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AJNR Am J Neuroradiol. 2004 Aug;25(7):1144-6.

Intralesional bleomycin injections for the palliation of epistaxis in hereditary hemorrhagic telangiectasia.

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Unitas Interventional Unit, Centurion, South Africa.


Epistaxis is a common complication in patients with hereditary hemorrhagic telangiectasia. Its treatment is generally aimed at controlling the frequency and severity of nasal hemorrhage and involves surgery, transcatheter embolization, topical treatment, or a combination. Despite this multitude of treatment methods, the long-term prognosis for many patients remains poor. We describe a patient in whom direct intralesional injections of bleomycin successfully palliated severe recurrent epistaxis for almost 2 years without the need for adjuvant therapy.

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