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Items: 24


Tissue signals imprint ILC2 identity with anticipatory function.

Ricardo-Gonzalez RR, Van Dyken SJ, Schneider C, Lee J, Nussbaum JC, Liang HE, Vaka D, Eckalbar WL, Molofsky AB, Erle DJ, Locksley RM.

Nat Immunol. 2018 Oct;19(10):1093-1099. doi: 10.1038/s41590-018-0201-4. Epub 2018 Sep 10.


Chitins and chitinase activity in airway diseases.

Van Dyken SJ, Locksley RM.

J Allergy Clin Immunol. 2018 Aug;142(2):364-369. doi: 10.1016/j.jaci.2018.06.017. Epub 2018 Jun 28.


Pulmonary neuroendocrine cells amplify allergic asthma responses.

Sui P, Wiesner DL, Xu J, Zhang Y, Lee J, Van Dyken S, Lashua A, Yu C, Klein BS, Locksley RM, Deutsch G, Sun X.

Science. 2018 Jun 8;360(6393). pii: eaan8546. doi: 10.1126/science.aan8546. Epub 2018 Mar 29.


Innate Lymphoid Cells Mediate Pulmonary Eosinophilic Inflammation, Airway Mucous Cell Metaplasia, and Type 2 Immunity in Mice Exposed to Ozone.

Kumagai K, Lewandowski RP, Jackson-Humbles DN, Buglak N, Li N, White K, Van Dyken SJ, Wagner JG, Harkema JR.

Toxicol Pathol. 2017 Aug;45(6):692-704. doi: 10.1177/0192623317728135. Epub 2017 Sep 11.


Spontaneous Chitin Accumulation in Airways and Age-Related Fibrotic Lung Disease.

Van Dyken SJ, Liang HE, Naikawadi RP, Woodruff PG, Wolters PJ, Erle DJ, Locksley RM.

Cell. 2017 Apr 20;169(3):497-509.e13. doi: 10.1016/j.cell.2017.03.044.


A tissue checkpoint regulates type 2 immunity.

Van Dyken SJ, Nussbaum JC, Lee J, Molofsky AB, Liang HE, Pollack JL, Gate RE, Haliburton GE, Ye CJ, Marson A, Erle DJ, Locksley RM.

Nat Immunol. 2016 Dec;17(12):1381-1387. doi: 10.1038/ni.3582. Epub 2016 Oct 17.


Ozone-Induced Nasal Type 2 Immunity in Mice Is Dependent on Innate Lymphoid Cells.

Kumagai K, Lewandowski R, Jackson-Humbles DN, Li N, Van Dyken SJ, Wagner JG, Harkema JR.

Am J Respir Cell Mol Biol. 2016 Jun;54(6):782-91. doi: 10.1165/rcmb.2015-0118OC.


Group 2 innate lymphoid cells utilize the IRF4-IL-9 module to coordinate epithelial cell maintenance of lung homeostasis.

Mohapatra A, Van Dyken SJ, Schneider C, Nussbaum JC, Liang HE, Locksley RM.

Mucosal Immunol. 2016 Jan;9(1):275-86. doi: 10.1038/mi.2015.59. Epub 2015 Jul 1.


Interleukin-33 and Interferon-γ Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation.

Molofsky AB, Van Gool F, Liang HE, Van Dyken SJ, Nussbaum JC, Lee J, Bluestone JA, Locksley RM.

Immunity. 2015 Jul 21;43(1):161-74. doi: 10.1016/j.immuni.2015.05.019. Epub 2015 Jun 16.


Eosinophils are recruited in response to chitin exposure and enhance Th2-mediated immune pathology in Aspergillus fumigatus infection.

O'Dea EM, Amarsaikhan N, Li H, Downey J, Steele E, Van Dyken SJ, Locksley RM, Templeton SP.

Infect Immun. 2014 Aug;82(8):3199-205. doi: 10.1128/IAI.01990-14. Epub 2014 May 19.


Chitin activates parallel immune modules that direct distinct inflammatory responses via innate lymphoid type 2 and γδ T cells.

Van Dyken SJ, Mohapatra A, Nussbaum JC, Molofsky AB, Thornton EE, Ziegler SF, McKenzie AN, Krummel MF, Liang HE, Locksley RM.

Immunity. 2014 Mar 20;40(3):414-24. doi: 10.1016/j.immuni.2014.02.003. Epub 2014 Mar 13.


Type 2 innate lymphoid cells control eosinophil homeostasis.

Nussbaum JC, Van Dyken SJ, von Moltke J, Cheng LE, Mohapatra A, Molofsky AB, Thornton EE, Krummel MF, Chawla A, Liang HE, Locksley RM.

Nature. 2013 Oct 10;502(7470):245-8. doi: 10.1038/nature12526. Epub 2013 Sep 15.


Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages.

Molofsky AB, Nussbaum JC, Liang HE, Van Dyken SJ, Cheng LE, Mohapatra A, Chawla A, Locksley RM.

J Exp Med. 2013 Mar 11;210(3):535-49. doi: 10.1084/jem.20121964. Epub 2013 Feb 18.


Interleukin-4- and interleukin-13-mediated alternatively activated macrophages: roles in homeostasis and disease.

Van Dyken SJ, Locksley RM.

Annu Rev Immunol. 2013;31:317-43. doi: 10.1146/annurev-immunol-032712-095906. Epub 2013 Jan 3. Review.


Fungal chitin from asthma-associated home environments induces eosinophilic lung infiltration.

Van Dyken SJ, Garcia D, Porter P, Huang X, Quinlan PJ, Blanc PD, Corry DB, Locksley RM.

J Immunol. 2011 Sep 1;187(5):2261-7. doi: 10.4049/jimmunol.1100972. Epub 2011 Aug 8.


Autoimmunity: altered self-N-glycans trigger innate-mediated autoimmunity.

Van Dyken SJ, Locksley RM.

Immunol Cell Biol. 2007 Nov-Dec;85(8):572-4. Epub 2007 Oct 2. No abstract available.


T-cell activation results in microheterogeneous changes in glycosylation of CD45.

Hernandez JD, Klein J, Van Dyken SJ, Marth JD, Baum LG.

Int Immunol. 2007 Jul;19(7):847-56. Epub 2007 Jul 2.


Structural and mechanistic features of protein O glycosylation linked to CD8+ T-cell apoptosis.

Van Dyken SJ, Green RS, Marth JD.

Mol Cell Biol. 2007 Feb;27(3):1096-111. Epub 2006 Nov 13.


Sialylation regulates peripheral tolerance in CD4+ T cells.

Brennan PJ, Saouaf SJ, Van Dyken S, Marth JD, Li B, Bhandoola A, Greene MI.

Int Immunol. 2006 May;18(5):627-35. Epub 2005 Nov 15.


Ozone exposure enhances endotoxin-induced mucous cell metaplasia in rat pulmonary airways.

Wagner JG, Van Dyken SJ, Wierenga JR, Hotchkiss JA, Harkema JR.

Toxicol Sci. 2003 Aug;74(2):437-46. Epub 2003 May 28.


Topically applied 15-(S)-HETE stimulates mucin production by corneal epithelium.

Ubels JL, Aupperlee MD, Jackson RS 2nd, Van Dyken SJ, McCartney MD.

Adv Exp Med Biol. 2002;506(Pt A):317-21. No abstract available.


Sialic acid capping of CD8beta core 1-O-glycans controls thymocyte-major histocompatibility complex class I interaction.

Moody AM, North SJ, Reinhold B, Van Dyken SJ, Rogers ME, Panico M, Dell A, Morris HR, Marth JD, Reinherz EL.

J Biol Chem. 2003 Feb 28;278(9):7240-6. Epub 2002 Nov 28.


The eicosanoid, 15-(S)-HETE, stimulates secretion of mucin-like glycoprotein by the corneal epithelium.

Jackson RS 2nd, Van Dyken SJ, McCartney MD, Ubels JL.

Cornea. 2001 Jul;20(5):516-21.


Endotoxin enhancement of ozone-induced mucous cell metaplasia is neutrophil-dependent in rat nasal epithelium.

Wagner JG, Van Dyken SJ, Hotchkiss JA, Harkema JR.

Toxicol Sci. 2001 Apr;60(2):338-47.


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