Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 100

1.

Translational research: What can we learn from the predictability of anesthetized guinea-pig and dog models for cardiovascular safety findings in man?

Jansen H, Urmaliya V, Van Ammel K, van der Linde H, Rohrbacher J, Teisman A, Gallacher DJ.

J Pharmacol Toxicol Methods. 2019 Sep - Oct;99:106595. doi: 10.1016/j.vascn.2019.05.129. Epub 2019 Oct 17. No abstract available.

PMID:
31962981
2.

An integrated translational analysis summary: Prediction of HERG, isolated wedge preparation, anaesthetized guinea pig and dog towards phase I clinical data for drugs with different QT/TdP risk categories.

Urmaliya V, Van Ammel K, Rohrbacher J, van der Linde H, Lu HR, Jansen H, Gallacher DJ, Teisman A.

J Pharmacol Toxicol Methods. 2019 Sep - Oct;99:106595. doi: 10.1016/j.vascn.2019.05.130. Epub 2019 Oct 17. No abstract available.

PMID:
31962980
3.

Loss of UGP2 in brain leads to a severe epileptic encephalopathy, emphasizing that bi-allelic isoform-specific start-loss mutations of essential genes can cause genetic diseases.

Perenthaler E, Nikoncuk A, Yousefi S, Berdowski WM, Alsagob M, Capo I, van der Linde HC, van den Berg P, Jacobs EH, Putar D, Ghazvini M, Aronica E, van IJcken WFJ, de Valk WG, Medici-van den Herik E, van Slegtenhorst M, Brick L, Kozenko M, Kohler JN, Bernstein JA, Monaghan KG, Begtrup A, Torene R, Al Futaisi A, Al Murshedi F, Mani R, Al Azri F, Kamsteeg EJ, Mojarrad M, Eslahi A, Khazaei Z, Darmiyan FM, Doosti M, Karimiani EG, Vandrovcova J, Zafar F, Rana N, Kandaswamy KK, Hertecant J, Bauer P, AlMuhaizea MA, Salih MA, Aldosary M, Almass R, Al-Quait L, Qubbaj W, Coskun S, Alahmadi KO, Hamad MHA, Alwadaee S, Awartani K, Dababo AM, Almohanna F, Colak D, Dehghani M, Mehrjardi MYV, Gunel M, Ercan-Sencicek AG, Passi GR, Cheema HA, Efthymiou S, Houlden H, Bertoli-Avella AM, Brooks AS, Retterer K, Maroofian R, Kaya N, van Ham TJ, Barakat TS.

Acta Neuropathol. 2020 Mar;139(3):415-442. doi: 10.1007/s00401-019-02109-6. Epub 2019 Dec 9.

PMID:
31820119
4.

Identification of antiparkinsonian drugs in the 6-hydroxydopamine zebrafish model.

Vaz RL, Sousa S, Chapela D, van der Linde HC, Willemsen R, Correia AD, Outeiro TF, Afonso ND.

Pharmacol Biochem Behav. 2020 Feb;189:172828. doi: 10.1016/j.pbb.2019.172828. Epub 2019 Nov 28.

PMID:
31785245
5.

Biallelic Variants in ASNA1, Encoding a Cytosolic Targeting Factor of Tail-Anchored Proteins, Cause Rapidly Progressive Pediatric Cardiomyopathy.

Verhagen JMA, van den Born M, van der Linde HC, G J Nikkels P, Verdijk RM, Kivlen MH, van Unen LMA, Baas AF, Ter Heide H, van Osch-Gevers L, Hoogeveen-Westerveld M, Herkert JC, Bertoli-Avella AM, van Slegtenhorst MA, Wessels MW, Verheijen FW, Hassel D, Hofstra RMW, Hegde RS, van Hasselt PM, van Ham TJ, van de Laar IMBH.

Circ Genom Precis Med. 2019 Sep;12(9):397-406. doi: 10.1161/CIRCGEN.119.002507. Epub 2019 Aug 28.

PMID:
31461301
6.

Hexb enzyme deficiency leads to lysosomal abnormalities in radial glia and microglia in zebrafish brain development.

Kuil LE, López Martí A, Carreras Mascaro A, van den Bosch JC, van den Berg P, van der Linde HC, Schoonderwoerd K, Ruijter GJG, van Ham TJ.

Glia. 2019 Sep;67(9):1705-1718. doi: 10.1002/glia.23641. Epub 2019 May 29.

7.

Homozygous Mutations in CSF1R Cause a Pediatric-Onset Leukoencephalopathy and Can Result in Congenital Absence of Microglia.

Oosterhof N, Chang IJ, Karimiani EG, Kuil LE, Jensen DM, Daza R, Young E, Astle L, van der Linde HC, Shivaram GM, Demmers J, Latimer CS, Keene CD, Loter E, Maroofian R, van Ham TJ, Hevner RF, Bennett JT.

Am J Hum Genet. 2019 May 2;104(5):936-947. doi: 10.1016/j.ajhg.2019.03.010. Epub 2019 Apr 11.

8.

Variability of non-clinical behavioral CNS safety assessment: An intercompany comparison.

Himmel HM; Irwin/FOB Consortium Members, Delaunois A, Deurinck M, Dinklo T, Eriksson Faelker TM, Habermann C, Heers C, Hempel K, Lorenz H, Rosch A, Schauerte H, Teuns G, Traebert M, van Amsterdam C, van der Linde H.

J Pharmacol Toxicol Methods. 2019 Sep - Oct;99:106571. doi: 10.1016/j.vascn.2019.03.002. Epub 2019 Mar 27.

PMID:
30928509
9.

Reverse genetic screen reveals that Il34 facilitates yolk sac macrophage distribution and seeding of the brain.

Kuil LE, Oosterhof N, Geurts SN, van der Linde HC, Meijering E, van Ham TJ.

Dis Model Mech. 2019 Mar 8;12(3). pii: dmm037762. doi: 10.1242/dmm.037762.

10.

Colony-Stimulating Factor 1 Receptor (CSF1R) Regulates Microglia Density and Distribution, but Not Microglia Differentiation In Vivo.

Oosterhof N, Kuil LE, van der Linde HC, Burm SM, Berdowski W, van Ijcken WFJ, van Swieten JC, Hol EM, Verheijen MHG, van Ham TJ.

Cell Rep. 2018 Jul 31;24(5):1203-1217.e6. doi: 10.1016/j.celrep.2018.06.113.

11.

IDH1-mutated transgenic zebrafish lines: An in-vivo model for drug screening and functional analysis.

Gao Y, de Wit M, Struys EA, van der Linde HCZ, Salomons GS, Lamfers MLM, Willemsen R, Sillevis Smitt PAE, French PJ.

PLoS One. 2018 Jun 28;13(6):e0199737. doi: 10.1371/journal.pone.0199737. eCollection 2018.

12.

Do in vitro assays in rat primary neurons predict drug-induced seizure liability in humans?

Kreir M, Van Deuren B, Versweyveld S, De Bondt A, Van den Wyngaert I, Van der Linde H, Lu HR, Teuns G, Gallacher DJ.

Toxicol Appl Pharmacol. 2018 May 1;346:45-57. doi: 10.1016/j.taap.2018.03.028. Epub 2018 Mar 26.

PMID:
29596924
13.

CXorf56, a dendritic neuronal protein, identified as a new candidate gene for X-linked intellectual disability.

Verkerk AJMH, Zeidler S, Breedveld G, Overbeek L, Huigh D, Koster L, van der Linde H, de Esch C, Severijnen LA, de Vries BBA, Swagemakers SMA, Willemsen R, Hoogeboom AJM, van der Spek PJ, Oostra BA.

Eur J Hum Genet. 2018 Apr;26(4):552-560. doi: 10.1038/s41431-017-0051-9. Epub 2018 Jan 26.

14.

Whole exome sequencing coupled with unbiased functional analysis reveals new Hirschsprung disease genes.

Gui H, Schriemer D, Cheng WW, Chauhan RK, Antiňolo G, Berrios C, Bleda M, Brooks AS, Brouwer RW, Burns AJ, Cherny SS, Dopazo J, Eggen BJ, Griseri P, Jalloh B, Le TL, Lui VC, Luzón-Toro B, Matera I, Ngan ES, Pelet A, Ruiz-Ferrer M, Sham PC, Shepherd IT, So MT, Sribudiani Y, Tang CS, van den Hout MC, van der Linde HC, van Ham TJ, van IJcken WF, Verheij JB, Amiel J, Borrego S, Ceccherini I, Chakravarti A, Lyonnet S, Tam PK, Garcia-Barceló MM, Hofstra RM.

Genome Biol. 2017 Mar 8;18(1):48. doi: 10.1186/s13059-017-1174-6.

15.

New insights into the genetics of primary open-angle glaucoma based on meta-analyses of intraocular pressure and optic disc characteristics.

Springelkamp H, Iglesias AI, Mishra A, Höhn R, Wojciechowski R, Khawaja AP, Nag A, Wang YX, Wang JJ, Cuellar-Partida G, Gibson J, Bailey JN, Vithana EN, Gharahkhani P, Boutin T, Ramdas WD, Zeller T, Luben RN, Yonova-Doing E, Viswanathan AC, Yazar S, Cree AJ, Haines JL, Koh JY, Souzeau E, Wilson JF, Amin N, Müller C, Venturini C, Kearns LS, Kang JH; NEIGHBORHOOD Consortium, Tham YC, Zhou T, van Leeuwen EM, Nickels S, Sanfilippo P, Liao J, van der Linde H, Zhao W, van Koolwijk LM, Zheng L, Rivadeneira F, Baskaran M, van der Lee SJ, Perera S, de Jong PT, Oostra BA, Uitterlinden AG, Fan Q, Hofman A, Tai ES, Vingerling JR, Sim X, Wolfs RC, Teo YY, Lemij HG, Khor CC, Willemsen R, Lackner KJ, Aung T, Jansonius NM, Montgomery G, Wild PS, Young TL, Burdon KP, Hysi PG, Pasquale LR, Wong TY, Klaver CC, Hewitt AW, Jonas JB, Mitchell P, Lotery AJ, Foster PJ, Vitart V, Pfeiffer N, Craig JE, Mackey DA, Hammond CJ, Wiggs JL, Cheng CY, van Duijn CM, MacGregor S.

Hum Mol Genet. 2017 Jan 15;26(2):438-453. doi: 10.1093/hmg/ddw399.

16.

Retraction Note to: A new inducible transgenic mouse model for C9orf72-associated GGGGCC repeat expansion supports a gain-of-function mechanism in C9orf72-associated ALS and FTD.

Hukema RK, Riemslagh FW, Melhem S, van der Linde HC, Severijnen LW, Edbauer D, Maas A, Charlet-Berguerand N, Willemsen R, van Swieten JC.

Acta Neuropathol Commun. 2016 Dec 9;4(1):129. No abstract available.

17.

Identification of a conserved and acute neurodegeneration-specific microglial transcriptome in the zebrafish.

Oosterhof N, Holtman IR, Kuil LE, van der Linde HC, Boddeke EW, Eggen BJ, van Ham TJ.

Glia. 2017 Jan;65(1):138-149. doi: 10.1002/glia.23083. Epub 2016 Oct 19.

18.

Instruments for assessment of impairments and activity limitations in patients with hand conditions: A European Delphi study.

van de Ven-Stevens LA, Graff MJ, Selles RW, Schreuders TA, van der Linde H, Spauwen PH, Geurts AC.

J Rehabil Med. 2015 Nov;47(10):948-56. doi: 10.2340/16501977-2015.

19.

Construct validity of the canadian occupational performance measure in participants with tendon injury and Dupuytren disease.

van de Ven-Stevens LA, Graff MJ, Peters MA, van der Linde H, Geurts AC.

Phys Ther. 2015 May;95(5):750-7. doi: 10.2522/ptj.20130590. Epub 2014 Dec 18.

PMID:
25524872
20.

A new inducible transgenic mouse model for C9orf72-associated GGGGCC repeat expansion supports a gain-of-function mechanism in C9orf72-associated ALS and FTD.

Hukema RK, Riemslagh FW, Melhem S, van der Linde HC, Severijnen LA, Edbauer D, Maas A, Charlet-Berguerand N, Willemsen R, van Swieten JC.

Acta Neuropathol Commun. 2014 Dec 13;2:166. doi: 10.1186/s40478-014-0166-y. No abstract available. Retraction in: Acta Neuropathol Commun. 2016 Dec 9;4(1):129.

21.

Characterization of an anesthetized dog model of transient cardiac ischemia and rapid pacing: a pilot study for preclinical assessment of the potential for proarrhythmic risk of novel drug candidates.

Damiano BP, van der Linde HJ, Van Deuren B, Somers Y, Lubomirski M, Teisman A, Gallacher DJ.

J Pharmacol Toxicol Methods. 2015 Mar-Apr;72:72-84. doi: 10.1016/j.vascn.2014.10.006. Epub 2014 Oct 23.

PMID:
25450838
22.

Dutch evidence-based guidelines for amputation and prosthetics of the lower extremity: Rehabilitation process and prosthetics. Part 2.

Geertzen J, van der Linde H, Rosenbrand K, Conradi M, Deckers J, Koning J, Rietman HS, van der Schaaf D, van der Ploeg R, Schapendonk J, Schrier E, Duijzentkunst RS, Spruit-van Eijk M, Versteegen G, Voesten H.

Prosthet Orthot Int. 2015 Oct;39(5):361-71. doi: 10.1177/0309364614542725. Epub 2014 Jul 24. Review.

PMID:
25060393
23.

Dutch evidence-based guidelines for amputation and prosthetics of the lower extremity: Amputation surgery and postoperative management. Part 1.

Geertzen J, van der Linde H, Rosenbrand K, Conradi M, Deckers J, Koning J, Rietman HS, van der Schaaf D, van der Ploeg R, Schapendonk J, Schrier E, Smit Duijzentkunst R, Spruit-van Eijk M, Versteegen G, Voesten H.

Prosthet Orthot Int. 2015 Oct;39(5):351-60. doi: 10.1177/0309364614541460. Epub 2014 Jul 24. Review.

PMID:
25060392
24.

Interventricular differences in β-adrenergic responses in the canine heart: role of phosphodiesterases.

Molina CE, Johnson DM, Mehel H, Spätjens RL, Mika D, Algalarrondo V, Slimane ZH, Lechêne P, Abi-Gerges N, van der Linde HJ, Leroy J, Volders PG, Fischmeister R, Vandecasteele G.

J Am Heart Assoc. 2014 Jun 5;3(3):e000858. doi: 10.1161/JAHA.114.000858.

25.

Exome sequencing and functional analyses suggest that SIX6 is a gene involved in an altered proliferation-differentiation balance early in life and optic nerve degeneration at old age.

Iglesias AI, Springelkamp H, van der Linde H, Severijnen LA, Amin N, Oostra B, Kockx CE, van den Hout MC, van Ijcken WF, Hofman A, Uitterlinden AG, Verdijk RM, Klaver CC, Willemsen R, van Duijn CM.

Hum Mol Genet. 2014 Mar 1;23(5):1320-32. doi: 10.1093/hmg/ddt522. Epub 2013 Oct 22.

PMID:
24150847
26.

Diastolic spontaneous calcium release from the sarcoplasmic reticulum increases beat-to-beat variability of repolarization in canine ventricular myocytes after β-adrenergic stimulation.

Johnson DM, Heijman J, Bode EF, Greensmith DJ, van der Linde H, Abi-Gerges N, Eisner DA, Trafford AW, Volders PG.

Circ Res. 2013 Jan 18;112(2):246-56. doi: 10.1161/CIRCRESAHA.112.275735. Epub 2012 Nov 13.

PMID:
23149594
27.

The zebrafish homologue of Parkinson's disease ATP13A2 is essential for embryonic survival.

Lopes da Fonseca T, Correia A, Hasselaar W, van der Linde HC, Willemsen R, Outeiro TF.

Brain Res Bull. 2013 Jan;90:118-26. doi: 10.1016/j.brainresbull.2012.09.017. Epub 2012 Oct 31.

PMID:
23123961
28.

Residual complaints after neuralgic amyotrophy.

Cup EH, Ijspeert J, Janssen RJ, Bussemaker-Beumer C, Jacobs J, Pieterse AJ, van der Linde H, van Alfen N.

Arch Phys Med Rehabil. 2013 Jan;94(1):67-73. doi: 10.1016/j.apmr.2012.07.014. Epub 2012 Jul 28.

PMID:
22850488
29.

Determinants of quality of life in older adults after lower limb amputation and rehabilitation in skilled nursing facilities.

Buijck BI, van Eijk MS, Zuidema SU, Gerritsen DL, Koopmans RT, van der Linde H.

J Am Geriatr Soc. 2012 Apr;60(4):796-8. doi: 10.1111/j.1532-5415.2011.03880.x. No abstract available. Erratum in: J Am Geriatr Soc. 2012 Jun;60(6):1198.

PMID:
22494294
30.

Locomotor activity assay in zebrafish larvae: influence of age, strain and ethanol.

de Esch C, van der Linde H, Slieker R, Willemsen R, Wolterbeek A, Woutersen R, De Groot D.

Neurotoxicol Teratol. 2012 Jul;34(4):425-33. doi: 10.1016/j.ntt.2012.03.002. Epub 2012 Mar 29.

PMID:
22484456
31.

Predicting prosthetic use in elderly patients after major lower limb amputation.

van Eijk MS, van der Linde H, Buijck B, Geurts A, Zuidema S, Koopmans R.

Prosthet Orthot Int. 2012 Mar;36(1):45-52. doi: 10.1177/0309364611430885. Epub 2012 Jan 17.

PMID:
22252778
32.

Geriatric rehabilitation of lower limb amputees: a multicenter study.

Eijk MS, van der Linde H, Buijck BI, Zuidema SU, Koopmans RT.

Disabil Rehabil. 2012;34(2):145-50. doi: 10.3109/09638288.2011.591888. Epub 2011 Sep 29.

PMID:
21958418
33.

The fentanyl/etomidate-anesthetized beagle (FEAB) model in safety pharmacology assessment.

van der Linde HJ, Deuren BV, Somers Y, Teisman A, Gallacher DJ.

Curr Protoc Pharmacol. 2011 Sep;Chapter 10:Unit10.13. doi: 10.1002/0471141755.ph1013s54.

PMID:
21898330
34.

Effects of aerobic exercise therapy and cognitive behavioural therapy on functioning and quality of life in amyotrophic lateral sclerosis: protocol of the FACTS-2-ALS trial.

van Groenestijn AC, van de Port IG, Schröder CD, Post MW, Grupstra HF, Kruitwagen ET, van der Linde H, van Vliet RO, van de Weerd MG, van den Berg LH, Lindeman E.

BMC Neurol. 2011 Jun 14;11:70. doi: 10.1186/1471-2377-11-70.

35.

AFQ056, a new mGluR5 antagonist for treatment of fragile X syndrome.

Levenga J, Hayashi S, de Vrij FM, Koekkoek SK, van der Linde HC, Nieuwenhuizen I, Song C, Buijsen RA, Pop AS, Gomezmancilla B, Nelson DL, Willemsen R, Gasparini F, Oostra BA.

Neurobiol Dis. 2011 Jun;42(3):311-7. doi: 10.1016/j.nbd.2011.01.022. Epub 2011 Feb 21.

PMID:
21316452
36.

The Electro-Mechanical window: a risk marker for Torsade de Pointes in a canine model of drug induced arrhythmias.

van der Linde HJ, Van Deuren B, Somers Y, Loenders B, Towart R, Gallacher DJ.

Br J Pharmacol. 2010 Dec;161(7):1444-54. doi: 10.1111/j.1476-5381.2010.00934.x.

37.

EEG in the FEAB model: measurement of electroencephalographical burst suppression and seizure liability in safety pharmacology.

van der Linde HJ, Van Deuren B, Somers Y, Teisman A, Drinkenburg WH, Gallacher DJ.

J Pharmacol Toxicol Methods. 2011 Jan-Feb;63(1):96-101. doi: 10.1016/j.vascn.2010.06.002. Epub 2010 Jun 22.

PMID:
20601023
38.

Torcetrapib produces endothelial dysfunction independent of cholesteryl ester transfer protein inhibition.

Connelly MA, Parry TJ, Giardino EC, Huang Z, Cheung WM, Chen C, Cools F, Van der Linde H, Gallacher DJ, Kuo GH, Sarich TC, Demarest KT, Damiano BP.

J Cardiovasc Pharmacol. 2010 May;55(5):459-68. doi: 10.1097/FJC.0b013e3181cf03cb.

PMID:
20051879
39.

Generation and characterization of FMR1 knockout zebrafish.

den Broeder MJ, van der Linde H, Brouwer JR, Oostra BA, Willemsen R, Ketting RF.

PLoS One. 2009 Nov 19;4(11):e7910. doi: 10.1371/journal.pone.0007910.

40.

Reduction in fragile X related 1 protein causes cardiomyopathy and muscular dystrophy in zebrafish.

Van't Padje S, Chaudhry B, Severijnen LA, van der Linde HC, Mientjes EJ, Oostra BA, Willemsen R.

J Exp Biol. 2009 Aug;212(Pt 16):2564-70. doi: 10.1242/jeb.032532.

41.

Blockade of the I(Ks) potassium channel: an overlooked cardiovascular liability in drug safety screening?

Towart R, Linders JT, Hermans AN, Rohrbacher J, van der Linde HJ, Ercken M, Cik M, Roevens P, Teisman A, Gallacher DJ.

J Pharmacol Toxicol Methods. 2009 Jul-Aug;60(1):1-10. doi: 10.1016/j.vascn.2009.04.197. Epub 2009 May 9. Review.

PMID:
19439185
42.

The fentanyl/etomidate-anaesthetised beagle (FEAB) dog: a versatile in vivo model in cardiovascular safety research.

Van Deuren B, Van Ammel K, Somers Y, Cools F, Straetemans R, van der Linde HJ, Gallacher DJ.

J Pharmacol Toxicol Methods. 2009 Jul-Aug;60(1):11-23. doi: 10.1016/j.vascn.2009.04.195. Epub 2009 May 5. Review.

PMID:
19422925
43.

Evidence for bilaterally delayed and decreased obstacle avoidance responses while walking with a lower limb prosthesis.

Hofstad CJ, Weerdesteyn V, van der Linde H, Nienhuis B, Geurts AC, Duysens J.

Clin Neurophysiol. 2009 May;120(5):1009-15. doi: 10.1016/j.clinph.2009.03.003. Epub 2009 Apr 11.

PMID:
19362881
44.

The mobility scale for lower limb amputees: the SIGAM/WAP mobility scale.

Rommers GM, Ryall NH, Kap A, De Laat F, Van der Linde H.

Disabil Rehabil. 2008;30(15):1106-15.

PMID:
19230132
45.

Clinimetric properties of instruments to assess activities in patients with hand injury: a systematic review of the literature.

van de Ven-Stevens LA, Munneke M, Terwee CB, Spauwen PH, van der Linde H.

Arch Phys Med Rehabil. 2009 Jan;90(1):151-69. doi: 10.1016/j.apmr.2008.06.024. Review.

PMID:
19154842
46.

Study of the human pelvis using CAT-scan: gender differences and anatomy of the ramus ossis ischii.

van de Meent H, Jansen H, van der Linde H.

Prosthet Orthot Int. 2008 Dec;32(4):385-9. doi: 10.1080/03093640802258629.

PMID:
18985549
47.

The effect of changes in core body temperature on the QT interval in beagle dogs: a previously ignored phenomenon, with a method for correction.

van der Linde HJ, Van Deuren B, Teisman A, Towart R, Gallacher DJ.

Br J Pharmacol. 2008 Aug;154(7):1474-81. doi: 10.1038/bjp.2008.265. Epub 2008 Jun 23.

48.

Rescue of behavioral phenotype and neuronal protrusion morphology in Fmr1 KO mice.

de Vrij FM, Levenga J, van der Linde HC, Koekkoek SK, De Zeeuw CI, Nelson DL, Oostra BA, Willemsen R.

Neurobiol Dis. 2008 Jul;31(1):127-32. doi: 10.1016/j.nbd.2008.04.002. Epub 2008 Apr 25.

49.

In vivo mechanisms precipitating torsades de pointes in a canine model of drug-induced long-QT1 syndrome.

Gallacher DJ, Van de Water A, van der Linde H, Hermans AN, Lu HR, Towart R, Volders PG.

Cardiovasc Res. 2007 Nov 1;76(2):247-56. Epub 2007 Jun 29.

PMID:
17669388
50.

From satisfaction to expectation: the patient's perspective in lower limb prosthetic care.

Van der Linde H, Hofstad CJ, Geertzen JH, Postema K, Van Limbeek J.

Disabil Rehabil. 2007 Jul 15;29(13):1049-55.

PMID:
17612990

Supplemental Content

Loading ...
Support Center