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Items: 1 to 50 of 161

1.

Family-wide analysis of aminoacyl-sulfamoyl-3-deazaadenosine analogues as inhibitors of aminoacyl-tRNA synthetases.

Zhang B, De Graef S, Nautiyal M, Pang L, Gadakh B, Froeyen M, Van Mellaert L, Strelkov SV, Weeks SD, Van Aerschot A.

Eur J Med Chem. 2018 Mar 25;148:384-396. doi: 10.1016/j.ejmech.2018.02.013. Epub 2018 Feb 14.

PMID:
29477072
2.

Spectroscopic Investigation of the Formation and Disruption of Hydrogen Bonds in Pharmaceutical Semicrystalline Dispersions.

Van Duong T, Reekmans G, Venkatesham A, Van Aerschot A, Adriaensens P, Van Humbeeck J, Van den Mooter G.

Mol Pharm. 2017 May 1;14(5):1726-1741. doi: 10.1021/acs.molpharmaceut.6b01172. Epub 2017 Apr 11.

PMID:
28363028
3.

A Trojan-Horse Peptide-Carboxymethyl-Cytidine Antibiotic from Bacillus amyloliquefaciens.

Serebryakova M, Tsibulskaya D, Mokina O, Kulikovsky A, Nautiyal M, Van Aerschot A, Severinov K, Dubiley S.

J Am Chem Soc. 2016 Dec 7;138(48):15690-15698. Epub 2016 Nov 29.

4.

Aminopurine and aminoquinazoline scaffolds for development of potential dengue virus inhibitors.

Venkatesham A, Saudi M, Kaptein S, Neyts J, Rozenski J, Froeyen M, Van Aerschot A.

Eur J Med Chem. 2017 Jan 27;126:101-109. doi: 10.1016/j.ejmech.2016.10.008. Epub 2016 Oct 5.

PMID:
27750144
5.

Synthetic strategy and antiviral evaluation of diamide containing heterocycles targeting dengue and yellow fever virus.

Saudi M, Zmurko J, Kaptein S, Rozenski J, Gadakh B, Chaltin P, Marchand A, Neyts J, Van Aerschot A.

Eur J Med Chem. 2016 Oct 4;121:158-168. doi: 10.1016/j.ejmech.2016.05.043. Epub 2016 May 21.

6.

Oligonucleotides containing a ribo-configured cyclohexanyl nucleoside: probing the role of sugar conformation in base pairing selectivity.

Paolella C, D'Alonzo D, Schepers G, Van Aerschot A, Di Fabio G, Palumbo G, Herdewijn P, Guaragna A.

Org Biomol Chem. 2015 Oct 21;13(39):10041-9. doi: 10.1039/c5ob01449b.

PMID:
26293202
7.

1',5'-Anhydro-L-ribo-hexitol Adenine Nucleic Acids (α-L-HNA-A): Synthesis and Chiral Selection Properties in the Mirror Image World.

D'Alonzo D, Froeyen M, Schepers G, Di Fabio G, Van Aerschot A, Herdewijn P, Palumbo G, Guaragna A.

J Org Chem. 2015 May 15;80(10):5014-22. doi: 10.1021/acs.joc.5b00406. Epub 2015 Apr 30.

PMID:
25853790
8.

Renaissance in Antibiotic Discovery: Some Novel Approaches for Finding Drugs to Treat Bad Bugs.

Gadakh B, Van Aerschot A.

Curr Med Chem. 2015;22(18):2140-58. Review.

PMID:
25787965
9.

Hybridisation potential of 1',3'-Di-O-methylaltropyranoside nucleic acids.

Venkatesham A, Kachare D, Schepers G, Rozenski J, Froeyen M, Van Aerschot A.

Molecules. 2015 Mar 3;20(3):4020-41. doi: 10.3390/molecules20034020.

10.

N-acylated sulfonamide congeners of fosmidomycin lack any inhibitory activity against DXR.

Gadakh B, Pouyez J, Wouters J, Venkatesham A, Cos P, Van Aerschot A.

Bioorg Med Chem Lett. 2015 Apr 1;25(7):1577-9. doi: 10.1016/j.bmcl.2015.02.006. Epub 2015 Feb 12.

PMID:
25726328
11.

5'-(N-aminoacyl)-sulfonamido-5'-deoxyadenosine: attempts for a stable alternative for aminoacyl-sulfamoyl adenosines as aaRS inhibitors.

Gadakh B, Smaers S, Rozenski J, Froeyen M, Van Aerschot A.

Eur J Med Chem. 2015 Mar 26;93:227-36. doi: 10.1016/j.ejmech.2015.02.010. Epub 2015 Feb 9.

PMID:
25686591
12.

Synthesis and evaluation of imidazole-4,5- and pyrazine-2,3-dicarboxamides targeting dengue and yellow fever virus.

Saudi M, Zmurko J, Kaptein S, Rozenski J, Neyts J, Van Aerschot A.

Eur J Med Chem. 2014 Nov 24;87:529-39. doi: 10.1016/j.ejmech.2014.09.062. Epub 2014 Sep 22.

13.

The RimL transacetylase provides resistance to translation inhibitor microcin C.

Kazakov T, Kuznedelov K, Semenova E, Mukhamedyarov D, Datsenko KA, Metlitskaya A, Vondenhoff GH, Tikhonov A, Agarwal V, Nair S, Van Aerschot A, Severinov K.

J Bacteriol. 2014 Oct;196(19):3377-85. doi: 10.1128/JB.01584-14. Epub 2014 Jul 7.

14.

Base substituted 5'-O-(N-isoleucyl)sulfamoyl nucleoside analogues as potential antibacterial agents.

Gadakh B, Vondenhoff G, Lescrinier E, Rozenski J, Froeyen M, Van Aerschot A.

Bioorg Med Chem. 2014 May 15;22(10):2875-86. doi: 10.1016/j.bmc.2014.03.040. Epub 2014 Apr 5.

PMID:
24746466
15.

In search of Flavivirus inhibitors part 2: tritylated, diphenylmethylated and other alkylated nucleoside analogues.

Saudi M, Zmurko J, Kaptein S, Rozenski J, Neyts J, Van Aerschot A.

Eur J Med Chem. 2014 Apr 9;76:98-109. doi: 10.1016/j.ejmech.2014.02.011. Epub 2014 Feb 10.

PMID:
24583349
16.

N-alkylated aminoacyl sulfamoyladenosines as potential inhibitors of aminoacylation reactions and microcin C analogues containing D-amino acids.

Vondenhoff GH, Pugach K, Gadakh B, Carlier L, Rozenski J, Froeyen M, Severinov K, Van Aerschot A.

PLoS One. 2013 Nov 4;8(11):e79234. doi: 10.1371/journal.pone.0079234. eCollection 2013.

17.

A straightforward diphenylmethyl protection method and deprotection of some pyrimidine nucleosides.

Saudi M, van Aerschot A.

Molecules. 2013 Jul 18;18(7):8524-34. doi: 10.3390/molecules18078524.

18.

In search of flavivirus inhibitors: evaluation of different tritylated nucleoside analogues.

Chatelain G, Debing Y, De Burghgraeve T, Zmurko J, Saudi M, Rozenski J, Neyts J, Van Aerschot A.

Eur J Med Chem. 2013 Jul;65:249-55. doi: 10.1016/j.ejmech.2013.04.034. Epub 2013 Apr 24.

PMID:
23721953
19.

Enantiomeric selection properties of β-homoDNA: enhanced pairing for heterochiral complexes.

D'Alonzo D, Amato J, Schepers G, Froeyen M, Van Aerschot A, Herdewijn P, Guaragna A.

Angew Chem Int Ed Engl. 2013 Jun 24;52(26):6662-5. doi: 10.1002/anie.201301659. Epub 2013 May 13. No abstract available.

PMID:
23670912
20.

3',5'Di-O-trityluridine inhibits in vitro flavivirus replication.

De Burghgraeve T, Selisko B, Kaptein S, Chatelain G, Leyssen P, Debing Y, Jacobs M, Van Aerschot A, Canard B, Neyts J.

Antiviral Res. 2013 May;98(2):242-7. doi: 10.1016/j.antiviral.2013.01.011. Epub 2013 Mar 5.

PMID:
23470860
21.

Aminoacyl-tRNA synthetase inhibitors as antimicrobial agents: a patent review from 2006 till present.

Gadakh B, Van Aerschot A.

Expert Opin Ther Pat. 2012 Dec;22(12):1453-65. doi: 10.1517/13543776.2012.732571. Epub 2012 Oct 12. Review.

PMID:
23062029
22.

Hybridization potential of oligonucleotides comprising 3'-O-methylated altritol nucleosides.

Chatelain G, Schepers G, Rozenski J, Van Aerschot A.

Mol Divers. 2012 Nov;16(4):825-37. doi: 10.1007/s11030-012-9402-1. Epub 2012 Oct 9.

PMID:
23054535
23.

Microcin C and albomycin analogues with aryl-tetrazole substituents as nucleobase isosters are selective inhibitors of bacterial aminoacyl tRNA synthetases but lack efficient uptake.

Vondenhoff GH, Gadakh B, Severinov K, Van Aerschot A.

Chembiochem. 2012 Sep 3;13(13):1959-69. doi: 10.1002/cbic.201200174. Epub 2012 Jul 30.

PMID:
22847961
24.

Structural and functional characterization of microcin C resistance peptidase MccF from Bacillus anthracis.

Nocek B, Tikhonov A, Babnigg G, Gu M, Zhou M, Makarova KS, Vondenhoff G, Van Aerschot A, Kwon K, Anderson WF, Severinov K, Joachimiak A.

J Mol Biol. 2012 Jul 20;420(4-5):366-83. doi: 10.1016/j.jmb.2012.04.011. Epub 2012 Apr 16.

25.

Using chemical approaches to understand RNA structure and function in biology.

Stetsenko DA, van Aerschot A.

J Nucleic Acids. 2012;2012:972575. doi: 10.1155/2012/972575. Epub 2012 Feb 16. No abstract available.

26.

Aminoacyl-tRNA synthetase inhibitors as potential antibiotics.

Vondenhoff GH, Van Aerschot A.

Eur J Med Chem. 2011 Nov;46(11):5227-36. doi: 10.1016/j.ejmech.2011.08.049. Epub 2011 Sep 16. Review.

PMID:
21968372
27.

Microcin C: biosynthesis, mode of action, and potential as a lead in antibiotics development.

Vondenhoff GH, Van Aerschot A.

Nucleosides Nucleotides Nucleic Acids. 2011 Jul-Aug;30(7-8):465-74. doi: 10.1080/15257770.2011.583972.

PMID:
21888539
28.

Extended targeting potential and improved synthesis of Microcin C analogs as antibacterials.

Vondenhoff GH, Dubiley S, Severinov K, Lescrinier E, Rozenski J, Van Aerschot A.

Bioorg Med Chem. 2011 Sep 15;19(18):5462-7. doi: 10.1016/j.bmc.2011.07.052. Epub 2011 Aug 3.

PMID:
21855353
29.

Single-molecule FRET reveals a cooperative effect of two methyl group modifications in the folding of human mitochondrial tRNA(Lys).

Kobitski AY, Hengesbach M, Seidu-Larry S, Dammertz K, Chow CS, van Aerschot A, Nienhaus GU, Helm M.

Chem Biol. 2011 Jul 29;18(7):928-36. doi: 10.1016/j.chembiol.2011.03.016.

30.

Substituted 2-aminothiazoles are exceptional inhibitors of neuronal degeneration in tau-driven models of Alzheimer's disease.

Lagoja I, Pannecouque C, Griffioen G, Wera S, Rojasdelaparra VM, Van Aerschot A.

Eur J Pharm Sci. 2011 Aug 17;43(5):386-92. doi: 10.1016/j.ejps.2011.05.014. Epub 2011 Jun 2.

PMID:
21664968
31.

Characterization of peptide chain length and constituency requirements for YejABEF-mediated uptake of microcin C analogues.

Vondenhoff GH, Blanchaert B, Geboers S, Kazakov T, Datsenko KA, Wanner BL, Rozenski J, Severinov K, Van Aerschot A.

J Bacteriol. 2011 Jul;193(14):3618-23. doi: 10.1128/JB.00172-11. Epub 2011 May 20.

32.

The mechanism of microcin C resistance provided by the MccF peptidase.

Tikhonov A, Kazakov T, Semenova E, Serebryakova M, Vondenhoff G, Van Aerschot A, Reader JS, Govorun VM, Severinov K.

J Biol Chem. 2010 Dec 3;285(49):37944-52. doi: 10.1074/jbc.M110.179135. Epub 2010 Sep 27.

33.

Toward L-homo-DNA: stereoselective de novo synthesis of β-L-erythro-hexopyranosyl nucleosides.

D'Alonzo D, Guaragna A, Van Aerschot A, Herdewijn P, Palumbo G.

J Org Chem. 2010 Oct 1;75(19):6402-10. doi: 10.1021/jo100691y.

PMID:
20825234
34.

Crystallization and preliminary X-ray study of the D-altritol oligonucleotide GTGTACAC.

Ovaere M, Van Aerschot A, Abramov M, Herdewijn P, Van Meervelt L.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Apr 1;66(Pt 4):460-2. doi: 10.1107/S1744309110007050. Epub 2010 Mar 31.

35.

MccE provides resistance to protein synthesis inhibitor microcin C by acetylating the processed form of the antibiotic.

Novikova M, Kazakov T, Vondenhoff GH, Semenova E, Rozenski J, Metlytskaya A, Zukher I, Tikhonov A, Van Aerschot A, Severinov K.

J Biol Chem. 2010 Apr 23;285(17):12662-9. doi: 10.1074/jbc.M109.080192. Epub 2010 Feb 16.

36.

Synthesis and base pairing properties of 1',5'-anhydro-L-hexitol nucleic acids (L-HNA).

D'Alonzo D, Van Aerschot A, Guaragna A, Palumbo G, Schepers G, Capone S, Rozenski J, Herdewijn P.

Chemistry. 2009 Oct 5;15(39):10121-31. doi: 10.1002/chem.200901847.

PMID:
19739223
37.

Evaluation of the type I signal peptidase as antibacterial target for biofilm-associated infections of Staphylococcus epidermidis.

Bockstael K, Geukens N, Van Mellaert L, Herdewijn P, Anné J, Van Aerschot A.

Microbiology. 2009 Nov;155(Pt 11):3719-29. doi: 10.1099/mic.0.031765-0. Epub 2009 Aug 20.

PMID:
19696105
38.

Synthetic microcin C analogs targeting different aminoacyl-tRNA synthetases.

Van de Vijver P, Vondenhoff GH, Kazakov TS, Semenova E, Kuznedelov K, Metlitskaya A, Van Aerschot A, Severinov K.

J Bacteriol. 2009 Oct;191(20):6273-80. doi: 10.1128/JB.00829-09. Epub 2009 Aug 14.

39.

An easy and fast method for the evaluation of Staphylococcus epidermidis type I signal peptidase inhibitors.

Bockstael K, Geukens N, Rao CV, Herdewijn P, Anné J, Van Aerschot A.

J Microbiol Methods. 2009 Aug;78(2):231-7. doi: 10.1016/j.mimet.2009.06.006. Epub 2009 Jun 17.

PMID:
19539664
40.

Biological effects of hexitol and altritol-modified siRNAs targeting B-Raf.

Fisher M, Abramov M, Van Aerschot A, Rozenski J, Dixit V, Juliano RL, Herdewijn P.

Eur J Pharmacol. 2009 Mar 15;606(1-3):38-44. doi: 10.1016/j.ejphar.2009.01.030. Epub 2009 Jan 30.

41.

Detection of RNA hybridization by pyrene-labeled probes.

Wang G, Bobkov GV, Mikhailov SN, Schepers G, Van Aerschot A, Rozenski J, Van der Auweraer M, Herdewijn P, De Feyter S.

Chembiochem. 2009 May 4;10(7):1175-85. doi: 10.1002/cbic.200900031.

PMID:
19373795
42.

Patient experiences of over-the-counter medicine purchases in Flemish community pharmacies.

Simoens S, Lobeau M, Verbeke K, van Aerschot A.

Pharm World Sci. 2009 Aug;31(4):450-457. doi: 10.1007/s11096-009-9293-0. Epub 2009 Mar 31.

PMID:
19333777
43.

A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity.

Bramsen JB, Laursen MB, Nielsen AF, Hansen TB, Bus C, Langkjaer N, Babu BR, Højland T, Abramov M, Van Aerschot A, Odadzic D, Smicius R, Haas J, Andree C, Barman J, Wenska M, Srivastava P, Zhou C, Honcharenko D, Hess S, Müller E, Bobkov GV, Mikhailov SN, Fava E, Meyer TF, Chattopadhyaya J, Zerial M, Engels JW, Herdewijn P, Wengel J, Kjems J.

Nucleic Acids Res. 2009 May;37(9):2867-81. doi: 10.1093/nar/gkp106. Epub 2009 Mar 12.

44.

Maturation of the translation inhibitor microcin C.

Metlitskaya A, Kazakov T, Vondenhoff GH, Novikova M, Shashkov A, Zatsepin T, Semenova E, Zaitseva N, Ramensky V, Van Aerschot A, Severinov K.

J Bacteriol. 2009 Apr;191(7):2380-7. doi: 10.1128/JB.00999-08. Epub 2009 Jan 23.

45.

Antibacterial 5'-O-(N-dipeptidyl)-sulfamoyladenosines.

Van de Vijver P, Vondenhoff GH, Denivelle S, Rozenski J, Verhaegen J, Van Aerschot A, Herdewijn P.

Bioorg Med Chem. 2009 Jan 1;17(1):260-9. doi: 10.1016/j.bmc.2008.11.054. Epub 2008 Nov 27.

PMID:
19070499
46.

Dendritic nucleotides: interaction with an aliphatic acid monolayer.

Wang G, Abramov M, Van Aerschot A, Rozenski J, Lei S, Klymchenko A, Van der Auweraer M, De Feyter S, Herdewijn P.

Chem Biodivers. 2008 Sep;5(9):1675-82. doi: 10.1002/cbdv.200890156.

PMID:
18816520
47.

Impact of spacers on the hybridization efficiency of mixed self-assembled DNA/alkanethiol films.

Peeters S, Stakenborg T, Reekmans G, Laureyn W, Lagae L, Van Aerschot A, Van Ranst M.

Biosens Bioelectron. 2008 Sep 15;24(1):72-7. doi: 10.1016/j.bios.2008.03.012. Epub 2008 Mar 22.

PMID:
18440798
48.

Aminoacyl-tRNA synthetase inhibitors as potent and synergistic immunosuppressants.

Van de Vijver P, Ostrowski T, Sproat B, Goebels J, Rutgeerts O, Van Aerschot A, Waer M, Herdewijn P.

J Med Chem. 2008 May 22;51(10):3020-9. doi: 10.1021/jm8000746. Epub 2008 Apr 26.

PMID:
18438987
49.

Synthesis of 1,5-anhydrohexitol building blocks for oligonucleotide synthesis.

Lagoja IM, Marchand A, Van Aerschot A, Herdewijn P.

Curr Protoc Nucleic Acid Chem. 2003 Nov;Chapter 1:Unit 1.9. doi: 10.1002/0471142700.nc0109s14. Review.

PMID:
18428902
50.

HNA and ANA high-affinity arrays for detections of DNA and RNA single-base mismatches.

Abramov M, Schepers G, Van Aerschot A, Van Hummelen P, Herdewijn P.

Biosens Bioelectron. 2008 Jun 15;23(11):1728-32. doi: 10.1016/j.bios.2008.01.033. Epub 2008 Feb 13.

PMID:
18378134

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