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Stressing Out about Cancer Immunotherapy.

He XY, Ng D, Van Aelst L, Egeblad M.

Cancer Cell. 2019 Nov 11;36(5):468-470. doi: 10.1016/j.ccell.2019.10.013.


Long-term outcome of cardiac allograft vasculopathy: Importance of the International Society for Heart and Lung Transplantation angiographic grading scale.

Van Keer JM, Van Aelst LNL, Rega F, Droogne W, Voros G, Meyns B, Vanhaecke J, Emonds MP, Janssens S, Naesens M, Van Cleemput J.

J Heart Lung Transplant. 2019 Nov;38(11):1189-1196. doi: 10.1016/j.healun.2019.08.005. Epub 2019 Aug 10.


Clinical and ECG variables to predict the outcome of genetic testing in hypertrophic cardiomyopathy.

Robyns T, Breckpot J, Nuyens D, Vandenberk B, Corveleyn A, Kuiperi C, Van Aelst L, Van Cleemput J, Willems R.

Eur J Med Genet. 2019 Sep 9:103754. doi: 10.1016/j.ejmg.2019.103754. [Epub ahead of print]


Axo-axonic Innervation of Neocortical Pyramidal Neurons by GABAergic Chandelier Cells Requires AnkyrinG-Associated L1CAM.

Tai Y, Gallo NB, Wang M, Yu JR, Van Aelst L.

Neuron. 2019 Apr 17;102(2):358-372.e9. doi: 10.1016/j.neuron.2019.02.009. Epub 2019 Mar 4.


Urinary proteomic signatures associated with β-blockade and heart rate in heart transplant recipients.

Huang QF, Van Keer J, Zhang ZY, Trenson S, Nkuipou-Kenfack E, Van Aelst LNL, Yang WY, Thijs L, Wei FF, Ciarka A, Vanhaecke J, Janssens S, Van Cleemput J, Mischak H, Staessen JA.

PLoS One. 2018 Sep 24;13(9):e0204439. doi: 10.1371/journal.pone.0204439. eCollection 2018.


Urinary peptidomic biomarkers of renal function in heart transplant recipients.

Huang QF, Zhang ZY, Van Keer J, Trenson S, Nkuipou-Kenfack E, Yang WY, Thijs L, Vanhaecke J, Van Aelst LNL, Van Cleemput J, Janssens S, Verhamme P, Mischak H, Staessen JA.

Nephrol Dial Transplant. 2018 Jul 2. doi: 10.1093/ndt/gfy185. [Epub ahead of print]


Biomarkers to Assess Right Heart Pressures in Recipients of a Heart Transplant: A Proof-of-Concept Study.

Huang QF, Trenson S, Zhang ZY, Van Keer J, Van Aelst LNL, Yang WY, Nkuipou-Kenfack E, Thijs L, Wei FF, Mujaj B, Ciarka A, Droogné W, Vanhaecke J, Janssens S, Van Cleemput J, Mischak H, Staessen JA.

Transplant Direct. 2018 Apr 23;4(5):e346. doi: 10.1097/TXD.0000000000000783. eCollection 2018 May.


Antibody-mediated rejection induced cardiogenic shock: Too late for conventional therapy.

Coutance G, Van Aelst L, Hékimian G, Vidal C, Rouvier P, Saheb S, Gautreau C, Leprince P, Varnous S.

Clin Transplant. 2018 May;32(5):e13253. doi: 10.1111/ctr.13253. Epub 2018 Apr 30.


Beyond left ventricular ejection fraction there is a right heart that pumps: reply.

Van Aelst LNL, Mebazaa A.

Eur J Heart Fail. 2018 Jun;20(6):1076-1077. doi: 10.1002/ejhf.1184. Epub 2018 Apr 6. No abstract available.


How to obtain and maintain favorable results after heart transplantation: keys to success?

Van Cleemput JJA, Verbelen TOM, Van Aelst LNL, Rega FRL.

Ann Cardiothorac Surg. 2018 Jan;7(1):106-117. doi: 10.21037/acs.2017.12.03.


East Asia may have a better 1-year survival following an acute heart failure episode compared with Europe: results from an international observational cohort.

Akiyama E, Van Aelst LNL, Arrigo M, Lassus J, Miró Ò, Čelutkienė J, Choi DJ, Cohen-Solal A, Ishihara S, Kajimoto K, Laribi S, Maggioni AP, Motiejunaite J, Mueller C, Parenica J, Park JJ, Sato N, Spinar J, Zhang J, Zhang Y, Kimura K, Tamura K, Gayat E, Mebazaa A; GREAT (Global Research on Acute Conditions Team) Network.

Eur J Heart Fail. 2018 Jun;20(6):1071-1075. doi: 10.1002/ejhf.1152. Epub 2018 Feb 12. No abstract available.


Acutely decompensated heart failure with preserved and reduced ejection fraction present with comparable haemodynamic congestion.

Van Aelst LNL, Arrigo M, Placido R, Akiyama E, Girerd N, Zannad F, Manivet P, Rossignol P, Badoz M, Sadoune M, Launay JM, Gayat E, Lam CSP, Cohen-Solal A, Mebazaa A, Seronde MF.

Eur J Heart Fail. 2018 Apr;20(4):738-747. doi: 10.1002/ejhf.1050. Epub 2017 Dec 18.


Dual role for DOCK7 in tangential migration of interneuron precursors in the postnatal forebrain.

Nakamuta S, Yang YT, Wang CL, Gallo NB, Yu JR, Tai Y, Van Aelst L.

J Cell Biol. 2017 Dec 4;216(12):4313-4330. doi: 10.1083/jcb.201704157. Epub 2017 Oct 31.


Urinary Proteomics in Predicting Heart Transplantation Outcomes (uPROPHET)-Rationale and database description.

Huang QF, Trenson S, Zhang ZY, Yang WY, Van Aelst L, Nkuipou-Kenfack E, Wei FF, Mujaj B, Thijs L, Ciarka A, Zoidakis J, Droogné W, Vlahou A, Janssens S, Vanhaecke J, Van Cleemput J, Staessen JA.

PLoS One. 2017 Sep 7;12(9):e0184443. doi: 10.1371/journal.pone.0184443. eCollection 2017.


High body mass index is a predictor of left ventricular reverse remodelling in heart failure with reduced ejection fraction.

Cescau A, Van Aelst LNL, Baudet M, Cohen Solal A, Logeart D.

ESC Heart Fail. 2017 Nov;4(4):686-689. doi: 10.1002/ehf2.12172. Epub 2017 Jul 27.


Towards Holistic Heart Failure Management-How to Tackle the Iron Deficiency Epidemic?

Van Aelst LNL, Mazure D, Cohen-Solal A.

Curr Heart Fail Rep. 2017 Aug;14(4):223-234. doi: 10.1007/s11897-017-0338-8. Review.


Iron status and inflammatory biomarkers in patients with acutely decompensated heart failure: early in-hospital phase and 30-day follow-up.

Van Aelst LNL, Abraham M, Sadoune M, Lefebvre T, Manivet P, Logeart D, Launay JM, Karim Z, Puy H, Cohen-Solal A.

Eur J Heart Fail. 2017 Aug;19(8):1075-1076. doi: 10.1002/ejhf.837. Epub 2017 May 17. No abstract available.


Natriuretic peptides in addition to Zwolle score to enhance safe and early discharge after acute myocardial infarction: A prospective observational cohort study.

Ganovska E, Arrigo M, Helanova K, Littnerova S, Sadoune M, Kubena P, Pavlusova M, Jarkovsky J, Gottwaldova J, Kala P, Dastych M, Ishihara S, Van Aelst LN, Cohen-Solal A, Gayat E, Spinar J, Parenica J, Mebazaa A; GREAT Network.

Int J Cardiol. 2016 Jul 15;215:527-31. doi: 10.1016/j.ijcard.2016.04.148. Epub 2016 Apr 21.


Advanced heart failure: look right to prognosticate right!

Van Aelst LN, Čelutkienė J, Mebazaa A.

Eur J Heart Fail. 2016 May;18(5):573-5. doi: 10.1002/ejhf.533. No abstract available.


miR-21 promotes fibrosis in an acute cardiac allograft transplantation model.

Gupta SK, Itagaki R, Zheng X, Batkai S, Thum S, Ahmad F, Van Aelst LN, Sharma A, Piccoli MT, Weinberger F, Fiedler J, Heuser M, Heymans S, Falk CS, Förster R, Schrepfer S, Thum T.

Cardiovasc Res. 2016 May 15;110(2):215-26. doi: 10.1093/cvr/cvw030. Epub 2016 Feb 9.


RNA Profiling in Human and Murine Transplanted Hearts: Identification and Validation of Therapeutic Targets for Acute Cardiac and Renal Allograft Rejection.

Van Aelst LN, Summer G, Li S, Gupta SK, Heggermont W, De Vusser K, Carai P, Naesens M, Van Cleemput J, Van de Werf F, Vanhaecke J, Thum T, Waer M, Papageorgiou AP, Schroen B, Heymans S.

Am J Transplant. 2016 Jan;16(1):99-110. doi: 10.1111/ajt.13421. Epub 2015 Aug 6.


PTP1B inhibition suggests a therapeutic strategy for Rett syndrome.

Krishnan N, Krishnan K, Connors CR, Choy MS, Page R, Peti W, Van Aelst L, Shea SD, Tonks NK.

J Clin Invest. 2015 Aug 3;125(8):3163-77. doi: 10.1172/JCI80323. Epub 2015 Jul 27.


TGF-β/Smad signaling through DOCK4 facilitates lung adenocarcinoma metastasis.

Yu JR, Tai Y, Jin Y, Hammell MC, Wilkinson JE, Roe JS, Vakoc CR, Van Aelst L.

Genes Dev. 2015 Feb 1;29(3):250-61. doi: 10.1101/gad.248963.114.


The paraventricular thalamus controls a central amygdala fear circuit.

Penzo MA, Robert V, Tucciarone J, De Bundel D, Wang M, Van Aelst L, Darvas M, Parada LF, Palmiter RD, He M, Huang ZJ, Li B.

Nature. 2015 Mar 26;519(7544):455-9. doi: 10.1038/nature13978. Epub 2015 Jan 19.


Osteoglycin prevents cardiac dilatation and dysfunction after myocardial infarction through infarct collagen strengthening.

Van Aelst LN, Voss S, Carai P, Van Leeuwen R, Vanhoutte D, Sanders-van Wijk S, Eurlings L, Swinnen M, Verheyen FK, Verbeken E, Nef H, Troidl C, Cook SA, Brunner-La Rocca HP, Möllmann H, Papageorgiou AP, Heymans S.

Circ Res. 2015 Jan 30;116(3):425-36. doi: 10.1161/CIRCRESAHA.116.304599. Epub 2014 Dec 17.


The X-linked mental retardation protein OPHN1 interacts with Homer1b/c to control spine endocytic zone positioning and expression of synaptic potentiation.

Nakano-Kobayashi A, Tai Y, Nadif Kasri N, Van Aelst L.

J Neurosci. 2014 Jun 25;34(26):8665-71. doi: 10.1523/JNEUROSCI.0894-14.2014.


Guanine nucleotide exchange factor Dock7 mediates HGF-induced glioblastoma cell invasion via Rac activation.

Murray DW, Didier S, Chan A, Paulino V, Van Aelst L, Ruggieri R, Tran NL, Byrne AT, Symons M.

Br J Cancer. 2014 Mar 4;110(5):1307-15. doi: 10.1038/bjc.2014.39. Epub 2014 Feb 11.


Regulation of chandelier cell cartridge and bouton development via DOCK7-mediated ErbB4 activation.

Tai Y, Janas JA, Wang CL, Van Aelst L.

Cell Rep. 2014 Jan 30;6(2):254-63. doi: 10.1016/j.celrep.2013.12.034. Epub 2014 Jan 16.


WNT3 inhibits cerebellar granule neuron progenitor proliferation and medulloblastoma formation via MAPK activation.

Anne SL, Govek EE, Ayrault O, Kim JH, Zhu X, Murphy DA, Van Aelst L, Roussel MF, Hatten ME.

PLoS One. 2013 Nov 26;8(11):e81769. doi: 10.1371/journal.pone.0081769. eCollection 2013.


DOK2 inhibits EGFR-mutated lung adenocarcinoma.

Berger AH, Chen M, Morotti A, Janas JA, Niki M, Bronson RT, Taylor BS, Ladanyi M, Van Aelst L, Politi K, Varmus HE, Pandolfi PP.

PLoS One. 2013 Nov 8;8(11):e79526. doi: 10.1371/journal.pone.0079526. eCollection 2013.


Percutaneous left cardiac sympathetic denervation in a patient with long-QT syndrome.

Nagels W, Brabant S, Van Aelst L, Pollet P, Anné W, Goethals M.

J Cardiothorac Vasc Anesth. 2014 Dec;28(6):1580-2. doi: 10.1053/j.jvca.2013.06.006. Epub 2013 Oct 11. No abstract available.


Introduction to the ECR special issue on the roles of small GTPases.

Boettner B, Van Aelst L.

Exp Cell Res. 2013 Sep 10;319(15):2309. doi: 10.1016/j.yexcr.2013.07.009. Epub 2013 Jul 18. No abstract available.


MicroRNAs as biomarkers for ischemic heart disease.

Van Aelst LN, Heymans S.

J Cardiovasc Transl Res. 2013 Aug;6(4):458-70. doi: 10.1007/s12265-013-9466-z. Epub 2013 May 29. Review.


The role of staphylothrombin-mediated fibrin deposition in catheter-related Staphylococcus aureus infections.

Vanassche T, Peetermans M, Van Aelst LN, Peetermans WE, Verhaegen J, Missiakas DM, Schneewind O, Hoylaerts MF, Verhamme P.

J Infect Dis. 2013 Jul;208(1):92-100. doi: 10.1093/infdis/jit130. Epub 2013 Mar 26.


Matricellular proteins and matrix metalloproteinases mark the inflammatory and fibrotic response in human cardiac allograft rejection.

Vanhoutte D, van Almen GC, Van Aelst LN, Van Cleemput J, Droogné W, Jin Y, Van de Werf F, Carmeliet P, Vanhaecke J, Papageorgiou AP, Heymans S.

Eur Heart J. 2013 Jul;34(25):1930-41. doi: 10.1093/eurheartj/ehs375. Epub 2012 Nov 8.


DOCK7 interacts with TACC3 to regulate interkinetic nuclear migration and cortical neurogenesis.

Yang YT, Wang CL, Van Aelst L.

Nat Neurosci. 2012 Sep;15(9):1201-10. doi: 10.1038/nn.3171. Epub 2012 Jul 29.


Signaling and gradients: what's going down?

Hill CS, Van Aelst L.

Curr Opin Cell Biol. 2012 Apr;24(2):155-7. doi: 10.1016/ Epub 2012 Mar 17. No abstract available.


Functional analysis of the protein phosphatase activity of PTEN.

Zhang XC, Piccini A, Myers MP, Van Aelst L, Tonks NK.

Biochem J. 2012 Jun 15;444(3):457-64. doi: 10.1042/BJ20120098.


Bone morphogenetic protein 4 promotes vascular smooth muscle contractility by activating microRNA-21 (miR-21), which down-regulates expression of family of dedicator of cytokinesis (DOCK) proteins.

Kang H, Davis-Dusenbery BN, Nguyen PH, Lal A, Lieberman J, Van Aelst L, Lagna G, Hata A.

J Biol Chem. 2012 Feb 3;287(6):3976-86. doi: 10.1074/jbc.M111.303156. Epub 2011 Dec 9.


Rapid synthesis of the X-linked mental retardation protein OPHN1 mediates mGluR-dependent LTD through interaction with the endocytic machinery.

Nadif Kasri N, Nakano-Kobayashi A, Van Aelst L.

Neuron. 2011 Oct 20;72(2):300-15. doi: 10.1016/j.neuron.2011.09.001.


The role of Rho GTPase proteins in CNS neuronal migration.

Govek EE, Hatten ME, Van Aelst L.

Dev Neurobiol. 2011 Jun;71(6):528-53. doi: 10.1002/dneu.20850. Review.


Oncogenic tyrosine kinases target Dok-1 for ubiquitin-mediated proteasomal degradation to promote cell transformation.

Janas JA, Van Aelst L.

Mol Cell Biol. 2011 Jul;31(13):2552-65. doi: 10.1128/MCB.05045-11. Epub 2011 May 2.


Regulation of the postsynaptic cytoskeleton: roles in development, plasticity, and disorders.

Svitkina T, Lin WH, Webb DJ, Yasuda R, Wayman GA, Van Aelst L, Soderling SH.

J Neurosci. 2010 Nov 10;30(45):14937-42. doi: 10.1523/JNEUROSCI.4276-10.2010. Review.


Signaling mechanisms.

Van Aelst L, Caroni P.

Curr Opin Neurobiol. 2010 Aug;20(4):397-9. doi: 10.1016/j.conb.2010.08.003. Epub 2010 Aug 22. No abstract available.


The peri-implant sulcus compared with internal implant and suprastructure components: a microbiological analysis.

Cosyn J, Van Aelst L, Collaert B, Persson GR, De Bruyn H.

Clin Implant Dent Relat Res. 2011 Dec;13(4):286-95. doi: 10.1111/j.1708-8208.2009.00220.x. Epub 2009 Aug 5.


Control of cell adhesion dynamics by Rap1 signaling.

Boettner B, Van Aelst L.

Curr Opin Cell Biol. 2009 Oct;21(5):684-93. doi: 10.1016/ Epub 2009 Jul 16. Review.


The Rho-linked mental retardation protein oligophrenin-1 controls synapse maturation and plasticity by stabilizing AMPA receptors.

Nadif Kasri N, Nakano-Kobayashi A, Malinow R, Li B, Van Aelst L.

Genes Dev. 2009 Jun 1;23(11):1289-302. doi: 10.1101/gad.1783809.


The Rho-linked mental retardation protein OPHN1 controls synaptic vesicle endocytosis via endophilin A1.

Nakano-Kobayashi A, Kasri NN, Newey SE, Van Aelst L.

Curr Biol. 2009 Jul 14;19(13):1133-9. doi: 10.1016/j.cub.2009.05.022. Epub 2009 May 28.


[Guidelines for periodontal diagnosis in Belgium].

Van Aelst L, Cosyn J, De Bruyn H; Societe Belge de Parodontologie.

Rev Belge Med Dent (1984). 2008;63(2):59-63. French.


Ras signaling mechanisms underlying impaired GluR1-dependent plasticity associated with fragile X syndrome.

Hu H, Qin Y, Bochorishvili G, Zhu Y, van Aelst L, Zhu JJ.

J Neurosci. 2008 Jul 30;28(31):7847-62. doi: 10.1523/JNEUROSCI.1496-08.2008.

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