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Protection of Cystinotic Mice by Kidney-Specific Megalin Ablation Supports an Endocytosis-Based Mechanism for Nephropathic Cystinosis Progression.

Janssens V, Gaide Chevronnay HP, Marie S, Vincent MF, Van Der Smissen P, Nevo N, Vainio S, Nielsen R, Christensen EI, Jouret F, Antignac C, Pierreux CE, Courtoy PJ.

J Am Soc Nephrol. 2019 Nov;30(11):2177-2190. doi: 10.1681/ASN.2019040371. Epub 2019 Sep 23.


Clinical Protocol to Prevent Thrombogenic Effect of Liver-Derived Mesenchymal Cells for Cell-Based Therapies.

Coppin L, Najimi M, Bodart J, Rouchon MS, van der Smissen P, Eeckhoudt S, Dahlqvist G, Castanares-Zapatero D, Komuta M, Brouns SL, Baaten CC, Heemskerk JWM, Horman S, Belmonte N, Sokal E, Stéphenne X.

Cells. 2019 Aug 7;8(8). pii: E846. doi: 10.3390/cells8080846.


Dysosmobacter welbionis gen. nov., sp. nov., isolated from human faeces and emended description of the genus Oscillibacter.

Le Roy T, Van der Smissen P, Paquot A, Delzenne N, Muccioli GG, Collet JF, Cani PD.

Int J Syst Evol Microbiol. 2019 Jun 24. doi: 10.1099/ijsem.0.003547. [Epub ahead of print]


Antimicrobial activity of amphiphilic neamine derivatives: Understanding the mechanism of action on Gram-positive bacteria.

Swain J, El Khoury M, Flament A, Dezanet C, Briée F, Van Der Smissen P, Décout JL, Mingeot-Leclercq MP.

Biochim Biophys Acta Biomembr. 2019 Oct 1;1861(10):182998. doi: 10.1016/j.bbamem.2019.05.020. Epub 2019 May 31.


Butyricimonas faecalis sp. nov., isolated from human faeces and emended description of the genus Butyricimonas.

Le Roy T, Van der Smissen P, Paquot A, Delzenne N, Muccioli GG, Collet JF, Cani PD.

Int J Syst Evol Microbiol. 2019 Mar;69(3):833-838. doi: 10.1099/ijsem.0.003249. Epub 2019 Feb 1.


Vps34/PI3KC3 deletion in kidney proximal tubules impairs apical trafficking and blocks autophagic flux, causing a Fanconi-like syndrome and renal insufficiency.

Grieco G, Janssens V, Gaide Chevronnay HP, N'Kuli F, Van Der Smissen P, Wang T, Shan J, Vainio S, Bilanges B, Jouret F, Vanhaesebroeck B, Pierreux CE, Courtoy PJ.

Sci Rep. 2018 Sep 20;8(1):14133. doi: 10.1038/s41598-018-32389-z.


Effect of cardiolipin on the antimicrobial activity of a new amphiphilic aminoglycoside derivative on Pseudomonas aeruginosa.

Swain J, El Khoury M, Kempf J, Briée F, Van Der Smissen P, Décout JL, Mingeot-Leclercq MP.

PLoS One. 2018 Aug 20;13(8):e0201752. doi: 10.1371/journal.pone.0201752. eCollection 2018.


Extracellular vesicles from endothelial progenitor cells promote thyroid follicle formation.

Degosserie J, Heymans C, Spourquet C, Halbout M, D'Auria L, Van Der Smissen P, Vertommen D, Courtoy PJ, Tyteca D, Pierreux CE.

J Extracell Vesicles. 2018 Jun 28;7(1):1487250. doi: 10.1080/20013078.2018.1487250. eCollection 2018.


Targeting Bacterial Cardiolipin Enriched Microdomains: An Antimicrobial Strategy Used by Amphiphilic Aminoglycoside Antibiotics.

El Khoury M, Swain J, Sautrey G, Zimmermann L, Van Der Smissen P, Décout JL, Mingeot-Leclercq MP.

Sci Rep. 2017 Sep 6;7(1):10697. doi: 10.1038/s41598-017-10543-3.


Contribution of plasma membrane lipid domains to red blood cell (re)shaping.

Leonard C, Conrard L, Guthmann M, Pollet H, Carquin M, Vermylen C, Gailly P, Van Der Smissen P, Mingeot-Leclercq MP, Tyteca D.

Sci Rep. 2017 Jun 27;7(1):4264. doi: 10.1038/s41598-017-04388-z.


V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog A Synthetic Modified mRNA Drives Reprogramming of Human Pancreatic Duct-Derived Cells Into Insulin-Secreting Cells.

Corritore E, Lee YS, Pasquale V, Liberati D, Hsu MJ, Lombard CA, Van Der Smissen P, Vetere A, Bonner-Weir S, Piemonti L, Sokal E, Lysy PA.

Stem Cells Transl Med. 2016 Nov;5(11):1525-1537. doi: 10.5966/sctm.2015-0318. Epub 2016 Jul 12.


Tubular proteinuria in patients with HNF1α mutations: HNF1α drives endocytosis in the proximal tubule.

Terryn S, Tanaka K, Lengelé JP, Olinger E, Dubois-Laforgue D, Garbay S, Kozyraki R, Van Der Smissen P, Christensen EI, Courtoy PJ, Bellanné-Chantelot C, Timsit J, Pontoglio M, Devuyst O.

Kidney Int. 2016 May;89(5):1075-1089. doi: 10.1016/j.kint.2016.01.027. Epub 2016 Mar 29.


Thyroid follicle development requires Smad1/5- and endothelial cell-dependent basement membrane assembly.

Villacorte M, Delmarcelle AS, Lernoux M, Bouquet M, Lemoine P, Bolsée J, Umans L, de Sousa Lopes SC, Van Der Smissen P, Sasaki T, Bommer G, Henriet P, Refetoff S, Lemaigre FP, Zwijsen A, Courtoy PJ, Pierreux CE.

Development. 2016 Jun 1;143(11):1958-70. doi: 10.1242/dev.134171. Epub 2016 Apr 11.


Hematopoietic Stem Cells Transplantation Can Normalize Thyroid Function in a Cystinosis Mouse Model.

Gaide Chevronnay HP, Janssens V, Van Der Smissen P, Rocca CJ, Liao XH, Refetoff S, Pierreux CE, Cherqui S, Courtoy PJ.

Endocrinology. 2016 Apr;157(4):1363-71. doi: 10.1210/en.2015-1762. Epub 2016 Jan 26.


ATG24 Represses Autophagy and Differentiation and Is Essential for Homeostasy of the Flagellar Pocket in Trypanosoma brucei.

Brennand A, Rico E, Rigden DJ, Van Der Smissen P, Courtoy PJ, Michels PA.

PLoS One. 2015 Jun 19;10(6):e0130365. doi: 10.1371/journal.pone.0130365. eCollection 2015.


Cholesterol segregates into submicrometric domains at the living erythrocyte membrane: evidence and regulation.

Carquin M, Conrard L, Pollet H, Van Der Smissen P, Cominelli A, Veiga-da-Cunha M, Courtoy PJ, Tyteca D.

Cell Mol Life Sci. 2015 Dec;72(23):4633-51. doi: 10.1007/s00018-015-1951-x. Epub 2015 Jun 16.


A mouse model suggests two mechanisms for thyroid alterations in infantile cystinosis: decreased thyroglobulin synthesis due to endoplasmic reticulum stress/unfolded protein response and impaired lysosomal processing.

Gaide Chevronnay HP, Janssens V, Van Der Smissen P, Liao XH, Abid Y, Nevo N, Antignac C, Refetoff S, Cherqui S, Pierreux CE, Courtoy PJ.

Endocrinology. 2015 Jun;156(6):2349-64. doi: 10.1210/en.2014-1672. Epub 2015 Mar 26.


Induction of post-menstrual regeneration by ovarian steroid withdrawal in the functionalis of xenografted human endometrium.

Coudyzer P, Lemoine P, Po C, Jordan BF, Van Der Smissen P, Courtoy PJ, Henriet P, Marbaix E.

Hum Reprod. 2015 May;30(5):1156-68. doi: 10.1093/humrep/dev043. Epub 2015 Mar 6.


Regulation of macrophage motility by the water channel aquaporin-1: crucial role of M0/M2 phenotype switch.

Tyteca D, Nishino T, Debaix H, Van Der Smissen P, N'Kuli F, Hoffmann D, Cnops Y, Rabolli V, van Loo G, Beyaert R, Huaux F, Devuyst O, Courtoy PJ.

PLoS One. 2015 Feb 26;10(2):e0117398. doi: 10.1371/journal.pone.0117398. eCollection 2015.


Endogenous sphingomyelin segregates into submicrometric domains in the living erythrocyte membrane.

Carquin M, Pollet H, Veiga-da-Cunha M, Cominelli A, Van Der Smissen P, N'kuli F, Emonard H, Henriet P, Mizuno H, Courtoy PJ, Tyteca D.

J Lipid Res. 2014 Jul;55(7):1331-42. doi: 10.1194/jlr.M048538. Epub 2014 May 14.


A short treatment with galactomannan GM-CT-01 corrects the functions of freshly isolated human tumor-infiltrating lymphocytes.

Demotte N, Bigirimana R, Wieërs G, Stroobant V, Squifflet JL, Carrasco J, Thielemans K, Baurain JF, Van Der Smissen P, Courtoy PJ, van der Bruggen P.

Clin Cancer Res. 2014 Apr 1;20(7):1823-33. doi: 10.1158/1078-0432.CCR-13-2459. Epub 2014 Feb 13.


Time course of pathogenic and adaptation mechanisms in cystinotic mouse kidneys.

Gaide Chevronnay HP, Janssens V, Van Der Smissen P, N'Kuli F, Nevo N, Guiot Y, Levtchenko E, Marbaix E, Pierreux CE, Cherqui S, Antignac C, Courtoy PJ.

J Am Soc Nephrol. 2014 Jun;25(6):1256-69. doi: 10.1681/ASN.2013060598. Epub 2014 Feb 13.


Ubiquitination of the glycosomal matrix protein receptor PEX5 in Trypanosoma brucei by PEX4 displays novel features.

Gualdrón-López M, Chevalier N, Van Der Smissen P, Courtoy PJ, Rigden DJ, Michels PAM.

Biochim Biophys Acta. 2013 Dec;1833(12):3076-3092. doi: 10.1016/j.bbamcr.2013.08.008. Epub 2013 Aug 27.


Reciprocal epithelial:endothelial paracrine interactions during thyroid development govern follicular organization and C-cells differentiation.

Hick AC, Delmarcelle AS, Bouquet M, Klotz S, Copetti T, Forez C, Van Der Smissen P, Sonveaux P, Collet JF, Feron O, Courtoy PJ, Pierreux CE.

Dev Biol. 2013 Sep 1;381(1):227-40. doi: 10.1016/j.ydbio.2013.04.022. Epub 2013 May 21.


Class III phosphoinositide 3-kinase/VPS34 and dynamin are critical for apical endocytic recycling.

Carpentier S, N'Kuli F, Grieco G, Van Der Smissen P, Janssens V, Emonard H, Bilanges B, Vanhaesebroeck B, Gaide Chevronnay HP, Pierreux CE, Tyteca D, Courtoy PJ.

Traffic. 2013 Aug;14(8):933-48. doi: 10.1111/tra.12079. Epub 2013 Jun 3.


In vitro correction of disorders of lysosomal transport by microvesicles derived from baculovirus-infected Spodoptera cells.

Thoene J, Goss T, Witcher M, Mullet J, N'Kuli F, Van Der Smissen P, Courtoy P, Hahn SH.

Mol Genet Metab. 2013 May;109(1):77-85. doi: 10.1016/j.ymgme.2013.01.014. Epub 2013 Feb 4.


Micrometric segregation of fluorescent membrane lipids: relevance for endogenous lipids and biogenesis in erythrocytes.

D'Auria L, Fenaux M, Aleksandrowicz P, Van Der Smissen P, Chantrain C, Vermylen C, Vikkula M, Courtoy PJ, Tyteca D.

J Lipid Res. 2013 Apr;54(4):1066-76. doi: 10.1194/jlr.M034314. Epub 2013 Jan 14. Erratum in: J Lipid Res. 2013 Jul;54(7):2029.


Segregation of fluorescent membrane lipids into distinct micrometric domains: evidence for phase compartmentation of natural lipids?

D'auria L, Van der Smissen P, Bruyneel F, Courtoy PJ, Tyteca D.

PLoS One. 2011 Feb 28;6(2):e17021. doi: 10.1371/journal.pone.0017021.


A galectin-3 ligand corrects the impaired function of human CD4 and CD8 tumor-infiltrating lymphocytes and favors tumor rejection in mice.

Demotte N, Wieërs G, Van Der Smissen P, Moser M, Schmidt C, Thielemans K, Squifflet JL, Weynand B, Carrasco J, Lurquin C, Courtoy PJ, van der Bruggen P.

Cancer Res. 2010 Oct 1;70(19):7476-88. doi: 10.1158/0008-5472.CAN-10-0761. Epub 2010 Aug 18.


ZONAB promotes proliferation and represses differentiation of proximal tubule epithelial cells.

Lima WR, Parreira KS, Devuyst O, Caplanusi A, N'kuli F, Marien B, Van Der Smissen P, Alves PM, Verroust P, Christensen EI, Terzi F, Matter K, Balda MS, Pierreux CE, Courtoy PJ.

J Am Soc Nephrol. 2010 Mar;21(3):478-88. doi: 10.1681/ASN.2009070698. Epub 2010 Feb 4.


Restoring the association of the T cell receptor with CD8 reverses anergy in human tumor-infiltrating lymphocytes.

Demotte N, Stroobant V, Courtoy PJ, Van Der Smissen P, Colau D, Luescher IF, Hivroz C, Nicaise J, Squifflet JL, Mourad M, Godelaine D, Boon T, van der Bruggen P.

Immunity. 2008 Mar;28(3):414-24. doi: 10.1016/j.immuni.2008.01.011.


Differential subcellular membrane recruitment of Src may specify its downstream signalling.

de Diesbach P, Medts T, Carpentier S, D'Auria L, Van Der Smissen P, Platek A, Mettlen M, Caplanusi A, van den Hove MF, Tyteca D, Courtoy PJ.

Exp Cell Res. 2008 Apr 15;314(7):1465-79. doi: 10.1016/j.yexcr.2008.01.015. Epub 2008 Jan 26.


Intravital multi-photon microscopy reveals several levels of heterogeneity in endocytic uptake by mouse renal proximal tubules.

Caplanusi A, Parreira KS, Lima WR, Marien B, Van Der Smissen P, de Diesbach P, Devuyst O, Courtoy PJ.

J Cell Mol Med. 2008 Jan-Feb;12(1):351-4. Epub 2007 Dec 10.


Decrease of elastic moduli of DOPC bilayers induced by a macrolide antibiotic, azithromycin.

Fa N, Lins L, Courtoy PJ, Dufrêne Y, Van Der Smissen P, Brasseur R, Tyteca D, Mingeot-Leclercq MP.

Biochim Biophys Acta. 2007 Jul;1768(7):1830-8. Epub 2007 Apr 24.


Characterization of the role of the receptors PEX5 and PEX7 in the import of proteins into glycosomes of Trypanosoma brucei.

Galland N, Demeure F, Hannaert V, Verplaetse E, Vertommen D, Van der Smissen P, Courtoy PJ, Michels PA.

Biochim Biophys Acta. 2007 Apr;1773(4):521-35. Epub 2007 Jan 20.


Src triggers circular ruffling and macropinocytosis at the apical surface of polarized MDCK cells.

Mettlen M, Platek A, Van Der Smissen P, Carpentier S, Amyere M, Lanzetti L, de Diesbach P, Tyteca D, Courtoy PJ.

Traffic. 2006 May;7(5):589-603.


Control of liver cell fate decision by a gradient of TGF beta signaling modulated by Onecut transcription factors.

Clotman F, Jacquemin P, Plumb-Rudewiez N, Pierreux CE, Van der Smissen P, Dietz HC, Courtoy PJ, Rousseau GG, Lemaigre FP.

Genes Dev. 2005 Aug 15;19(16):1849-54.


Gentamicin-induced apoptosis in LLC-PK1 cells: involvement of lysosomes and mitochondria.

Servais H, Van Der Smissen P, Thirion G, Van der Essen G, Van Bambeke F, Tulkens PM, Mingeot-Leclercq MP.

Toxicol Appl Pharmacol. 2005 Aug 15;206(3):321-33.


Endocytosis of the somatostatin analogue, octreotide, by the proximal tubule-derived opossum kidney (OK) cell line.

Barone R, Van Der Smissen P, Devuyst O, Beaujean V, Pauwels S, Courtoy PJ, Jamar F.

Kidney Int. 2005 Mar;67(3):969-76.


Loss of chloride channel ClC-5 impairs endocytosis by defective trafficking of megalin and cubilin in kidney proximal tubules.

Christensen EI, Devuyst O, Dom G, Nielsen R, Van der Smissen P, Verroust P, Leruth M, Guggino WB, Courtoy PJ.

Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8472-7. Epub 2003 Jun 18.


Altered polarity and expression of H+-ATPase without ultrastructural changes in kidneys of Dent's disease patients.

Moulin P, Igarashi T, Van der Smissen P, Cosyns JP, Verroust P, Thakker RV, Scheinman SJ, Courtoy PJ, Devuyst O.

Kidney Int. 2003 Apr;63(4):1285-95.


Azithromycin, a lysosomotropic antibiotic, has distinct effects on fluid-phase and receptor-mediated endocytosis, but does not impair phagocytosis in J774 macrophages.

Tyteca D, Van Der Smissen P, Mettlen M, Van Bambeke F, Tulkens PM, Mingeot-Leclercq MP, Courtoy PJ.

Exp Cell Res. 2002 Nov 15;281(1):86-100.


Membrane destabilization induced by beta-amyloid peptide 29-42: importance of the amino-terminus.

Mingeot-Leclercq MP, Lins L, Bensliman M, Van Bambeke F, Van Der Smissen P, Peuvot J, Schanck A, Brasseur R.

Chem Phys Lipids. 2002 Dec;120(1-2):57-74.


Origin, originality, functions, subversions and molecular signalling of macropinocytosis.

Amyere M, Mettlen M, Van Der Smissen P, Platek A, Payrastre B, Veithen A, Courtoy PJ.

Int J Med Microbiol. 2002 Feb;291(6-7):487-94. Review.


Azithromycin, a lysosomotropic antibiotic, impairs fluid-phase pinocytosis in cultured fibroblasts.

Tyteca D, Van Der Smissen P, Van Bambeke F, Leys K, Tulkens PM, Courtoy PJ, Mingeot-Leclercq MP.

Eur J Cell Biol. 2001 Jul;80(7):466-78.


Topical gene transfer into rat skin using electroporation.

Dujardin N, Van Deŕ Smissen P, Préat V.

Pharm Res. 2001 Jan;18(1):61-6.


Expression and role of Bcl-2 in rat blastocysts exposed to high D-glucose.

Pampfer S, Cordi S, Vanderheyden I, Van Der Smissen P, Courtoy PJ, Van Cauwenberge A, Alexandre H, Donnay I, De Hertogh R.

Diabetes. 2001 Jan;50(1):143-9.


Constitutive macropinocytosis in oncogene-transformed fibroblasts depends on sequential permanent activation of phosphoinositide 3-kinase and phospholipase C.

Amyere M, Payrastre B, Krause U, Van Der Smissen P, Veithen A, Courtoy PJ.

Mol Biol Cell. 2000 Oct;11(10):3453-67.


Regulation of macropinocytosis in v-Src-transformed fibroblasts: cyclic AMP selectively promotes regurgitation of macropinosomes.

Veithen A, Amyere M, Van Der Smissen P, Cupers P, Courtoy PJ.

J Cell Sci. 1998 Aug;111 ( Pt 16):2329-35.

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