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Items: 1 to 50 of 102

1.

High Salt Inhibits Tumor Growth by Enhancing Anti-tumor Immunity.

Willebrand R, Hamad I, Van Zeebroeck L, Kiss M, Bruderek K, Geuzens A, Swinnen D, Côrte-Real BF, Markó L, Lebegge E, Laoui D, Kemna J, Kammertoens T, Brandau S, Van Ginderachter JA, Kleinewietfeld M.

Front Immunol. 2019 Jun 4;10:1141. doi: 10.3389/fimmu.2019.01141. eCollection 2019.

2.

A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment.

Van Hove H, Martens L, Scheyltjens I, De Vlaminck K, Pombo Antunes AR, De Prijck S, Vandamme N, De Schepper S, Van Isterdael G, Scott CL, Aerts J, Berx G, Boeckxstaens GE, Vandenbroucke RE, Vereecke L, Moechars D, Guilliams M, Van Ginderachter JA, Saeys Y, Movahedi K.

Nat Neurosci. 2019 Jun;22(6):1021-1035. doi: 10.1038/s41593-019-0393-4. Epub 2019 May 6.

PMID:
31061494
3.

Single-domain antibody fusion proteins can target and shuttle functional proteins into macrophage mannose receptor expressing macrophages.

De Vlaeminck Y, Lecocq Q, Giron P, Heirman C, Geeraerts X, Bolli E, Movahedi K, Massa S, Schoonooghe S, Thielemans K, Goyvaerts C, Van Ginderachter JA, Breckpot K.

J Control Release. 2019 Apr 10;299:107-120. doi: 10.1016/j.jconrel.2019.02.023. Epub 2019 Feb 21.

PMID:
30797866
4.

Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity.

Vriens K, Christen S, Parik S, Broekaert D, Yoshinaga K, Talebi A, Dehairs J, Escalona-Noguero C, Schmieder R, Cornfield T, Charlton C, Romero-Pérez L, Rossi M, Rinaldi G, Orth MF, Boon R, Kerstens A, Kwan SY, Faubert B, Méndez-Lucas A, Kopitz CC, Chen T, Fernandez-Garcia J, Duarte JAG, Schmitz AA, Steigemann P, Najimi M, Hägebarth A, Van Ginderachter JA, Sokal E, Gotoh N, Wong KK, Verfaillie C, Derua R, Munck S, Yuneva M, Beretta L, DeBerardinis RJ, Swinnen JV, Hodson L, Cassiman D, Verslype C, Christian S, Grünewald S, Grünewald TGP, Fendt SM.

Nature. 2019 Feb;566(7744):403-406. doi: 10.1038/s41586-019-0904-1. Epub 2019 Feb 6.

PMID:
30728499
5.

Clinical Translation of [68Ga]Ga-NOTA-anti-MMR-sdAb for PET/CT Imaging of Protumorigenic Macrophages.

Xavier C, Blykers A, Laoui D, Bolli E, Vaneyken I, Bridoux J, Baudhuin H, Raes G, Everaert H, Movahedi K, Van Ginderachter JA, Devoogdt N, Caveliers V, Lahoutte T, Keyaerts M.

Mol Imaging Biol. 2019 Jan 22. doi: 10.1007/s11307-018-01302-5. [Epub ahead of print]

PMID:
30671739
6.

Tumor microenvironment modulation enhances immunologic benefit of chemoradiotherapy.

Hanoteau A, Newton JM, Krupar R, Huang C, Liu HC, Gaspero A, Gartrell RD, Saenger YM, Hart TD, Santegoets SJ, Laoui D, Spanos C, Parikh F, Jayaraman P, Zhang B, Van der Burg SH, Van Ginderachter JA, Melief CJM, Sikora AG.

J Immunother Cancer. 2019 Jan 15;7(1):10. doi: 10.1186/s40425-018-0485-9.

7.

Myeloid-derived suppressor cells induce multiple myeloma cell survival by activating the AMPK pathway.

De Veirman K, Menu E, Maes K, De Beule N, De Smedt E, Maes A, Vlummens P, Fostier K, Kassambara A, Moreaux J, Van Ginderachter JA, De Bruyne E, Vanderkerken K, Van Valckenborgh E.

Cancer Lett. 2019 Feb 1;442:233-241. doi: 10.1016/j.canlet.2018.11.002. Epub 2018 Nov 9.

PMID:
30419344
8.

The Transcription Factor ZEB2 Is Required to Maintain the Tissue-Specific Identities of Macrophages.

Scott CL, T'Jonck W, Martens L, Todorov H, Sichien D, Soen B, Bonnardel J, De Prijck S, Vandamme N, Cannoodt R, Saelens W, Vanneste B, Toussaint W, De Bleser P, Takahashi N, Vandenabeele P, Henri S, Pridans C, Hume DA, Lambrecht BN, De Baetselier P, Milling SWF, Van Ginderachter JA, Malissen B, Berx G, Beschin A, Saeys Y, Guilliams M.

Immunity. 2018 Aug 21;49(2):312-325.e5. doi: 10.1016/j.immuni.2018.07.004. Epub 2018 Jul 31.

9.

Interactions among myeloid regulatory cells in cancer.

Umansky V, Adema GJ, Baran J, Brandau S, Van Ginderachter JA, Hu X, Jablonska J, Mojsilovic S, Papadaki HA, Pico de Coaña Y, Santegoets KCM, Santibanez JF, Serre K, Si Y, Sieminska I, Velegraki M, Fridlender ZG.

Cancer Immunol Immunother. 2019 Apr;68(4):645-660. doi: 10.1007/s00262-018-2200-6. Epub 2018 Jul 12. Review.

PMID:
30003321
10.

Neuropilin-1 upregulation elicits adaptive resistance to oncogene-targeted therapies.

Rizzolio S, Cagnoni G, Battistini C, Bonelli S, Isella C, Van Ginderachter JA, Bernards R, Di Nicolantonio F, Giordano S, Tamagnone L.

J Clin Invest. 2018 Aug 31;128(9):3976-3990. doi: 10.1172/JCI99257. Epub 2018 Aug 13.

11.

Targeting Protumoral Tumor-Associated Macrophages with Nanobody-Functionalized Nanogels through Strain Promoted Azide Alkyne Cycloaddition Ligation.

Nuhn L, Bolli E, Massa S, Vandenberghe I, Movahedi K, Devreese B, Van Ginderachter JA, De Geest BG.

Bioconjug Chem. 2018 Jul 18;29(7):2394-2405. doi: 10.1021/acs.bioconjchem.8b00319. Epub 2018 Jun 28.

PMID:
29889515
12.

How to measure the immunosuppressive activity of MDSC: assays, problems and potential solutions.

Bruger AM, Dorhoi A, Esendagli G, Barczyk-Kahlert K, van der Bruggen P, Lipoldova M, Perecko T, Santibanez J, Saraiva M, Van Ginderachter JA, Brandau S.

Cancer Immunol Immunother. 2019 Apr;68(4):631-644. doi: 10.1007/s00262-018-2170-8. Epub 2018 May 21. Review.

PMID:
29785656
13.

The role of hepatic macrophages in liver metastasis.

Keirsse J, Van Damme H, Geeraerts X, Beschin A, Raes G, Van Ginderachter JA.

Cell Immunol. 2018 Aug;330:202-215. doi: 10.1016/j.cellimm.2018.03.010. Epub 2018 Apr 6. Review.

PMID:
29661474
14.

RoMo: An efficient strategy for functional mosaic analysis via stochastic Cre recombination and gene targeting in the ROSA26 locus.

Movahedi K, Wiegmann R, De Vlaminck K, Van Ginderachter JA, Nikolaev VO.

Biotechnol Bioeng. 2018 Jul;115(7):1778-1792. doi: 10.1002/bit.26594. Epub 2018 Mar 31.

PMID:
29573361
15.

African Trypanosomiasis-Associated Anemia: The Contribution of the Interplay between Parasites and the Mononuclear Phagocyte System.

Stijlemans B, De Baetselier P, Magez S, Van Ginderachter JA, De Trez C.

Front Immunol. 2018 Feb 15;9:218. doi: 10.3389/fimmu.2018.00218. eCollection 2018. Review.

16.

Novel half-life extended anti-MIF nanobodies protect against endotoxic shock.

Sparkes A, De Baetselier P, Brys L, Cabrito I, Sterckx YG, Schoonooghe S, Muyldermans S, Raes G, Bucala R, Vanlandschoot P, Van Ginderachter JA, Stijlemans B.

FASEB J. 2018 Jun;32(6):3411-3422. doi: 10.1096/fj.201701189R. Epub 2018 Jan 25.

17.

Paracrine interactions of cancer-associated fibroblasts, macrophages and endothelial cells: tumor allies and foes.

Ronca R, Van Ginderachter JA, Turtoi A.

Curr Opin Oncol. 2018 Jan;30(1):45-53. doi: 10.1097/CCO.0000000000000420. Review.

PMID:
29084000
18.

Dusp3 deletion in mice promotes experimental lung tumour metastasis in a macrophage dependent manner.

Vandereyken M, Jacques S, Van Overmeire E, Amand M, Rocks N, Delierneux C, Singh P, Singh M, Ghuysen C, Wathieu C, Zurashvili T, Sounni NE, Moutschen M, Gilles C, Oury C, Cataldo D, Van Ginderachter JA, Rahmouni S.

PLoS One. 2017 Oct 11;12(10):e0185786. doi: 10.1371/journal.pone.0185786. eCollection 2017.

19.

Beyond the M-CSF receptor - novel therapeutic targets in tumor-associated macrophages.

Bonelli S, Geeraerts X, Bolli E, Keirsse J, Kiss M, Pombo Antunes AR, Van Damme H, De Vlaminck K, Movahedi K, Laoui D, Raes G, Van Ginderachter JA.

FEBS J. 2018 Feb;285(4):777-787. doi: 10.1111/febs.14202. Epub 2017 Sep 6. Review.

20.

Nanobodies As Tools to Understand, Diagnose, and Treat African Trypanosomiasis.

Stijlemans B, De Baetselier P, Caljon G, Van Den Abbeele J, Van Ginderachter JA, Magez S.

Front Immunol. 2017 Jun 30;8:724. doi: 10.3389/fimmu.2017.00724. eCollection 2017. Review.

21.

CCR2-dependent monocyte-derived macrophages resolve inflammation and restore gut motility in postoperative ileus.

Farro G, Stakenborg M, Gomez-Pinilla PJ, Labeeuw E, Goverse G, Di Giovangiulio M, Stakenborg N, Meroni E, D'Errico F, Elkrim Y, Laoui D, Lisowski ZM, Sauter KA, Hume DA, Van Ginderachter JA, Boeckxstaens GE, Matteoli G.

Gut. 2017 Dec;66(12):2098-2109. doi: 10.1136/gutjnl-2016-313144. Epub 2017 Jun 14.

22.

Reprint of: The non-mammalian MIF superfamily.

Sparkes A, De Baetselier P, Roelants K, De Trez C, Magez S, Van Ginderachter JA, Raes G, Bucala R, Stijlemans B.

Immunobiology. 2017 Jun;222(6):858-867. doi: 10.1016/j.imbio.2017.05.004. Epub 2017 May 26. Review.

PMID:
28552269
23.

Exploiting tumor-associated dendritic cell heterogeneity for novel cancer therapies.

Keirsse J, Van Damme H, Van Ginderachter JA, Laoui D.

J Leukoc Biol. 2017 Aug;102(2):317-324. doi: 10.1189/jlb.4MR1116-466R. Epub 2017 Apr 7. Review.

PMID:
28389620
24.

Macrophage Metabolism As Therapeutic Target for Cancer, Atherosclerosis, and Obesity.

Geeraerts X, Bolli E, Fendt SM, Van Ginderachter JA.

Front Immunol. 2017 Mar 15;8:289. doi: 10.3389/fimmu.2017.00289. eCollection 2017. Review.

25.

Erratum to: Inhibition of pannexin1 channels alleviates acetaminophen-induced hepatotoxicity.

Maes M, McGill MR, da Silva TC, Abels C, Lebofsky M, Weemhoff JL, Tiburcio T, Pereira IVA, Willebrords J, Yanguas SC, Farhood A, Beschin A, Van Ginderachter JA, Penuela S, Jaeschke H, Cogliati B, Vinken M.

Arch Toxicol. 2017 May;91(5):2263-2264. doi: 10.1007/s00204-016-1929-y. No abstract available.

PMID:
28243680
26.

The tumour microenvironment harbours ontogenically distinct dendritic cell populations with opposing effects on tumour immunity.

Laoui D, Keirsse J, Morias Y, Van Overmeire E, Geeraerts X, Elkrim Y, Kiss M, Bolli E, Lahmar Q, Sichien D, Serneels J, Scott CL, Boon L, De Baetselier P, Mazzone M, Guilliams M, Van Ginderachter JA.

Nat Commun. 2016 Dec 23;7:13720. doi: 10.1038/ncomms13720.

27.

Tumour-associated macrophage-mediated survival of myeloma cells through STAT3 activation.

De Beule N, De Veirman K, Maes K, De Bruyne E, Menu E, Breckpot K, De Raeve H, Van Rampelbergh R, Van Ginderachter JA, Schots R, Van Valckenborgh E, Vanderkerken K.

J Pathol. 2017 Mar;241(4):534-546. doi: 10.1002/path.4860. Epub 2017 Jan 30.

PMID:
27976373
28.

Inhibition of pannexin1 channels alleviates acetaminophen-induced hepatotoxicity.

Maes M, McGill MR, da Silva TC, Abels C, Lebofsky M, Weemhoff JL, Tiburcio T, Veloso Alves Pereira I, Willebrords J, Crespo Yanguas S, Farhood A, Beschin A, Van Ginderachter JA, Penuela S, Jaeschke H, Cogliati B, Vinken M.

Arch Toxicol. 2017 May;91(5):2245-2261. doi: 10.1007/s00204-016-1885-6. Epub 2016 Nov 8. Erratum in: Arch Toxicol. 2017 May;91(5):2263-2264.

29.

Novel insights in the regulation and function of macrophages in the tumor microenvironment.

Bolli E, Movahedi K, Laoui D, Van Ginderachter JA.

Curr Opin Oncol. 2017 Jan;29(1):55-61. Review.

PMID:
27792052
30.

The Ontogeny and Microenvironmental Regulation of Tumor-Associated Macrophages.

Movahedi K, Van Ginderachter JA.

Antioxid Redox Signal. 2016 Nov 10;25(14):775-791. Epub 2016 May 17.

PMID:
27020982
31.

The non-mammalian MIF superfamily.

Sparkes A, De Baetselier P, Roelants K, De Trez C, Magez S, Van Ginderachter JA, Raes G, Bucala R, Stijlemans B.

Immunobiology. 2017 Mar;222(3):473-482. doi: 10.1016/j.imbio.2016.10.006. Epub 2016 Oct 12. Review.

32.

MIF-Mediated Hemodilution Promotes Pathogenic Anemia in Experimental African Trypanosomosis.

Stijlemans B, Brys L, Korf H, Bieniasz-Krzywiec P, Sparkes A, Vansintjan L, Leng L, Vanbekbergen N, Mazzone M, Caljon G, Van Den Abbeele J, Odongo S, De Trez C, Magez S, Van Ginderachter JA, Beschin A, Bucala R, De Baetselier P.

PLoS Pathog. 2016 Sep 15;12(9):e1005862. doi: 10.1371/journal.ppat.1005862. eCollection 2016 Sep.

33.

Expression of the inhibitory Ly49E receptor is not critically involved in the immune response against cutaneous, pulmonary or liver tumours.

Filtjens J, Keirsse J, Van Ammel E, Taveirne S, Van Acker A, Kerre T, Taghon T, Vandekerckhove B, Plum J, Van Ginderachter JA, Leclercq G.

Sci Rep. 2016 Jul 29;6:30564. doi: 10.1038/srep30564.

34.

Immune Evasion Strategies of Trypanosoma brucei within the Mammalian Host: Progression to Pathogenicity.

Stijlemans B, Caljon G, Van Den Abbeele J, Van Ginderachter JA, Magez S, De Trez C.

Front Immunol. 2016 Jun 24;7:233. doi: 10.3389/fimmu.2016.00233. eCollection 2016. Review.

35.

Genetic ablation of IP3 receptor 2 increases cytokines and decreases survival of SOD1G93A mice.

Staats KA, Humblet-Baron S, Bento-Abreu A, Scheveneels W, Nikolaou A, Deckers K, Lemmens R, Goris A, Van Ginderachter JA, Van Damme P, Hisatsune C, Mikoshiba K, Liston A, Robberecht W, Van Den Bosch L.

Hum Mol Genet. 2016 Aug 15;25(16):3491-3499. doi: 10.1093/hmg/ddw190. Epub 2016 Jul 4.

36.

Molecular Imaging with Kupffer Cell-Targeting Nanobodies for Diagnosis and Prognosis in Mouse Models of Liver Pathogenesis.

Zheng F, Sparkes A, De Baetselier P, Schoonooghe S, Stijlemans B, Muyldermans S, Flamand V, Van Ginderachter JA, Devoogdt N, Raes G, Beschin A.

Mol Imaging Biol. 2017 Feb;19(1):49-58. doi: 10.1007/s11307-016-0976-3.

PMID:
27339464
37.

Involvement of connexin43 in acetaminophen-induced liver injury.

Maes M, McGill MR, da Silva TC, Abels C, Lebofsky M, Maria Monteiro de Araújo C, Tiburcio T, Veloso Alves Pereira I, Willebrords J, Crespo Yanguas S, Farhood A, Beschin A, Van Ginderachter JA, Zaidan Dagli ML, Jaeschke H, Cogliati B, Vinken M.

Biochim Biophys Acta. 2016 Jun;1862(6):1111-21. doi: 10.1016/j.bbadis.2016.02.007. Epub 2016 Feb 18.

38.

M-CSF and GM-CSF Receptor Signaling Differentially Regulate Monocyte Maturation and Macrophage Polarization in the Tumor Microenvironment.

Van Overmeire E, Stijlemans B, Heymann F, Keirsse J, Morias Y, Elkrim Y, Brys L, Abels C, Lahmar Q, Ergen C, Vereecke L, Tacke F, De Baetselier P, Van Ginderachter JA, Laoui D.

Cancer Res. 2016 Jan 1;76(1):35-42. doi: 10.1158/0008-5472.CAN-15-0869. Epub 2015 Nov 16.

39.

E-cadherin expression in macrophages dampens their inflammatory responsiveness in vitro, but does not modulate M2-regulated pathologies in vivo.

Van den Bossche J, Laoui D, Naessens T, Smits HH, Hokke CH, Stijlemans B, Grooten J, De Baetselier P, Van Ginderachter JA.

Sci Rep. 2015 Jul 31;5:12599. doi: 10.1038/srep12599.

40.

Tissue-resident versus monocyte-derived macrophages in the tumor microenvironment.

Lahmar Q, Keirsse J, Laoui D, Movahedi K, Van Overmeire E, Van Ginderachter JA.

Biochim Biophys Acta. 2016 Jan;1865(1):23-34. doi: 10.1016/j.bbcan.2015.06.009. Epub 2015 Jul 2. Review.

PMID:
26145884
41.

Iron Homeostasis and Trypanosoma brucei Associated Immunopathogenicity Development: A Battle/Quest for Iron.

Stijlemans B, Beschin A, Magez S, Van Ginderachter JA, De Baetselier P.

Biomed Res Int. 2015;2015:819389. doi: 10.1155/2015/819389. Epub 2015 May 18. Review.

42.

PET Imaging of Macrophage Mannose Receptor-Expressing Macrophages in Tumor Stroma Using 18F-Radiolabeled Camelid Single-Domain Antibody Fragments.

Blykers A, Schoonooghe S, Xavier C, D'hoe K, Laoui D, D'Huyvetter M, Vaneycken I, Cleeren F, Bormans G, Heemskerk J, Raes G, De Baetselier P, Lahoutte T, Devoogdt N, Van Ginderachter JA, Caveliers V.

J Nucl Med. 2015 Aug;56(8):1265-71. doi: 10.2967/jnumed.115.156828. Epub 2015 Jun 11.

43.

Estrogen Receptor α Regulates β-Cell Formation During Pancreas Development and Following Injury.

Yuchi Y, Cai Y, Legein B, De Groef S, Leuckx G, Coppens V, Van Overmeire E, Staels W, De Leu N, Martens G, Van Ginderachter JA, Heimberg H, Van de Casteele M.

Diabetes. 2015 Sep;64(9):3218-28. doi: 10.2337/db14-1798. Epub 2015 May 26.

44.

DUSP3 Genetic Deletion Confers M2-like Macrophage-Dependent Tolerance to Septic Shock.

Singh P, Dejager L, Amand M, Theatre E, Vandereyken M, Zurashvili T, Singh M, Mack M, Timmermans S, Musumeci L, Dejardin E, Mustelin T, Van Ginderachter JA, Moutschen M, Oury C, Libert C, Rahmouni S.

J Immunol. 2015 May 15;194(10):4951-62. doi: 10.4049/jimmunol.1402431. Epub 2015 Apr 15.

45.

Multiple myeloma induces Mcl-1 expression and survival of myeloid-derived suppressor cells.

De Veirman K, Van Ginderachter JA, Lub S, De Beule N, Thielemans K, Bautmans I, Oyajobi BO, De Bruyne E, Menu E, Lemaire M, Van Riet I, Vanderkerken K, Van Valckenborgh E.

Oncotarget. 2015 Apr 30;6(12):10532-47.

46.

Concise Review: Macrophages: Versatile Gatekeepers During Pancreatic β-Cell Development, Injury, and Regeneration.

Van Gassen N, Staels W, Van Overmeire E, De Groef S, Sojoodi M, Heremans Y, Leuckx G, Van de Casteele M, Van Ginderachter JA, Heimberg H, De Leu N.

Stem Cells Transl Med. 2015 Jun;4(6):555-63. doi: 10.5966/sctm.2014-0272. Epub 2015 Apr 6. Review.

47.

Macrophage dynamics are regulated by local macrophage proliferation and monocyte recruitment in injured pancreas.

Van Gassen N, Van Overmeire E, Leuckx G, Heremans Y, De Groef S, Cai Y, Elkrim Y, Gysemans C, Stijlemans B, Van de Casteele M, De Baetselier P, De Leu N, Heimberg H, Van Ginderachter JA.

Eur J Immunol. 2015 May;45(5):1482-93. doi: 10.1002/eji.201445013. Epub 2015 Mar 19.

48.

Myeloid-derived suppressor cells as therapeutic target in hematological malignancies.

De Veirman K, Van Valckenborgh E, Lahmar Q, Geeraerts X, De Bruyne E, Menu E, Van Riet I, Vanderkerken K, Van Ginderachter JA.

Front Oncol. 2014 Dec 8;4:349. doi: 10.3389/fonc.2014.00349. eCollection 2014. Review.

49.

Molecular profiling reveals a tumor-promoting phenotype of monocytes and macrophages in human cancer progression.

Chittezhath M, Dhillon MK, Lim JY, Laoui D, Shalova IN, Teo YL, Chen J, Kamaraj R, Raman L, Lum J, Thamboo TP, Chiong E, Zolezzi F, Yang H, Van Ginderachter JA, Poidinger M, Wong AS, Biswas SK.

Immunity. 2014 Nov 20;41(5):815-29. doi: 10.1016/j.immuni.2014.09.014. Epub 2014 Oct 30.

50.

Targeting cell-intrinsic and cell-extrinsic mechanisms of intravasation in invasive breast cancer.

Keirsse J, Laoui D, Van Overmeire E, Van Ginderachter JA.

Sci Signal. 2014 Nov 25;7(353):pe28. doi: 10.1126/scisignal.aaa2104.

PMID:
25429075

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