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Items: 1 to 50 of 114

1.

Cyclic O3 exposure synergizes with aging leading to memory impairment in male APOE ε3, but not APOE ε4, targeted replacement mice.

Jiang C, Stewart LT, Kuo HC, McGilberry W, Wall SB, Liang B, van Groen T, Bailey SM, Kim YI, Tipple TE, Jones DP, McMahon LL, Liu RM.

Neurobiol Aging. 2019 May 17;81:9-21. doi: 10.1016/j.neurobiolaging.2019.05.006. [Epub ahead of print]

PMID:
31207469
2.

A Small Molecule Inhibitor of Plasminogen Activator Inhibitor-1 Reduces Brain Amyloid-β Load and Improves Memory in an Animal Model of Alzheimer's Disease.

Akhter H, Huang WT, van Groen T, Kuo HC, Miyata T, Liu RM.

J Alzheimers Dis. 2018;64(2):447-457. doi: 10.3233/JAD-180241.

PMID:
29914038
3.

Behavioral and SCN neurophysiological disruption in the Tg-SwDI mouse model of Alzheimer's disease.

Paul JR, Munir HA, van Groen T, Gamble KL.

Neurobiol Dis. 2018 Jun;114:194-200. doi: 10.1016/j.nbd.2018.03.007. Epub 2018 Mar 11.

4.

Inhibition of amyloid Aβ aggregation by high pressures or specific d-enantiomeric peptides.

Cavini IA, Munte CE, Erlach MB, van Groen T, Kadish I, Zhang T, Ziehm T, Nagel-Steger L, Kutzsche J, Kremer W, Willbold D, Kalbitzer HR.

Chem Commun (Camb). 2018 Mar 27;54(26):3294-3297. doi: 10.1039/c8cc01458b.

PMID:
29537428
5.

Altered phosphorylation, electrophysiology, and behavior on attenuation of PDE4B action in hippocampus.

Campbell SL, van Groen T, Kadish I, Smoot LHM, Bolger GB.

BMC Neurosci. 2017 Dec 2;18(1):77. doi: 10.1186/s12868-017-0396-6.

6.

The Aβ oligomer eliminating D-enantiomeric peptide RD2 improves cognition without changing plaque pathology.

van Groen T, Schemmert S, Brener O, Gremer L, Ziehm T, Tusche M, Nagel-Steger L, Kadish I, Schartmann E, Elfgen A, Jürgens D, Willuweit A, Kutzsche J, Willbold D.

Sci Rep. 2017 Nov 24;7(1):16275. doi: 10.1038/s41598-017-16565-1.

7.

Optimization of d-Peptides for Aβ Monomer Binding Specificity Enhances Their Potential to Eliminate Toxic Aβ Oligomers.

Klein AN, Ziehm T, van Groen T, Kadish I, Elfgen A, Tusche M, Thomaier M, Reiss K, Brener O, Gremer L, Kutzsche J, Willbold D.

ACS Chem Neurosci. 2017 Sep 20;8(9):1889-1900. doi: 10.1021/acschemneuro.7b00045. Epub 2017 Jun 23.

PMID:
28581708
8.

Vitamin A and retinoic acid combination attenuates neonatal hyperoxia-induced neurobehavioral impairment in adult mice.

Ramani M, van Groen T, Kadish I, Ambalavanan N, McMahon LL.

Neurobiol Learn Mem. 2017 May;141:209-216. doi: 10.1016/j.nlm.2017.04.013. Epub 2017 Apr 27.

PMID:
28458035
9.

Retinal changes in the Tg-SwDI mouse model of Alzheimer's disease.

Oliveira-Souza FG, DeRamus ML, van Groen T, Lambert AE, Bolding MS, Strang CE.

Neuroscience. 2017 Jun 23;354:43-53. doi: 10.1016/j.neuroscience.2017.04.021. Epub 2017 Apr 25.

10.

Observational research rigour alone does not justify causal inference.

Ejima K, Li P, Smith DL Jr, Nagy TR, Kadish I, van Groen T, Dawson JA, Yang Y, Patki A, Allison DB.

Eur J Clin Invest. 2016 Dec;46(12):985-993. doi: 10.1111/eci.12681. Epub 2016 Oct 28.

11.

Treatment of traumatic brain injury with 17α-ethinylestradiol-3-sulfate in a rat model.

Kim H, Yu T, Cam-Etoz B, van Groen T, Hubbard WJ, Chaudry IH.

J Neurosurg. 2017 Jul;127(1):23-31. doi: 10.3171/2016.7.JNS161263. Epub 2016 Sep 23.

PMID:
27662529
12.

Blood-brain barrier penetration of an Aβ-targeted, arginine-rich, d-enantiomeric peptide.

Jiang N, Frenzel D, Schartmann E, van Groen T, Kadish I, Shah NJ, Langen KJ, Willbold D, Willuweit A.

Biochim Biophys Acta. 2016 Nov;1858(11):2717-2724. doi: 10.1016/j.bbamem.2016.07.002. Epub 2016 Jul 14.

13.

Memory-enhancing and brain protein expression-stimulating effects of novel calcium antagonist in Alzheimer's disease transgenic female mice.

Jansone B, Kadish I, van Groen T, Beitnere U, Plotniece A, Pajuste K, Klusa V.

Pharmacol Res. 2016 Nov;113(Pt B):781-787. doi: 10.1016/j.phrs.2016.06.020. Epub 2016 Jun 21.

14.

Increase of Positive Net Charge and Conformational Rigidity Enhances the Efficacy of d-Enantiomeric Peptides Designed to Eliminate Cytotoxic Aβ Species.

Ziehm T, Brener O, van Groen T, Kadish I, Frenzel D, Tusche M, Kutzsche J, Reiß K, Gremer L, Nagel-Steger L, Willbold D.

ACS Chem Neurosci. 2016 Aug 17;7(8):1088-96. doi: 10.1021/acschemneuro.6b00047. Epub 2016 Jun 9.

PMID:
27240424
15.

Dietary composition affects the development of cognitive deficits in WT and Tg AD model mice.

Kadish I, Kumar A, Beitnere U, Jennings E, McGilberry W, van Groen T.

Exp Gerontol. 2016 Dec 15;86:39-49. doi: 10.1016/j.exger.2016.05.003. Epub 2016 May 7.

16.

Allelic series of Huntington's disease knock-in mice reveals expression discorrelates.

Kumar A, Zhang J, Tallaksen-Greene S, Crowley MR, Crossman DK, Morton AJ, Van Groen T, Kadish I, Albin RL, Lesort M, Detloff PJ.

Hum Mol Genet. 2016 Apr 15;25(8):1619-36. doi: 10.1093/hmg/ddw040. Epub 2016 Feb 14.

17.

QIAD assay for quantitating a compound's efficacy in elimination of toxic Aβ oligomers.

Brener O, Dunkelmann T, Gremer L, van Groen T, Mirecka EA, Kadish I, Willuweit A, Kutzsche J, Jürgens D, Rudolph S, Tusche M, Bongen P, Pietruszka J, Oesterhelt F, Langen KJ, Demuth HU, Janssen A, Hoyer W, Funke SA, Nagel-Steger L, Willbold D.

Sci Rep. 2015 Sep 23;5:13222. doi: 10.1038/srep13222.

18.

Cyclic Ozone Exposure Induces Gender-Dependent Neuropathology and Memory Decline in an Animal Model of Alzheimer's Disease.

Akhter H, Ballinger C, Liu N, van Groen T, Postlethwait EM, Liu RM.

Toxicol Sci. 2015 Sep;147(1):222-34. doi: 10.1093/toxsci/kfv124. Epub 2015 Jun 26.

19.

Ghrelin agonist does not foster insulin resistance but improves cognition in an Alzheimer's disease mouse model.

Kunath N, van Groen T, Allison DB, Kumar A, Dozier-Sharpe M, Kadish I.

Sci Rep. 2015 Jun 19;5:11452. doi: 10.1038/srep11452.

20.

A Novel 1,4-Dihydropyridine Derivative Improves Spatial Learning and Memory and Modifies Brain Protein Expression in Wild Type and Transgenic APPSweDI Mice.

Jansone B, Kadish I, van Groen T, Beitnere U, Moore DR, Plotniece A, Pajuste K, Klusa V.

PLoS One. 2015 Jun 4;10(6):e0127686. doi: 10.1371/journal.pone.0127686. eCollection 2015.

21.

α(2A) adrenergic receptor promotes amyloidogenesis through disrupting APP-SorLA interaction.

Chen Y, Peng Y, Che P, Gannon M, Liu Y, Li L, Bu G, van Groen T, Jiao K, Wang Q.

Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):17296-301. doi: 10.1073/pnas.1409513111. Epub 2014 Nov 17.

22.
23.

Mildronate improves cognition and reduces amyloid-β pathology in transgenic Alzheimer's disease mice.

Beitnere U, van Groen T, Kumar A, Jansone B, Klusa V, Kadish I.

J Neurosci Res. 2014 Mar;92(3):338-46. doi: 10.1002/jnr.23315. Epub 2013 Nov 22.

24.

In vivo and in vitro effects of an apolipoprotein e mimetic peptide on amyloid-β pathology.

Handattu SP, Monroe CE, Nayyar G, Palgunachari MN, Kadish I, van Groen T, Anantharamaiah GM, Garber DW.

J Alzheimers Dis. 2013;36(2):335-47. doi: 10.3233/JAD-122377.

25.

Hunger in the absence of caloric restriction improves cognition and attenuates Alzheimer's disease pathology in a mouse model.

Dhurandhar EJ, Allison DB, van Groen T, Kadish I.

PLoS One. 2013;8(4):e60437. doi: 10.1371/journal.pone.0060437. Epub 2013 Apr 2.

26.

Treatment with D3 removes amyloid deposits, reduces inflammation, and improves cognition in aged AβPP/PS1 double transgenic mice.

van Groen T, Kadish I, Funke SA, Bartnik D, Willbold D.

J Alzheimers Dis. 2013;34(3):609-20. doi: 10.3233/JAD-121792.

27.

Neurodevelopmental impairment following neonatal hyperoxia in the mouse.

Ramani M, van Groen T, Kadish I, Bulger A, Ambalavanan N.

Neurobiol Dis. 2013 Feb;50:69-75. doi: 10.1016/j.nbd.2012.10.005. Epub 2012 Oct 12.

28.

Treatment with Aβ42 binding D-amino acid peptides reduce amyloid deposition and inflammation in APP/PS1 double transgenic mice.

van Groen T, Kadish I, Funke A, Bartnik D, Willbold D.

Adv Protein Chem Struct Biol. 2012;88:133-52. doi: 10.1016/B978-0-12-398314-5.00005-2.

PMID:
22814708
29.

Insufficient DNA methylation affects healthy aging and promotes age-related health problems.

Liu L, van Groen T, Kadish I, Li Y, Wang D, James SR, Karpf AR, Tollefsbol TO.

Clin Epigenetics. 2011 Aug;2(2):349-60. doi: 10.1007/s13148-011-0042-6. Epub 2011 Jun 12.

30.

Tissue transglutaminase overexpression does not modify the disease phenotype of the R6/2 mouse model of Huntington's disease.

Kumar A, Kneynsberg A, Tucholski J, Perry G, van Groen T, Detloff PJ, Lesort M.

Exp Neurol. 2012 Sep;237(1):78-89. doi: 10.1016/j.expneurol.2012.05.015. Epub 2012 Jun 12.

31.

Motor restlessness, sleep disturbances, thermal sensory alterations and elevated serum iron levels in Btbd9 mutant mice.

DeAndrade MP, Johnson RL Jr, Unger EL, Zhang L, van Groen T, Gamble KL, Li Y.

Hum Mol Genet. 2012 Sep 15;21(18):3984-92. doi: 10.1093/hmg/dds221. Epub 2012 Jun 7.

32.

Reviewing reasons for the decreased CSF Abeta42 concentration in Alzheimer disease.

Spies PE, Verbeek MM, van Groen T, Claassen JA.

Front Biosci (Landmark Ed). 2012 Jun 1;17:2024-34. Review.

PMID:
22652762
33.

Transgenic AD model mice, effects of potential anti-AD treatments on inflammation, and pathology.

van Groen T, Miettinen P, Kadish I.

J Alzheimers Dis. 2011;24(2):301-13. doi: 10.3233/JAD-2011-101479.

PMID:
21239852
34.

Distinct growth hormone receptor signaling modes regulate skeletal muscle development and insulin sensitivity in mice.

Mavalli MD, DiGirolamo DJ, Fan Y, Riddle RC, Campbell KS, van Groen T, Frank SJ, Sperling MA, Esser KA, Bamman MM, Clemens TL.

J Clin Invest. 2010 Nov;120(11):4007-20. doi: 10.1172/JCI42447.

35.

Characterization of Atp1a3 mutant mice as a model of rapid-onset dystonia with parkinsonism.

DeAndrade MP, Yokoi F, van Groen T, Lingrel JB, Li Y.

Behav Brain Res. 2011 Jan 20;216(2):659-65. doi: 10.1016/j.bbr.2010.09.009. Epub 2010 Sep 17.

36.

Oral treatment with the d-enantiomeric peptide D3 improves the pathology and behavior of Alzheimer's Disease transgenic mice.

Aileen Funke S, van Groen T, Kadish I, Bartnik D, Nagel-Steger L, Brener O, Sehl T, Batra-Safferling R, Moriscot C, Schoehn G, Horn AH, Müller-Schiffmann A, Korth C, Sticht H, Willbold D.

ACS Chem Neurosci. 2010 Sep 15;1(9):639-48. doi: 10.1021/cn100057j. Epub 2010 Aug 2.

37.

Mitochondrial calcium uptake capacity as a therapeutic target in the R6/2 mouse model of Huntington's disease.

Perry GM, Tallaksen-Greene S, Kumar A, Heng MY, Kneynsberg A, van Groen T, Detloff PJ, Albin RL, Lesort M.

Hum Mol Genet. 2010 Sep 1;19(17):3354-71. doi: 10.1093/hmg/ddq247. Epub 2010 Jun 17.

38.

Characterization of a novel transgenic rat carrying human tau with mutation P301L.

Korhonen P, van Groen T, Thornell A, Kyrylenko S, Soininen ML, Ojala J, Peltomaa E, Tanila H, Salminen A, Mandelkow EM, Soininen H.

Neurobiol Aging. 2011 Dec;32(12):2314-5. doi: 10.1016/j.neurobiolaging.2009.12.022. Epub 2010 Jan 25.

PMID:
20097445
39.

Age-related brain pathology in Octodon degu: blood vessel, white matter and Alzheimer-like pathology.

van Groen T, Kadish I, Popović N, Popović M, Caballero-Bleda M, Baño-Otálora B, Vivanco P, Rol MÁ, Madrid JA.

Neurobiol Aging. 2011 Sep;32(9):1651-61. doi: 10.1016/j.neurobiolaging.2009.10.008. Epub 2009 Nov 11.

PMID:
19910078
40.

Knockout of plasminogen activator inhibitor 1 gene reduces amyloid beta peptide burden in a mouse model of Alzheimer's disease.

Liu RM, van Groen T, Katre A, Cao D, Kadisha I, Ballinger C, Wang L, Carroll SL, Li L.

Neurobiol Aging. 2011 Jun;32(6):1079-89. doi: 10.1016/j.neurobiolaging.2009.06.003. Epub 2009 Jul 14.

41.

Lesion-induced hippocampal plasticity in transgenic Alzheimer's disease mouse models: influences of age, genotype, and estrogen.

Kadish I, van Groen T.

J Alzheimers Dis. 2009;18(2):429-45. doi: 10.3233/JAD-2009-1157.

PMID:
19584452
42.

Functional roles of amyloid-beta protein precursor and amyloid-beta peptides: evidence from experimental studies.

Hiltunen M, van Groen T, Jolkkonen J.

J Alzheimers Dis. 2009;18(2):401-12. doi: 10.3233/JAD-2009-1154. Review.

PMID:
19584429
43.

Focal cerebral ischemia in rats alters APP processing and expression of Abeta peptide degrading enzymes in the thalamus.

Hiltunen M, Mäkinen P, Peräniemi S, Sivenius J, van Groen T, Soininen H, Jolkkonen J.

Neurobiol Dis. 2009 Jul;35(1):103-13. doi: 10.1016/j.nbd.2009.04.009. Epub 2009 May 5.

PMID:
19426802
44.

Oral apolipoprotein A-I mimetic peptide improves cognitive function and reduces amyloid burden in a mouse model of Alzheimer's disease.

Handattu SP, Garber DW, Monroe CE, van Groen T, Kadish I, Nayyar G, Cao D, Palgunachari MN, Li L, Anantharamaiah GM.

Neurobiol Dis. 2009 Jun;34(3):525-34. doi: 10.1016/j.nbd.2009.03.007. Epub 2009 Apr 1.

45.

DHA and cholesterol containing diets influence Alzheimer-like pathology, cognition and cerebral vasculature in APPswe/PS1dE9 mice.

Hooijmans CR, Van der Zee CE, Dederen PJ, Brouwer KM, Reijmer YD, van Groen T, Broersen LM, Lütjohann D, Heerschap A, Kiliaan AJ.

Neurobiol Dis. 2009 Mar;33(3):482-98. doi: 10.1016/j.nbd.2008.12.002. Epub 2008 Dec 16.

PMID:
19130883
46.

Pulmonary angiogenesis in a rat model of hepatopulmonary syndrome.

Zhang J, Luo B, Tang L, Wang Y, Stockard CR, Kadish I, Van Groen T, Grizzle WE, Ponnazhagan S, Fallon MB.

Gastroenterology. 2009 Mar;136(3):1070-80. doi: 10.1053/j.gastro.2008.12.001. Epub 2008 Dec 3.

47.

In vitro and in vivo staining characteristics of small, fluorescent, Abeta42-binding D-enantiomeric peptides in transgenic AD mouse models.

van Groen T, Kadish I, Wiesehan K, Funke SA, Willbold D.

ChemMedChem. 2009 Feb;4(2):276-82. doi: 10.1002/cmdc.200800289.

PMID:
19072935
48.

Reduction of Alzheimer's disease amyloid plaque load in transgenic mice by D3, A D-enantiomeric peptide identified by mirror image phage display.

van Groen T, Wiesehan K, Funke SA, Kadish I, Nagel-Steger L, Willbold D.

ChemMedChem. 2008 Dec;3(12):1848-52. doi: 10.1002/cmdc.200800273. No abstract available.

PMID:
19016284
49.

Forkhead box, class O transcription factors in brain: regulation and behavioral manifestation.

Polter A, Yang S, Zmijewska AA, van Groen T, Paik JH, Depinho RA, Peng SL, Jope RS, Li X.

Biol Psychiatry. 2009 Jan 15;65(2):150-9. doi: 10.1016/j.biopsych.2008.08.005. Epub 2008 Sep 27.

50.

Subfield and layer-specific depletion in calbindin-D28K, calretinin and parvalbumin immunoreactivity in the dentate gyrus of amyloid precursor protein/presenilin 1 transgenic mice.

Popović M, Caballero-Bleda M, Kadish I, Van Groen T.

Neuroscience. 2008 Jul 31;155(1):182-91. doi: 10.1016/j.neuroscience.2008.05.023. Epub 2008 May 24.

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