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Items: 1 to 50 of 166

1.

Elevated levels of Secreted-Frizzled-Related-Protein 1 contribute to Alzheimer's disease pathogenesis.

Esteve P, Rueda-Carrasco J, Inés Mateo M, Martin-Bermejo MJ, Draffin J, Pereyra G, Sandonís Á, Crespo I, Moreno I, Aso E, Garcia-Esparcia P, Gomez-Tortosa E, Rábano A, Fortea J, Alcolea D, Lleo A, Heneka MT, Valpuesta JM, Esteban JA, Ferrer I, Domínguez M, Bovolenta P.

Nat Neurosci. 2019 Jul 15. doi: 10.1038/s41593-019-0432-1. [Epub ahead of print]

PMID:
31308530
2.

Structural insights into the ability of nucleoplasmin to assemble and chaperone histone octamers for DNA deposition.

Franco A, Arranz R, Fernández-Rivero N, Velázquez-Campoy A, Martín-Benito J, Segura J, Prado A, Valpuesta JM, Muga A.

Sci Rep. 2019 Jul 1;9(1):9487. doi: 10.1038/s41598-019-45726-7.

3.

Structural and functional analysis of the role of the chaperonin CCT in mTOR complex assembly.

Cuéllar J, Ludlam WG, Tensmeyer NC, Aoba T, Dhavale M, Santiago C, Bueno-Carrasco MT, Mann MJ, Plimpton RL, Makaju A, Franklin S, Willardson BM, Valpuesta JM.

Nat Commun. 2019 Jun 28;10(1):2865. doi: 10.1038/s41467-019-10781-1.

4.

The cochaperone CHIP marks Hsp70- and Hsp90-bound substrates for degradation through a very flexible mechanism.

Quintana-Gallardo L, Martín-Benito J, Marcilla M, Espadas G, Sabidó E, Valpuesta JM.

Sci Rep. 2019 Mar 25;9(1):5102. doi: 10.1038/s41598-019-41060-0.

5.

Structure and Function of the Cochaperone Prefoldin.

Arranz R, Martín-Benito J, Valpuesta JM.

Adv Exp Med Biol. 2018;1106:119-131. doi: 10.1007/978-3-030-00737-9_9.

PMID:
30484157
6.

Hsp70 chaperone: a master player in protein homeostasis.

Fernández-Fernández MR, Valpuesta JM.

F1000Res. 2018 Sep 19;7. pii: F1000 Faculty Rev-1497. doi: 10.12688/f1000research.15528.1. eCollection 2018. Review.

7.

Expression, Functional Characterization, and Preliminary Crystallization of the Cochaperone Prefoldin from the Thermophilic Fungus Chaetomium thermophilum.

Morita K, Yamamoto YY, Hori A, Obata T, Uno Y, Shinohara K, Noguchi K, Noi K, Ogura T, Ishii K, Kato K, Kikumoto M, Arranz R, Valpuesta JM, Yohda M.

Int J Mol Sci. 2018 Aug 19;19(8). pii: E2452. doi: 10.3390/ijms19082452.

8.

The chaperonin CCT promotes the formation of fibrillar aggregates of γ-tubulin.

Pouchucq L, Lobos-Ruiz P, Araya G, Valpuesta JM, Monasterio O.

Biochim Biophys Acta Proteins Proteom. 2018 Apr;1866(4):519-526. doi: 10.1016/j.bbapap.2018.01.007. Epub 2018 Jan 12.

PMID:
29339327
9.

Domain topology of human Rasal.

Cuellar J, Valpuesta JM, Wittinghofer A, Sot B.

Biol Chem. 2017 Dec 20;399(1):63-72. doi: 10.1515/hsz-2017-0159.

PMID:
28885980
10.

Hsp70 - a master regulator in protein degradation.

Fernández-Fernández MR, Gragera M, Ochoa-Ibarrola L, Quintana-Gallardo L, Valpuesta JM.

FEBS Lett. 2017 Sep;591(17):2648-2660. doi: 10.1002/1873-3468.12751. Epub 2017 Jul 25. Review.

11.

Structural characterization of the NAP; the major adhesion complex of the human pathogen Mycoplasma genitalium.

Scheffer MP, Gonzalez-Gonzalez L, Seybert A, Ratera M, Kunz M, Valpuesta JM, Fita I, Querol E, Piñol J, Martín-Benito J, Frangakis AS.

Mol Microbiol. 2017 Sep;105(6):869-879. doi: 10.1111/mmi.13743. Epub 2017 Jul 17.

12.

The chaperonin CCT inhibits assembly of α-synuclein amyloid fibrils by a specific, conformation-dependent interaction.

Sot B, Rubio-Muñoz A, Leal-Quintero A, Martínez-Sabando J, Marcilla M, Roodveldt C, Valpuesta JM.

Sci Rep. 2017 Jan 19;7:40859. doi: 10.1038/srep40859.

13.

Beyond the known functions of the CCR4-NOT complex in gene expression regulatory mechanisms: New structural insights to unravel CCR4-NOT mRNA processing machinery.

Ukleja M, Valpuesta JM, Dziembowski A, Cuellar J.

Bioessays. 2016 Oct;38(10):1048-58. doi: 10.1002/bies.201600092. Epub 2016 Aug 9. Review.

PMID:
27502453
14.

Clathrin-coat disassembly illuminates the mechanisms of Hsp70 force generation.

Sousa R, Liao HS, Cuéllar J, Jin S, Valpuesta JM, Jin AJ, Lafer EM.

Nat Struct Mol Biol. 2016 Sep;23(9):821-9. doi: 10.1038/nsmb.3272. Epub 2016 Aug 1.

15.

Molecular chaperones: functional mechanisms and nanotechnological applications.

Fernández-Fernández MR, Sot B, Valpuesta JM.

Nanotechnology. 2016 Aug 12;27(32):324004. doi: 10.1088/0957-4484/27/32/324004. Epub 2016 Jul 1.

PMID:
27363314
16.

High resolution atomic force microscopy of double-stranded RNA.

Ares P, Fuentes-Perez ME, Herrero-Galán E, Valpuesta JM, Gil A, Gomez-Herrero J, Moreno-Herrero F.

Nanoscale. 2016 Jun 9;8(23):11818-26. doi: 10.1039/c5nr07445b.

PMID:
26876486
17.

Identification of Key Amino Acid Residues Modulating Intracellular and In vitro Microcin E492 Amyloid Formation.

Aguilera P, Marcoleta A, Lobos-Ruiz P, Arranz R, Valpuesta JM, Monasterio O, Lagos R.

Front Microbiol. 2016 Jan 28;7:35. doi: 10.3389/fmicb.2016.00035. eCollection 2016.

18.

The architecture of the Schizosaccharomyces pombe CCR4-NOT complex.

Ukleja M, Cuellar J, Siwaszek A, Kasprzak JM, Czarnocki-Cieciura M, Bujnicki JM, Dziembowski A, Valpuesta JM.

Nat Commun. 2016 Jan 25;7:10433. doi: 10.1038/ncomms10433.

19.

Electron microscopy: the coming of age of a structural biology technique.

Valpuesta JM, Carrascosa JL.

Arch Biochem Biophys. 2015 Sep 1;581:1-2. doi: 10.1016/j.abb.2015.06.018. Epub 2015 Jun 30. No abstract available.

PMID:
26142372
20.

Dynamics, flexibility, and allostery in molecular chaperonins.

Skjærven L, Cuellar J, Martinez A, Valpuesta JM.

FEBS Lett. 2015 Sep 14;589(19 Pt A):2522-32. doi: 10.1016/j.febslet.2015.06.019. Epub 2015 Jun 30. Review.

21.

The structure of the complex between α-tubulin, TBCE and TBCB reveals a tubulin dimer dissociation mechanism.

Serna M, Carranza G, Martín-Benito J, Janowski R, Canals A, Coll M, Zabala JC, Valpuesta JM.

J Cell Sci. 2015 May 1;128(9):1824-34. doi: 10.1242/jcs.167387. Epub 2015 Apr 23.

22.

Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation.

Chen SW, Drakulic S, Deas E, Ouberai M, Aprile FA, Arranz R, Ness S, Roodveldt C, Guilliams T, De-Genst EJ, Klenerman D, Wood NW, Knowles TP, Alfonso C, Rivas G, Abramov AY, Valpuesta JM, Dobson CM, Cremades N.

Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):E1994-2003. doi: 10.1073/pnas.1421204112. Epub 2015 Apr 8.

23.

Mechano-chemical kinetics of DNA replication: identification of the translocation step of a replicative DNA polymerase.

Morin JA, Cao FJ, Lázaro JM, Arias-Gonzalez JR, Valpuesta JM, Carrascosa JL, Salas M, Ibarra B.

Nucleic Acids Res. 2015 Apr 20;43(7):3643-52. doi: 10.1093/nar/gkv204. Epub 2015 Mar 23.

24.

Arc is a flexible modular protein capable of reversible self-oligomerization.

Myrum C, Baumann A, Bustad HJ, Flydal MI, Mariaule V, Alvira S, Cuéllar J, Haavik J, Soulé J, Valpuesta JM, Márquez JA, Martinez A, Bramham CR.

Biochem J. 2015 May 15;468(1):145-58. doi: 10.1042/BJ20141446.

25.

Modulation of the chaperone DnaK allosterism by the nucleotide exchange factor GrpE.

Melero R, Moro F, Pérez-Calvo MÁ, Perales-Calvo J, Quintana-Gallardo L, Llorca O, Muga A, Valpuesta JM.

J Biol Chem. 2015 Apr 17;290(16):10083-92. doi: 10.1074/jbc.M114.623371. Epub 2015 Mar 4.

26.

Structures of the Gβ-CCT and PhLP1-Gβ-CCT complexes reveal a mechanism for G-protein β-subunit folding and Gβγ dimer assembly.

Plimpton RL, Cuéllar J, Lai CW, Aoba T, Makaju A, Franklin S, Mathis AD, Prince JT, Carrascosa JL, Valpuesta JM, Willardson BM.

Proc Natl Acad Sci U S A. 2015 Feb 24;112(8):2413-8. doi: 10.1073/pnas.1419595112. Epub 2015 Feb 9.

27.

Structural characterization of the substrate transfer mechanism in Hsp70/Hsp90 folding machinery mediated by Hop.

Alvira S, Cuéllar J, Röhl A, Yamamoto S, Itoh H, Alfonso C, Rivas G, Buchner J, Valpuesta JM.

Nat Commun. 2014 Nov 19;5:5484. doi: 10.1038/ncomms6484.

PMID:
25407331
28.

Phosphoinositide 3-kinase beta protects nuclear envelope integrity by controlling RCC1 localization and Ran activity.

Redondo-Muñoz J, Pérez-García V, Rodríguez MJ, Valpuesta JM, Carrera AC.

Mol Cell Biol. 2015 Jan;35(1):249-63. doi: 10.1128/MCB.01184-14. Epub 2014 Oct 27.

29.

Yeast mitochondrial RNAP conformational changes are regulated by interactions with the mitochondrial transcription factor.

Drakulic S, Wang L, Cuéllar J, Guo Q, Velázquez G, Martín-Benito J, Sousa R, Valpuesta JM.

Nucleic Acids Res. 2014;42(17):11246-60. doi: 10.1093/nar/gku795. Epub 2014 Sep 2.

30.

Phosphorylation dependence and stoichiometry of the complex formed by tyrosine hydroxylase and 14-3-3γ.

Kleppe R, Rosati S, Jorge-Finnigan A, Alvira S, Ghorbani S, Haavik J, Valpuesta JM, Heck AJ, Martinez A.

Mol Cell Proteomics. 2014 Aug;13(8):2017-30. doi: 10.1074/mcp.M113.035709. Epub 2014 Jun 19.

31.

Assisted protein folding at low temperature: evolutionary adaptation of the Antarctic fish chaperonin CCT and its client proteins.

Cuellar J, Yébenes H, Parker SK, Carranza G, Serna M, Valpuesta JM, Zabala JC, Detrich HW 3rd.

Biol Open. 2014 Apr 15;3(4):261-70. doi: 10.1242/bio.20147427.

32.

Modulation of the Hsp90 chaperone cycle by a stringent client protein.

Lorenz OR, Freiburger L, Rutz DA, Krause M, Zierer BK, Alvira S, Cuéllar J, Valpuesta JM, Madl T, Sattler M, Buchner J.

Mol Cell. 2014 Mar 20;53(6):941-53. doi: 10.1016/j.molcel.2014.02.003. Epub 2014 Mar 6.

33.

Molecular determinants of the ATP hydrolysis asymmetry of the CCT chaperonin complex.

Chagoyen M, Carrascosa JL, Pazos F, Valpuesta JM.

Proteins. 2014 May;82(5):703-7. doi: 10.1002/prot.24510. Epub 2014 Feb 12.

PMID:
24420718
34.

Programmed cell death protein 5 interacts with the cytosolic chaperonin containing tailless complex polypeptide 1 (CCT) to regulate β-tubulin folding.

Tracy CM, Gray AJ, Cuéllar J, Shaw TS, Howlett AC, Taylor RM, Prince JT, Ahn NG, Valpuesta JM, Willardson BM.

J Biol Chem. 2014 Feb 14;289(7):4490-502. doi: 10.1074/jbc.M113.542159. Epub 2013 Dec 27.

35.

The intrinsically disordered distal face of nucleoplasmin recognizes distinct oligomerization states of histones.

Ramos I, Fernández-Rivero N, Arranz R, Aloria K, Finn R, Arizmendi JM, Ausió J, Valpuesta JM, Muga A, Prado A.

Nucleic Acids Res. 2014 Jan;42(2):1311-25. doi: 10.1093/nar/gkt899. Epub 2013 Oct 10.

36.

Structural characterization of the bacteriophage T7 tail machinery.

Cuervo A, Pulido-Cid M, Chagoyen M, Arranz R, González-García VA, Garcia-Doval C, Castón JR, Valpuesta JM, van Raaij MJ, Martín-Benito J, Carrascosa JL.

J Biol Chem. 2013 Sep 6;288(36):26290-9. doi: 10.1074/jbc.M113.491209. Epub 2013 Jul 24.

37.

Microcin e492 amyloid formation is retarded by posttranslational modification.

Marcoleta A, Marín M, Mercado G, Valpuesta JM, Monasterio O, Lagos R.

J Bacteriol. 2013 Sep;195(17):3995-4004. doi: 10.1128/JB.00564-13. Epub 2013 Jul 8.

38.

Segregated ordered lipid phases and protein-promoted membrane cohesivity are required for pulmonary surfactant films to stabilize and protect the respiratory surface.

Bernardino de la Serna J, Vargas R, Picardi V, Cruz A, Arranz R, Valpuesta JM, Mateu L, Pérez-Gil J.

Faraday Discuss. 2013;161:535-48; discussion 563-89.

PMID:
23805757
39.

Interaction of p53 with the CCT complex promotes protein folding and wild-type p53 activity.

Trinidad AG, Muller PA, Cuellar J, Klejnot M, Nobis M, Valpuesta JM, Vousden KH.

Mol Cell. 2013 Jun 27;50(6):805-17. doi: 10.1016/j.molcel.2013.05.002. Epub 2013 Jun 6.

40.

Structure and non-structure of centrosomal proteins.

Dos Santos HG, Abia D, Janowski R, Mortuza G, Bertero MG, Boutin M, Guarín N, Méndez-Giraldez R, Nuñez A, Pedrero JG, Redondo P, Sanz M, Speroni S, Teichert F, Bruix M, Carazo JM, Gonzalez C, Reina J, Valpuesta JM, Vernos I, Zabala JC, Montoya G, Coll M, Bastolla U, Serrano L.

PLoS One. 2013 May 9;8(5):e62633. doi: 10.1371/journal.pone.0062633. Print 2013.

41.

Large terminase conformational change induced by connector binding in bacteriophage T7.

Daudén MI, Martín-Benito J, Sánchez-Ferrero JC, Pulido-Cid M, Valpuesta JM, Carrascosa JL.

J Biol Chem. 2013 Jun 7;288(23):16998-7007. doi: 10.1074/jbc.M112.448951. Epub 2013 Apr 30.

42.

Structural insights into the chaperone activity of the 40-kDa heat shock protein DnaJ: binding and remodeling of a native substrate.

Cuéllar J, Perales-Calvo J, Muga A, Valpuesta JM, Moro F.

J Biol Chem. 2013 May 24;288(21):15065-74. doi: 10.1074/jbc.M112.430595. Epub 2013 Apr 11.

43.

Recognition of membrane-bound fusion-peptide/MPER complexes by the HIV-1 neutralizing 2F5 antibody: implications for anti-2F5 immunogenicity.

Huarte N, Araujo A, Arranz R, Lorizate M, Quendler H, Kunert R, Valpuesta JM, Nieva JL.

PLoS One. 2012;7(12):e52740. doi: 10.1371/journal.pone.0052740. Epub 2012 Dec 21.

44.

Mechanical identities of RNA and DNA double helices unveiled at the single-molecule level.

Herrero-Galán E, Fuentes-Perez ME, Carrasco C, Valpuesta JM, Carrascosa JL, Moreno-Herrero F, Arias-Gonzalez JR.

J Am Chem Soc. 2013 Jan 9;135(1):122-31. doi: 10.1021/ja3054755. Epub 2012 Dec 24.

PMID:
23214411
45.

The structure of native influenza virion ribonucleoproteins.

Arranz R, Coloma R, Chichón FJ, Conesa JJ, Carrascosa JL, Valpuesta JM, Ortín J, Martín-Benito J.

Science. 2012 Dec 21;338(6114):1634-7. doi: 10.1126/science.1228172. Epub 2012 Nov 22.

46.

Phosphoinositide 3-kinase beta controls replication factor C assembly and function.

Redondo-Muñoz J, Rodríguez MJ, Silió V, Pérez-García V, Valpuesta JM, Carrera AC.

Nucleic Acids Res. 2013 Jan;41(2):855-68. doi: 10.1093/nar/gks1095. Epub 2012 Nov 21.

47.

The hexameric structure of a conjugative VirB4 protein ATPase provides new insights for a functional and phylogenetic relationship with DNA translocases.

Peña A, Matilla I, Martín-Benito J, Valpuesta JM, Carrascosa JL, de la Cruz F, Cabezón E, Arechaga I.

J Biol Chem. 2012 Nov 16;287(47):39925-32. doi: 10.1074/jbc.M112.413849. Epub 2012 Oct 3.

48.

The yeast THO complex forms a 5-subunit assembly that directly interacts with active chromatin.

Gewartowski K, Cuéllar J, Dziembowski A, Valpuesta JM.

Bioarchitecture. 2012 Jul-Aug;2(4):134-7. doi: 10.4161/bioa.21181. Epub 2012 Jul 1.

49.

Manipulation of single polymerase-DNA complexes: a mechanical view of DNA unwinding during replication.

Morin JA, Cao FJ, Valpuesta JM, Carrascosa JL, Salas M, Ibarra B.

Cell Cycle. 2012 Aug 15;11(16):2967-8. doi: 10.4161/cc.21389. Epub 2012 Aug 8. No abstract available.

50.

Active DNA unwinding dynamics during processive DNA replication.

Morin JA, Cao FJ, Lázaro JM, Arias-Gonzalez JR, Valpuesta JM, Carrascosa JL, Salas M, Ibarra B.

Proc Natl Acad Sci U S A. 2012 May 22;109(21):8115-20. doi: 10.1073/pnas.1204759109. Epub 2012 May 9.

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