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Items: 1 to 50 of 115

1.

Functional coupling of GABAA/B receptors and the channel TRPV4 mediates rapid progesterone signaling in the oviduct.

Jung C, Fernández-Dueñas V, Plata C, Garcia-Elias A, Ciruela F, Fernández-Fernández JM, Valverde MA.

Sci Signal. 2018 Aug 14;11(543). pii: eaam6558. doi: 10.1126/scisignal.aam6558.

PMID:
30108184
2.

The TRPV4 channel links calcium influx to DDX3X activity and viral infectivity.

Doñate-Macián P, Jungfleisch J, Pérez-Vilaró G, Rubio-Moscardo F, Perálvarez-Marín A, Diez J, Valverde MA.

Nat Commun. 2018 Jun 13;9(1):2307. doi: 10.1038/s41467-018-04776-7.

3.

DYRK1A Kinase Positively Regulates Angiogenic Responses in Endothelial Cells.

Rozen EJ, Roewenstrunk J, Barallobre MJ, Di Vona C, Jung C, Figueiredo AF, Luna J, Fillat C, Arbonés ML, Graupera M, Valverde MA, de la Luna S.

Cell Rep. 2018 May 8;23(6):1867-1878. doi: 10.1016/j.celrep.2018.04.008.

4.

Piezo2 channel regulates RhoA and actin cytoskeleton to promote cell mechanobiological responses.

Pardo-Pastor C, Rubio-Moscardo F, Vogel-González M, Serra SA, Afthinos A, Mrkonjic S, Destaing O, Abenza JF, Fernández-Fernández JM, Trepat X, Albiges-Rizo C, Konstantopoulos K, Valverde MA.

Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):1925-1930. doi: 10.1073/pnas.1718177115. Epub 2018 Feb 5.

5.

Health services research in patients with breast cancer (CAMISS-prospective): study protocol for an observational prospective study.

García-Gutierrez S, Orive M, Sarasqueta C, Legarreta MJ, Gonzalez N, Redondo M, Rivero A, Serrano-Aguilar P, Castells X, Quintana JM, Sala M; REDISSEC-CaMISS group.

BMC Cancer. 2018 Jan 8;18(1):54. doi: 10.1186/s12885-017-3926-9.

6.

Constitutive Cyclin O deficiency results in penetrant hydrocephalus, impaired growth and infertility.

Núnez-Ollé M, Jung C, Terré B, Balsiger NA, Plata C, Roset R, Pardo-Pastor C, Garrido M, Rojas S, Alameda F, Lloreta J, Martín-Caballero J, Flores JM, Stracker TH, Valverde MA, Muñoz FJ, Gil-Gómez G.

Oncotarget. 2017 Oct 12;8(59):99261-99273. doi: 10.18632/oncotarget.21818. eCollection 2017 Nov 21.

7.

Silica nanoparticles inhibit the cation channel TRPV4 in airway epithelial cells.

Sanchez A, Alvarez JL, Demydenko K, Jung C, Alpizar YA, Alvarez-Collazo J, Cokic SM, Valverde MA, Hoet PH, Talavera K.

Part Fibre Toxicol. 2017 Nov 3;14(1):43. doi: 10.1186/s12989-017-0224-2.

8.

TRPV4 activation triggers protective responses to bacterial lipopolysaccharides in airway epithelial cells.

Alpizar YA, Boonen B, Sanchez A, Jung C, López-Requena A, Naert R, Steelant B, Luyts K, Plata C, De Vooght V, Vanoirbeek JAJ, Meseguer VM, Voets T, Alvarez JL, Hellings PW, Hoet PHM, Nemery B, Valverde MA, Talavera K.

Nat Commun. 2017 Oct 20;8(1):1059. doi: 10.1038/s41467-017-01201-3.

9.

Structural determinants of 5',6'-epoxyeicosatrienoic acid binding to and activation of TRPV4 channel.

Berna-Erro A, Izquierdo-Serra M, Sepúlveda RV, Rubio-Moscardo F, Doñate-Macián P, Serra SA, Carrillo-Garcia J, Perálvarez-Marín A, González-Nilo F, Fernández-Fernández JM, Valverde MA.

Sci Rep. 2017 Sep 5;7(1):10522. doi: 10.1038/s41598-017-11274-1.

10.

TRPV1 polymorphisms influence capsaicin cough sensitivity in men.

Sadofsky LR, Cantero-Recasens G, Wright C, Valverde MA, Morice AH.

J Thorac Dis. 2017 Mar;9(3):839-840. doi: 10.21037/jtd.2017.03.50. No abstract available.

11.

Glutamatergic stimulation induces GluN2B translation by the nitric oxide-Heme-Regulated eIF2α kinase in cortical neurons.

Ramos-Fernández E, Tajes M, Ill-Raga G, Vargas L, Busquets-García A, Bosch-Morató M, Guivernau B, Valls-Comamala V, Gomis M, Grau C, Fandos C, Rosen MD, Rabinowitz MH, Inestrosa N, Maldonado R, Altafaj X, Ozaita A, Alvarez A, Vicente R, Valverde MA, Muñoz FJ.

Oncotarget. 2016 Sep 13;7(37):58876-58892. doi: 10.18632/oncotarget.11417.

12.

In vitro and in vivo evidence for an inflammatory role of the calcium channel TRPV4 in lung epithelium: Potential involvement in cystic fibrosis.

Henry CO, Dalloneau E, Pérez-Berezo MT, Plata C, Wu Y, Guillon A, Morello E, Aimar RF, Potier-Cartereau M, Esnard F, Coraux C, Börnchen C, Kiefmann R, Vandier C, Touqui L, Valverde MA, Cenac N, Si-Tahar M.

Am J Physiol Lung Cell Mol Physiol. 2016 Sep 1;311(3):L664-75. doi: 10.1152/ajplung.00442.2015. Epub 2016 Aug 5.

13.

Confinement Sensing and Signal Optimization via Piezo1/PKA and Myosin II Pathways.

Hung WC, Yang JR, Yankaskas CL, Wong BS, Wu PH, Pardo-Pastor C, Serra SA, Chiang MJ, Gu Z, Wirtz D, Valverde MA, Yang JT, Zhang J, Konstantopoulos K.

Cell Rep. 2016 May 17;15(7):1430-1441. doi: 10.1016/j.celrep.2016.04.035. Epub 2016 May 5.

14.

Correction: Cutting Edge: TRPV4-Mediated Detection of Hyposmotic Stress by Skin Keratinocytes Activates Developmental Immunity.

Galindo-Villegas J, Montalban-Arques A, Liarte S, de Oliveira S, Pardo-Pastor C, Rubio-Moscardo F, Meseguer J, Valverde MA, Mulero V.

J Immunol. 2016 Apr 15;196(8):3494. doi: 10.4049/jimmunol.1600243. No abstract available.

15.

GEMC1 is a critical regulator of multiciliated cell differentiation.

Terré B, Piergiovanni G, Segura-Bayona S, Gil-Gómez G, Youssef SA, Attolini CS, Wilsch-Bräuninger M, Jung C, Rojas AM, Marjanović M, Knobel PA, Palenzuela L, López-Rovira T, Forrow S, Huttner WB, Valverde MA, de Bruin A, Costanzo V, Stracker TH.

EMBO J. 2016 May 2;35(9):942-60. doi: 10.15252/embj.201592821. Epub 2016 Mar 1.

16.

TRPV4-Mediated Detection of Hyposmotic Stress by Skin Keratinocytes Activates Developmental Immunity.

Galindo-Villegas J, Montalban-Arques A, Liarte S, de Oliveira S, Pardo-Pastor C, Rubio-Moscardo F, Meseguer J, Valverde MA, Mulero V.

J Immunol. 2016 Jan 15;196(2):738-49. doi: 10.4049/jimmunol.1501729. Epub 2015 Dec 16. Erratum in: J Immunol. 2016 Apr 15;196(8):3494.

17.

Endothelial Progenitor Cells Predict Cardiovascular Events after Atherothrombotic Stroke and Acute Myocardial Infarction. A PROCELL Substudy.

Cuadrado-Godia E, Regueiro A, Núñez J, Díaz-Ricard M, Novella S, Oliveras A, Valverde MA, Marrugat J, Ois A, Giralt-Steinhauer E, Sanchís J, Escolar G, Hermenegildo C, Heras M, Roquer J.

PLoS One. 2015 Sep 2;10(9):e0132415. doi: 10.1371/journal.pone.0132415. eCollection 2015.

18.

Interaction between the Linker, Pre-S1, and TRP Domains Determines Folding, Assembly, and Trafficking of TRPV Channels.

Garcia-Elias A, Berna-Erro A, Rubio-Moscardo F, Pardo-Pastor C, Mrkonjić S, Sepúlveda RV, Vicente R, González-Nilo F, Valverde MA.

Structure. 2015 Aug 4;23(8):1404-1413. doi: 10.1016/j.str.2015.05.018. Epub 2015 Jul 2.

19.

Tungstate-targeting of BKαβ1 channels tunes ERK phosphorylation and cell proliferation in human vascular smooth muscle.

Fernández-Mariño AI, Cidad P, Zafra D, Nocito L, Domínguez J, Oliván-Viguera A, Köhler R, López-López JR, Pérez-García MT, Valverde MÁ, Guinovart JJ, Fernández-Fernández JM.

PLoS One. 2015 Feb 6;10(2):e0118148. doi: 10.1371/journal.pone.0118148. eCollection 2015.

20.

Mobilization of endothelial progenitor cells in acute cardiovascular events in the PROCELL study: time-course after acute myocardial infarction and stroke.

Regueiro A, Cuadrado-Godia E, Bueno-Betí C, Diaz-Ricart M, Oliveras A, Novella S, Gené GG, Jung C, Subirana I, Ortiz-Pérez JT, Roqué M, Freixa X, Núñez J, Escolar G, Marrugat J, Hermenegildo C, Valverde MA, Roquer J, Sanchis J, Heras M.

J Mol Cell Cardiol. 2015 Mar;80:146-55. doi: 10.1016/j.yjmcc.2015.01.005. Epub 2015 Jan 22.

PMID:
25619946
21.

TRPV4 participates in the establishment of trailing adhesions and directional persistence of migrating cells.

Mrkonjić S, Garcia-Elias A, Pardo-Pastor C, Bazellières E, Trepat X, Vriens J, Ghosh D, Voets T, Vicente R, Valverde MA.

Pflugers Arch. 2015 Oct;467(10):2107-19. doi: 10.1007/s00424-014-1679-8. Epub 2015 Jan 6.

PMID:
25559845
22.

Fibrinogen nitrotyrosination after ischemic stroke impairs thrombolysis and promotes neuronal death.

Ill-Raga G, Palomer E, Ramos-Fernández E, Guix FX, Bosch-Morató M, Guivernau B, Tajes M, Valls-Comamala V, Jiménez-Conde J, Ois A, Pérez-Asensio F, Reyes-Navarro M, Caballo C, Gil-Gómez G, Lopez-Vilchez I, Galan AM, Alameda F, Escolar G, Opazo C, Planas AM, Roquer J, Valverde MA, Muñoz FJ.

Biochim Biophys Acta. 2015 Mar;1852(3):421-8. doi: 10.1016/j.bbadis.2014.12.007. Epub 2014 Dec 12.

23.

The TRPV4 channel.

Garcia-Elias A, Mrkonjić S, Jung C, Pardo-Pastor C, Vicente R, Valverde MA.

Handb Exp Pharmacol. 2014;222:293-319. doi: 10.1007/978-3-642-54215-2_12. Review.

PMID:
24756711
24.

Extreme population differences in the human zinc transporter ZIP4 (SLC39A4) are explained by positive selection in Sub-Saharan Africa.

Engelken J, Carnero-Montoro E, Pybus M, Andrews GK, Lalueza-Fox C, Comas D, Sekler I, de la Rasilla M, Rosas A, Stoneking M, Valverde MA, Vicente R, Bosch E.

PLoS Genet. 2014 Feb 20;10(2):e1004128. doi: 10.1371/journal.pgen.1004128. eCollection 2014 Feb.

25.

Posttranslational nitro-glycative modifications of albumin in Alzheimer's disease: implications in cytotoxicity and amyloid-β peptide aggregation.

Ramos-Fernández E, Tajes M, Palomer E, Ill-Raga G, Bosch-Morató M, Guivernau B, Román-Dégano I, Eraso-Pichot A, Alcolea D, Fortea J, Nuñez L, Paez A, Alameda F, Fernández-Busquets X, Lleó A, Elosúa R, Boada M, Valverde MA, Muñoz FJ.

J Alzheimers Dis. 2014;40(3):643-57. doi: 10.3233/JAD-130914.

PMID:
24503620
26.

Screening of CACNA1A and ATP1A2 genes in hemiplegic migraine: clinical, genetic, and functional studies.

Carreño O, Corominas R, Serra SA, Sintas C, Fernández-Castillo N, Vila-Pueyo M, Toma C, Gené GG, Pons R, Llaneza M, Sobrido MJ, Grinberg D, Valverde MÁ, Fernández-Fernández JM, Macaya A, Cormand B.

Mol Genet Genomic Med. 2013 Nov;1(4):206-22. doi: 10.1002/mgg3.24. Epub 2013 Jul 2.

27.

A loss-of-function CACNA1A mutation causing benign paroxysmal torticollis of infancy.

Vila-Pueyo M, Gené GG, Flotats-Bastardes M, Elorza X, Sintas C, Valverde MA, Cormand B, Fernández-Fernández JM, Macaya A.

Eur J Paediatr Neurol. 2014 May;18(3):430-3. doi: 10.1016/j.ejpn.2013.12.011. Epub 2014 Jan 8.

PMID:
24445160
28.

BK channel activation by tungstate requires the β1 subunit extracellular loop residues essential to modulate voltage sensor function and channel gating.

Fernández-Mariño AI, Valverde MA, Fernández-Fernández JM.

Pflugers Arch. 2014 Jul;466(7):1365-75. doi: 10.1007/s00424-013-1379-9. Epub 2013 Oct 26.

PMID:
24158430
29.

Rare variants in calcium homeostasis modulator 1 (CALHM1) found in early onset Alzheimer's disease patients alter calcium homeostasis.

Rubio-Moscardo F, Setó-Salvia N, Pera M, Bosch-Morató M, Plata C, Belbin O, Gené G, Dols-Icardo O, Ingelsson M, Helisalmi S, Soininen H, Hiltunen M, Giedraitis V, Lannfelt L, Frank A, Bullido MJ, Combarros O, Sánchez-Juan P, Boada M, Tárraga L, Pastor P, Pérez-Tur J, Baquero M, Molinuevo JL, Sánchez-Valle R, Fuentes-Prior P, Fortea J, Blesa R, Muñoz FJ, Lleó A, Valverde MA, Clarimón J.

PLoS One. 2013 Sep 17;8(9):e74203. doi: 10.1371/journal.pone.0074203. eCollection 2013.

30.

Nitro-oxidative stress after neuronal ischemia induces protein nitrotyrosination and cell death.

Tajes M, Ill-Raga G, Palomer E, Ramos-Fernández E, Guix FX, Bosch-Morató M, Guivernau B, Jiménez-Conde J, Ois A, Pérez-Asensio F, Reyes-Navarro M, Caballo C, Galán AM, Alameda F, Escolar G, Opazo C, Planas A, Roquer J, Valverde MA, Muñoz FJ.

Oxid Med Cell Longev. 2013;2013:826143. doi: 10.1155/2013/826143. Epub 2013 Aug 1.

31.

New serovars of Leptospira isolated from patients in Costa Rica: implications for public health.

Valverde Mde L, Goris MG, González V, Anchia ME, Díaz P, Ahmed A, Hartskeerl RA.

J Med Microbiol. 2013 Sep;62(Pt 9):1263-71. doi: 10.1099/jmm.0.058545-0. Epub 2013 Jun 20.

PMID:
23788592
32.

TRPM5-mediated calcium uptake regulates mucin secretion from human colon goblet cells.

Mitrovic S, Nogueira C, Cantero-Recasens G, Kiefer K, Fernández-Fernández JM, Popoff JF, Casano L, Bard FA, Gomez R, Valverde MA, Malhotra V.

Elife. 2013 May 28;2:e00658. doi: 10.7554/eLife.00658.

33.

Phosphatidylinositol-4,5-biphosphate-dependent rearrangement of TRPV4 cytosolic tails enables channel activation by physiological stimuli.

Garcia-Elias A, Mrkonjic S, Pardo-Pastor C, Inada H, Hellmich UA, Rubio-Moscardó F, Plata C, Gaudet R, Vicente R, Valverde MA.

Proc Natl Acad Sci U S A. 2013 Jun 4;110(23):9553-8. doi: 10.1073/pnas.1220231110. Epub 2013 May 20.

34.

ORMDL3 modulates store-operated calcium entry and lymphocyte activation.

Carreras-Sureda A, Cantero-Recasens G, Rubio-Moscardo F, Kiefer K, Peinelt C, Niemeyer BA, Valverde MA, Vicente R.

Hum Mol Genet. 2013 Feb 1;22(3):519-30. doi: 10.1093/hmg/dds450. Epub 2012 Oct 25.

35.

Tungstate activates BK channels in a β subunit- and Mg2+-dependent manner: relevance for arterial vasodilatation.

Fernández-Mariño AI, Porras-González C, González-Rodríguez P, Selent J, Pastor M, Ureña J, Castellano A, Valverde MA, Fernández-Fernández JM.

Cardiovasc Res. 2012 Jul 1;95(1):29-38. doi: 10.1093/cvr/cvs139. Epub 2012 Apr 2.

PMID:
22473360
36.

Transient receptor potential genes, smoking, occupational exposures and cough in adults.

Smit LA, Kogevinas M, Antó JM, Bouzigon E, González JR, Le Moual N, Kromhout H, Carsin AE, Pin I, Jarvis D, Vermeulen R, Janson C, Heinrich J, Gut I, Lathrop M, Valverde MA, Demenais F, Kauffmann F.

Respir Res. 2012 Mar 23;13:26. doi: 10.1186/1465-9921-13-26.

37.

Ion channels in asthma.

Valverde MA, Cantero-Recasens G, Garcia-Elias A, Jung C, Carreras-Sureda A, Vicente R.

J Biol Chem. 2011 Sep 23;286(38):32877-82. doi: 10.1074/jbc.R110.215491. Epub 2011 Jul 28. Review.

38.

ADF/cofilin regulates secretory cargo sorting at the TGN via the Ca2+ ATPase SPCA1.

von Blume J, Alleaume AM, Cantero-Recasens G, Curwin A, Carreras-Sureda A, Zimmermann T, van Galen J, Wakana Y, Valverde MA, Malhotra V.

Dev Cell. 2011 May 17;20(5):652-62. doi: 10.1016/j.devcel.2011.03.014.

39.

A gain-of-function SNP in TRPC4 cation channel protects against myocardial infarction.

Jung C, Gené GG, Tomás M, Plata C, Selent J, Pastor M, Fandos C, Senti M, Lucas G, Elosua R, Valverde MA.

Cardiovasc Res. 2011 Aug 1;91(3):465-71. doi: 10.1093/cvr/cvr083. Epub 2011 Mar 22.

PMID:
21427121
40.

The TRPV4 Channel in Ciliated Epithelia.

Andrade YN, Fernandes J, Lorenzo IM, Arniges M, Valverde MA.

In: Liedtke WB, Heller S, editors. TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades. Boca Raton (FL): CRC Press/Taylor & Francis; 2007. Chapter 30.

41.

Loss of function of transient receptor potential vanilloid 1 (TRPV1) genetic variant is associated with lower risk of active childhood asthma.

Cantero-Recasens G, Gonzalez JR, Fandos C, Duran-Tauleria E, Smit LA, Kauffmann F, Antó JM, Valverde MA.

J Biol Chem. 2010 Sep 3;285(36):27532-5. doi: 10.1074/jbc.C110.159491. Epub 2010 Jul 18.

42.

A mutation in the first intracellular loop of CACNA1A prevents P/Q channel modulation by SNARE proteins and lowers exocytosis.

Serra SA, Cuenca-León E, Llobet A, Rubio-Moscardo F, Plata C, Carreño O, Fernàndez-Castillo N, Corominas R, Valverde MA, Macaya A, Cormand B, Fernández-Fernández JM.

Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1672-7. doi: 10.1073/pnas.0908359107. Epub 2010 Jan 8.

43.

The asthma-associated ORMDL3 gene product regulates endoplasmic reticulum-mediated calcium signaling and cellular stress.

Cantero-Recasens G, Fandos C, Rubio-Moscardo F, Valverde MA, Vicente R.

Hum Mol Genet. 2010 Jan 1;19(1):111-21. doi: 10.1093/hmg/ddp471.

PMID:
19819884
44.

The progesterone receptor regulates the expression of TRPV4 channel.

Jung C, Fandos C, Lorenzo IM, Plata C, Fernandes J, Gené GG, Vázquez E, Valverde MA.

Pflugers Arch. 2009 Nov;459(1):105-13. doi: 10.1007/s00424-009-0706-7. Epub 2009 Aug 23.

PMID:
19701771
45.

A loss-of-function nonsynonymous polymorphism in the osmoregulatory TRPV4 gene is associated with human hyponatremia.

Tian W, Fu Y, Garcia-Elias A, Fernández-Fernández JM, Vicente R, Kramer PL, Klein RF, Hitzemann R, Orwoll ES, Wilmot B, McWeeney S, Valverde MA, Cohen DM.

Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):14034-9. doi: 10.1073/pnas.0904084106. Epub 2009 Aug 4.

46.

Amyloid-dependent triosephosphate isomerase nitrotyrosination induces glycation and tau fibrillation.

Guix FX, Ill-Raga G, Bravo R, Nakaya T, de Fabritiis G, Coma M, Miscione GP, Villà-Freixa J, Suzuki T, Fernàndez-Busquets X, Valverde MA, de Strooper B, Muñoz FJ.

Brain. 2009 May;132(Pt 5):1335-45. doi: 10.1093/brain/awp023. Epub 2009 Feb 27.

PMID:
19251756
47.

Late-onset episodic ataxia type 2 associated with a novel loss-of-function mutation in the CACNA1A gene.

Cuenca-León E, Banchs I, Serra SA, Latorre P, Fernàndez-Castillo N, Corominas R, Valverde MA, Volpini V, Fernández-Fernández JM, Macaya A, Cormand B.

J Neurol Sci. 2009 May 15;280(1-2):10-4. doi: 10.1016/j.jns.2009.01.005. Epub 2009 Feb 20.

PMID:
19232643
48.

The hemiplegic migraine-associated Y1245C mutation in CACNA1A results in a gain of channel function due to its effect on the voltage sensor and G-protein-mediated inhibition.

Serra SA, Fernàndez-Castillo N, Macaya A, Cormand B, Valverde MA, Fernández-Fernández JM.

Pflugers Arch. 2009 Jul;458(3):489-502. doi: 10.1007/s00424-009-0637-3. Epub 2009 Feb 3.

PMID:
19189122
49.

Genetic variation in the KCNMA1 potassium channel alpha subunit as risk factor for severe essential hypertension and myocardial infarction.

Tomás M, Vázquez E, Fernández-Fernández JM, Subirana I, Plata C, Heras M, Vila J, Marrugat J, Valverde MA, Sentí M.

J Hypertens. 2008 Nov;26(11):2147-53. doi: 10.1097/HJH.0b013e32831103d8.

PMID:
18854754
50.

IP3 receptor binds to and sensitizes TRPV4 channel to osmotic stimuli via a calmodulin-binding site.

Garcia-Elias A, Lorenzo IM, Vicente R, Valverde MA.

J Biol Chem. 2008 Nov 14;283(46):31284-8. doi: 10.1074/jbc.C800184200. Epub 2008 Sep 30.

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