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Items: 1 to 50 of 56

1.

In utero and postnatal VX-770 administration rescues multiorgan disease in a ferret model of cystic fibrosis.

Sun X, Yi Y, Yan Z, Rosen BH, Liang B, Winter MC, Evans TIA, Rotti PG, Yang Y, Gray JS, Park SY, Zhou W, Zhang Y, Moll SR, Woody L, Tran DM, Jiang L, Vonk AM, Beekman JM, Negulescu P, Van Goor F, Fiorino DF, Gibson-Corley KN, Engelhardt JF.

Sci Transl Med. 2019 Mar 27;11(485). pii: eaau7531. doi: 10.1126/scitranslmed.aau7531.

2.

VX-659-Tezacaftor-Ivacaftor in Patients with Cystic Fibrosis and One or Two Phe508del Alleles.

Davies JC, Moskowitz SM, Brown C, Horsley A, Mall MA, McKone EF, Plant BJ, Prais D, Ramsey BW, Taylor-Cousar JL, Tullis E, Uluer A, McKee CM, Robertson S, Shilling RA, Simard C, Van Goor F, Waltz D, Xuan F, Young T, Rowe SM; VX16-659-101 Study Group.

N Engl J Med. 2018 Oct 25;379(17):1599-1611. doi: 10.1056/NEJMoa1807119. Epub 2018 Oct 18.

3.

VX-445-Tezacaftor-Ivacaftor in Patients with Cystic Fibrosis and One or Two Phe508del Alleles.

Keating D, Marigowda G, Burr L, Daines C, Mall MA, McKone EF, Ramsey BW, Rowe SM, Sass LA, Tullis E, McKee CM, Moskowitz SM, Robertson S, Savage J, Simard C, Van Goor F, Waltz D, Xuan F, Young T, Taylor-Cousar JL; VX16-445-001 Study Group.

N Engl J Med. 2018 Oct 25;379(17):1612-1620. doi: 10.1056/NEJMoa1807120. Epub 2018 Oct 18.

4.

Correlation of sweat chloride and percent predicted FEV1 in cystic fibrosis patients treated with ivacaftor.

Fidler MC, Beusmans J, Panorchan P, Van Goor F.

J Cyst Fibros. 2017 Jan;16(1):41-44. doi: 10.1016/j.jcf.2016.10.002. Epub 2016 Oct 20.

5.

Discovery of N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide (VX-770, ivacaftor), a potent and orally bioavailable CFTR potentiator.

Hadida S, Van Goor F, Zhou J, Arumugam V, McCartney J, Hazlewood A, Decker C, Negulescu P, Grootenhuis PD.

J Med Chem. 2014 Dec 11;57(23):9776-95. doi: 10.1021/jm5012808. Epub 2014 Dec 2.

PMID:
25441013
6.

Spectral purification and infrared light recycling in extreme ultraviolet lithography sources.

Bayraktar M, van Goor FA, Boller KJ, Bijkerk F.

Opt Express. 2014 Apr 7;22(7):8633-9. doi: 10.1364/OE.22.008633.

PMID:
24718234
7.

Sweat chloride as a biomarker of CFTR activity: proof of concept and ivacaftor clinical trial data.

Accurso FJ, Van Goor F, Zha J, Stone AJ, Dong Q, Ordonez CL, Rowe SM, Clancy JP, Konstan MW, Hoch HE, Heltshe SL, Ramsey BW, Campbell PW, Ashlock MA.

J Cyst Fibros. 2014 Mar;13(2):139-47.

8.

Defining the disease liability of variants in the cystic fibrosis transmembrane conductance regulator gene.

Sosnay PR, Siklosi KR, Van Goor F, Kaniecki K, Yu H, Sharma N, Ramalho AS, Amaral MD, Dorfman R, Zielenski J, Masica DL, Karchin R, Millen L, Thomas PJ, Patrinos GP, Corey M, Lewis MH, Rommens JM, Castellani C, Penland CM, Cutting GR.

Nat Genet. 2013 Oct;45(10):1160-7. doi: 10.1038/ng.2745. Epub 2013 Aug 25.

9.

VX-809 corrects folding defects in cystic fibrosis transmembrane conductance regulator protein through action on membrane-spanning domain 1.

Ren HY, Grove DE, De La Rosa O, Houck SA, Sopha P, Van Goor F, Hoffman BJ, Cyr DM.

Mol Biol Cell. 2013 Oct;24(19):3016-24. doi: 10.1091/mbc.E13-05-0240. Epub 2013 Aug 7.

10.

Effect of ivacaftor on CFTR forms with missense mutations associated with defects in protein processing or function.

Van Goor F, Yu H, Burton B, Hoffman BJ.

J Cyst Fibros. 2014 Jan;13(1):29-36. doi: 10.1016/j.jcf.2013.06.008. Epub 2013 Jul 23.

11.

The predictive potential of the sweat chloride test in cystic fibrosis patients with the G551D mutation.

Seliger VI, Rodman D, Van Goor F, Schmelz A, Mueller P.

J Cyst Fibros. 2013 Dec;12(6):706-13. doi: 10.1016/j.jcf.2013.03.004. Epub 2013 Apr 28.

12.

Wavelength separation from extreme ultraviolet mirrors using phaseshift reflection.

van den Boogaard AJ, van Goor FA, Louis E, Bijkerk F.

Opt Lett. 2012 Jan 15;37(2):160-2. doi: 10.1364/OL.37.000160.

PMID:
22854453
13.

Ivacaftor potentiation of multiple CFTR channels with gating mutations.

Yu H, Burton B, Huang CJ, Worley J, Cao D, Johnson JP Jr, Urrutia A, Joubran J, Seepersaud S, Sussky K, Hoffman BJ, Van Goor F.

J Cyst Fibros. 2012 May;11(3):237-45. doi: 10.1016/j.jcf.2011.12.005. Epub 2012 Jan 30.

14.

Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809.

Van Goor F, Hadida S, Grootenhuis PD, Burton B, Stack JH, Straley KS, Decker CJ, Miller M, McCartney J, Olson ER, Wine JJ, Frizzell RA, Ashlock M, Negulescu PA.

Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):18843-8. doi: 10.1073/pnas.1105787108. Epub 2011 Oct 5.

15.

Use of primary cultures of human bronchial epithelial cells isolated from cystic fibrosis patients for the pre-clinical testing of CFTR modulators.

Neuberger T, Burton B, Clark H, Van Goor F.

Methods Mol Biol. 2011;741:39-54. doi: 10.1007/978-1-61779-117-8_4.

PMID:
21594777
16.

Generating ultrarelativistic attosecond electron bunches with laser wakefield accelerators.

Luttikhof MJ, Khachatryan AG, van Goor FA, Boller KJ.

Phys Rev Lett. 2010 Sep 17;105(12):124801. Epub 2010 Sep 14.

PMID:
20867647
17.

Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770.

Van Goor F, Hadida S, Grootenhuis PD, Burton B, Cao D, Neuberger T, Turnbull A, Singh A, Joubran J, Hazlewood A, Zhou J, McCartney J, Arumugam V, Decker C, Yang J, Young C, Olson ER, Wine JJ, Frizzell RA, Ashlock M, Negulescu P.

Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18825-30. doi: 10.1073/pnas.0904709106. Epub 2009 Oct 21.

18.

Multiple roles of Gi/o protein-coupled receptors in control of action potential secretion coupling in pituitary lactotrophs.

Stojilkovic SS, Murano T, Gonzalez-Iglesias AE, Andric SA, Popovic MA, Van Goor F, Tomić M.

Ann N Y Acad Sci. 2009 Jan;1152:174-86. doi: 10.1111/j.1749-6632.2008.03994.x. Review.

19.

Mechanism of spontaneous and receptor-controlled electrical activity in pituitary somatotrophs: experiments and theory.

Tsaneva-Atanasova K, Sherman A, van Goor F, Stojilkovic SS.

J Neurophysiol. 2007 Jul;98(1):131-44. Epub 2007 May 9.

20.

Rescue of DeltaF508-CFTR trafficking and gating in human cystic fibrosis airway primary cultures by small molecules.

Van Goor F, Straley KS, Cao D, González J, Hadida S, Hazlewood A, Joubran J, Knapp T, Makings LR, Miller M, Neuberger T, Olson E, Panchenko V, Rader J, Singh A, Stack JH, Tung R, Grootenhuis PD, Negulescu P.

Am J Physiol Lung Cell Mol Physiol. 2006 Jun;290(6):L1117-30. Epub 2006 Jan 27.

21.

Biophysical basis of pituitary cell type-specific Ca2+ signaling-secretion coupling.

Stojilkovic SS, Zemkova H, Van Goor F.

Trends Endocrinol Metab. 2005 May-Jun;16(4):152-9. Review.

PMID:
15860411
22.

Interaction of free charged particles with a chirped electromagnetic pulse.

Khachatryan AG, van Goor FA, Boller KJ.

Phys Rev E Stat Nonlin Soft Matter Phys. 2004 Dec;70(6 Pt 2):067601. Epub 2004 Dec 2.

PMID:
15697564
23.

Nitric oxide inhibits prolactin secretion in pituitary cells downstream of voltage-gated calcium influx.

Andric SA, Gonzalez-Iglesias AE, Van Goor F, Tomić M, Stojilkovic SS.

Endocrinology. 2003 Jul;144(7):2912-21.

PMID:
12810546
24.

F(ab)'2-mediated neutralization of C3a and C5a anaphylatoxins: a novel effector function of immunoglobulins.

Basta M, Van Goor F, Luccioli S, Billings EM, Vortmeyer AO, Baranyi L, Szebeni J, Alving CR, Carroll MC, Berkower I, Stojilkovic SS, Metcalfe DD.

Nat Med. 2003 Apr;9(4):431-8. Epub 2003 Mar 3.

PMID:
12612546
25.

Simple model for laser-produced, mass-limited water-droplet plasmas.

Garloff K, van den Donker M, van der Mullen J, van Goor F, Brummans R, Jonkers J.

Phys Rev E Stat Nonlin Soft Matter Phys. 2002 Sep;66(3 Pt 2B):036403. Epub 2002 Sep 18.

PMID:
12366263
26.

Ca(2+)-mobilizing endothelin-A receptors inhibit voltage-gated Ca(2+) influx through G(i/o) signaling pathway in pituitary lactotrophs.

Tomić M, Van Goor F, He ML, Zivadinovic D, Stojilkovic SS.

Mol Pharmacol. 2002 Jun;61(6):1329-39.

PMID:
12021394
28.

Dependence of pituitary hormone secretion on the pattern of spontaneous voltage-gated calcium influx. Cell type-specific action potential secretion coupling.

Van Goor F, Zivadinovic D, Martinez-Fuentes AJ, Stojilkovic SS.

J Biol Chem. 2001 Sep 7;276(36):33840-6. Epub 2001 Jul 16.

29.

Differential expression of ionic channels in rat anterior pituitary cells.

Van Goor F, Zivadinovic D, Stojilkovic SS.

Mol Endocrinol. 2001 Jul;15(7):1222-36.

PMID:
11435620
30.

Characterization of calcium signaling by purinergic receptor-channels expressed in excitable cells.

Koshimizu TA, Van Goor F, Tomić M, Wong AO, Tanoue A, Tsujimoto G, Stojilkovic SS.

Mol Pharmacol. 2000 Nov;58(5):936-45.

PMID:
11040040
31.

Amplitude-dependent spike-broadening and enhanced Ca(2+) signaling in GnRH-secreting neurons.

Van Goor F, LeBeau AP, Krsmanovic LZ, Sherman A, Catt KJ, Stojilkovic SS.

Biophys J. 2000 Sep;79(3):1310-23.

32.

Expression of purinergic P2X2 receptor-channels and their role in calcium signaling in pituitary cells.

Stojilkovic SS, Tomic M, Van Goor F, Koshimizu T.

Biochem Cell Biol. 2000;78(3):393-404.

PMID:
10949088
33.

Autocrine regulation of calcium influx and gonadotropin-releasing hormone secretion in hypothalamic neurons.

Van Goor F, Krsmanovic LZ, Catt KJ, Stojilkovic SS.

Biochem Cell Biol. 2000;78(3):359-70. Review.

PMID:
10949086
34.

Signal transduction mechanisms mediating secretion in goldfish gonadotropes and somatotropes.

Chang JP, Johnson JD, Van Goor F, Wong CJ, Yunker WK, Uretsky AD, Taylor D, Jobin RM, Wong AO, Goldberg JI.

Biochem Cell Biol. 2000;78(3):139-53. Review.

PMID:
10949070
36.

Two endogenous gonadotropin-releasing hormones generate dissimilar Ca(2+) signals in identified goldfish gonadotropes.

Johnson JD, Van Goor F, Wong CJ, Goldberg JI, Chang JP.

Gen Comp Endocrinol. 1999 Nov;116(2):178-91.

PMID:
10562448
37.

Expression of Ca(2+)-mobilizing endothelin(A) receptors and their role in the control of Ca(2+) influx and growth hormone secretion in pituitary somatotrophs.

Tomić M, Zivadinovic D, Van Goor F, Yuan D, Koshimizu T, Stojilkovic SS.

J Neurosci. 1999 Sep 15;19(18):7721-31.

38.

Control of action potential-driven calcium influx in GT1 neurons by the activation status of sodium and calcium channels.

Van Goor F, Krsmanovic LZ, Catt KJ, Stojilkovic SS.

Mol Endocrinol. 1999 Apr;13(4):587-603.

PMID:
10194765
39.

Coordinate regulation of gonadotropin-releasing hormone neuronal firing patterns by cytosolic calcium and store depletion.

Van Goor F, Krsmanovic LZ, Catt KJ, Stojilkovic SS.

Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):4101-6.

40.

Functional role of alternative splicing in pituitary P2X2 receptor-channel activation and desensitization.

Koshimizu T, Tomić M, Van Goor F, Stojilkovic SS.

Mol Endocrinol. 1998 Jul;12(7):901-13.

PMID:
9658396
41.
42.

Uncoupling of calcium mobilization and entry pathways in endothelin-stimulated pituitary lactotrophs.

Lachowicz A, Van Goor F, Katzur AC, Bonhomme G, Stojilkovic SS.

J Biol Chem. 1997 Nov 7;272(45):28308-14.

43.

Extracellular sodium dependence of GnRH-stimulated growth hormone release in goldfish pituitary cells.

Van Goor F, Goldberg JI, Chang JP.

J Neuroendocrinol. 1997 Mar;9(3):207-16.

PMID:
9089472
44.
45.

Electrical membrane properties and ionic currents in cultured goldfish gonadotrophs.

Van Goor F, Goldberg JI, Chang JP.

Can J Physiol Pharmacol. 1996 Jun;74(6):729-43.

PMID:
8909786
47.

Role of arachidonic acid and calmodulin in mediating dopamine D1- and GnRH-stimulated growth hormone release in goldfish pituitary cells.

Chang JP, Abele JT, Van Goor F, Wong AO, Neumann CM.

Gen Comp Endocrinol. 1996 Apr;102(1):88-101.

PMID:
8860313
48.

GnRH signaling in goldfish pituitary cells.

Chang JP, Van Goor F, Jobin RM, Lo A.

Biol Signals. 1996 Mar-Apr;5(2):70-80. Review.

PMID:
8836490
50.

Entry of extracellular calcium mediates dopamine D1-stimulated growth hormone release from goldfish pituitary cells.

Wong AO, Van Goor F, Chang JP.

Gen Comp Endocrinol. 1994 Jun;94(3):316-28.

PMID:
7926640

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