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Items: 9


Defense contracts: molecular protection in insect-microbe symbioses.

Van Arnam EB, Currie CR, Clardy J.

Chem Soc Rev. 2018 Mar 5;47(5):1638-1651. doi: 10.1039/c7cs00340d. Review.


Selvamicin, an atypical antifungal polyene from two alternative genomic contexts.

Van Arnam EB, Ruzzini AC, Sit CS, Horn H, Pinto-Tomás AA, Currie CR, Clardy J.

Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):12940-12945. Epub 2016 Nov 1.


A Rebeccamycin Analog Provides Plasmid-Encoded Niche Defense.

Van Arnam EB, Ruzzini AC, Sit CS, Currie CR, Clardy J.

J Am Chem Soc. 2015 Nov 18;137(45):14272-4. doi: 10.1021/jacs.5b09794. Epub 2015 Nov 10.


Variable genetic architectures produce virtually identical molecules in bacterial symbionts of fungus-growing ants.

Sit CS, Ruzzini AC, Van Arnam EB, Ramadhar TR, Currie CR, Clardy J.

Proc Natl Acad Sci U S A. 2015 Oct 27;112(43):13150-4. doi: 10.1073/pnas.1515348112. Epub 2015 Oct 5. Erratum in: Proc Natl Acad Sci U S A. 2015 Dec 1;112(48):E6717.


In vivo incorporation of non-canonical amino acids by using the chemical aminoacylation strategy: a broadly applicable mechanistic tool.

Dougherty DA, Van Arnam EB.

Chembiochem. 2014 Aug 18;15(12):1710-20. doi: 10.1002/cbic.201402080. Epub 2014 Jul 2. Review.


Functional probes of drug-receptor interactions implicated by structural studies: Cys-loop receptors provide a fertile testing ground.

Van Arnam EB, Dougherty DA.

J Med Chem. 2014 Aug 14;57(15):6289-300. doi: 10.1021/jm500023m. Epub 2014 Mar 10. Review.


An unusual pattern of ligand-receptor interactions for the α7 nicotinic acetylcholine receptor, with implications for the binding of varenicline.

Van Arnam EB, Blythe EE, Lester HA, Dougherty DA.

Mol Pharmacol. 2013 Aug;84(2):201-7. doi: 10.1124/mol.113.085795. Epub 2013 May 16.


Binding interactions with the complementary subunit of nicotinic receptors.

Blum AP, Van Arnam EB, German LA, Lester HA, Dougherty DA.

J Biol Chem. 2013 Mar 8;288(10):6991-7. doi: 10.1074/jbc.M112.439968. Epub 2013 Jan 24.


Dissecting the functions of conserved prolines within transmembrane helices of the D2 dopamine receptor.

Van Arnam EB, Lester HA, Dougherty DA.

ACS Chem Biol. 2011 Oct 21;6(10):1063-8. doi: 10.1021/cb200153g. Epub 2011 Jul 28.

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