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Serine Integrase attP Binding and Specificity.

Li H, Sharp R, Rutherford K, Gupta K, Van Duyne GD.

J Mol Biol. 2018 Oct 19;430(21):4401-4418. doi: 10.1016/j.jmb.2018.09.007. Epub 2018 Sep 15.


Self-oligomerization regulates stability of survival motor neuron protein isoforms by sequestering an SCFSlmb degron.

Gray KM, Kaifer KA, Baillat D, Wen Y, Bonacci TR, Ebert AD, Raimer AC, Spring AM, Have ST, Glascock JJ, Gupta K, Van Duyne GD, Emanuele MJ, Lamond AI, Wagner EJ, Lorson CL, Matera AG.

Mol Biol Cell. 2018 Jan 15;29(2):96-110. doi: 10.1091/mbc.E17-11-0627. Epub 2017 Nov 22.


Coiled-coil interactions mediate serine integrase directionality.

Gupta K, Sharp R, Yuan JB, Li H, Van Duyne GD.

Nucleic Acids Res. 2017 Jul 7;45(12):7339-7353. doi: 10.1093/nar/gkx474.


Control of Recombination Directionality by the Listeria Phage A118 Protein Gp44 and the Coiled-Coil Motif of Its Serine Integrase.

Mandali S, Gupta K, Dawson AR, Van Duyne GD, Johnson RC.

J Bacteriol. 2017 May 9;199(11). pii: e00019-17. doi: 10.1128/JB.00019-17. Print 2017 Jun 1.


Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase.

Gupta K, Turkki V, Sherrill-Mix S, Hwang Y, Eilers G, Taylor L, McDanal C, Wang P, Temelkoff D, Nolte RT, Velthuisen E, Jeffrey J, Van Duyne GD, Bushman FD.

PLoS Biol. 2016 Dec 9;14(12):e1002584. doi: 10.1371/journal.pbio.1002584. eCollection 2016 Dec.


Introduction: Genome Modifying Mechanisms.

Kohli RM, Van Duyne GD.

Chem Rev. 2016 Oct 26;116(20):12653-12654. No abstract available.


Tankyrase-1 Ankyrin Repeats Form an Adaptable Binding Platform for Targets of ADP-Ribose Modification.

Eisemann T, McCauley M, Langelier MF, Gupta K, Roy S, Van Duyne GD, Pascal JM.

Structure. 2016 Oct 4;24(10):1679-1692. doi: 10.1016/j.str.2016.07.014. Epub 2016 Sep 1.


A critical examination of the recently reported crystal structures of the human SMN protein.

Weiss MS, Diederichs K, Read RJ, Panjikar S, Van Duyne GD, Matera AG, Fischer U, Grimm C.

Hum Mol Genet. 2016 Aug 29;25(21):4717–4725. doi: 10.1093/hmg/ddw298.


Structure of a Holliday junction complex reveals mechanisms governing a highly regulated DNA transaction.

Laxmikanthan G, Xu C, Brilot AF, Warren D, Steele L, Seah N, Tong W, Grigorieff N, Landy A, Van Duyne GD.

Elife. 2016 May 25;5. pii: e14313. doi: 10.7554/eLife.14313.


Structure and Metal Binding Properties of a Poxvirus Resolvase.

Li H, Hwang Y, Perry K, Bushman F, Van Duyne GD.

J Biol Chem. 2016 May 20;291(21):11094-104. doi: 10.1074/jbc.M115.709139. Epub 2016 Mar 24.


Cre Recombinase.

Van Duyne GD.

Microbiol Spectr. 2015 Feb;3(1):MDNA3-0014-2014. doi: 10.1128/microbiolspec.MDNA3-0014-2014. Review.


Oligomeric Properties of Survival Motor Neuron·Gemin2 Complexes.

Gupta K, Martin R, Sharp R, Sarachan KL, Ninan NS, Van Duyne GD.

J Biol Chem. 2015 Aug 14;290(33):20185-99. doi: 10.1074/jbc.M115.667279. Epub 2015 Jun 19.


Chromosomes. CENP-C reshapes and stabilizes CENP-A nucleosomes at the centromere.

Falk SJ, Guo LY, Sekulic N, Smoak EM, Mani T, Logsdon GA, Gupta K, Jansen LE, Van Duyne GD, Vinogradov SA, Lampson MA, Black BE.

Science. 2015 May 8;348(6235):699-703. doi: 10.1126/science.1259308.


p100/IκBδ sequesters and inhibits NF-κB through kappaBsome formation.

Tao Z, Fusco A, Huang DB, Gupta K, Young Kim D, Ware CF, Van Duyne GD, Ghosh G.

Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):15946-51. doi: 10.1073/pnas.1408552111. Epub 2014 Oct 27.


SMA-causing missense mutations in survival motor neuron (Smn) display a wide range of phenotypes when modeled in Drosophila.

Praveen K, Wen Y, Gray KM, Noto JJ, Patlolla AR, Van Duyne GD, Matera AG.

PLoS Genet. 2014 Aug 21;10(8):e1004489. doi: 10.1371/journal.pgen.1004489. eCollection 2014 Aug.


Mapping the λ Integrase bridges in the nucleoprotein Holliday junction intermediates of viral integrative and excisive recombination.

Tong W, Warren D, Seah NE, Laxmikanthan G, Van Duyne GD, Landy A.

Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12366-71. doi: 10.1073/pnas.1413007111. Epub 2014 Aug 11.


Nucleoprotein architectures regulating the directionality of viral integration and excision.

Seah NE, Warren D, Tong W, Laxmikanthan G, Van Duyne GD, Landy A.

Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12372-7. doi: 10.1073/pnas.1413019111. Epub 2014 Aug 11.


Allosteric inhibition of human immunodeficiency virus integrase: late block during viral replication and abnormal multimerization involving specific protein domains.

Gupta K, Brady T, Dyer BM, Malani N, Hwang Y, Male F, Nolte RT, Wang L, Velthuisen E, Jeffrey J, Van Duyne GD, Bushman FD.

J Biol Chem. 2014 Jul 25;289(30):20477-88.


Quaternary arrangement of an active, native group II intron ribonucleoprotein complex revealed by small-angle X-ray scattering.

Gupta K, Contreras LM, Smith D, Qu G, Huang T, Spruce LA, Seeholzer SH, Belfort M, Van Duyne GD.

Nucleic Acids Res. 2014 Apr;42(8):5347-60. doi: 10.1093/nar/gku140. Epub 2014 Feb 24.


The ins and outs of serine integrase site-specific recombination.

Rutherford K, Van Duyne GD.

Curr Opin Struct Biol. 2014 Feb;24:125-31. doi: 10.1016/ Epub 2014 Feb 11. Review.


Large serine recombinase domain structure and attachment site binding.

Van Duyne GD, Rutherford K.

Crit Rev Biochem Mol Biol. 2013 Sep-Oct;48(5):476-91. doi: 10.3109/10409238.2013.831807. Epub 2013 Aug 28. Review.


Attachment site recognition and regulation of directionality by the serine integrases.

Rutherford K, Yuan P, Perry K, Sharp R, Van Duyne GD.

Nucleic Acids Res. 2013 Sep;41(17):8341-56. doi: 10.1093/nar/gkt580. Epub 2013 Jul 2.


The survival motor neuron protein forms soluble glycine zipper oligomers.

Martin R, Gupta K, Ninan NS, Perry K, Van Duyne GD.

Structure. 2012 Nov 7;20(11):1929-39. doi: 10.1016/j.str.2012.08.024. Epub 2012 Sep 27.


Solution conformations of prototype foamy virus integrase and its stable synaptic complex with U5 viral DNA.

Gupta K, Curtis JE, Krueger S, Hwang Y, Cherepanov P, Bushman FD, Van Duyne GD.

Structure. 2012 Nov 7;20(11):1918-28. doi: 10.1016/j.str.2012.08.023. Epub 2012 Sep 20.


Interaction of the HIV-1 intasome with transportin 3 protein (TNPO3 or TRN-SR2).

Larue R, Gupta K, Wuensch C, Shkriabai N, Kessl JJ, Danhart E, Feng L, Taltynov O, Christ F, Van Duyne GD, Debyser Z, Foster MP, Kvaratskhelia M.

J Biol Chem. 2012 Oct 5;287(41):34044-58. doi: 10.1074/jbc.M112.384669. Epub 2012 Aug 7.


Solution structure of the core SMN-Gemin2 complex.

Sarachan KL, Valentine KG, Gupta K, Moorman VR, Gledhill JM Jr, Bernens M, Tommos C, Wand AJ, Van Duyne GD.

Biochem J. 2012 Aug 1;445(3):361-70. doi: 10.1042/BJ20120241.


Disorder-to-order transition underlies the structural basis for the assembly of a transcriptionally active PGC-1α/ERRγ complex.

Devarakonda S, Gupta K, Chalmers MJ, Hunt JF, Griffin PR, Van Duyne GD, Spiegelman BM.

Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):18678-83. doi: 10.1073/pnas.1113813108. Epub 2011 Nov 2.


The group II intron ribonucleoprotein precursor is a large, loosely packed structure.

Huang T, Shaikh TR, Gupta K, Contreras-Martin LM, Grassucci RA, Van Duyne GD, Frank J, Belfort M.

Nucleic Acids Res. 2011 Apr;39(7):2845-54. doi: 10.1093/nar/gkq1202. Epub 2010 Dec 3.


Requirements for catalysis in the Cre recombinase active site.

Gibb B, Gupta K, Ghosh K, Sharp R, Chen J, Van Duyne GD.

Nucleic Acids Res. 2010 Sep;38(17):5817-32. doi: 10.1093/nar/gkq384. Epub 2010 May 12.


Structural properties of HIV integrase. Lens epithelium-derived growth factor oligomers.

Gupta K, Diamond T, Hwang Y, Bushman F, Van Duyne GD.

J Biol Chem. 2010 Jun 25;285(26):20303-15. doi: 10.1074/jbc.M110.114413. Epub 2010 Apr 20.


Insights from the structure of a smallpox virus topoisomerase-DNA transition state mimic.

Perry K, Hwang Y, Bushman FD, Van Duyne GD.

Structure. 2010 Jan 13;18(1):127-37. doi: 10.1016/j.str.2009.10.020.


Role of pICLn in methylation of Sm proteins by PRMT5.

Pesiridis GS, Diamond E, Van Duyne GD.

J Biol Chem. 2009 Aug 7;284(32):21347-59. doi: 10.1074/jbc.M109.015578. Epub 2009 Jun 11.


Teaching Cre to follow directions.

Van Duyne GD.

Proc Natl Acad Sci U S A. 2009 Jan 6;106(1):4-5. doi: 10.1073/pnas.0811624106. Epub 2008 Dec 31. No abstract available.


Structural coupling between FKBP12 and buried water.

Szep S, Park S, Boder ET, Van Duyne GD, Saven JG.

Proteins. 2009 Feb 15;74(3):603-11. doi: 10.1002/prot.22176.


Tetrameric structure of a serine integrase catalytic domain.

Yuan P, Gupta K, Van Duyne GD.

Structure. 2008 Aug 6;16(8):1275-86. doi: 10.1016/j.str.2008.04.018.


Protein-nucleic acid complexes: large, small, old, and new.

Van Duyne GD, Yang W.

Curr Opin Struct Biol. 2008 Feb;18(1):67-9. doi: 10.1016/ Epub 2008 Feb 11. No abstract available.


Synapsis of loxP sites by Cre recombinase.

Ghosh K, Guo F, Van Duyne GD.

J Biol Chem. 2007 Aug 17;282(33):24004-16. Epub 2007 Jun 15.


Variola virus topoisomerase: DNA cleavage specificity and distribution of sites in Poxvirus genomes.

Minkah N, Hwang Y, Perry K, Van Duyne GD, Hendrickson R, Lefkowitz EJ, Hannenhalli S, Bushman FD.

Virology. 2007 Aug 15;365(1):60-9. Epub 2007 Apr 25.


Regulation of catalysis by the smallpox virus topoisomerase.

Hwang Y, Minkah N, Perry K, Van Duyne GD, Bushman FD.

J Biol Chem. 2006 Dec 8;281(49):38052-60. Epub 2006 Oct 10.


Structural basis for specificity in the poxvirus topoisomerase.

Perry K, Hwang Y, Bushman FD, Van Duyne GD.

Mol Cell. 2006 Aug 4;23(3):343-54.


Preferential synapsis of loxP sites drives ordered strand exchange in Cre-loxP site-specific recombination.

Ghosh K, Lau CK, Gupta K, Van Duyne GD.

Nat Chem Biol. 2005 Oct;1(5):275-82. Epub 2005 Sep 11.


Lambda integrase: armed for recombination.

Van Duyne GD.

Curr Biol. 2005 Sep 6;15(17):R658-60. Review.


Bending and cutting forks and flaps.

Van Duyne GD.

Structure. 2005 Aug;13(8):1092-3. No abstract available.


The Gemin6-Gemin7 heterodimer from the survival of motor neurons complex has an Sm protein-like structure.

Ma Y, Dostie J, Dreyfuss G, Van Duyne GD.

Structure. 2005 Jun;13(6):883-92.


Peptide trapping of the Holliday junction intermediate in Cre-loxP site-specific recombination.

Ghosh K, Lau CK, Guo F, Segall AM, Van Duyne GD.

J Biol Chem. 2005 Mar 4;280(9):8290-9. Epub 2004 Dec 8.


Structure of the Y14-Magoh core of the exon junction complex.

Lau CK, Diem MD, Dreyfuss G, Van Duyne GD.

Curr Biol. 2003 May 27;13(11):933-41.


Cre-loxP biochemistry.

Ghosh K, Van Duyne GD.

Methods. 2002 Nov;28(3):374-83. Review.


The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins.

Friesen WJ, Paushkin S, Wyce A, Massenet S, Pesiridis GS, Van Duyne G, Rappsilber J, Mann M, Dreyfuss G.

Mol Cell Biol. 2001 Dec;21(24):8289-300.


A structural view of cre-loxp site-specific recombination.

Van Duyne GD.

Annu Rev Biophys Biomol Struct. 2001;30:87-104. Review.


Thermostability, oligomerization and DNA-binding properties of the regulatory protein ArgR from the hyperthermophilic bacterium Thermotoga neapolitana.

Dimova D, Weigel P, Takahashi M, Marc F, Van Duyne GD, Sakanyan V.

Mol Gen Genet. 2000 Feb;263(1):119-30.


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