welch RC, Song Y, Nannemann DP, Taylor KC, Sisco NJ, George AL Jr, Meiler J, Vanoye CG, Sanders CR.

Sci Adv. 2016 Sep 9;2(9):e1501228. doi: 10.1126/sciadv.1501228. eCollection 2016 Sep.


Structural Insights into Conformation Differences between DNA/TNA and RNA/TNA Chimeric Duplexes.

Anosova I, Kowal EA, Sisco NJ, Sau S, Liao JY, Bala S, Rozners E, Egli M, Chaput JC, Van Horn WD.

Chembiochem. 2016 Sep 15;17(18):1705-8. doi: 10.1002/cbic.201600349. Epub 2016 Jul 29.


The structural diversity of artificial genetic polymers.

Anosova I, Kowal EA, Dunn MR, Chaput JC, Van Horn WD, Egli M.

Nucleic Acids Res. 2016 Feb 18;44(3):1007-21. doi: 10.1093/nar/gkv1472. Epub 2015 Dec 15. Review.


Implications of Human Transient Receptor Potential Melastatin 8 (TRPM8) Channel Gating from Menthol Binding Studies of the Sensing Domain.

Rath P, Hilton JK, Sisco NJ, Van Horn WD.

Biochemistry. 2016 Jan 12;55(1):114-24. doi: 10.1021/acs.biochem.5b00931. Epub 2015 Dec 23.


NMR Structure of Francisella tularensis Virulence Determinant Reveals Structural Homology to Bet v1 Allergen Proteins.

Zook J, Mo G, Sisco NJ, Craciunescu FM, Hansen DT, Baravati B, Cherry BR, Sykes K, Wachter R, Van Horn WD, Fromme P.

Structure. 2015 Jun 2;23(6):1116-22. doi: 10.1016/j.str.2015.03.025. Epub 2015 May 21.


Understanding thermosensitive transient receptor potential channels as versatile polymodal cellular sensors.

Hilton JK, Rath P, Helsell CV, Beckstein O, Van Horn WD.

Biochemistry. 2015 Apr 21;54(15):2401-13. doi: 10.1021/acs.biochem.5b00071. Epub 2015 Apr 3. Review.


VKORC1 ER mislocalization causes rare disease.

Van Horn WD.

Blood. 2014 Aug 21;124(8):1215-6. doi: 10.1182/blood-2014-07-586032. No abstract available.


Purification and structural study of the voltage-sensor domain of the human KCNQ1 potassium ion channel.

Peng D, Kim JH, Kroncke BM, Law CL, Xia Y, Droege KD, Van Horn WD, Vanoye CG, Sanders CR.

Biochemistry. 2014 Apr 1;53(12):2032-42. doi: 10.1021/bi500102w. Epub 2014 Mar 18.


Structural and functional insights into human vitamin K epoxide reductase and vitamin K epoxide reductase-like1.

Van Horn WD.

Crit Rev Biochem Mol Biol. 2013 Jul-Aug;48(4):357-72. doi: 10.3109/10409238.2013.791659. Epub 2013 Apr 30. Review.


The quiet renaissance of protein nuclear magnetic resonance.

Barrett PJ, Chen J, Cho MK, Kim JH, Lu Z, Mathew S, Peng D, Song Y, Van Horn WD, Zhuang T, Sönnichsen FD, Sanders CR.

Biochemistry. 2013 Feb 26;52(8):1303-20. doi: 10.1021/bi4000436. Epub 2013 Feb 12. Review.


Enhancing integrin α1 inserted (I) domain affinity to ligand potentiates integrin α1β1-mediated down-regulation of collagen synthesis.

Shi M, Pedchenko V, Greer BH, Van Horn WD, Santoro SA, Sanders CR, Hudson BG, Eichman BF, Zent R, Pozzi A.

J Biol Chem. 2012 Oct 12;287(42):35139-52. doi: 10.1074/jbc.M112.358648. Epub 2012 Aug 10.


The amyloid precursor protein has a flexible transmembrane domain and binds cholesterol.

Barrett PJ, Song Y, Van Horn WD, Hustedt EJ, Schafer JM, Hadziselimovic A, Beel AJ, Sanders CR.

Science. 2012 Jun 1;336(6085):1168-71. doi: 10.1126/science.1219988.


Prokaryotic diacylglycerol kinase and undecaprenol kinase.

Van Horn WD, Sanders CR.

Annu Rev Biophys. 2012;41:81-101. doi: 10.1146/annurev-biophys-050511-102330. Epub 2011 Dec 20. Review.


Bicelles at low concentrations.

Lu Z, Van Horn WD, Chen J, Mathew S, Zent R, Sanders CR.

Mol Pharm. 2012 Apr 2;9(4):752-61. doi: 10.1021/mp2004687. Epub 2012 Jan 20.


Working model for the structural basis for KCNE1 modulation of the KCNQ1 potassium channel.

Van Horn WD, Vanoye CG, Sanders CR.

Curr Opin Struct Biol. 2011 Apr;21(2):283-91. doi: 10.1016/ Epub 2011 Feb 4. Review.


Recent Advances in the Application of Solution NMR Spectroscopy to Multi-Span Integral Membrane Proteins.

Kim HJ, Howell SC, Van Horn WD, Jeon YH, Sanders CR.

Prog Nucl Magn Reson Spectrosc. 2009 Nov 1;55(4):335-360. No abstract available.


Functional delivery of a membrane protein into oocyte membranes using bicelles.

Kang C, Vanoye CG, Welch RC, Van Horn WD, Sanders CR.

Biochemistry. 2010 Feb 2;49(4):653-5. doi: 10.1021/bi902155t.


The impact of window functions on NMR-based paramagnetic relaxation enhancement measurements in membrane proteins.

Van Horn WD, Beel AJ, Kang C, Sanders CR.

Biochim Biophys Acta. 2010 Feb;1798(2):140-9. doi: 10.1016/j.bbamem.2009.08.022. Epub 2009 Sep 12.


Solution nuclear magnetic resonance structure of membrane-integral diacylglycerol kinase.

Van Horn WD, Kim HJ, Ellis CD, Hadziselimovic A, Sulistijo ES, Karra MD, Tian C, Sönnichsen FD, Sanders CR.

Science. 2009 Jun 26;324(5935):1726-9. doi: 10.1126/science.1171716.


Reverse micelle encapsulation as a model for intracellular crowding.

Van Horn WD, Ogilvie ME, Flynn PF.

J Am Chem Soc. 2009 Jun 17;131(23):8030-9. doi: 10.1021/ja901871n.


Use of reverse micelles in membrane protein structural biology.

Van Horn WD, Ogilvie ME, Flynn PF.

J Biomol NMR. 2008 Mar;40(3):203-11. doi: 10.1007/s10858-008-9227-5. Epub 2008 Feb 23.


Dynamics of low temperature induced water shedding from AOT reverse micelles.

Simorellis AK, Van Horn WD, Flynn PF.

J Am Chem Soc. 2006 Apr 19;128(15):5082-90.


Low-temperature studies of encapsulated proteins.

Van Horn WD, Simorellis AK, Flynn PF.

J Am Chem Soc. 2005 Oct 5;127(39):13553-60.


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